1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

Mariko Goto, Koh ichi Akimoto, Kazumasa Aoki, Mitsuru Shindo, Kenji Koga

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.

Original languageEnglish
Pages (from-to)8129-8132
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number46
DOIs
Publication statusPublished - Nov 12 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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