TY - JOUR
T1 - 5-Aryl-1,3,4-oxadiazole-2-thiols as a new series of trans-cinnamate 4-hydroxylase inhibitors
AU - Yamada, Naotaka
AU - Kataoka, Yuki
AU - Nagami, Takamichi
AU - Hong, Soonsung
AU - Kawai, Shinya
AU - Kuwano, Eiichi
PY - 2004
Y1 - 2004
N2 - A series of 5-aryl-1,3,4-oxadiazole-2-thiols was found to inhibit trans-cinnamate 4-hydroxylase (C4H) from Populus kitakamiensis, which was expressed in yeast. 5-Phenyl-1,3,4-oxadiazole-2-thiol showed inhibitory activity comparable to 2-hydroxy-1-naphthoic acid, a known C4H inhibitor. Studies on the structure-activity relationship indicated that the presence of a thiol group was significant for stronger activity. Of the compounds tested, 5-(3-fluorophenyl)-1,3,4-oxadiazole-2-thiol was the most active.
AB - A series of 5-aryl-1,3,4-oxadiazole-2-thiols was found to inhibit trans-cinnamate 4-hydroxylase (C4H) from Populus kitakamiensis, which was expressed in yeast. 5-Phenyl-1,3,4-oxadiazole-2-thiol showed inhibitory activity comparable to 2-hydroxy-1-naphthoic acid, a known C4H inhibitor. Studies on the structure-activity relationship indicated that the presence of a thiol group was significant for stronger activity. Of the compounds tested, 5-(3-fluorophenyl)-1,3,4-oxadiazole-2-thiol was the most active.
UR - http://www.scopus.com/inward/record.url?scp=11444264694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11444264694&partnerID=8YFLogxK
U2 - 10.1584/jpestics.29.205
DO - 10.1584/jpestics.29.205
M3 - Article
AN - SCOPUS:11444264694
SN - 1348-589X
VL - 29
SP - 205
EP - 208
JO - Journal of Pesticide Sciences
JF - Journal of Pesticide Sciences
IS - 3
ER -