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2017

Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases.

Nakabeppu, Y., Apr 1 2017, The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design . World Scientific Publishing Co. Pte Ltd, p. 523-556 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011
42 Citations (Scopus)

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

Oka, S. & Nakabeppu, Y., Apr 1 2011, In : Cancer Science. 102, 4, p. 677-682 6 p.

Research output: Contribution to journalReview article

DNA Glycosylases
Carcinogenesis
Oxidative Stress
Cell Death
DNA
2013
22 Citations (Scopus)

FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., Apr 1 2013, In : Neuropsychopharmacology. 38, 5, p. 895-906 12 p.

Research output: Contribution to journalArticle

Neurogenesis
Epilepsy
Hippocampus
Lateral Ventricles
Depression
2014
7 Citations (Scopus)

Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage

Jalland, C. M. O., Benestad, S. L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjørås, M. & Tranulis, M. A., Jan 1 2014, In : Free Radical Biology and Medicine. 68, p. 1-7 7 p.

Research output: Contribution to journalArticle

Prion Diseases
Prions
DNA Damage
Repair
DNA Repair
2015
17 Citations (Scopus)

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Bjørge, M. D., Hildrestrand, G. A., Scheffler, K., Suganthan, R., Rolseth, V., Kuśnierczyk, A., Rowe, A. D., Vågbø, C. B., Vetlesen, S., Eide, L., Slupphaug, G., Nakabeppu, Y., Bredy, T. W., Klungland, A. & Bjørås, M., Dec 29 2015, In : Cell Reports. 13, 12, p. 2671-2678 8 p.

Research output: Contribution to journalArticle

Open Access
DNA Glycosylases
Gene expression
Repair
Anxiety
Genes
2017
11 Citations (Scopus)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

Waz, S., Nakamura, T., Hirata, K., Ogawa, Y. K., Chirifu, M., Arimori, T., Tamada, T., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2785-2794 10 p.

Research output: Contribution to journalArticle

Substrate Specificity
Nucleotides
Kinetics
Substrates
Neoplasms
2014
81 Citations (Scopus)
nucleotides
DNA Glycosylases
Nucleotides
Cell Survival
Carcinogenesis
2012
12 Citations (Scopus)

Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines

Nishimura, Y., Takiguchi, S., Yoshioka, K., Nakabeppu, Y. & Itoh, K., Oct 1 2012, In : International journal of oncology. 41, 4, p. 1520-1530 11 p.

Research output: Contribution to journalArticle

Endosomes
Endocytosis
Non-Small Cell Lung Carcinoma
Small Interfering RNA
Lung Neoplasms
2014
18 Citations (Scopus)

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., Jun 1 2014, In : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

T Cell Transcription Factor 1
Glycogen Synthase Kinase 3
Phosphorylation
Cyclin D1
Tumors
2019
1 Citation (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain
Insulin
Neurology
Glucose
Central Nervous System
2014
21 Citations (Scopus)

Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes

Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K. & Kitazono, T., Jan 1 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

Xanthine Dehydrogenase
Adipocytes
Lipids
Genes
White Adipose Tissue
2018
3 Citations (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers
2016
4 Citations (Scopus)

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

Torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Sakumi, K., Torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., Oct 1 2016, In : Genes to Cells. 21, 10, p. 1030-1048 19 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Lipid Metabolism
Atherosclerosis
High Fat Diet
Dyslipidemias
2019
2 Citations (Scopus)

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidative stress
Brain
Alzheimer Disease
Oxidative Stress
Medical problems
2017
5 Citations (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., Sep 1 2017, In : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

Research output: Contribution to journalArticle

Ghrelin
Parkinson Disease
Hydrogen
Water
Knockout Mice
2014
118 Citations (Scopus)

Altered expression of diabetes-related genes in Alzheimer's disease brains: The Hisayama study

Hokama, M., Oka, S., Leon, J., Ninomiya, T., Honda, H., Sasaki, K., Iwaki, T., Ohara, T., Sasaki, T., LaFerla, F. M., Kiyohara, Y. & Nakabeppu, Y., Sep 2014, In : Cerebral Cortex. 24, 9, p. 2476-2488 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Brain
Genes
Diabetes Mellitus
Brain Diseases
7 Citations (Scopus)

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains

Hamasaki, H., Honda, H., Suzuki, S. O., Hokama, M., Kiyohara, Y., Nakabeppu, Y. & Iwaki, T., Jun 2014, In : Neuropathology. 34, 3, p. 284-290 7 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Hippocampus
Alzheimer Disease
Down-Regulation
Pyramidal Cells
2012
60 Citations (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., Dec 17 2012, In : PloS one. 7, 12, e51697.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
obesity
Obesity
Fats
2017
4 Citations (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. & Toyokuni, S., Nov 2017, In : Pathology International. 67, 11, p. 564-574 11 p.

