TY - JOUR
T1 - 3-hydroxy-3-methylglutaryl coa reductase inhibitor retards chicken embryonic growth
AU - Sato, Momoka
AU - Furuse, Mitsuhiro
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - In order to clarify the mechanism by which liver cholesterol content is elevated during chicken (Gallus gallus domesticus) embryonic development, fertilized eggs were administrated pravastatin in ovo, a 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase) inhibitor, at embryonic day 14 (E14). Embryonic growth and hepatic lipid content were determined at embryonic day 18 (El 8). Embryonic growth was retarded by pravastatin in a dose-dependent manner. In addition, hepatic total cholesterol, triacylglycerol and phospholipid contents were decreased with increased pravastatin. These results suggest that higher hepatic cholesterol was associated with HMG-CoA reductase activity and embryonic growth was affected by cholesterol synthesis.
AB - In order to clarify the mechanism by which liver cholesterol content is elevated during chicken (Gallus gallus domesticus) embryonic development, fertilized eggs were administrated pravastatin in ovo, a 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase) inhibitor, at embryonic day 14 (E14). Embryonic growth and hepatic lipid content were determined at embryonic day 18 (El 8). Embryonic growth was retarded by pravastatin in a dose-dependent manner. In addition, hepatic total cholesterol, triacylglycerol and phospholipid contents were decreased with increased pravastatin. These results suggest that higher hepatic cholesterol was associated with HMG-CoA reductase activity and embryonic growth was affected by cholesterol synthesis.
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U2 - 10.1080/09712119.2009.9707020
DO - 10.1080/09712119.2009.9707020
M3 - Article
AN - SCOPUS:77749346002
VL - 36
SP - 7
JO - Journal of Applied Animal Research
JF - Journal of Applied Animal Research
SN - 0971-2119
IS - 1
ER -