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2015
8 Citations (Scopus)

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding

Igawa, T., Abe, Y., Tsuda, M., Inoue, K. & Ueda, T., Mar 12 2015, In : FEBS Letters. 589, 6, p. 680-686 7 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Rats
Metals
Head
Cations
2018
8 Citations (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.

Research output: Contribution to journalArticle

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
2012
42 Citations (Scopus)

Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration

Ohsawa, K., Sanagi, T., Nakamura, Y., Suzuki, E., Inoue, K. & Kohsaka, S., Apr 1 2012, In : Journal of Neurochemistry. 121, 2, p. 217-227 11 p.

Research output: Contribution to journalArticle

Adenosine A3 Receptors
Microglia
Adenosine Diphosphate
Adenosine Triphosphate
Adenosine
2018

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Jan 1 2018, In : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia
2016
24 Citations (Scopus)

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Wu, Z., Kohsaka, S., Inoue, K. & Nakanishi, H., May 31 2016, In : Nature communications. 7, 11697.

Research output: Contribution to journalArticle

morphine
Large-Conductance Calcium-Activated Potassium Channels
Hyperalgesia
Microglia
Morphine
2011
56 Citations (Scopus)

Microglial Ca 2+-activated K + channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain

Hayashi, Y., Kawaji, K., Sun, L., Zhang, X., Koyano, K., Yokoyama, T., Kohsaka, S., Inoue, K. & Nakanishi, H., Nov 30 2011, In : Journal of Neuroscience. 31, 48, p. 17370-17382 13 p.

Research output: Contribution to journalArticle

Ketamine
Neuralgia
Microglia
Analgesics
Hyperalgesia
2017
3 Citations (Scopus)

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Koga, K., Kanehisa, K., Kohro, Y., Shiratori-Hayashi, M., Tozaki-Saitoh, H., Inoue, K., Furue, H. & Tsuda, M., Dec 1 2017, In : Scientific reports. 7, 1, 4739.

Research output: Contribution to journalArticle

Interneurons
Morphine
N-Methyl-D-Aspartate Receptors
Designer Drugs
Substantia Gelatinosa
2014
11 Citations (Scopus)

Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Tozaki-Saitoh, H., Tamura, T., Mizumura, K., Tsuda, M., Kiyama, H. & Inoue, K., 2014, In : Journal of Pharmacological Sciences. 126, 2, p. 172-176 5 p.

Research output: Contribution to journalArticle

Hyperalgesia
Microglia
Rodentia
interferon regulatory factor-8
Knockout Mice
2013
77 Citations (Scopus)

Microglial regulation of neuropathic pain

Tsuda, M., Masuda, T., Tozaki-Saitoh, H. & Inoue, K., Feb 26 2013, In : Journal of Pharmacological Sciences. 121, 2, p. 89-94 6 p.

Research output: Contribution to journalReview article

Neuralgia
Microglia
Wounds and Injuries
Posterior Horn Cells
Gene Expression
51 Citations (Scopus)

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

Hayashi, Y., Koyanagi, S., Kusunose, N., Okada, R., Wu, Z., Tozaki-Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S. & Nakanishi, H., Oct 14 2013, In : Scientific reports. 3, 2744.

Research output: Contribution to journalArticle

cathepsin S
Microglia
Cats
Neurons
Spine
1 Citation (Scopus)

Intrathecal infusion of microglia cells

Masuda, T., Tsuda, M., Tozaki-Saitoh, H. & Inoue, K., Jul 18 2013, Microglia: Methods and Protocols. p. 291-294 4 p. (Methods in Molecular Biology; vol. 1041).

Research output: Chapter in Book/Report/Conference proceedingChapter

Microglia
Peripheral Nerve Injuries
Subarachnoid Space
Neuralgia
Cultured Cells
2019

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori-Hayashi, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Kido-Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Tsuda, M., Mar 2019, In : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

Research output: Contribution to journalArticle

Purinergic P2X3 Receptors
2011
16 Citations (Scopus)

Platelet-activating factor and pain

Tsuda, M., Tozaki-Saitoh, H. & Inoue, K., Aug 1 2011, In : Biological and Pharmaceutical Bulletin. 34, 8, p. 1159-1162 4 p.

