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  • Hiroyuki Tsutsui
2013

Suppression of ventricular fibrillation by electrical modification of the Purkinje system in hypertrophic cardiomyopathy

Yokoshiki, H., Mitsuyama, H., Watanabe, M., Mizukami, K. & Tsutsui, H., Jan 1 2013, In : Heart and Vessels. 29, 5, p. 709-717 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction

Chiba, S., Naya, M., Iwano, H., Yoshinaga, K., Katoh, C., Manabe, O., Yamada, S., Wakasa, S., Kubota, S., Matsui, Y., Tamaki, N. & Tsutsui, H., Feb 1 2013, In : European Journal of Nuclear Medicine and Molecular Imaging. 40, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

2012

Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction: Report from the Hokkaido acute myocardial infarction registry

Satoh, H., Ishimori, N., Sakakibara, M., Yamada, S., Kawashima, N., Urasawa, K., Fujii, S. & Tsutsui, H., Apr 1 2012, In : Hypertension Research. 35, 4, p. 463-469 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2013

Exercise intolerance in chronic heart failure - Skeletal muscle dysfunction and potential therapies

Okita, K., Kinugawa, S. & Tsutsui, H., Feb 4 2013, In : Circulation Journal. 77, 2, p. 293-300 8 p.

Research output: Contribution to journalReview article

61 Citations (Scopus)
2012

Conduction and refractory disorders in the diabetic atrium

Watanabe, M., Yokoshiki, H., Mitsuyama, H., Mizukami, K., Ono, T. & Tsutsui, H., Jul 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 1, p. H86-H95

Research output: Contribution to journalArticle

41 Citations (Scopus)
2013

Unique preferential conduction within the isolated septal substrate in a patient with ventricular tachycardia complicated with non-ischemic dilated cardiomyopathy

Watanabe, M., Yokoshiki, H., Mitsuyama, H., Mizukami, K. & Tsutsui, H., Nov 1 2013, In : Journal of Electrocardiology. 46, 6, p. 682-685 4 p.

Research output: Contribution to journalArticle

[Multidisciplinary management for heart failure --prevention, diagnosis and updated treatment].

Yokoshiki, H., Tsutsui, H., Goto, D., Kinugawa, S. & Ooka, T., Jan 1 2013, In : Unknown Journal. 88, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

2012

Cardiac (18)F-FDG PET/CT with heparin detects infective vegetation in a patient with mechanical valve replacement.

Klaipetch, A., Manabe, O., Oyama-Manabe, N., Chiba, S., Naya, M., Yamada, S., Hirata, K., Tsutsui, H. & Tamaki, N., Jan 1 2012, In : Clinical nuclear medicine. 37, 12, p. 1184-1185 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Blood flow restriction exercise in sprinters and endurance runners

Takada, S., Okita, K., Suga, T., Omokawa, M., Morita, N., Horiuchi, M., Kadoguchi, T., Takahashi, M., Hirabayashi, K., Yokota, T., Kinugawa, S. & Tsutsui, H., Mar 1 2012, In : Medicine and Science in Sports and Exercise. 44, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2011

Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization

Ikesue, M., Matsui, Y., Ohta, D., Danzaki, K., Ito, K., Kanayama, M., Kurotaki, D., Morimoto, J., Kojima, T., Tsutsui, H. & Uede, T., May 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 5, p. 1066-1074 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2012
2011

Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction

Matsui, Y., Ikesue, M., Danzaki, K., Morimoto, J., Sato, M., Tanaka, S., Kojima, T., Tsutsui, H. & Uede, T., May 27 2011, In : Circulation research. 108, 11, p. 1328-1339 12 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2015

Assessment of coronary flow reserve by dynamic single-photon emission computed tomography

Naya, M. & Tsutsui, H., Jan 1 2015, In : Circulation Journal. 79, 3, p. 515-516 2 p.

Research output: Contribution to journalEditorial

2013
2019

Unexpected, but reasonable association between anderson-fabry disease and coronary vasospasm

Matoba, T., Nakano, Y. & Tsutsui, H., Feb 2019, In : Circulation Journal. 83, 2, p. 283-284 2 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., Apr 2019, In : Physiological Reports. 7, 7, e14025.

Research output: Contribution to journalArticle

Open Access
2015

Small-conductance Ca2+-activated K+ current is upregulated via the phosphorylation of CaMKII in cardiac hypertrophy from spontaneously hypertensive rats

Mizukami, K., Yokoshiki, H., Mitsuyama, H., Watanabe, M., Tenma, T., Takada, S. & Tsutsui, H., Sep 18 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 6, p. H1066-H1074

Research output: Contribution to journalArticle

10 Citations (Scopus)

Persistent depression is a significant risk factor for the development of arteriosclerosis in middle-aged Japanese male subjects

Satoh, H., Fujii, S. & Tsutsui, H., Jan 8 2015, In : Hypertension Research. 38, 1, p. 84-88 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Relation Between Dabigatran Concentration, as Assessed Using the Direct Thrombin Inhibitor Assay, and Activated Clotting Time/Activated Partial Thromboplastin Time in Patients With Atrial Fibrillation

Okubo, K., Kuwahara, T., Takagi, K., Takigawa, M., Nakajima, J., Watari, Y., Nakashima, E., Yamao, K., Fujino, T., Tsutsui, H. & Takahashi, A., Jun 15 2015, In : American Journal of Cardiology. 115, 12, p. 1696-1699 4 p., 21051.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan.

