TY - JOUR
T1 - 5-HT2A receptor stimulation by DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
AU - Kuroki, Toshihide
AU - Meltzer, Herbert Y.
AU - Ichikawa, Junji
PY - 2003/5/16
Y1 - 2003/5/16
N2 - (±)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT2A/2C agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.
AB - (±)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT2A/2C agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.
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U2 - 10.1016/S0006-8993(03)02516-2
DO - 10.1016/S0006-8993(03)02516-2
M3 - Article
C2 - 12711095
AN - SCOPUS:0037449148
VL - 972
SP - 216
EP - 221
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1-2
ER -