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2017

Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases.

Nakabeppu, Y., Apr 1 2017, The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design . World Scientific Publishing Co. Pte Ltd, p. 523-556 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016
4 Citations (Scopus)

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

Torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Sakumi, K., Torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., Oct 1 2016, In : Genes to Cells. 21, 10, p. 1030-1048 19 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Lipid Metabolism
Atherosclerosis
High Fat Diet
Dyslipidemias
2017
5 Citations (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., Sep 1 2017, In : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

Research output: Contribution to journalArticle

Ghrelin
Parkinson Disease
Hydrogen
Water
Knockout Mice
11 Citations (Scopus)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

Waz, S., Nakamura, T., Hirata, K., Ogawa, Y. K., Chirifu, M., Arimori, T., Tamada, T., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2785-2794 10 p.

Research output: Contribution to journalArticle

Substrate Specificity
Nucleotides
Kinetics
Substrates
Neoplasms
2019
1 Citation (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain
Insulin
Neurology
Glucose
Central Nervous System
2 Citations (Scopus)

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidative stress
Brain
Alzheimer Disease
Oxidative Stress
Medical problems
2018
3 Citations (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers
2019

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Galactose
Oxidative Stress
Tissue
Liver
2017
4 Citations (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. & Toyokuni, S., Nov 2017, In : Pathology International. 67, 11, p. 564-574 11 p.

Research output: Contribution to journalArticle

Chromosome Aberrations
Carcinogenesis
Kidney
Genotype
Methylation
2016
16 Citations (Scopus)

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine

Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Różalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Oliński, R. & Cooke, M. S., Oct 1 2016, In : Free Radical Biology and Medicine. 99, p. 385-391 7 p.

Research output: Contribution to journalArticle

DNA Repair
Repair
Nucleotides
DNA
Transcription
10 Citations (Scopus)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., Mar 10 2016, In : Scientific reports. 6, 22991.

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Premature Mortality
Malformations of Cortical Development
Epilepsy
Neurons
2017
11 Citations (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., Jan 1 2017, In : Cancer Medicine. 6, 1, p. 258-266 9 p.

Research output: Contribution to journalArticle

Neoplasms
Survival
Pyrophosphatases
Messenger RNA
Neoadjuvant Therapy
2016

MUTYH promotes oxidative microglial activation and inherited retinal degeneration.

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., Sep 22 2016, In : JCI insight. 1, 15, 15 p., e87781.

Research output: Contribution to journalArticle

Retinal Degeneration
Retinitis Pigmentosa
Microglia
Oxidative Stress
DNA Repair
2017

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 6528.

Research output: Contribution to journalArticle

Open Access
Adenosine Kinase
p38 Mitogen-Activated Protein Kinases
Adenosine Triphosphate
Cell Death
Nucleoside-Triphosphatase
2018
5 Citations (Scopus)

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice

Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., May 1 2018, In : Neuroscience. 377, p. 87-97 11 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Pharmaceutical Preparations
Rivastigmine
Cognition
2016
22 Citations (Scopus)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., Torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. & 8 others, Aldhekri, H., Meffre, E., Mizui, M., Tsokos, G. C., Manis, J. P., Al-Herz, W., Wallace, S. S. & Geha, R. S., Nov 1 2016, In : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
Autoimmunity
DNA Repair
B-Lymphocytes
Enzymes
2017
12 Citations (Scopus)

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., Dec 1 2017, In : Brain Research. 1676, p. 77-82 6 p.

Research output: Contribution to journalArticle

Neurogenesis
Haloperidol
Bromodeoxyuridine
olanzapine
Antipsychotic Agents
2 Citations (Scopus)

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes

Seifermann, M., Ulges, A., Bopp, T., Melcea, S., Schäfer, A., Oka, S., Nakabeppu, Y., Klungland, A., Niehrs, C. & Epe, B., Oct 2017, In : DNA Repair. 58, p. 13-20 8 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair
Repair
Chemical activation
Macrophages
14 Citations (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., Jan 1 2017, In : Cancer Science. 108, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
2018
1 Citation (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., Jun 2018, In : Neuropathology. 38, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Amyotrophic Lateral Sclerosis
Pyramidal Cells
Kidney
Cerebral Cortex
2017
38 Citations (Scopus)

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., Jan 15 2017, In : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.

