5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction-Extraction System Using a Microreactor and Extractor

Yosuke Muranaka; Kenta Matsubara; Taisuke Maki; Shusaku Asano; Hiroyuki Nakagawa; Kazuhiro Mae

doi:10.1021/acsomega.0c00399

5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction-Extraction System Using a Microreactor and Extractor

Yosuke Muranaka, Kenta Matsubara, Taisuke Maki, Shusaku Asano, Hiroyuki Nakagawa, Kazuhiro Mae

Department of Advanced Device Materials

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.

Original language	English
Journal	ACS Omega
DOIs	https://doi.org/10.1021/acsomega.0c00399
Publication status	Accepted/In press - 2020

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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10.1021/acsomega.0c00399

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title = "5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction-Extraction System Using a Microreactor and Extractor",

abstract = "5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.",

author = "Yosuke Muranaka and Kenta Matsubara and Taisuke Maki and Shusaku Asano and Hiroyuki Nakagawa and Kazuhiro Mae",

note = "Funding Information: This work was financially supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan Grant-in-Aid for Young Scientists (grant no. 19K15350). ",

year = "2020",

doi = "10.1021/acsomega.0c00399",

language = "English",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

}

TY - JOUR

T1 - 5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction-Extraction System Using a Microreactor and Extractor

AU - Muranaka, Yosuke

AU - Matsubara, Kenta

AU - Maki, Taisuke

AU - Asano, Shusaku

AU - Nakagawa, Hiroyuki

AU - Mae, Kazuhiro

N1 - Funding Information: This work was financially supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan Grant-in-Aid for Young Scientists (grant no. 19K15350).

PY - 2020

Y1 - 2020

N2 - 5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.

AB - 5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.

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