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Author

  • Hiroyuki Tsutsui
2016

Myocardial immunocompetent cells and macrophage phenotypes as histopathological surrogates for diagnosis of cardiac sarcoidosis in Japanese

Honda, Y., Nagai, T., Ikeda, Y., Sakakibara, M., Asakawa, N., Nagano, N., Nakai, M., Nishimura, K., Sugano, Y., Ohta-Ogo, K., Asaumi, Y., Aiba, T., Kanzaki, H., Kusano, K., Noguchi, T., Yasuda, S., Tsutsui, H., Ishibashi-Ueda, H. & Anzai, T., Nov 2016, In : Journal of the American Heart Association. 5, 11, e004019.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2019

Prescription rates of guideline-directed medications are associated with in-hospital mortality among Japanese patients with acute myocardial infarction: A report from JROAD-DPC study

Nakao, K., Yasuda, S., Nishimura, K., Noguchi, T., Nakai, M., Miyamoto, Y., Sumita, Y., Shishido, T., Anzai, T., Ito, H., Tsutsui, H., Saito, Y., Komuro, I. & Ogawa, H., Jan 1 2019, In : Journal of the American Heart Association. 8, 7, e009692.

Research output: Contribution to journalArticle

Open Access

Impact of population density on mortality in patients hospitalized for heart failure – JROAD-DPC Registry Analysis –

Konishi, M., Matsuzawa, Y., Ebina, T., Kosuge, M., Gohbara, M., Nishimura, K., Nakai, M., Miyamoto, Y., Saito, Y., Tsutsui, H., Komuro, I., Ogawa, H., Tamura, K. & Kimura, K., Jan 1 2019, (Accepted/In press) In : Journal of Cardiology. 75, 4, p. 447-453 7 p.

Research output: Contribution to journalArticle

2020

Left ventricular noncompaction with multiple thrombi in apical aneurysm

Yakabe, D., Matsushima, S., Uchino, S., Ohtani, K., Ide, T., Higo, T. & Tsutsui, H., Feb 1 2020, In : Internal Medicine. 59, 3, p. 377-381 5 p.

Research output: Contribution to journalArticle

Open Access
2015

Adaptive servo-ventilation therapy for patients with chronic heart failure in a confirmatory, multicenter, randomized, controlled study

SAVIOR-C Investigators, Jan 1 2015, In : Circulation Journal. 79, 5, p. 982-990 9 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2014

Evidence of drug therapy for HFpEF

Tsutsui, H., 2014, In : Respiration and Circulation. 62, 5, p. 481-486 6 p.

Research output: Contribution to journalComment/debate

2011

Long-term smoking causes more advanced coronary endothelial dysfunction in middle-aged smokers compared to young smokers

Naya, M., Morita, K., Yoshinaga, K., Manabe, O., Goto, D., Hirata, K., Katoh, C., Tamaki, N. & Tsutsui, H., Mar 1 2011, In : European Journal of Nuclear Medicine and Molecular Imaging. 38, 3, p. 491-498 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in postinfarct heart failure

Ohta, Y., Kinugawa, S., Matsushima, S., Ono, T., Sobirin, M. A., Inoue, N., Yokota, T., Hirabayashi, K. & Tsutsui, H., May 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 5

Research output: Contribution to journalArticle

34 Citations (Scopus)
2014

Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects

Okada, K., Mikami, T., Kaga, S., Nakabachi, M., Abe, A., Yokoyama, S., Nishino, H., Nishida, M., Shimizu, C., Iwano, H., Yamada, S. & Tsutsui, H., Jan 1 2014, In : Journal of Clinical Ultrasound. 42, 6, p. 341-347 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Characteristics of inoperable patients with severe aortic valve stenosis—in the era of transcatheter aortic valve replacement

Seki, T., Sakakibara, M., Shingu, Y., Katoh, H., Wakasa, S., Tsutsui, H. & Matsui, Y., Jan 1 2015, In : Annals of Thoracic and Cardiovascular Surgery. 21, 2, p. 132-138 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2011

Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus

Tsutsui, H., Kinugawa, S., Matsushima, S. & Yokota, T., Jan 1 2011, In : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 68-71 4 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)
2019

Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T: Comparison with 15O-labeled water positron emission tomography

Kikuchi, Y., Naya, M., Manabe, N. O., Manabe, O., Sugimori, H., Kudo, K., Kato, F., Aikawa, T., Tsutsui, H., Tamaki, N. & Shirato, H., Jan 1 2019, In : Magnetic Resonance in Medical Sciences. 18, 2, p. 134-141 8 p.

