Abstract
Starch is often used as a pharmaceutical diluent in dispensing.However,starch is susceptible to large errors in dividing weight because of its low fluidity.In the present study,we prepared granulated starch and a potato starch containing a stearic acid magnesium salt (St-starch) to improve the dispensing of powder medicines with starch diluent.These 2 starch diluents caused no problems in dispensing powder medicines in terms of pharmaceutical characteristics.In a dividing test,the coefficients of variation (C.V.) of the granulated starch and St-starch were much less than for potato starch,and met the dispensing criteria.In addition in the evaluation of ease of handling,St-starch was the best.Furthermore,the time for preparing the St-starch was much shorter (20 minutes for 2 persons) than that for granulated starch (3.5 hours).These results clearly show that St-starch is a useful starch diluent and enhances efficiency in the preparation of powder medicines with starch.
| Translated title of the contribution | Improving Preparation of Powder Medicines with Starch Diluent |
|---|---|
| Original language | Japanese |
| Pages (from-to) | 684-688 |
| Number of pages | 5 |
| Journal | 医療薬学 |
| Volume | 36 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2010 |