Research output: Contribution to journalArticle

Chromosome Aberrations
Carcinogenesis
Kidney
Genotype
Methylation
2019

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Galactose
Oxidative Stress
Tissue
Liver
2016
16 Citations (Scopus)

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine

Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Różalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Oliński, R. & Cooke, M. S., Oct 1 2016, In : Free Radical Biology and Medicine. 99, p. 385-391 7 p.

Research output: Contribution to journalArticle

DNA Repair
Repair
Nucleotides
DNA
Transcription
2014

International symposium on “germline mutagenesis and Biodiversification”

Uchimura, A., Hara, Y., Gondo, Y. & Nakabeppu, Y., Sep 1 2014, In : Genes and Genetic Systems. 89, 2, p. 93-95 3 p.

Research output: Contribution to journalEditorial

Molecular Evolution
Germ-Line Mutation
Mutagenesis
2016
10 Citations (Scopus)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., Mar 10 2016, In : Scientific reports. 6, 22991.

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Premature Mortality
Malformations of Cortical Development
Epilepsy
Neurons
2017
11 Citations (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., Jan 1 2017, In : Cancer Medicine. 6, 1, p. 258-266 9 p.

Research output: Contribution to journalArticle

Neoplasms
Survival
Pyrophosphatases
Messenger RNA
Neoadjuvant Therapy
2013
2 Citations (Scopus)

Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice

Tsuji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M. & Sado, T., May 1 2013, In : Journal of radiation research. 54, 3, p. 453-466 14 p.

Research output: Contribution to journalArticle

Radiation Effects
radiation effects
Thymocytes
mice
clone cells
2016

MUTYH promotes oxidative microglial activation and inherited retinal degeneration.

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., Sep 22 2016, In : JCI insight. 1, 15, 15 p., e87781.

Research output: Contribution to journalArticle

Retinal Degeneration
Retinitis Pigmentosa
Microglia
Oxidative Stress
DNA Repair
2014

What have we learned from cultured adult dorsal root ganglion neurons?

Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T. & Horie, H., Jan 1 2014, Ganglion Cells: Morphology, Functional Development and Role in Disease. Nova Science Publishers, Inc., p. 125-148 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spinal Ganglia
Neurons
Cell culture
Ganglia
Regeneration
2011
9 Citations (Scopus)

Nucleotides function as endogenous chemical sensors for oxidative stress signaling

Ihara, H., Sawa, T., Nakabeppu, Y. & Akaike, T., Jan 1 2011, In : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 33-39 7 p.

Research output: Contribution to journalReview article

Oxidative stress
Chemical sensors
Oxidative Stress
Nucleotides
Nitrogen Oxides
22 Citations (Scopus)

FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔfosB

Ohnishi, Y. N., Ohnishi, Y. H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Kunihiko, S., Nestler, E. J. & Nakabeppu, Y., Sep 1 2011, In : Biological Psychiatry. 70, 5, p. 487-495 9 p.

Research output: Contribution to journalArticle

Cadherins
Genes
Alleles
Locomotion
Mood Disorders
2014
5 Citations (Scopus)

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells

Guikema, J. E. J., Linehan, E. K., Esa, N., Tsuchimoto, D., Nakabeppu, Y., Woodland, R. T. & Schrader, C. E., Jul 15 2014, In : Journal of Immunology. 193, 2, p. 931-939 9 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Germinal Center
DNA Damage
B-Lymphocytes
DNA Repair
2011
1 Citation (Scopus)

Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice.

Tsuzuki, T., Piao, J. S., Isoda, T., Sakumi, K., Nakabeppu, Y. & Nakatsu, Y., Mar 1 2011, In : Health physics. 100, 3, p. 293-294 2 p.

Research output: Contribution to journalConference article

DNA Mutational Analysis
Bromates
Neoplastic Cell Transformation
Radiation-Induced Neoplasms
DNA Repair-Deficiency Disorders
2012
18 Citations (Scopus)

MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration

Murakami, Y., Ikeda, Y., Yoshida, N., Notomi, S., Hisatomi, T., Oka, S., De Luca, G., Yonemitsu, Y., Bignami, M., Nakabeppu, Y. & Ishibashi, T., Oct 1 2012, In : American Journal of Pathology. 181, 4, p. 1378-1386 9 p.

