Find Research Outputs

Search concepts
Selected filters
2011
164 Citations (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. & Suda, T., Sep 2 2011, In : Cell stem cell. 9, 3, p. 247-261 15 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Hematopoietic Stem Cells
Cell Cycle
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p57
2012
12 Citations (Scopus)

The amelioration of renal damage in Skp2-deficient mice canceled by p27Kip1 deficiency in Skp2-/- p27-/- mice

Suzuki, S., Fukasawa, H., Misaki, T., Togawa, A., Ohashi, N., Kitagawa, K., Kotake, Y., Liu, N., Niida, H., Nakayama, K., Nakayama, K. I., Yamamoto, T. & Kitagawa, M., Apr 27 2012, In : PloS one. 7, 4, e36249.

Research output: Contribution to journalArticle

Ureteral Obstruction
kidneys
Kidney
Cyclin A
Cyclin E
2013
20 Citations (Scopus)

Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1

Yamamoto, A., Takeya, R., Matsumoto, M., Nakayama, K. & Sumimoto, H., Oct 1 2013, In : FEBS Journal. 280, 20, p. 5145-5159 15 p.

Research output: Contribution to journalArticle

Phosphorylation
Threonine
Superoxides
Acetates
Protein Kinase C
2014
34 Citations (Scopus)

Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.

Takeishi, S. & Nakayama, K. I., Sep 9 2014, In : British journal of cancer. 111, 6, p. 1054-1059 6 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Maintenance
Cell Cycle
Stem Cells
Neoplasms
2015
3 Citations (Scopus)

Phosphorylation of p27Kip1on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K. I., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, 1 p.

Research output: Contribution to journalComment/debate

Cell Nucleus Active Transport
Serine
Phosphorylation
2018

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., Oct 15 2018, In : Neuroscience Letters. 685, p. 50-54 5 p.

Research output: Contribution to journalArticle

Acetaldehyde
Inbred C57BL Mouse
Knockout Mice
Dopamine
Serotonin
2013
66 Citations (Scopus)

P57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis

Furutachi, S., Matsumoto, A., Nakayama, K. I. & Gotoh, Y., Apr 3 2013, In : EMBO Journal. 32, 7, p. 970-981 12 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Neural Stem Cells
Neurogenesis
Stem cells
Cyclin-Dependent Kinase Inhibitor p57
2012
3 Citations (Scopus)

Erratum: The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis (Cell (2012) 149 (1098-1111))

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., Nov 9 2012, In : Cell. 151, 4, p. 913-914 2 p.

Research output: Contribution to journalComment/debate

2016
5 Citations (Scopus)

p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome

Duquesnes, N., Callot, C., Jeannot, P., Daburon, V., Nakayama, K. I., Manenti, S., Davy, A. & Besson, A., Jul 1 2016, In : Journal of Pathology. 239, 3, p. 250-261 12 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Point Mutation
Epigenomics
Neoplasms
Cell Cycle
2014
24 Citations (Scopus)

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway

Adachi, S., Homoto, M., Tanaka, R., Hioki, Y., Murakami, H., Suga, H., Matsumoto, M., Nakayama, K. I., Hatta, T., Iemura, S. I. & Natsume, T., Jan 1 2014, In : Nucleic acids research. 42, 15, p. 10037-10049 13 p.

Research output: Contribution to journalArticle

LDL Receptors
RNA Stability
Phosphotransferases
Messenger RNA
Antisense Oligonucleotides
11 Citations (Scopus)

Identification and characterization of a neuron-specific isoform of protrudin

Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S. & Nakayama, K. I., Feb 1 2014, In : Genes to Cells. 19, 2, p. 97-111 15 p.

Research output: Contribution to journalArticle

Protein Isoforms
Neurons
R-SNARE Proteins
Messenger RNA
Oligodendroglia
2011
16 Citations (Scopus)

Proteome of ubiquitin/MVB pathway: Possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

Tachiyama, R., Ishikawa, D., Matsumoto, M., Nakayama, K. I., Yoshimori, T., Yokota, S., Himeno, M., Tanaka, Y. & Fujita, H., Apr 1 2011, In : Genes to Cells. 16, 4, p. 448-466 19 p.