Research output: Contribution to journalReview article

Platelet Activating Factor
Pain
Neuralgia
Spinal Ganglia
Wounds and Injuries
2019
4 Citations (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Tozaki-Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Tsuda, M., Apr 2019, In : GLIA. 67, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity
2013
4 Citations (Scopus)

Lentiviral transduction of cultured microglia

Masuda, T., Makoto, T., Saitoh, H. & Inoue, K., 2013, Microglia: Methods and Protocols. Vol. 1041. p. 63-67 5 p. (Methods in Molecular Biology; vol. 1041).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Transfer Techniques
Microglia
Neuroglia
Nervous System
Cultured Cells
2019

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., Jan 25 2019, In : Purinergic Signalling.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head
2018
2 Citations (Scopus)

A state-of-the-art perspective on microgliopathic pain

Inoue, K., Nov 1 2018, In : Open Biology. 8, 11, 180154.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Pain
Peripheral Nerve Injuries
Chronic Pain
2014
29 Citations (Scopus)

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Ochi-ishi, R., Nagata, K., Inoue, T., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., Aug 15 2014, In : Molecular Pain. 10, 1, 53.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
CC Chemokines
Hyperalgesia
Paclitaxel
Chemokines
2016
4 Citations (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Matsunaga, N., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. & 7 others, Amamoto, T., Aramaki, H., Tsuda, M., Inoue, K., Ojida, A., Koyanagi, S. & Ohdo, S., Nov 1 2016, In : EBioMedicine. 13, p. 262-273 12 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
2013
32 Citations (Scopus)

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Nakaya, M., Tajima, M., Kosako, H., Nakaya, T., Hashimoto, A., Watari, K., Nishihara, H., Ohba, M., Komiya, S., Tani, N., Nishida, M., Taniguchi, H., Sato, Y., Matsumoto, M., Tsuda, M., Kuroda, M., Inoue, K. & Kurose, H., Mar 11 2013, In : Nature communications. 4, 1532.

Research output: Contribution to journalArticle

clearances
Autoimmune Diseases
mice
Cells
proteins
2015
1 Citation (Scopus)

Effect of adenosine system in the action of oseltamivir on behavior in mice

Uchiyama, H., Hiromura, M., Shiratani, T., Kuroki, H., Honda, S., Kosako, K., Soeda, S., Inoue, K. & Toda, A., Jul 1 2015, In : Neuroscience Letters. 599, p. 7-11 5 p.

Research output: Contribution to journalArticle

Oseltamivir
Adenosine
Walking
Caffeine
Adenosine A2 Receptor Antagonists
2012
47 Citations (Scopus)

Purinergic systems, neuropathic pain and the role of microglia

Inoue, K. & Tsuda, M., Apr 1 2012, In : Experimental Neurology. 234, 2, p. 293-301 9 p.

Research output: Contribution to journalReview article

Purinergic Receptors
Microglia
Neuralgia
Purinergic P2Y12 Receptors
Purinergic P2X4 Receptors
6 Citations (Scopus)

(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects

Muratake, H., Ito, A., Toda, T., Suzuki, H., Fukasawa, H., Makoto, T., Inoue, K., Sugiyama, K. & Shudo, K., Dec 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7602-7604 3 p.

Research output: Contribution to journalArticle

Neurology
Neuralgia
Central Nervous System
Anticonvulsants
Aminobutyrates
2011
38 Citations (Scopus)

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-κB

Nishida, M., Ogushi, M., Suda, R., Toyotaka, M., Saiki, S., Kitajima, N., Nakaya, M., Kim, K. M., Ide, T., Sato, Y., Inoue, K. & Kurose, H., Apr 19 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 16, p. 6662-6667 6 p.

