20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng

Sri Fatmawati, Taslim Ersam, Hongshan Yu, Chunzhi Zhang, Fengxie Jin, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The root of Panax ginseng C. A. Meyer (Araliaceae) is a well-known herbal medicine in East Asia. The major bioactive metabolites in this root are commonly identified as ginsenosides. A series of ginsenosides were determined for in vitro human recombinant aldose reductase. This Letter aims to clarify the structural requirement for aldose reductase inhibition. We discovered that only ginsenoside 20(S)-Rh2 showed potent against aldose reductase, with an IC50of 147.3 μM. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in aldose reductase inhibition. An understanding of these requirements is considered necessary in order to develop a new type of aldose reductase inhibitor. Furthermore, P. ginseng might be an important herbal medicine in preventing diabetic complications.

Original languageEnglish
Pages (from-to)4407-4409
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number18
DOIs
Publication statusPublished - Sep 15 2014

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Aldehyde Reductase
Panax
Ginsenosides
Herbal Medicine
Araliaceae
Stereochemistry
Far East
Diabetes Complications
Metabolites
Hydroxyl Radical
ginsenoside Rh2

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng. / Fatmawati, Sri; Ersam, Taslim; Yu, Hongshan; Zhang, Chunzhi; Jin, Fengxie; Shimizu, Kuniyoshi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 24, No. 18, 15.09.2014, p. 4407-4409.

Research output: Contribution to journalArticle

Fatmawati, Sri ; Ersam, Taslim ; Yu, Hongshan ; Zhang, Chunzhi ; Jin, Fengxie ; Shimizu, Kuniyoshi. / 20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng. In: Bioorganic and Medicinal Chemistry Letters. 2014 ; Vol. 24, No. 18. pp. 4407-4409.
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