1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

Mariko Goto; Koh ichi Akimoto; Kazumasa Aoki; Mitsuru Shindo; Kenji Koga

doi:10.1016/S0040-4039(99)01721-9

1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

Mariko Goto, Koh ichi Akimoto, Kazumasa Aoki, Mitsuru Shindo, Kenji Koga

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.

Original language	English
Pages (from-to)	8129-8132
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	46
DOIs	https://doi.org/10.1016/S0040-4039(99)01721-9
Publication status	Published - Nov 12 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(99)01721-9

Fingerprint Dive into the research topics of '1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides'. Together they form a unique fingerprint.

Cite this

1,1,4,7,10,10-Hexamethyltriethylenetetramine : A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides. / Goto, Mariko; Akimoto, Koh ichi; Aoki, Kazumasa; Shindo, Mitsuru; Koga, Kenji.

In: Tetrahedron Letters, Vol. 40, No. 46, 12.11.1999, p. 8129-8132.

Research output: Contribution to journal › Article › peer-review

@article{836435d36f994652ae6f33d657f0912b,

title = "1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides",

abstract = "The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.",

author = "Mariko Goto and Akimoto, {Koh ichi} and Kazumasa Aoki and Mitsuru Shindo and Kenji Koga",

year = "1999",

month = nov,

day = "12",

doi = "10.1016/S0040-4039(99)01721-9",

language = "English",

volume = "40",

pages = "8129--8132",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "46",

}

TY - JOUR

T1 - 1,1,4,7,10,10-Hexamethyltriethylenetetramine

T2 - A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

AU - Goto, Mariko

AU - Akimoto, Koh ichi

AU - Aoki, Kazumasa

AU - Shindo, Mitsuru

AU - Koga, Kenji

PY - 1999/11/12

Y1 - 1999/11/12

N2 - The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.

AB - The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.

UR - http://www.scopus.com/inward/record.url?scp=0033550194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033550194&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(99)01721-9

DO - 10.1016/S0040-4039(99)01721-9

M3 - Article

AN - SCOPUS:0033550194

VL - 40

SP - 8129

EP - 8132

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 46

ER -