Research output: Contribution to journalArticle

Purinergic P2Y2 Receptors
Angiotensin Type 1 Receptor
Down-Regulation
Adenosine Triphosphate
Arrestins
2016

The frontline of drug creation for neuropathic pain

Inoue, K., Jan 1 2016, In : Japanese Journal of Anesthesiology. 65, p. S136-S142

Research output: Contribution to journalArticle

Neuralgia
Pharmaceutical Preparations
2019

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., Mar 30 2019, In : Journal of neuroinflammation. 16, 1, 67.

Research output: Contribution to journalArticle

Open Access
Chronic Fatigue Syndrome
Microglia
Pain
Neurons
Spinal Cord
2013
6 Citations (Scopus)

Preparation and characterization of a monoclonal antibody against the refolded and functional extracellular domain of rat P2X4 receptor

Igawa, T., Higashi, S., Abe, Y., Ohkuri, T., Tanaka, H., Morimoto, S., Yamashita, T., Makoto, T., Inoue, K. & Ueda, T., Mar 1 2013, In : Journal of Biochemistry. 153, 3, p. 275-282 8 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Rats
Monoclonal Antibodies
Molecules
Neuralgia
2019
1 Citation (Scopus)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
spinal cord injuries
macrophages
healing
interferon
lesions
2014
26 Citations (Scopus)

A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation

Yasui, M., Yoshimura, T., Takeuchi, S., Tokizane, K., Tsuda, M., Inoue, K. & Kiyama, H., Sep 2014, In : GLIA. 62, 9, p. 1407-1417 11 p.

Research output: Contribution to journalArticle

Chronic Fatigue Syndrome
Hyperalgesia
Pain
Microglia
Minocycline
2016
33 Citations (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., Aug 31 2016, In : Scientific reports. 6, 32461.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
2018
3 Citations (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., May 1 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde
2013
2 Citations (Scopus)

The Neuropharmacological study for ATP receptors especially in pain

Inoue, K., Jan 1 2013, In : Yakugaku Zasshi. 133, 10, p. 1035-1039 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Microglia
Purinergic P2X4 Receptors
Neuralgia
Pain
2016
41 Citations (Scopus)

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Tsuda, M. & Inoue, K., May 1 2016, In : Neuropharmacology. 104, p. 76-81 6 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Neurons
Purinergic P2Y Receptors
Purinergic P2X Receptors

Role of IRF transcription factor family in regulating reactive phenotype of microglia

Masuda, T., Tsuda, M. & Inoue, K., Jan 1 2016, In : Seikagaku. 88, 1, p. 124-127 4 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Animals
Transcription Factors
Microglia
2011
56 Citations (Scopus)
Purinergic P2Y1 Receptors
Middle Cerebral Artery Infarction
Brain Ischemia
Chemokines
Chemokine CXCL10
18 Citations (Scopus)

Role of Purinergic Receptors in CNS Function and Neuroprotection

Saitoh, H., Makoto, T. & Inoue, K., Jan 1 2011, Advances in Pharmacology. Academic Press Inc., p. 495-528 34 p. (Advances in Pharmacology; vol. 61).

Research output: Chapter in Book/Report/Conference proceedingChapter

Purinergic Receptors
Microglia
Central Nervous System
Neuroglia
Oligodendroglia
2014

Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia

Shimoyama, H., Makoto, T., Masuda, T., Yoshinaga, R., Tsukamoto, K., Saitoh, H. & Inoue, K., Jan 1 2014, In : Open Pain Journal. 7, 1

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Microglia
Neuralgia
Cannabinoid Receptor CB2
Spinal Cord
2016
31 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
2014

Neuropathic pain

Tsuda, M., Matsushita, K. & Inoue, K., 2014, In : Folia Pharmacologica Japonica. 143, 4, p. 215-216 2 p.

Research output: Contribution to journalComment/debate

Purinergic P2Y12 Receptors
Purinergic P2X4 Receptors
Interferon Regulatory Factors
Molecular Targeted Therapy
Animal Disease Models
2012
9 Citations (Scopus)

Role of the glia in neuropathic pain caused by peripheral nerve injury

Inoue, K., Makoto, T. & Saitoh, H., Nov 2012, In : Brain and Nerve. 64, 11, p. 1233-1239 7 p.

