8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis

Keishi Sugimachi; Rui Yamaguchi; Hidetoshi Eguchi; Masami Ueda; Atsushi Niida; Shotaro Sakimura; Hidenari Hirata; Ryutaro Uchi; Yoshiaki Shinden; Tomohiro Iguchi; Kazutoyo Morita; Ken Yamamoto; Satoru Miyano; Masaki Mori; Yoshihiko Maehara; Koshi Mimori

doi:10.1245/s10434-016-5374-1

8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis

Keishi Sugimachi, Rui Yamaguchi, Hidetoshi Eguchi, Masami Ueda, Atsushi Niida, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Yoshiaki Shinden, Tomohiro Iguchi, Kazutoyo Morita, Ken Yamamoto, Satoru Miyano, Masaki Mori, Yoshihiko Maehara, Koshi Mimori

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background: Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. Methods: 8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed. Results: Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients. Conclusions: Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.

Original language	English
Pages (from-to)	546-551
Number of pages	6
Journal	Annals of Surgical Oncology
Volume	23
DOIs	https://doi.org/10.1245/s10434-016-5374-1
Publication status	Published - Aug 1 2016

All Science Journal Classification (ASJC) codes

Surgery
Oncology

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Sugimachi, K., Yamaguchi, R., Eguchi, H., Ueda, M., Niida, A., Sakimura, S., Hirata, H., Uchi, R., Shinden, Y., Iguchi, T., Morita, K., Yamamoto, K., Miyano, S., Mori, M., Maehara, Y., & Mimori, K. (2016). 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis. Annals of Surgical Oncology, 23, 546-551. https://doi.org/10.1245/s10434-016-5374-1

8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis. / Sugimachi, Keishi; Yamaguchi, Rui; Eguchi, Hidetoshi; Ueda, Masami; Niida, Atsushi; Sakimura, Shotaro; Hirata, Hidenari; Uchi, Ryutaro; Shinden, Yoshiaki; Iguchi, Tomohiro; Morita, Kazutoyo; Yamamoto, Ken; Miyano, Satoru; Mori, Masaki; Maehara, Yoshihiko; Mimori, Koshi.

In: Annals of Surgical Oncology, Vol. 23, 01.08.2016, p. 546-551.

Research output: Contribution to journal › Article › peer-review

Sugimachi, K, Yamaguchi, R, Eguchi, H, Ueda, M, Niida, A, Sakimura, S, Hirata, H, Uchi, R, Shinden, Y, Iguchi, T, Morita, K, Yamamoto, K, Miyano, S, Mori, M, Maehara, Y & Mimori, K 2016, '8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis', Annals of Surgical Oncology, vol. 23, pp. 546-551. https://doi.org/10.1245/s10434-016-5374-1

Sugimachi, Keishi ; Yamaguchi, Rui ; Eguchi, Hidetoshi ; Ueda, Masami ; Niida, Atsushi ; Sakimura, Shotaro ; Hirata, Hidenari ; Uchi, Ryutaro ; Shinden, Yoshiaki ; Iguchi, Tomohiro ; Morita, Kazutoyo ; Yamamoto, Ken ; Miyano, Satoru ; Mori, Masaki ; Maehara, Yoshihiko ; Mimori, Koshi. / 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis. In: Annals of Surgical Oncology. 2016 ; Vol. 23. pp. 546-551.

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abstract = "Background: Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. Methods: 8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed. Results: Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients. Conclusions: Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.",

author = "Keishi Sugimachi and Rui Yamaguchi and Hidetoshi Eguchi and Masami Ueda and Atsushi Niida and Shotaro Sakimura and Hidenari Hirata and Ryutaro Uchi and Yoshiaki Shinden and Tomohiro Iguchi and Kazutoyo Morita and Ken Yamamoto and Satoru Miyano and Masaki Mori and Yoshihiko Maehara and Koshi Mimori",

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AU - Sugimachi, Keishi

AU - Yamaguchi, Rui

AU - Eguchi, Hidetoshi

AU - Ueda, Masami

AU - Niida, Atsushi

AU - Sakimura, Shotaro

AU - Hirata, Hidenari

AU - Uchi, Ryutaro

AU - Shinden, Yoshiaki

AU - Iguchi, Tomohiro

AU - Morita, Kazutoyo

AU - Yamamoto, Ken

AU - Miyano, Satoru

AU - Mori, Masaki

AU - Maehara, Yoshihiko

AU - Mimori, Koshi

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background: Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. Methods: 8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed. Results: Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients. Conclusions: Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.

AB - Background: Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. Methods: 8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed. Results: Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients. Conclusions: Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.

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