Research output: Contribution to journalArticle

Multivesicular Bodies
Transferrin Receptors
Ubiquitination
Proteome
Ubiquitin
17 Citations (Scopus)

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

Matsumoto, A., Tateishi, Y., Onoyama, I., Okita, Y., Nakayama, K. & Nakayama, K., Apr 1 2011, In : Cancer Science. 102, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Oxidative Stress
Cell Membrane
Protein Isoforms
F-Box Proteins
2016
1 Citation (Scopus)

Ribophorin ii is involved in the tissue factor expression mediated by phosphatidylserinedependent antiprothrombin antibody on monocytes

Fujieda, Y., Amengual, O., Matsumoto, M., Kuroki, K., Takahashi, H., Kono, M., Kurita, T., Otomo, K., Kato, M., Oku, K., Bohgaki, T., Horita, T., Yasuda, S., Maenaka, K., Hatakeyama, S., Nakayama, K. & Atsumi, T., Jun 1 2016, In : Rheumatology (United Kingdom). 55, 6, p. 1117-1126 10 p.

Research output: Contribution to journalArticle

Thromboplastin
Prothrombin
Monocytes
Antibodies
Surface Plasmon Resonance
2015
7 Citations (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., Nov 2015, In : STEM CELLS. 33, 11, p. 3327-3340 14 p.

Research output: Contribution to journalArticle

Placentation
Trophoblasts
Stem Cells
Placenta
Aldehyde Dehydrogenase
2014
15 Citations (Scopus)

Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development

Kitagawa, K., Shibat, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H. & Kitagawa, M., Jul 2014, In : Molecular and cellular biology. 34, 14, p. 2732-2744 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
Proteolysis
T-Lymphocytes
Phosphorylation
Thymocytes
2012
18 Citations (Scopus)

Regulation of APC/C Cdc20 activity by RASSF1A-APC/C Cdc20 circuitry

Chow, C., Wong, N., Pagano, M., Lun, S. W. M., Nakayama, K. I., Nakayama, K. & Lo, K. W., Apr 12 2012, In : Oncogene. 31, 15, p. 1975-1987 13 p.

Research output: Contribution to journalArticle

Mitosis
Cyclin A
Ubiquitination
Prometaphase
Tumor Suppressor Genes
2016
12 Citations (Scopus)

UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., Jan 1 2016, In : Molecular and cellular biology. 36, 3, p. 394-406 13 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Phosphorylation
Cell Proliferation
Replication Origin
DNA Damage
2018
17 Citations (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Jun 19 2018, In : Immunity. 48, 6, p. 1119-1134.e7

Research output: Contribution to journalArticle

Transcription Factors
T-Lymphocytes
Gene Expression
Genes
Binding Sites
2016
3 Citations (Scopus)

Identification of low-abundance proteins in serum via the isolation of HSP72 complexes

Tanaka, M., Shiota, M., Nakao, T., Uemura, R., Nishi, S., Ohkawa, Y., Matsumoto, M., Yamaguchi, M., Osada-Oka, M., Inagaki, A., Takahashi, K., Nakayama, K. I., Gi, M., Izumi, Y., Miura, K. & Iwao, H., Mar 16 2016, In : Journal of Proteomics. 136, p. 214-221 8 p.

Research output: Contribution to journalArticle

HSP72 Heat-Shock Proteins
Blood Proteins
Multiple Myeloma
Proteins
Tumors
2011
28 Citations (Scopus)

PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment

Shin, E. J., Duong, C. X., Nguyen, X. K. T., Bing, G., Bach, J. H., Park, D. H., Nakayama, K., Ali, S. F., Kanthasamy, A. G., Cadet, J. L., Nabeshima, T. & Kim, H. C., Aug 1 2011, In : Neurochemistry International. 59, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Methamphetamine
Tyrosine 3-Monooxygenase
Protein Kinase C
Phosphorylation
Therapeutics
2012
17 Citations (Scopus)

Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling

Liu, N., Matsumoto, M., Kitagawa, K., Kotake, Y., Suzuki, S., Shirasawa, S., Nakayama, K. I., Nakanishi, M., Niida, H. & Kitagawa, M., May 16 2012, In : EMBO Journal. 31, 10, p. 2365-2377 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Phosphorylation
Tumors
Chemical activation
Neoplasms
2015
4 Citations (Scopus)

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. & Takeuchi, T., Oct 16 2015, In : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Cell Cycle
Cells
Parturition
Cell Division
2017
10 Citations (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., Jul 17 2017, In : Nature communications. 8, 16114.

