μ-Oxo-Dinuclear-Iron(III)-Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of Tertiary Alcohols

Rikiya Horikawa, Chika Fujimoto, Ryo Yazaki, Takashi Ohshima

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A highly chemoselective and reactive μ-oxo-dinuclear iron(III) salen catalyst for transesterification was developed. The developed iron complex catalyzed acylation of aliphatic amino alcohols with nearly perfect O-selectivity, even when using activated esters, for which chemoselectivity is more difficult to control. In addition, O-selective transesterification of aromatic amino alcohols was achieved for the first time. The high activity of the iron complex enabled the use of sterically congested tertiary alcohols, including unprecedented tert-butanol.

Original languageEnglish
Pages (from-to)12278-12281
Number of pages4
JournalChemistry - A European Journal
Volume22
Issue number35
DOIs
Publication statusPublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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