室内におい香り環境評価のための数理モデル開発研究:数値気道モデルを用いた気相アセトン呼吸時における前鼻腔・後鼻腔性経路の輸送動態解析

Translated title of the contribution: RESEARCH FOR DEVELOPMENT OF NUMERICAL MODEL FOR EVALUATING ODORANT IN INDOOR ENVIRONMENT: NUMERICAL IDENTIFICATION OF DIFFERENCES BETWEEN ORTHONASAL AND RETRONASAL PATHWAYS OF INHALED GAS-PHASE ACETONE IN A HUMAN RESPIRATORY TRACT

Sara Hoshiyama, Kazuki Kuga, Shinji Yoshida, Kazuhide Ito

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, following the procedure of the perceptive air quality test described in ISO 16000-28 and ISO 16000-30, we numerically analyzed the odorant transportation from the odorant generator to human breathing zone using acetone which is considered as a standard substance for pi-scale evaluation. For the evaluation of access to olfactory receptors under a transient breathing cycle, the acetone adsorption flux to the olfactory epithelial cells was calculated by using computer simulated person (CSP) with numerical respiratory tract model and physiologically based pharmacokinetic (PBPK) model.

Gaseous odorants in the indoor air are low-molecular-weight organic compounds with a molecular weight of less than about 300. Inhaled odorants are generally deposited on the olfactory epithelium in the nasal cavity and dissolved in the olfactory mucus that covers the olfactory epithelium. The concentration of inhaled odorants causes differences in the probability of access to olfactory receptors. As a result, the adsorption rate to olfactory region affects odor intensity, pleasantness/displeasure, and odor concentration. However, it is not clear how the inhaled odorants related to the odor intensity. In this study, following the procedure of the perceptive air quality test described in ISO 16000-28 and ISO 16000-30, we numerically analyzed the odorant transportation from the odorant generator to human breathing zone using acetone which is considered as a standard substance for pi-scale evaluation. For the evaluation of access to olfactory receptors under a transient breathing, the acetone adsorption flux to the olfactory epithelial cells was calculated by using computer simulated person (CSP) with numerical respiratory tract model and physiologically based pharmacokinetic (PBPK) model. The numerical respiratory tract model consists of the detailed geometry from the nasal cavity to the fourth generation of bronchial tubes based on CT data. Additionally, to investigate the mixing effects of human thermal plume and exhalation on the intensity of inhaled odorants, the relative location of the odorant generator to the nasal openings was varied. Through a series of our simulations, we indicated that: (i) changes in the concentration of inhaled acetone every breath, and (ii) the acetone adsorption rate to the olfactory epithelial cells corresponding to the distance and angle between the odorant generator and nasal openings. These findings might contribute to more adequate design the perceptive air quality test.

Translated title of the contributionRESEARCH FOR DEVELOPMENT OF NUMERICAL MODEL FOR EVALUATING ODORANT IN INDOOR ENVIRONMENT: NUMERICAL IDENTIFICATION OF DIFFERENCES BETWEEN ORTHONASAL AND RETRONASAL PATHWAYS OF INHALED GAS-PHASE ACETONE IN A HUMAN RESPIRATORY TRACT
Original languageJapanese
Pages (from-to)541-549
Number of pages9
JournalJournal of Environmental Engineering (Japan)
Volume87
Issue number798
DOIs
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • Environmental Engineering

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