17α, 20β-Dihydroxy-4-pregnen-3-one (17α, 20β-DP), also known as a maturation-inducing hormone (MIH), is required for the meiotic maturation of oocytes and sperm maturation in teleost fish. It is produced in the ovarian follicle from the precursor, 17α-hydroxyprogesterone, by the enzyme 20β-hydroxysteroid dehydrogenase. The 17α, 20β-DP acts via its receptor, 17α, 20β-DPR, on the plasma membrane of oocytes. It also has a nuclear receptor-mediated action in the testis of the Japanese eel and the Nile tilapia.
|Title of host publication||Handbook of Hormones|
|Subtitle of host publication||Comparative Endocrinology for Basic and Clinical Research|
|Number of pages||2|
|Publication status||Published - Jan 1 2021|
All Science Journal Classification (ASJC) codes