5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

Jie Liu, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC50 of 10.6 μM and 41.9 μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.

Original languageEnglish
Pages (from-to)392-395
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2006

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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