1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

Mariko Goto, Koh ichi Akimoto, Kazumasa Aoki, Mitsuru Shindo, Kenji Koga

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.

Original languageEnglish
Pages (from-to)8129-8132
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number46
DOIs
Publication statusPublished - Nov 12 1999
Externally publishedYes

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Tetralones
Alkylation
Lithium
1,1,4,7,10,10-Hexamethyltriethylenetetramine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

1,1,4,7,10,10-Hexamethyltriethylenetetramine : A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides. / Goto, Mariko; Akimoto, Koh ichi; Aoki, Kazumasa; Shindo, Mitsuru; Koga, Kenji.

In: Tetrahedron Letters, Vol. 40, No. 46, 12.11.1999, p. 8129-8132.

Research output: Contribution to journal › Article

Goto, M, Akimoto, KI, Aoki, K, Shindo, M & Koga, K 1999, '1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides', Tetrahedron Letters, vol. 40, no. 46, pp. 8129-8132. https://doi.org/10.1016/S0040-4039(99)01721-9
Goto M, Akimoto KI, Aoki K, Shindo M, Koga K. 1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides. Tetrahedron Letters. 1999 Nov 12;40(46):8129-8132. https://doi.org/10.1016/S0040-4039(99)01721-9
Goto, Mariko ; Akimoto, Koh ichi ; Aoki, Kazumasa ; Shindo, Mitsuru ; Koga, Kenji. / 1,1,4,7,10,10-Hexamethyltriethylenetetramine : A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides. In: Tetrahedron Letters. 1999 ; Vol. 40, No. 46. pp. 8129-8132.
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