2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives

Takahiro Shirai, Motomu Kanai, Yoichiro Kuninobu

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


We developed 2-position-selective, direct C-H trifluoromethylation, pentafluoroethylation, and heptafluoropropylation of quinoline derivatives. Regioselective transformation was achieved without derivatization of the quinolines. The reaction proceeded at room temperature with high functional group tolerance, even in gram scale. Notably, the reaction was applicable to substrates containing a functional group sensitive to oxidation and a drug molecule.

Original languageEnglish
Pages (from-to)1593-1596
Number of pages4
JournalOrganic letters
Issue number6
Publication statusPublished - Mar 16 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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