Research output: Contribution to journalReview article

Peripheral Nerve Injuries
Neuralgia
Neuroglia
Microglia
Astrocytes
2013
64 Citations (Scopus)

P2X4 receptors and neuropathic pain

Tsuda, M., Masuda, T., Tozaki-Saitoh, H. & Inoue, K., Oct 28 2013, In : Frontiers in Cellular Neuroscience. OCT, 191.

Research output: Contribution to journalReview article

Purinergic P2X4 Receptors
Microglia
Neuralgia
Chemokine CCL21
CCR Receptors
2017
12 Citations (Scopus)
pathogenesis
Purinergic P2X4 Receptors
pain
neuroglia
Microglia
2012
131 Citations (Scopus)

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

Masuda, T., Makoto, T., Yoshinaga, R., Saitoh, H., Ozato, K., Tamura, T. & Inoue, K., Mar 19 2012, In : Cell Reports. 1, 4, p. 334-340 7 p.

Research output: Contribution to journalArticle

Microglia
Transcription Factors
Phenotype
Peripheral Nerve Injuries
Gene expression
2013
99 Citations (Scopus)

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

Koizumi, S., Ohsawa, K., Inoue, K. & Kohsaka, S., Jan 1 2013, In : GLIA. 61, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Purinergic Receptors
Microglia
Phenotype
Up-Regulation
Adenosine A2A Receptors
2017
7 Citations (Scopus)

Neuropharmacological study of atp receptors, especially in the relationship between glia and pain

Inoue, K., Jan 1 2017, In : Yakugaku Zasshi. 137, 5, p. 563-569 7 p.

Research output: Contribution to journalReview article

Microglia
Neuroglia
Pain
Purinergic P2X4 Receptors
Neuralgia
2013
79 Citations (Scopus)

Microglia and intractable chronic pain

Tsuda, M., Beggs, S., Salter, M. W. & Inoue, K., Jan 1 2013, In : GLIA. 61, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Intractable Pain
Microglia
Neuralgia
Chronic Pain
Peripheral Nervous System Diseases
2012
53 Citations (Scopus)

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

Toyomitsu, E., Tsuda, M., Yamashita, T., Tozaki-Saitoh, H., Tanaka, Y. & Inoue, K., Jun 1 2012, In : Purinergic Signalling. 8, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Microglia
Lysosomes
Exocytosis
Green Fluorescent Proteins
2013
1 Citation (Scopus)

Reply to: 'The discovery of a new class of synaptic transmitters in smooth muscle fifty years ago and amelioration of coronary artery thrombosis'

Abbracchio, M. P., Boeynaems, J. M., Cattaneo, M., Virgilio, F. D., Illes, P., Inoue, K., Jacobson, K. A., Teresa Miras-Portugal, M., Ralevic, V., Robson, S. C., Verkhratsky, A. & Zimmermann, H., Jun 1 2013, In : Acta Physiologica. 208, 2, p. 139-140 2 p.

Research output: Contribution to journalEditorial

Purinergic P2Y Receptors
Coronary Thrombosis
Smooth Muscle
Coronary Artery Disease
Coronary Vessels
2012
16 Citations (Scopus)

P2X4 receptors of microglia in neuropathic pain

Inoue, K. & Makoto, T., Nov 19 2012, In : CNS and Neurological Disorders - Drug Targets. 11, 6, p. 699-704 6 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Microglia
Neuralgia
Purinergic P2Y12 Receptors
Purinergic P2X7 Receptors
9 Citations (Scopus)

P2Y receptors in microglia and neuroinflammation

Saitoh, H., Makoto, T. & Inoue, K., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 493-501 9 p.

Research output: Contribution to journalReview article

Microglia
Central Nervous System
Purinergic Receptors
Cytophagocytosis
Uridine Diphosphate