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  • Hiroyuki Tsutsui
2019

Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in rats with pulmonary arterial hypertension

Shinoda, M., Saku, K., Oga, Y., Tohyama, T., Nishikawa, T., Abe, K., Yoshida, K., Kuwabara, Y., Fujii, K., Ishikawa, T., Kishi, T., Sunagawa, K. & Tsutsui, H., Aug 1 2019, In : Experimental Physiology. 104, 8, p. 1164-1178 15 p.

Research output: Contribution to journalArticle

2018

Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs

Saku, K., Kakino, T., Arimura, T., Sunagawa, G., Nishikawa, T., Sakamoto, T., Kishi, T., Tsutsui, H. & Sunagawa, K., May 1 2018, In : Circulation. Heart failure. 11, 5, p. e004397

Research output: Contribution to journalArticle

15 Citations (Scopus)
2016
12 Citations (Scopus)
2019

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Dewan, P., Jhund, P. S., Shen, L., Petrie, M. C., Abraham, W. T., Atif Ali, M., Chen, C. H., Desai, A. S., Dickstein, K., Huang, J., Kiatchoosakun, S., Kim, K. S., Køber, L., Lai, W. T., Liao, Y., Mogensen, U. M., Oh, B. H., Packer, M., Rouleau, J. L., Shi, V. & 7 others, Sibulo, A. S., Solomon, S. D., Sritara, P., Swedberg, K., Tsutsui, H., Zile, M. R. & McMurray, J. J. V., May 2019, In : European Journal of Heart Failure. 21, 5, p. 577-587 11 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2018

Three nights leg thermal therapy could improve sleep quality in patients with chronic heart failure

Sawatari, H., Nishizaka, M. K., Miyazono, M., Ando, S. I., Inoue, S., Takemoto, M., Sakamoto, T., Goto, D., Furumoto, T., Kinugawa, S., Hashiguchi, N., Rahmawati, A., Chishaki, H., Ohkusa, T., Magota, C., Tsutsui, H. & Chishaki, A., Feb 1 2018, In : Heart and Vessels. 33, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

The potential role and rationale for treatment of heart failure with sodium–glucose co-transporter 2 inhibitors

on behalf of the EMPEROR Trials Program, Nov 2017, In : European Journal of Heart Failure. 19, 11, p. 1390-1400 11 p.

Research output: Contribution to journalReview article

80 Citations (Scopus)
2016

Myocardial immunocompetent cells and macrophage phenotypes as histopathological surrogates for diagnosis of cardiac sarcoidosis in Japanese

Honda, Y., Nagai, T., Ikeda, Y., Sakakibara, M., Asakawa, N., Nagano, N., Nakai, M., Nishimura, K., Sugano, Y., Ohta-Ogo, K., Asaumi, Y., Aiba, T., Kanzaki, H., Kusano, K., Noguchi, T., Yasuda, S., Tsutsui, H., Ishibashi-Ueda, H. & Anzai, T., Nov 2016, In : Journal of the American Heart Association. 5, 11, e004019.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2013

Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Kinugawa, S., Tsuchihashi-Makaya, M., Goto, D., Yamada, S., Yokoshiki, H. & Tsutsui, H., Aug 1 2013, In : Journal of Cardiology. 62, 2, p. 95-101 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2017

Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency

Murai, D., Yamada, S., Hayashi, T., Okada, K., Nishino, H., Nakabachi, M., Yokoyama, S., Abe, A., Ichikawa, A., Ono, K., Kaga, S., Iwano, H., Mikami, T. & Tsutsui, H., May 1 2017, In : Heart and Vessels. 32, 5, p. 574-583 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure

Matsumoto, J., Takada, S., Kinugawa, S., Furihata, T., Nambu, H., Kakutani, N., Tsuda, M., Fukushima, A., Yokota, T., Tanaka, S., Takahashi, H., Watanabe, M., Hatakeyama, S., Matsumoto, M., Nakayama, K. I., Otsuka, Y., Sabe, H., Tsutsui, H. & Anzai, T., Jan 1 2018, In : Circulation. 138, 18, p. 2064-2066 3 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)
2019

