Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

Yasuko Sakurai; Hisashi Ohta; Takao Shimazoe; Yasufumi Kataoka; Michihiro Fujiwara; Showa Ueki

doi:10.1016/0024-3205(85)90569-7

Δ⁹-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

Yasuko Sakurai, Hisashi Ohta, Takao Shimazoe, Yasufumi Kataoka, Michihiro Fujiwara, Showa Ueki

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The present study was designed to examine the influence of Δ⁹-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.

Original language	English
Pages (from-to)	2181-2185
Number of pages	5
Journal	Life Sciences
Volume	37
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(85)90569-7
Publication status	Published - Dec 9 1985

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(85)90569-7

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title = "Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion",

abstract = "The present study was designed to examine the influence of Δ9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.",

author = "Yasuko Sakurai and Hisashi Ohta and Takao Shimazoe and Yasufumi Kataoka and Michihiro Fujiwara and Showa Ueki",

note = "Funding Information: This study was partly supported by Grant-in-Aid for Scientific Research from Japanese Ministry of Education, and Culture.",

year = "1985",

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T1 - Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

AU - Sakurai, Yasuko

AU - Ohta, Hisashi

AU - Shimazoe, Takao

AU - Kataoka, Yasufumi

AU - Fujiwara, Michihiro

AU - Ueki, Showa

N1 - Funding Information: This study was partly supported by Grant-in-Aid for Scientific Research from Japanese Ministry of Education, and Culture.

PY - 1985/12/9

Y1 - 1985/12/9

N2 - The present study was designed to examine the influence of Δ9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.

AB - The present study was designed to examine the influence of Δ9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.

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Δ⁹-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

Abstract

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