3,5-dihydroxyphenyl-glycine: A potent agonist of metabotropic glutamate receptors

I. Ito, A. Kohda, S. Tanabe, E. Hirose, M. Hayashi, S. Mitsunaga, H. Sugiyama

Research output: Contribution to journalArticlepeer-review

191 Citations (Scopus)

Abstract

An amino acid, 3,5-dihydroxyphenylglycine (DHPG) induced current responses in Xenopus oocytes expressing a metabotropic glutamate receptor clone mGIuRl. Apparent EC50 of DHPG for mGluRl was slightly lower than that of (±)-l-aminocyclopentane-trans-l,3-dicarboxylic acid (ACPD). DHPG responses were partially inhibited by 2-amino-3-phosphonopropionic acid (AP-3). DHPG had no effect on ionotropic glutamate receptors whose expression was induced in the oocytes following injection of poly(A)+ mRNA of rat brains. In hippocampal slices, DHPG produced slow excitation of pyramidal cells, resulting from a depression of Ca2+-dependent K+ current and a voltage-dependent K+ current. These results indicate that DHPG is a specific and potent agonist of mGluRs.

Original languageEnglish
Pages (from-to)1013-1016
Number of pages4
JournalNeuroReport
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 1992

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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