1-methyl-4-phenylpyridinium (MPP+) inhibits mitochondrial oxygen consumption mediated by succinate as well as malate in rat pheochromocytoma PC12 cells

E. Hasegawa, H. Asagami, D. Kang, S. Minakami, K. Takeshige

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

When rat pheochromocytoma PC12 cells are cultured with 1 mM 1-methyl-4-phenylpyridinium (MPP+), the number of viable cells decreases to one third in 4 days while the number increases ten-fold without MPP+. Oxygen consumption by mitochondria in the presence of malate is inhibited about 80% by the treatment of the cells with MPP+ for 4 days. Unexpectedly, succinate-dependent oxygen consumption is also inhibited to essentially the same extent as malate-dependent one. These results suggest that the impairment of the respiration mediated by succinate as well as malate is important as a mechanism of MPP+-induced cell death.

Original languageEnglish
Pages (from-to)409-413
Number of pages5
JournalBiochemistry and Molecular Biology International
Volume35
Issue number2
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of '1-methyl-4-phenylpyridinium (MPP<sup>+</sup>) inhibits mitochondrial oxygen consumption mediated by succinate as well as malate in rat pheochromocytoma PC12 cells'. Together they form a unique fingerprint.

  • Cite this