3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus

Enos Tangke Arung, Kuniyoshi Shimizu, Hiroyuki Tanaka, Ryuichiro Kondo

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC 50 of mushroom tyrosinase inhibitotry activity of 1 was 76.3 μM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC 50 of 1 was 56.7 μM with less cytotoxicity.

Original languageEnglish
Pages (from-to)640-643
Number of pages4
JournalFitoterapia
Volume81
Issue number6
DOIs
Publication statusPublished - Sep 1 2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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