Architecture of the Japan ischemic heart disease multimodal prospective data acquisition for precision treatment (J-IMPACT) system

Matoba, T., Kohro, T., Fujita, H., Nakayama, M., Kiyosue, A., Miyamoto, Y., Nishimura, K., Hashimoto, H., Antoku, Y., Nakashima, N., Ohe, K., Ogawa, H., Tsutsui, H. & Nagai, R., Jan 1 2019, In : International heart journal. 60, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

Open Access
2011

Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome

Yokota, T., Kinugawa, S., Okita, K., Hirabayashi, K., Suga, T., Hattori, M., Nakagawa, Y., Oyama-Manabe, N., Shirato, H. & Tsutsui, H., Sep 1 2011, In : Hypertension Research. 34, 9, p. 1029-1034 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2017

18F-FDG PET findings of pericardial lymphangiohemangioma

Aikawa, T., Naya, M., Oyama-Manabe, N., Maekawa, S., Nambu, H., Mitsuyama, H., Hirata, K., Kanno-Okada, H. & Tsutsui, H., Jun 1 2017, In : Journal of Nuclear Cardiology. 24, 3, p. 1107-1109 3 p.

Research output: Contribution to journalArticle

2012

Overweight causes left ventricular diastolic asynchrony and diastolic dysfunction: A study based on speckle tracking echocardiography in healthy subjects

Nakabachi, M., Mikami, T., Okada, K., Onozuka, H., Kaga, S., Inoue, M., Yokoyama, S., Nishida, M., Shimizu, C., Matsuno, K., Iwano, H., Yamada, S. & Tsutsui, H., Sep 1 2012, In : Journal of Echocardiography. 10, 3, p. 83-89 7 p.

Research output: Contribution to journalArticle

2011

Rationale and design of the Japanese Heart Failure Outpatients Disease Management and Cardiac Evaluation (J-HOMECARE)

Tsuchihashi-Makaya, M., Matsuo, H., Kakinoki, S., Takechi, S. & Tsutsui, H., Sep 1 2011, In : Journal of Cardiology. 58, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency in nonischemic and ischemic dilated cardiomyopathy

Sugiki, T., Naya, M., Manabe, O., Wakasa, S., Kubota, S., Chiba, S., Iwano, H., Yamada, S., Yoshinaga, K., Tamaki, N., Tsutsui, H. & Matsui, Y., Jul 1 2011, In : JACC: Cardiovascular Imaging. 4, 7, p. 762-770 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2019

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., Jul 1 2019, In : Cardiovascular research. 115, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2012

Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions

Takada, S., Okita, K., Suga, T., Omokawa, M., Kadoguchi, T., Sato, T., Takahashi, M., Yokota, T., Hirabayashi, K., Morita, N., Horiuchi, M., Kinugawa, S. & Tsutsui, H., Jul 15 2012, In : Journal of Applied Physiology. 113, 2, p. 199-205 7 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2019

Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Onoue, K., Soeda, T., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., Sep 17 2019, In : Journal of the American Heart Association. 8, 18, p. e012282

Research output: Contribution to journalArticle

Open Access
Open Access

Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway

Ikeda, S., Matsushima, S., Okabe, K., Ikeda, M., Ishikita, A., Tadokoro, T., Enzan, N., Yamamoto, T., Sada, M., Deguchi, H., Morimoto, S., Ide, T. & Tsutsui, H., Dec 1 2019, In : Scientific reports. 9, 1, 9850.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Association between prehospital supraglottic airway compared with bag-mask ventilation and Glasgow–Pittsburgh cerebral performance category 1 in patients with out-of-hospital cardiac arrest

Jinno, K., Hifumi, T., Okazaki, T., Kuroda, Y., Tahara, Y., Yonemoto, N., Nonogi, H., Nagao, K., Ikeda, T., Sato, N. & Tsutsui, H., Jan 1 2019, In : Circulation Journal. 83, 12, p. 2479-2486 8 p.

