5-HT2A promoter polymorphism is not associated with anorexia nervosa in Japanese patients

Tetsuya Ando, Gen Komaki, Masami Karibe, Noriyuki Kawamura, Shinichiro Hara, Masato Takii, Tetsuo Naruo, Nobuo Kurokawa, Michiko Takei, Naoko Tatsuta, Mariko Ohba, Shinichi Nozoe, Chiharu Kubo, Toshio Ishikawa

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Genetic factors have been implicated in playing a significant role in susceptibility to anorexia nervosa (AN). Among many candidate genes for AN, an association with the A allele of the -1438G/A polymorphism in the promoter region of the 5-HT2A receptor has been reported. However, these findings are controversial and all patients studied to date have been Caucasian. This study was designed to determine whether this association is reproducible in Japanese subjects. This case-control study of a cohort of 75 female Japanese AN sufferers and 127 normal female control subjects revealed no significant association between the 5-HT2A promoter polymorphism and AN. Thus, at least for Japanese subjects, the A-allele of the -1438G/A polymorphism in the promoter region of the 5-HT2A receptor gene does not contribute to a predisposition to AN.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalPsychiatric Genetics
Volume11
Issue number3
DOIs
Publication statusPublished - Oct 30 2001

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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