Research output: Contribution to journalArticle

Open Access
2014

Ca2+/calmodulin-dependent protein kinase II increases the susceptibility to the arrhythmogenic action potential alternans in spontaneously hypertensive rats

Mitsuyama, H., Yokoshiki, H., Watanabe, M., Mizukami, K., Shimokawa, J. & Tsutsui, H., Jul 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 2, p. H199-H206

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

Myocardial shortening in 3 orthogonal directions and its transmural variation in patients with nonobstructive hypertrophic cardiomyopathy

Okada, K., Yamada, S., Iwano, H., Nishino, H., Nakabachi, M., Yokoyama, S., Abe, A., Ichikawa, A., Kaga, S., Nishida, M., Hayashi, T., Murai, D., Mikami, T. & Tsutsui, H., Oct 23 2015, In : Circulation Journal. 79, 11, p. 2471-2479 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2019

Tolerability, efficacy, and safety of bisoprolol vs. Carvedilol in japanese patients with heart failure and reduced ejection fraction: The CIBIS-J trial

CIBIS-J Investigators, Jan 1 2019, In : Circulation Journal. 83, 6, p. 1269-1277 9 p.

Research output: Contribution to journalArticle

Open Access
2014

Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, S., Hirabayashi, K., Kinugawa, S., Yokota, T., Matsushima, S., Suga, T., Kadoguchi, T., Fukushima, A., Homma, T., Mizushima, W., Masaki, Y., Furihata, T., Katsuyama, R., Okita, K. & Tsutsui, H., Oct 5 2014, In : European Journal of Pharmacology. 740, p. 690-696 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Cardiac magnetic resonance performs better in the detection of functionally significant coronary artery Stenosis compared to single-photon emission computed Tomography and Dobutamine stress echocardiography

Kamiya, K., Sakakibara, M., Asakawa, N., Yamada, S., Yoshitani, T., Iwano, H., Komatsu, H., Naya, M., Chiba, S., Yamada, S., Manabe, O., Kikuchi, Y., Oyama-Manabe, N., Oba, K. & Tsutsui, H., Jan 1 2014, In : Circulation Journal. 78, 10, p. 2468-2476 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

Coexisting cardiac diseases and pressure recovery phenomenon contribute to discrepancy between the echocardiographic severity of aortic stenosis and left ventricular hypertrophy

Abe, A., Mikami, T., Kaga, S., Tsuji, K., Okada, K., Yokoyama, S., Nishino, H., Nakabachi, M., Nishida, M., Shimizu, C., Iwano, H., Yamada, S. & Tsutsui, H., Jun 1 2013, In : Journal of Echocardiography. 11, 2, p. 41-49 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Diabetes mellitus attenuates the pressure response against hypotensive stress by impairing the sympathetic regulation of the baroreflex afferent arc

Kamada, K., Saku, K., Tohyama, T., Kawada, T., Mannoji, H., Abe, K., Nishikawa, T., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Jan 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H35-H44

Research output: Contribution to journalArticle

2014

Weekend versus weekday hospital admission and outcomes during hospitalization for patients due to worsening heart failure: A report from Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Kinugawa, S., Tsuchihashi-Makaya, M., Goto, D. & Tsutsui, H., Jan 1 2014, In : Heart and Vessels. 29, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

Quantification of myocardial blood flow with dynamic perfusion 3.0 Tesla MRI: Validation with 15o-water PET

Tomiyama, Y., Manabe, O., Oyama-Manabe, N., Naya, M., Sugimori, H., Hirata, K., Mori, Y., Tsutsui, H., Kudo, K., Tamaki, N. & Katoh, C., Sep 1 2015, In : Journal of Magnetic Resonance Imaging. 42, 3, p. 754-762 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2019
2018

Pulmonary arterial input impedance reflects the mechanical properties of pulmonary arterial remodeling in rats with pulmonary hypertension

Nishikawa, T., Saku, K., Kishi, T., Tohyama, T., Abe, K., Oga, Y., Arimura, T., Sakamoto, T., Yoshida, K., Sunagawa, K. & Tsutsui, H., Nov 1 2018, In : Life Sciences. 212, p. 225-232 8 p.