Research output: Contribution to journalArticle

Open Access

Outcome of patients with functional single ventricular heart after pacemaker implantation: What makes it poor, and what can we do?

Kodama, Y., Kuraoka, A., Ishikawa, Y., Nakamura, M., Ushinohama, H., Sagawa, K., Umemoto, S., Hashimoto, T., Sakamoto, I., Ohtani, K., Ide, T., Tsutsui, H. & Ishikawa, S., Dec 2019, In : Heart Rhythm. 16, 12, p. 1870-1874 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study

Japanese Circulation Society with Resuscitation Science Study Group, Dec 21 2019, In : The Lancet. 394, 10216, p. 2255-2262 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Intensive treat-to-target statin therapy in high-risk Japanese patients with hypercholesterolemia and diabetic retinopathy: Report of a randomized study

Itoh, H., Komuro, I., Takeuchi, M., Akasaka, T., Daida, H., Egashira, Y., Fujita, H., Higaki, J., Hirata, K. I., Ishibashi, S., Isshiki, T., Ito, S., Kashiwagi, A., Kato, S., Kitagawa, K., Kitakaze, M., Kitazono, T., Kurabayashi, M., Miyauchi, K., Murakami, T. & 22 others, Murohara, T., Node, K., Ogawa, S., Saito, Y., Seino, Y., Shigeeda, T., Shindo, S., Sugawara, M., Sugiyama, S., Terauchi, Y., Tsutsui, H., Ueshima, K., Utsunomiya, K., Yamagishi, M., Yamazaki, T., Yo, S., Yokote, K., Yoshida, K., Yoshimura, M., Yoshimura, N., Nakao, K. & Nagai, R., Jun 1 2018, In : Diabetes care. 41, 6, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome

Yokota, T., Kinugawa, S., Hirabayashi, K., Suga, T., Takada, S., Omokawa, M., Kadoguchi, T., Takahashi, M., Fukushima, A., Matsushima, S., Yamato, M., Okita, K. & Tsutsui, H., Jul 2017, In : Journal of Diabetes Investigation. 8, 4, p. 535-541 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2014

Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion

Matsushima, S., Tsutsui, H. & Sadoshima, J., Jan 1 2014, In : Trends in Cardiovascular Medicine. 24, 5, p. 202-205 4 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)
2019
Open Access
1 Citation (Scopus)
2017

Functional loss of DHRS7C induces intracellular ca2+ overload and myotube enlargement in C2C12 cells via calpain activation

Arai, S., Ikeda, M., Ide, T., Matsuo, Y., Fujino, T., Hirano, K., Sunagawa, K. & Tsutsui, H., Jan 1 2017, In : American Journal of Physiology - Cell Physiology. 312, 1, p. C29-C39

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure

Fukushima, A., Kinugawa, S., Homma, T., Masaki, Y., Furihata, T., Yokota, T., Matsushima, S., Takada, S., Kadoguchi, T., Oba, K., Okita, K. & Tsutsui, H., Apr 1 2015, In : Journal of Cardiac Failure. 21, 4, p. 300-306 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice

Furihata, T., Kinugawa, S., Takada, S., Fukushima, A., Takahashi, M., Homma, T., Masaki, Y., Tsuda, M., Matsumoto, J., Mizushima, W., Matsushima, S., Yokota, T. & Tsutsui, H., Jun 1 2016, In : IJC Heart and Vasculature. 11, p. 24-28 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014

Clinical characteristics and CHADS2 score in patients with heart failure and atrial fibrillation: Insights from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Kinugawa, S., Matsushima, S., Fukushima, A., Yokota, T., Sakakibara, M., Yokoshiki, H., Tsuchihashi-Makaya, M. & Tsutsui, H., Jan 1 2014, In : International Journal of Cardiology. 176, 1, p. 239-242 4 p.

