125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: Synthesis and preliminary tissue distribution

Fumihiko Yamamoto, Eri Kuwano, Tetsuo Kaneshiro, Shigeki Sasaki, Minoru Maeda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Three 125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12-60% after HPLC purification. Biodistribution studies in tumor-bearing mice showed very different in vivo tissue uptake properties from previous results obtained with 14C-labeled ascorbic acid and 6-deoxy-6-[18F]fluoro-L-ascorbic acid. None of these seems to be suitable radioiodinated analogs of L-ascorbic acid for imaging study of its in vivo biochemistry.

Original languageEnglish
Pages (from-to)737-750
Number of pages14
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number8
DOIs
Publication statusPublished - Jul 1 2003

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Tissue Distribution
Ascorbic Acid
Bearings (structural)
Tissue
Derivatives
Biochemistry
Ascorbic acid
Purification
Tumors
Imaging techniques
High Pressure Liquid Chromatography
Neoplasms
6-deoxy-6-fluoroascorbic acid
Ac-Nal(1)-Cpa(2)-Pal(3,6)-Arg(5)-Ala(10)-lHRH

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid : Synthesis and preliminary tissue distribution. / Yamamoto, Fumihiko; Kuwano, Eri; Kaneshiro, Tetsuo; Sasaki, Shigeki; Maeda, Minoru.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, No. 8, 01.07.2003, p. 737-750.

Research output: Contribution to journalArticle

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