Fujita, T., Fujino, N., Anan, R., Tei, C., Kubo, T., Doi, Y., Kinugawa, S., Tsutsui, H., Kobayashi, S., Yano, M., Asakura, M., Kitakaze, M., Komuro, I., Konno, T., Hayashi, K., Kawashiri, M. A., Ino, H. & Yamagishi, M., Dec 1 2013, In : JACC: Heart Failure. 1, 6, p. 459-466 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014

Clinical characteristics and CHADS2 score in patients with heart failure and atrial fibrillation: Insights from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Kinugawa, S., Matsushima, S., Fukushima, A., Yokota, T., Sakakibara, M., Yokoshiki, H., Tsuchihashi-Makaya, M. & Tsutsui, H., Jan 1 2014, In : International Journal of Cardiology. 176, 1, p. 239-242 4 p.

Research output: Contribution to journalArticle

2011

Successful termination of recurrent ventricular arrhythmias by adaptive servo-ventilation in a patient with heart failure

Yamada, S., Sakakibara, M., Matsushima, S., Saito, A., Homma, T., Fukushima, A., Masaki, Y., Watanabe, M., Mitsuyama, H., Yokoshiki, H. & Tsutsui, H., Apr 1 2011, In : Journal of Cardiology Cases. 3, 2

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

TNF-α production in NKT cell hybridoma is regulated by sphingosine-1-phosphate: Implications for inflammation in atherosclerosis

Ito, S., Iwaki, S., Kondo, R., Satoh, M., Iwabuchi, K., Ohkawa, R., Mishima, Y., Yatomi, Y., Furumoto, T., Tsutsui, H. & Fujii, S., Jan 1 2014, In : Coronary Artery Disease. 25, 4, p. 311-320 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015
16 Citations (Scopus)
2019

Prior exposure to placental ischemia causes increased salt sensitivity of blood pressure via vasopressin production and secretion in postpartum rats

Matsuura, T., Shinohara, K., Iyonaga, T., Hirooka, Y. & Tsutsui, H., Aug 1 2019, In : Journal of hypertension. 37, 8, p. 1657-1667 11 p.

Research output: Contribution to journalArticle

Geographical differences and the national meeting effect in patients with out-of-hospital cardiac arrests: A JCS–ReSS study report

behalf of the Japanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group, Dec 2 2019, In : International journal of environmental research and public health. 16, 24, 5130.

Research output: Contribution to journalArticle

Open Access
2014

Assessment of quality of life during long-term treatment of tolvaptan in refractory heart failure: Design and rationale of the AQUA-TLV study

Imamura, T., Kinugawa, K., Ohtani, T., Sakata, Y., Higo, T., Kinugawa, S., Tsutsui, H., Sunagawa, K. & Komuro, I., 2014, In : International heart journal. 55, 3, p. 264-267 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2017
2013

Acute hemodynamic effects of adaptive servo-ventilation in patients with heart failure

Yamada, S., Sakakibara, M., Yokota, T., Kamiya, K., Asakawa, N., Iwano, H., Yamada, S., Oba, K. & Tsutsui, H., May 1 2013, In : Circulation Journal. 77, 5, p. 1214-1220 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2018

Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy

Tenma, T., Mitsuyama, H., Watanabe, M., Kakutani, N., Otsuka, Y., Mizukami, K., Kamada, R., Takahashi, M., Takada, S., Sabe, H., Tsutsui, H. & Yokoshiki, H., Aug 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H262-H272

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure

Fukushima, A., Kinugawa, S., Homma, T., Masaki, Y., Furihata, T., Yokota, T., Matsushima, S., Takada, S., Kadoguchi, T., Oba, K., Okita, K. & Tsutsui, H., Apr 1 2015, In : Journal of Cardiac Failure. 21, 4, p. 300-306 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2014

Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion

Matsushima, S., Tsutsui, H. & Sadoshima, J., Jan 1 2014, In : Trends in Cardiovascular Medicine. 24, 5, p. 202-205 4 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)
2017

Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension

Tanaka, M., Abe, K., Oka, M., Saku, K., Yoshida, K., Ishikawa, T., McMurtry, I. F., Sunagawa, K., Hoka, S. & Tsutsui, H., Dec 2017, In : Physiological Reports. 5, 23, e13537.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Impact of anteroinferior transseptal puncture on creation of a complete block at the mitral isthmus in patients with atrial fibrillation