Research output: Contribution to journalArticle

homeostasis
stem cells
Hematopoietic Stem Cells
Stem cells
maintenance
2014
26 Citations (Scopus)

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia

Hashimoto, Y., Shirane, M., Matsuzaki, F., Saita, S., Ohnishi, T. & Nakayama, K. I., Jan 1 2014, In : Journal of Biological Chemistry. 289, 19, p. 12946-12961 16 p.

Research output: Contribution to journalArticle

Hereditary Spastic Paraplegia
Endoplasmic Reticulum
Neurons
Paraplegia
Myelin Proteolipid Protein
2012
24 Citations (Scopus)

Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin

Bargagna-Mohan, P., Paranthan, R. R., Hamza, A., Zhan, C. G., Lee, D. M., Kim, K. B., Lau, D. L., Srinivasan, C., Nakayama, K., Nakayama, K., Herrmann, H. & Mohan, R., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 989-1006 18 p.

Research output: Contribution to journalArticle

Vimentin
Switches
Pharmacology
Desmin
Intermediate Filaments
2014
25 Citations (Scopus)

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity

Lu, Z., Bauzon, F., Fu, H., Cui, J., Zhao, H., Nakayama, K., Nakayama, K. & Zhu, L., Mar 17 2014, In : Nature communications. 5, 3463.

Research output: Contribution to journalArticle

Cyclin A
deletion
apoptosis
Tumors
Carcinogenesis
2018
13 Citations (Scopus)

Hidden peptides encoded by putative noncoding RNAs

Matsumoto, A. & Nakayama, K. I., Jan 1 2018, In : Cell structure and function. 43, 1, p. 75-83 9 p.

Research output: Contribution to journalShort survey

Untranslated RNA
Peptides
RNA
Amino Acids
Proteins
2016
22 Citations (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. & Kitamura, T., Mar 1 2016, In : Experimental Hematology. 44, 3, p. 172-176.e1

Research output: Contribution to journalArticle

Mutation
Neoplasms
Proteins
Myelodysplastic Syndromes
Hematologic Neoplasms
2011
75 Citations (Scopus)

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K. & Nakayama, K. I., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 342-354 13 p.

Research output: Contribution to journalArticle

Lipid Metabolism
F-Box Proteins
Liver
Biliary Tract
S-Phase Kinase-Associated Proteins
2019
1 Citation (Scopus)

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K. I., Jul 2019, In : Cancer Science. 110, 7, p. 2090-2099 10 p.

Research output: Contribution to journalReview article

Open Access
C Chemokines
CC Chemokines
Chemokine Receptors
Antineoplastic Agents
Inflammation
2016
16 Citations (Scopus)

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

Kitade, S., Onoyama, I., Kobayashi, H., Yagi, H., Yoshida, S., Kato, M., Tsunematsu, R., Asanoma, K., Sonoda, K., Wake, N., Hata, K., Nakayama, K. I. & Kato, K., Oct 1 2016, In : Cancer Science. 107, 10, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Phenotype
p53 Genes
DNA Methylation
Neoplasms
2012
67 Citations (Scopus)

A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples

Narumi, R., Murakami, T., Kuga, T., Adachi, J., Shiromizu, T., Muraoka, S., Kume, H., Kodera, Y., Matsumoto, M., Nakayama, K., Miyamoto, Y., Ishitobi, M., Inaji, H., Kato, K. & Tomonaga, T., Nov 2 2012, In : Journal of Proteome Research. 11, 11, p. 5311-5322 12 p.

Research output: Contribution to journalArticle

Phosphopeptides
Biomarkers
Phosphorylation
Tissue
Breast Neoplasms
2014
6 Citations (Scopus)

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against listeria monocytogenes infection

Hashiguchi, T., Oyamada, A., Sakuraba, K., Shimoda, K., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., May 15 2014, In : Journal of Immunology. 192, 10, p. 4739-4747 9 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Listeriosis
Th1 Cells
Listeria monocytogenes
Interleukin-12
2018
11 Citations (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., Mar 1 2018, In : Cancer Research. 78, 5, p. 1334-1346 13 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Neoplasm Metastasis
Mutation
Colorectal Neoplasms
Organoids
8 Citations (Scopus)

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K., Tanaka, T. & Rothenberg, E. V., Dec 1 2018, In : Nature Immunology. 19, 12, p. 1427-1440 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Gene Regulatory Networks
Genes
Transcription Factors
Proteomics
24 Citations (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., Mar 12 2018, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Growth
Neoplasms
Protein Isoforms
Neuroendocrine Tumors
2014
37 Citations (Scopus)
Cullin Proteins
Ligases
Ubiquitin
Stem Cells
Spermatogonia
2018
6 Citations (Scopus)

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., Feb 6 2018, In : International journal of molecular sciences. 19, 2, 474.