Research output: Contribution to journalArticle

2019

Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway

Ikeda, S., Matsushima, S., Okabe, K., Ikeda, M., Ishikita, A., Tadokoro, T., Enzan, N., Yamamoto, T., Sada, M., Deguchi, H., Morimoto, S., Ide, T. & Tsutsui, H., Dec 1 2019, In : Scientific reports. 9, 1, 9850.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Inhibition of TLR9-NF-κB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats

Yoshida, K., Abe, K., Ishikawa, M., Saku, K., Shinoda-Sakamoto, M., Ishikawa, T., Watanabe, T., Oka, M., Sunagawa, K. & Tsutsui, H., Mar 1 2019, In : Cardiovascular research. 115, 3, p. 658-668 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure

Fukushima, A., Kinugawa, S., Homma, T., Masaki, Y., Furihata, T., Yokota, T., Matsushima, S., Abe, T., Suga, T., Takada, S., Kadoguchi, T., Katsuyama, R., Oba, K., Okita, K. & Tsutsui, H., Oct 12 2013, In : International Journal of Cardiology. 168, 5

Research output: Contribution to journalArticle

21 Citations (Scopus)
2018

Diagnostic value of quantitative coronary flow reserve and myocardial blood flow estimated by dynamic 320 MDCT scanning in patients with obstructive coronary artery disease

Obara, M., Naya, M., Oyama-Manabe, N., Aikawa, T., Tomiyama, Y., Sasaki, T., Kikuchi, Y., Manabe, O., Katoh, C., Tamaki, N. & Tsutsui, H., Jul 1 2018, In : Medicine (United States). 97, 27, e11354.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Randomized trial of effect of urate-lowering agent febuxostat in chronic heart failure patients with hyperuricemia (LEAF-CHF) study design

Yokota, T., Fukushima, A., Kinugawa, S., Okumura, T., Murohara, T. & Tsutsui, H., Jan 1 2018, In : International heart journal. 59, 5, p. 976-982 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
4 Citations (Scopus)
2017

Arterial pressure lability is improved by sodium-glucose cotransporter 2 inhibitor in streptozotocin-induced diabetic rats

Yoshikawa, T., Kishi, T., Shinohara, K., Takesue, K., Shibata, R., Sonoda, N., Inoguchi, T., Sunagawa, K., Tsutsui, H. & Hirooka, Y., Jul 1 2017, In : Hypertension Research. 40, 7, p. 646-651 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2018

Three nights leg thermal therapy could improve sleep quality in patients with chronic heart failure

Sawatari, H., Nishizaka, M. K., Miyazono, M., Ando, S. I., Inoue, S., Takemoto, M., sakamoto, T., Goto, D., Furumoto, T., Kinugawa, S., Hashiguchi, N., Rahmawati, A., Chishaki, H., Ohkusa, T., Magota, C., Tsutsui, H. & Chishaki, A., Feb 1 2018, In : Heart and Vessels. 33, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017
1 Citation (Scopus)
2018

Impact of lipopolysaccharide-induced acute inflammation on baroreflex-controlled sympathetic arterial pressure regulation

Tohyama, T., Saku, K., Kawada, T., Kishi, T., Yoshida, K., Nishikawa, T., Mannoji, H., Kamada, K., Sunagawa, K. & Tsutsui, H., Jan 2018, In : PloS one. 13, 1, e0190830.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Evaluating the Efficacy, Safety, and Tolerability of Serelaxin When Added to Standard Therapy in Asian Patients With Acute Heart Failure: Design and Rationale of RELAX-AHF-ASIA Trial

Sato, N., Lam, C. S. P., Teerlink, J. R., Greenberg, B. H., Tsutsui, H., Oh, B. H., Zhang, J., Lefkowitz, M., Hua, T. A., Holbro, T., Marshood, M., Wang, X. L. & Ge, J., Jan 1 2017, In : Journal of Cardiac Failure. 23, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2018

Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

Yoshida, K., Saku, K., Kamada, K., Abe, K., Tanaka-Ishikawa, M., Tohyama, T., Nishikawa, T., Kishi, T., Sunagawa, K. & Tsutsui, H., Oct 2018, In : JACC: Basic to Translational Science. 3, 5, p. 657-671 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Prediction of hemodynamics under left ventricular assist device

