6-Vinylated guanosine as a novel cross-linking agent and its versatile synthesis from the 6-O-tosylate by Pd(0)-catalyzed cross-coupling

Fumi Nagatsugi, Kengo Uemura, Shouji Nakashima, Minoru Maeda, Shigeki Sasaki

Research output: Contribution to journalArticle

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Abstract

6-Vinylated guanosine (1) was designed as a novel cross-linking agent, and synthesized by a new Pd(0)-catalyzed cross-coupling reaction using guanosine 6-O-tosylate and vinyltributylstannane. Its potential as a cross-linking agent was demonstrated by adduct formation with guanosine and cytidine at the 7-N and 4-N positions, respectively.

Original languageEnglish
Pages (from-to)421-424
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number3
DOIs
Publication statusPublished - Jan 16 1995

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Guanosine
Cytidine
Cross Reactions

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

6-Vinylated guanosine as a novel cross-linking agent and its versatile synthesis from the 6-O-tosylate by Pd(0)-catalyzed cross-coupling. / Nagatsugi, Fumi; Uemura, Kengo; Nakashima, Shouji; Maeda, Minoru; Sasaki, Shigeki.

In: Tetrahedron Letters, Vol. 36, No. 3, 16.01.1995, p. 421-424.

Research output: Contribution to journalArticle

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