Research output: Contribution to journalArticle

fibrosis
Ubiquitin-Protein Ligases
Pulmonary Fibrosis
Bleomycin
Cells
2017
16 Citations (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., Dec 1 2017, In : Nature communications. 8, 1, 1625.

Research output: Contribution to journalArticle

lysosomes
GTP Phosphohydrolases
assembly
Lysosomes
nutrients
2012
195 Citations (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., May 25 2012, In : Cell. 149, 5, p. 1098-1111 14 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitination
Glycolysis
TNF Receptor-Associated Factor 6
Carcinogenesis
2015
11 Citations (Scopus)

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Nakayama, T., May 22 2015, In : Journal of Biological Chemistry. 290, 21, p. 13095-13103 9 p.

Research output: Contribution to journalArticle

Th2 Cells
Methylation
Transcriptional Activation
Genes
Cell Differentiation
2011
72 Citations (Scopus)

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I., Sep 7 2011, In : Cell metabolism. 14, 3, p. 339-351 13 p.

Research output: Contribution to journalArticle

Iron Regulatory Protein 2
Iron
Liver
Homeostasis
Acute Liver Failure
2012
4 Citations (Scopus)

Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation

Okita, Y., Matsumoto, A., Yumimoto, K., Isoshita, R. & Nakayama, K. I., Sep 1 2012, In : Genes to Cells. 17, 9, p. 768-777 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Embryonic Stem Cells
Fibroblasts
F-Box Proteins
Ligases
2014
10 Citations (Scopus)

Mitochondria: FKBP38 and mitochondrial degradation

Shirane, M. & Nakayama, K., Jan 1 2014, In : International Journal of Biochemistry and Cell Biology. 51, 1, p. 19-22 4 p.

Research output: Contribution to journalShort survey

Mitochondrial Degradation
Tacrolimus Binding Proteins
Mitochondria
Proteolysis
Degradation
2013
13 Citations (Scopus)

Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF Fbxl3) protein complex

Yumimoto, K., Muneoka, T., Tsuboi, T. & Nakayama, K. I., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32766-32776 11 p.

Research output: Contribution to journalArticle

F-Box Proteins
Substrates
Proteins
Cryptochromes
Circadian Clocks
2015
26 Citations (Scopus)

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B. R., Nakayama, K. I., Matusik, R. J. & Chen, Z., Jan 1 2015, In : Oncotarget. 6, 2, p. 771-788 18 p.

Research output: Contribution to journalArticle

Ubiquitination
Prostate
Prostatic Neoplasms
Carcinogenesis
TNF Receptor-Associated Factor 6
2011
64 Citations (Scopus)

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

Wu, H., Pomeroy, S. L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K. I., Hatakeyama, S., Tron, V. A., Saltibus, L. F., Spyracopoulos, L. & Leng, R. P., Mar 1 2011, In : Nature medicine. 17, 3, p. 347-355 9 p.

Research output: Contribution to journalArticle

Ubiquitination
Tumors
Degradation
Brain Neoplasms
Brain
2012
55 Citations (Scopus)

SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction

Fukushima, H., Matsumoto, A., Inuzuka, H., Zhai, B., Lau, A. W., Wan, L., Gao, D., Shaik, S., Yuan, M., Gygi, S. P., Jimi, E., Asara, J. M., Nakayama, K., Nakayama, K. I. & Wei, W., May 31 2012, In : Cell Reports. 1, 5, p. 434-443 10 p.

Research output: Contribution to journalArticle

T-cells
Ubiquitination
T-Lymphocytes
Ubiquitin-Protein Ligases
Cell death
2017
13 Citations (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. & 1 others, Wei, W., Jan 3 2017, In : Science Signaling. 10, 460

Research output: Contribution to journalArticle

Lipogenesis
Ubiquitin-Protein Ligases
Ubiquitination
Sterol Regulatory Element Binding Proteins
Degradation