Kakino, T., Saku, K., Sakamoto, T., Sakamoto, K., Akashi, T., Ikeda, M., Ide, T., Kishi, T., Tsutsui, H. & Sunagawa, K., Jan 1 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 1, p. H80-H88

Research output: Contribution to journalArticle

3 Citations (Scopus)
2019

Efficacy and safety of ivabradine in Japanese patients with chronic heart failure ― J-SHIFT study ―

behalf of the J-SHIFT Study Investigators, Jan 1 2019, In : Circulation Journal. 83, 10, p. 2049-2060 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2017

Pitfalls of 18F-FDG PET for evaluating myocardial viability

Manabe, O., Oyama-Manabe, N., Naya, M., Aikawa, T., Sakakibara, M., Tsutsui, H. & Tamaki, N., Jun 1 2017, In : Journal of Nuclear Cardiology. 24, 3, p. 1110-1113 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cardiac fibroma with high 18 F-FDG uptake mimicking malignant tumor

Masuda, A., Manabe, O., Oyama-Manabe, N., Naya, M., Obara, M., Sakakibara, M., Hirata, K., Yamada, S., Naka, T., Tsutsui, H. & Tamaki, N., Feb 1 2017, In : Journal of Nuclear Cardiology. 24, 1, p. 323-324 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

Whole body assessment by 18 F-FDG PET in a patient with infective endocarditis

Masuda, A., Manabe, O., Naya, M., Oyama-Manabe, N., Yamada, S., Matsushima, S., Gaertner, F., Yamada, S., Tsutsui, H. & Tamaki, N., Jan 1 2013, In : Journal of Nuclear Cardiology. 20, 4, p. 641-643 3 p.

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, S., Kinugawa, S., Hirabayashi, K., Suga, T., Yokota, T., Takahashi, M., Fukushima, A., Homma, T., Ono, T., Sobirin, M. A., Masaki, Y., Mizushima, W., Kadoguchi, T., Okita, K. & Tsutsui, H., Apr 1 2013, In : Journal of Applied Physiology. 114, 7, p. 844-857 14 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2019
2 Citations (Scopus)
2011

Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinalmyocardial relaxation

Okada, K., Mikami, T., Kaga, S., Onozuka, H., Inoue, M., Yokoyama, S., Nishino, H., Nishida, M., Matsuno, K., Iwano, H., Yamada, S. & Tsutsui, H., Dec 1 2011, In : European Journal of Echocardiography. 12, 12, p. 917-923 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2018

Lipid-Lowering Therapy with Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion

Honda, K., Matoba, T., Antoku, Y., Koga, J. I., Ichi, I., Nakano, K., Tsutsui, H. & Egashira, K., Apr 1 2018, In : Arteriosclerosis, thrombosis, and vascular biology. 38, 4, p. 757-771 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2019

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., Jul 1 2019, In : Cardiovascular research. 115, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018
3 Citations (Scopus)
2013

Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice

Homma, T., Kinugawa, S., Takahashi, M., Sobirin, M. A., Saito, A., Fukushima, A., Suga, T., Takada, S., Kadoguchi, T., Masaki, Y., Furihata, T., Taniguchi, M., Nakayama, T., Ishimori, N., Iwabuchi, K. & Tsutsui, H., Sep 1 2013, In : Journal of Molecular and Cellular Cardiology. 62, p. 179-188 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2016

The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice

Furihata, T., Kinugawa, S., Takada, S., Fukushima, A., Takahashi, M., Homma, T., Masaki, Y., Tsuda, M., Matsumoto, J., Mizushima, W., Matsushima, S., Yokota, T. & Tsutsui, H., Jun 1 2016, In : IJC Heart and Vasculature. 11, p. 24-28 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice

Fukushima, A., Kinugawa, S., Takada, S., Matsushima, S., Sobirin, M. A., Ono, T., Takahashi, M., Suga, T., Homma, T., Masaki, Y., Furihata, T., Kadoguchi, T., Yokota, T., Okita, K. & Tsutsui, H., Sep 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 6, p. E503-E514

Research output: Contribution to journalArticle

18 Citations (Scopus)