Research output: Contribution to journalArticle

Photoreceptor Cells
Retinal Degeneration
Retinitis Pigmentosa
DNA Damage
Cell Death
2011
15 Citations (Scopus)

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

Guikema, J. E. J., Gerstein, R. M., Linehan, E. K., Cloherty, E. K., Evan-Browning, E., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 1943-1950 8 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
B-Lymphoid Precursor Cells
Endonucleases
B-Lymphocytes
DNA Repair
2015
6 Citations (Scopus)

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., Feb 1 2015, In : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

Research output: Contribution to journalArticle

Galectin 1
Motor Neurons
Transgenic Mice
Amyotrophic Lateral Sclerosis
Axons
2011
25 Citations (Scopus)

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis

Kunisada, M., Yogianti, F., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., Dec 1 2011, In : American Journal of Pathology. 179, 6, p. 3056-3065 10 p.

Research output: Contribution to journalArticle

Versicans
Knockout Mice
Reactive Oxygen Species
Carcinogenesis
Skin
2017

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 6528.

Research output: Contribution to journalArticle

Open Access
Adenosine Kinase
p38 Mitogen-Activated Protein Kinases
Adenosine Triphosphate
Cell Death
Nucleoside-Triphosphatase
2013
31 Citations (Scopus)

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M. & Nakaya, H., Nov 29 2013, In : Scientific reports. 3, 3273.

Research output: Contribution to journalArticle

Ghrelin
Neuroprotective Agents
Parkinson Disease
Hydrogen
Atenolol
2012
67 Citations (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

Research output: Contribution to journalArticle

Microglia
DNA Repair
Carcinogenesis
Oxidative Stress
Apoptosis Inducing Factor
2014
26 Citations (Scopus)

Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y. & Nishigori, C., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2610-2619 10 p.

Research output: Contribution to journalArticle

Spirulina
Skin
Carcinogenesis
Tumors
Neoplasms
2018
5 Citations (Scopus)

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice

Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., May 1 2018, In : Neuroscience. 377, p. 87-97 11 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Pharmaceutical Preparations
Rivastigmine
Cognition
2016
22 Citations (Scopus)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., Torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. & 8 others, Aldhekri, H., Meffre, E., Mizui, M., Tsokos, G. C., Manis, J. P., Al-Herz, W., Wallace, S. S. & Geha, R. S., Nov 1 2016, In : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
Autoimmunity
DNA Repair
B-Lymphocytes
Enzymes
2017
12 Citations (Scopus)

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., Dec 1 2017, In : Brain Research. 1676, p. 77-82 6 p.

Research output: Contribution to journalArticle

Neurogenesis
Haloperidol
Bromodeoxyuridine
olanzapine
Antipsychotic Agents
2 Citations (Scopus)

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes

Seifermann, M., Ulges, A., Bopp, T., Melcea, S., Schäfer, A., Oka, S., Nakabeppu, Y., Klungland, A., Niehrs, C. & Epe, B., Oct 2017, In : DNA Repair. 58, p. 13-20 8 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair
Repair
Chemical activation
Macrophages
14 Citations (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., Jan 1 2017, In : Cancer Science. 108, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
2018
1 Citation (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., Jun 2018, In : Neuropathology. 38, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Amyotrophic Lateral Sclerosis
Pyramidal Cells
Kidney
Cerebral Cortex
2017
38 Citations (Scopus)

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., Jan 15 2017, In : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.

Research output: Contribution to journalArticle

DNA Damage
Alzheimer Disease
Glucose
DNA Glycosylases
Brain
10 Citations (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., Jul 2017, In : PloS one. 12, 7, e0181687.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
Lipid Metabolism
Metabolism
Muscle
19 Citations (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.

Research output: Contribution to journalArticle

Gene Expression Profiling
Amyloidosis
Alzheimer Disease
Genes
Neurofibrillary Tangles
5 Citations (Scopus)

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., Jul 1 2017, In : Lung Cancer. 109, p. 52-57 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Antioxidants
Nucleoside-Triphosphatase
2013
3 Citations (Scopus)

Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus

Koga, Y., Inazato, M., Nakamura, T., Hashikawa, C., Chirifu, M., Michi, A., Yamashita, T., Toma, S., Kuniyasu, A., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., Jan 1 2013, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 1, p. 45-48 4 p.

Research output: Contribution to journalArticle

X ray analysis
Crystallization
nucleosides
X-Rays
crystallization