TY - JOUR
T1 - 5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction-Extraction System Using a Microreactor and Extractor
AU - Muranaka, Yosuke
AU - Matsubara, Kenta
AU - Maki, Taisuke
AU - Asano, Shusaku
AU - Nakagawa, Hiroyuki
AU - Mae, Kazuhiro
N1 - Funding Information:
This work was financially supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan Grant-in-Aid for Young Scientists (grant no. 19K15350).
Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/4/28
Y1 - 2020/4/28
N2 - 5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.
AB - 5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.
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U2 - 10.1021/acsomega.0c00399
DO - 10.1021/acsomega.0c00399
M3 - Article
AN - SCOPUS:85083875188
VL - 5
SP - 9384
EP - 9390
JO - ACS Omega
JF - ACS Omega
SN - 2470-1343
IS - 16
ER -