2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Δ9- tetrahydrocannabinol-induced catalepsy-like immobilization in mice

Nobuaki Egashira, Emi Koushi, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of the serotonin 5-HT2A/2C-receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on Δ9- tetrahydrocannabinol (THC)-induced catalepsy-like immobilization was studied in mice. DOI (0.3 and 1 mg/kg, i.p.) significantly inhibited the catalepsy-like immobilization induced by THC (10 mg/kg, i.p.). In contrast, the selective 5-HT2C-receptor agonist 8,9-dichloro-2,3,4,4a-tetrahydro-1H- pyrazino[1,2-a]quinoxalin-5(6H)-one (WAY 161503) had no effect on this catalepsy-like immobilization. Moreover, the 5-HT2A-receptor antagonist ketanserin (0.3 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization caused by DOI (1 mg/kg), whereas the selective 5-HT2C-receptor antagonist 6-chloro-2,3-dihydro-5-methyl-N-[6-(2- methyl-3-pyridinyl)oxyl]-3-pyridinyl]-1H-indole-1-carboxyamide (SB 242084) did not affect this inhibitory effect of DOI. On the other hand, ketanserin (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). Thus, on the basis of these results, it appears that 5-HT 2A-receptor mechanisms might be responsible for the inhibitory effect of DOI on THC-induced catalepsy-like immobilization.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalJournal of Pharmacological Sciences
Volume105
Issue number4
DOIs
Publication statusPublished - Dec 1 2007

Fingerprint

Catalepsy
Dronabinol
Immobilization
Serotonin 5-HT2 Receptor Agonists
Receptor, Serotonin, 5-HT2C
Serotonin 5-HT2 Receptor Antagonists
Receptor, Serotonin, 5-HT2A
Ketanserin
4-iodoamphetamine

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Δ9- tetrahydrocannabinol-induced catalepsy-like immobilization in mice. / Egashira, Nobuaki; Koushi, Emi; Mishima, Kenichi; Iwasaki, Katsunori; Oishi, Ryozo; Fujiwara, Michihiro.

In: Journal of Pharmacological Sciences, Vol. 105, No. 4, 01.12.2007, p. 361-366.

Research output: Contribution to journalArticle

Egashira, Nobuaki ; Koushi, Emi ; Mishima, Kenichi ; Iwasaki, Katsunori ; Oishi, Ryozo ; Fujiwara, Michihiro. / 2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Δ9- tetrahydrocannabinol-induced catalepsy-like immobilization in mice. In: Journal of Pharmacological Sciences. 2007 ; Vol. 105, No. 4. pp. 361-366.
@article{c68cf05c8f8049a18afddfc14cef4a4e,
title = "2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Δ9- tetrahydrocannabinol-induced catalepsy-like immobilization in mice",
abstract = "The effect of the serotonin 5-HT2A/2C-receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on Δ9- tetrahydrocannabinol (THC)-induced catalepsy-like immobilization was studied in mice. DOI (0.3 and 1 mg/kg, i.p.) significantly inhibited the catalepsy-like immobilization induced by THC (10 mg/kg, i.p.). In contrast, the selective 5-HT2C-receptor agonist 8,9-dichloro-2,3,4,4a-tetrahydro-1H- pyrazino[1,2-a]quinoxalin-5(6H)-one (WAY 161503) had no effect on this catalepsy-like immobilization. Moreover, the 5-HT2A-receptor antagonist ketanserin (0.3 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization caused by DOI (1 mg/kg), whereas the selective 5-HT2C-receptor antagonist 6-chloro-2,3-dihydro-5-methyl-N-[6-(2- methyl-3-pyridinyl)oxyl]-3-pyridinyl]-1H-indole-1-carboxyamide (SB 242084) did not affect this inhibitory effect of DOI. On the other hand, ketanserin (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). Thus, on the basis of these results, it appears that 5-HT 2A-receptor mechanisms might be responsible for the inhibitory effect of DOI on THC-induced catalepsy-like immobilization.",
author = "Nobuaki Egashira and Emi Koushi and Kenichi Mishima and Katsunori Iwasaki and Ryozo Oishi and Michihiro Fujiwara",
year = "2007",
month = "12",
day = "1",
doi = "10.1254/jphs.FP0071247",
language = "English",
volume = "105",
pages = "361--366",
journal = "Journal of Pharmacological Sciences",
issn = "1347-8613",
publisher = "Japanese Pharmacological Society",
number = "4",

}

TY - JOUR

T1 - 2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Δ9- tetrahydrocannabinol-induced catalepsy-like immobilization in mice

AU - Egashira, Nobuaki

AU - Koushi, Emi

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

PY - 2007/12/1

Y1 - 2007/12/1

N2 - The effect of the serotonin 5-HT2A/2C-receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on Δ9- tetrahydrocannabinol (THC)-induced catalepsy-like immobilization was studied in mice. DOI (0.3 and 1 mg/kg, i.p.) significantly inhibited the catalepsy-like immobilization induced by THC (10 mg/kg, i.p.). In contrast, the selective 5-HT2C-receptor agonist 8,9-dichloro-2,3,4,4a-tetrahydro-1H- pyrazino[1,2-a]quinoxalin-5(6H)-one (WAY 161503) had no effect on this catalepsy-like immobilization. Moreover, the 5-HT2A-receptor antagonist ketanserin (0.3 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization caused by DOI (1 mg/kg), whereas the selective 5-HT2C-receptor antagonist 6-chloro-2,3-dihydro-5-methyl-N-[6-(2- methyl-3-pyridinyl)oxyl]-3-pyridinyl]-1H-indole-1-carboxyamide (SB 242084) did not affect this inhibitory effect of DOI. On the other hand, ketanserin (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). Thus, on the basis of these results, it appears that 5-HT 2A-receptor mechanisms might be responsible for the inhibitory effect of DOI on THC-induced catalepsy-like immobilization.

AB - The effect of the serotonin 5-HT2A/2C-receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on Δ9- tetrahydrocannabinol (THC)-induced catalepsy-like immobilization was studied in mice. DOI (0.3 and 1 mg/kg, i.p.) significantly inhibited the catalepsy-like immobilization induced by THC (10 mg/kg, i.p.). In contrast, the selective 5-HT2C-receptor agonist 8,9-dichloro-2,3,4,4a-tetrahydro-1H- pyrazino[1,2-a]quinoxalin-5(6H)-one (WAY 161503) had no effect on this catalepsy-like immobilization. Moreover, the 5-HT2A-receptor antagonist ketanserin (0.3 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization caused by DOI (1 mg/kg), whereas the selective 5-HT2C-receptor antagonist 6-chloro-2,3-dihydro-5-methyl-N-[6-(2- methyl-3-pyridinyl)oxyl]-3-pyridinyl]-1H-indole-1-carboxyamide (SB 242084) did not affect this inhibitory effect of DOI. On the other hand, ketanserin (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). Thus, on the basis of these results, it appears that 5-HT 2A-receptor mechanisms might be responsible for the inhibitory effect of DOI on THC-induced catalepsy-like immobilization.

UR - http://www.scopus.com/inward/record.url?scp=37549024193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37549024193&partnerID=8YFLogxK

U2 - 10.1254/jphs.FP0071247

DO - 10.1254/jphs.FP0071247

M3 - Article

C2 - 18057774

AN - SCOPUS:37549024193

VL - 105

SP - 361

EP - 366

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8613

IS - 4

ER -