17, 20β-Dihydroxy-4-pregnen-3-one

Yukiko Ogino, Shinichi Miyagawa, Taisen Iguchi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

17α, 20β-Dihydroxy-4-pregnen-3-one (17α, 20β-DP), also known as a maturation-inducing hormone (MIH), is required for the meiotic maturation of oocytes and sperm maturation in teleost fish. It is produced in the ovarian follicle from the precursor, 17α-hydroxyprogesterone, by the enzyme 20β-hydroxysteroid dehydrogenase. The 17α, 20β-DP acts via its receptor, 17α, 20β-DPR, on the plasma membrane of oocytes. It also has a nuclear receptor-mediated action in the testis of the Japanese eel and the Nile tilapia.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
PublisherElsevier
Pages911-912
Number of pages2
ISBN (Electronic)9780128206492
DOIs
Publication statusPublished - Jan 1 2021

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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