Abstract
17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DP), also known as a maturation-inducing hormone (MIH), is required for the meiotic maturation of oocytes and sperm maturation in teleost fish. It is produced in the ovarian follicle from the precursor, 17α-hydroxyprogesterone, by the enzyme 20β-hydroxysteroid dehydrogenase. The 17α,20β-DP acts via its receptor, 17α,20β-DPR, on the plasma membrane of oocytes. It also has a nuclear receptor-mediated action in the testis of the Japanese eel.
Original language | English |
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Title of host publication | Handbook of Hormones |
Subtitle of host publication | Comparative Endocrinology for Basic and Clinical Research |
Publisher | Elsevier |
Pages | 509-510 |
Number of pages | 2 |
ISBN (Electronic) | 9780128010280 |
ISBN (Print) | 9780128010679 |
DOIs | |
Publication status | Published - Jan 1 2015 |
All Science Journal Classification (ASJC) codes
- Medicine(all)