Okubo, K., Kuwahara, T., Takigawa, M., Tanaka, Y., Nakajima, J., Watari, Y., Nakashima, E., Yamao, K., Sagawa, Y., Takagi, K., Fujino, T., Tsutsui, H. & Takahashi, A., Apr 1 2017, In : Journal of Interventional Cardiac Electrophysiology. 48, 3, p. 317-325 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Central chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats

Saku, K., Tohyama, T., Shinoda, M., Kishi, T., Hosokawa, K., Nishikawa, T., Oga, Y., Sakamoto, T., Tsutsui, H., Miyamoto, T. & Sunagawa, K., Sep 12 2017, In : Physiological Reports. 5, 17, e13406.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2019

Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease

Aikawa, T., Naya, M., Obara, M., Manabe, O., Magota, K., Koyanagawa, K., Asakawa, N., Ito, Y. M., Shiga, T., Katoh, C., Anzai, T., Tsutsui, H., Murthy, V. L. & Tamaki, N., Jan 1 2019, In : Cardiovascular research. 115, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings

Mannoji, H., Saku, K., Nishikawa, T., Tohyama, T., Kamada, K., Abe, K., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Apr 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 4, p. H828-H839

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure

Matsumoto, J., Takada, S., Kinugawa, S., Furihata, T., Nambu, H., Kakutani, N., Tsuda, M., Fukushima, A., Yokota, T., Tanaka, S., Takahashi, H., Watanabe, M., Hatakeyama, S., Matsumoto, M., Nakayama, K. I., Otsuka, Y., Sabe, H., Tsutsui, H. & Anzai, T., Jan 1 2018, In : Circulation. 138, 18, p. 2064-2066 3 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

The impact of volume loading–induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats

Oga, Y., Saku, K., Nishikawa, T., Kishi, T., Tobushi, T., Hosokawa, K., Tohyama, T., Sakamoto, T., Sunagawa, K. & Tsutsui, H., Sep 2018, In : Physiological Reports. 6, 19, e13887.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

Skeletal muscle abnormalities in heart failure

Kinugawa, S., Takada, S., Matsushima, S., Okita, K. & Tsutsui, H., Sep 29 2015, In : International heart journal. 56, 5, p. 475-484 10 p.

Research output: Contribution to journalReview article

42 Citations (Scopus)
2017

Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study

Tsutsui, H., Momomura, S., Saito, Y., Ito, H., Yamamoto, K., Ohishi, T., Okino, N. & Guo, W., Sep 2017, In : Journal of Cardiology. 70, 3, p. 225-231 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs

Saku, K., Kakino, T., Arimura, T., Sunagawa, G., Nishikawa, T., Sakamoto, T., Kishi, T., Tsutsui, H. & Sunagawa, K., May 1 2018, In : Circulation. Heart failure. 11, 5, p. e004397

Research output: Contribution to journalArticle

13 Citations (Scopus)
2020

Spironolactone use is associated with improved outcomes in heart failure with mid-range ejection fraction

Enzan, N., Matsushima, S., Ide, T., Kaku, H., Higo, T., Tsuchihashi-Makaya, M. & Tsutsui, H., Jan 1 2020, (Accepted/In press) In : ESC Heart Failure.

Research output: Contribution to journalArticle

Open Access
2011

Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects

Yamato, M., Shiba, T., Ide, T., Honda, Y., Yamada, K. I. & Tsutsui, H., Jul 1 2011, In : Hypertension Research. 34, 7, p. 840-845 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle

Kadoguchi, T., Kinugawa, S., Takada, S., Fukushima, A., Furihata, T., Homma, T., Masaki, Y., Mizushima, W., Nishikawa, M., Takahashi, M., Yokota, T., Matsushima, S., Okita, K. & Tsutsui, H., Mar 1 2015, In : Experimental Physiology. 100, 3, p. 312-322 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2012

Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions

Takada, S., Okita, K., Suga, T., Omokawa, M., Kadoguchi, T., Sato, T., Takahashi, M., Yokota, T., Hirabayashi, K., Morita, N., Horiuchi, M., Kinugawa, S. & Tsutsui, H., Jul 15 2012, In : Journal of Applied Physiology. 113, 2, p. 199-205 7 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2013

Clinical characteristics and outcomes of dilated phase of hypertrophic cardiomyopathy: Report from the registry data in Japan

Goto, D., Kinugawa, S., Hamaguchi, S., Sakakibara, M., Tsuchihashi-Makaya, M., Yokota, T., Yamada, S., Yokoshiki, H. & Tsutsui, H., Jan 1 2013, In : Journal of Cardiology. 61, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2011

Incremental diagnostic value of regional myocardial blood flow quantification over relative perfusion imaging with generator-produced rubidium-82 PET

Yoshinaga, K., Katoh, C., Manabe, O., Klein, R., Naya, M., Sakakibara, M., Yamada, S., de Kemp, R. A., Tsutsui, H. & Tamaki, N., Oct 31 2011, In : Circulation Journal. 75, 11, p. 2628-2634 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)