5-HT2A receptor stimulation by DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens

Toshihide Kuroki; Herbert Y. Meltzer; Junji Ichikawa

doi:10.1016/S0006-8993(03)02516-2

5-HT_2A receptor stimulation by DOI, a 5-HT_2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens

Toshihide Kuroki, Herbert Y. Meltzer, Junji Ichikawa

Clinical Psychology Practice

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Abstract

(±)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT_2A/2C agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT_2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT_2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.

Original language	English
Pages (from-to)	216-221
Number of pages	6
Journal	Brain Research
Volume	972
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)02516-2
Publication status	Published - May 16 2003

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All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Cite this

Kuroki, T., Meltzer, H. Y., & Ichikawa, J. (2003). 5-HT_2A receptor stimulation by DOI, a 5-HT_2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Brain Research, 972(1-2), 216-221. https://doi.org/10.1016/S0006-8993(03)02516-2

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abstract = "(±)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT2A/2C agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.",

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10.1016/S0006-8993(03)02516-2