Research output: Contribution to journalArticle

DNA Damage
Alzheimer Disease
Glucose
DNA Glycosylases
Brain
10 Citations (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., Jul 2017, In : PloS one. 12, 7, e0181687.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
Lipid Metabolism
Metabolism
Muscle
19 Citations (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.

Research output: Contribution to journalArticle

Gene Expression Profiling
Amyloidosis
Alzheimer Disease
Genes
Neurofibrillary Tangles
5 Citations (Scopus)

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., Jul 1 2017, In : Lung Cancer. 109, p. 52-57 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Antioxidants
Nucleoside-Triphosphatase
2016

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., Jun 5 2016, In : AIMS Molecular Science. 3, 3, p. 325-337 13 p.

Research output: Contribution to journalReview article

Open Access
2019
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
2016
4 Citations (Scopus)
26 Citations (Scopus)
Mitochondrial DNA
Neurons
Antioxidants
Neurodegenerative Diseases
Cytosine
2017
4 Citations (Scopus)

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., Feb 1 2017, In : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.

Research output: Contribution to journalLetter

Neoplastic Gene Expression Regulation
Chemokine CXCL1
Radiation-Induced Neoplasms
Versicans
DNA Glycosylases
3 Citations (Scopus)

Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation

Kajitani, K., Yanagimoto, K. & Nakabeppu, Y., Oct 1 2017, In : Psychopharmacology. 234, 19, p. 2919-2927 9 p.

Research output: Contribution to journalArticle

Galectin 1
Galectin 3
Schizophrenia
Inflammation
Psychiatry
2016
1 Citation (Scopus)

Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., Jun 10 2016, In : Scientific reports. 6, 27164.

Research output: Contribution to journalComment/debate

2017
19 Citations (Scopus)

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Nakabeppu, Y., Ohta, E. & Abolhassani, N., Jun 1 2017, In : Free Radical Biology and Medicine. 107, p. 151-158 8 p.

Research output: Contribution to journalReview article

Nucleotides
Genes
Genome
Knockout Mice
DNA Glycosylases
2016
9 Citations (Scopus)

MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., Jan 1 2016, In : JCI Insight. 1, 15, e87781.

Research output: Contribution to journalArticle

Retinal Degeneration
Retinitis Pigmentosa
Microglia
Oxidative Stress
DNA Repair
2018
2 Citations (Scopus)

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., Dec 1 2018, In : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

Research output: Contribution to journalArticle

Polymorphism
Single Nucleotide Polymorphism
Hepatocellular Carcinoma
Nucleotides
Genes
2016
4 Citations (Scopus)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yoneshima, Y., Abolhassani, N., Iyama, T., Sakumi, K., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., Sep 13 2016, In : Scientific reports. 6, 32849.

Research output: Contribution to journalArticle

DNA
Growth
Deamination
deoxyinosine
triphosphoric acid
2019

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (ed.) & Ninomiya, T. (ed.), May 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

Research output: Book/ReportBook

Diabetes Mellitus
Alzheimer Disease
Insulin
Glucose
Vascular Dementia
2016
16 Citations (Scopus)

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., Nov 29 2016, In : Scientific reports. 6, 37889.

Research output: Contribution to journalArticle

Alzheimer Disease
Mitochondria
Prealbumin
Mitochondrial DNA
Oxidative Stress
2018
10 Citations (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., Jan 2018, In : Brain Pathology. 28, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

Adipocytes
Hippocampus
Carrier Proteins
Pathology
Alzheimer Disease
2020

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., Jan 1 2020, In : PloS one. 15, 1, e0227501.

Research output: Contribution to journalArticle

Open Access
Nutrition
inflammation
animal models
Inflammation
mice