Research output: Contribution to journalArticle

2016

Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice

Fukushima, A., Kinugawa, S., Takada, S., Matsumoto, J., Furihata, T., Mizushima, W., Tsuda, M., Yokota, T., Matsushima, S., Okita, K. & Tsutsui, H., May 15 2016, In : European Journal of Pharmacology. 779, p. 147-156 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

The impact of volume loading–induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats

Oga, Y., Saku, K., Nishikawa, T., Kishi, T., Tobushi, T., Hosokawa, K., Tohyama, T., Sakamoto, T., Sunagawa, K. & Tsutsui, H., Sep 2018, In : Physiological Reports. 6, 19, e13887.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2020

Smart Baroreceptor Activation Therapy Strikingly Attenuates Blood Pressure Variability in Hypertensive Rats With Impaired Baroreceptor

Tohyama, T., Hosokawa, K., Saku, K., Oga, Y., Tsutsui, H. & Sunagawa, K., Mar 1 2020, In : Hypertension (Dallas, Tex. : 1979). 75, 3, p. 885-892 8 p.

Research output: Contribution to journalArticle

2014

(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice

Fukushima, A., Kinugawa, S., Takada, S., Matsushima, S., Sobirin, M. A., Ono, T., Takahashi, M., Suga, T., Homma, T., Masaki, Y., Furihata, T., Kadoguchi, T., Yokota, T., Okita, K. & Tsutsui, H., Sep 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 6, p. E503-E514

Research output: Contribution to journalArticle

18 Citations (Scopus)
2019

Ivabradine for the treatment of cardiovascular diseases

Ide, T., Ohtani, K., Higo, T., Tanaka, M., Kawasaki, Y. & Tsutsui, H., Feb 2019, In : Circulation Journal. 83, 2, p. 252-260 9 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2012

High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice

Yamato, M., Shiba, T., Ide, T., Seri, N., Kudo, W., Ando, M., Yamada, K. I., Kinugawa, S. & Tsutsui, H., Jan 1 2012, In : Molecular and cellular biochemistry. 359, 1-2, p. 161-167 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017
1 Citation (Scopus)
2019
3 Citations (Scopus)
2011

Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in postinfarct heart failure

Ohta, Y., Kinugawa, S., Matsushima, S., Ono, T., Sobirin, M. A., Inoue, N., Yokota, T., Hirabayashi, K. & Tsutsui, H., May 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 5

Research output: Contribution to journalArticle

34 Citations (Scopus)
2015

Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes

Takada, S., Kinugawa, S., Matsushima, S., Takemoto, D., Furihata, T., Mizushima, W., Fukushima, A., Yokota, T., Ono, Y., Shibata, H., Okita, K. & Tsutsui, H., Nov 1 2015, In : Experimental Physiology. 100, 11, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

Poldip2 negatively regulates matrix synthesis at focal adhesions

Matsushima, S., Zablocki, D., Tsutsui, H. & Sadoshima, J., May 1 2016, In : Journal of Molecular and Cellular Cardiology. 94, p. 10-12 3 p.

Research output: Contribution to journalEditorial

2018

Fatal cardiac hemochromatosis in a patient with hereditary spherocytosis

Fujino, T., Inoue, S., Katsuki, S., Higo, T., Ide, T., Oda, Y. & Tsutsui, H., Jan 1 2018, In : International heart journal. 59, 2, p. 427-430 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2014

Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, S., Hirabayashi, K., Kinugawa, S., Yokota, T., Matsushima, S., Suga, T., Kadoguchi, T., Fukushima, A., Homma, T., Mizushima, W., Masaki, Y., Furihata, T., Katsuyama, R., Okita, K. & Tsutsui, H., Oct 5 2014, In : European Journal of Pharmacology. 740, p. 690-696 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2019

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2016

Epidemiology of heart failure with diabetes mellitus

Tsutsui, H., 2016, In : Journal of the Japan Diabetes Society. 59, 8, p. 550-553 4 p.

Research output: Contribution to journalArticle

2014
2011

Disease management program and cardiac rehabilitation for patients with heart failure

Makaya, M. & Tsutsui, H., Mar 15 2011, In : Respiration and Circulation. 59, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle