Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

Yasuko Sakurai, Hisashi Ohta, Takao Shimazoe, Yasufumi Kataoka, Michihiro Fujiwara, Showa Ueki

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The present study was designed to examine the influence of Δ9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.

Original languageEnglish
Pages (from-to)2181-2185
Number of pages5
JournalLife Sciences
Volume37
Issue number23
DOIs
Publication statusPublished - Dec 9 1985

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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