1,1,4,7,10,10-Hexamethyltriethylenetetramine

A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

Mariko Goto, Koh ichi Akimoto, Kazumasa Aoki, Mitsuru Shindo, Kenji Koga

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.

Original languageEnglish
Pages (from-to)8129-8132
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number46
DOIs
Publication statusPublished - Nov 12 1999
Externally publishedYes

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Tetralones
Alkylation
Lithium
1,1,4,7,10,10-Hexamethyltriethylenetetramine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

1,1,4,7,10,10-Hexamethyltriethylenetetramine : A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides. / Goto, Mariko; Akimoto, Koh ichi; Aoki, Kazumasa; Shindo, Mitsuru; Koga, Kenji.

In: Tetrahedron Letters, Vol. 40, No. 46, 12.11.1999, p. 8129-8132.

Research output: Contribution to journalArticle

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AU - Koga, Kenji

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