20-Hz flicker stimulus can isolate the cone function in rat retina

Yoshinobu Goto, Tetsujiro Yasuda, Shozo Tobimatsu, Motohiro Kato

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Cone electroretinograms (ERGs) are typically isolated in humans by flicker stimuli against rod-desensitizing adapting fields. To investigate the manner in which adapting-field luminance affects the cone ERGs, we recorded ERGs in normal albino Sprague-Dawley rats with flicker stimuli presented against adapting fields that ranged in luminance from -∞ to 1.75 log cd/m2. A flicker rate of 20 Hz was used to isolate the cone ERGs under all adaptation conditions. We found the amplitudes of cone ERGs to increase with increasing adapting-field luminance. These response characteristics are similar to human ERGs using 30-Hz flicker stimuli, which suggests that flicker stimuli are a useful technique to isolate the cone function in rats.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalOphthalmic Research
Volume30
Issue number6
DOIs
Publication statusPublished - Nov 1 1998

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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