ζ-COP, a subunit of coatomer, is required for COP-coated vesicle assembly

O. Kuge, S. Hara-Kuge, L. Orci, M. Ravazzola, M. Amherdt, G. Tanigawa, F. T. Wieland, J. E. Rothman

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Abstract

cDNA encoding the 20-kD subunit of coatomer, ζ-COP, predicts a protein of 177-amino acid residues, similar in sequence to AP17 and AP19, subunits of the clathrin adaptor complexes. Polyclonal antibody directed to ζ-COP blocks the binding of coatomer to Golgi membranes and prevents the assembly of COP- coated vesicles on Golgi cisternae. Unlike other coatomer subunits (β-, β'- , γ-, and ε-COP), ζ-COP exists in both coatomer bound and free pools.

Original languageEnglish
Pages (from-to)1727-1734
Number of pages8
JournalJournal of Cell Biology
Volume123
Issue number6 II
DOIs
Publication statusPublished - 1993

All Science Journal Classification (ASJC) codes

  • Cell Biology

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    Kuge, O., Hara-Kuge, S., Orci, L., Ravazzola, M., Amherdt, M., Tanigawa, G., Wieland, F. T., & Rothman, J. E. (1993). ζ-COP, a subunit of coatomer, is required for COP-coated vesicle assembly. Journal of Cell Biology, 123(6 II), 1727-1734. https://doi.org/10.1083/jcb.123.6.1727