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2017

Report on an 11-year analysis of neurology autopsy cases: Focusing on neurodegenerative diseases

Fujii, N., Watanabe, A., Arahata, H., Kawano, Y., Sasagasako, N. & Iwaki, T., May 2017, In : IRYO - Japanese Journal of National Medical Services. 71, 5, p. 199-203 5 p.

Research output: Contribution to journalArticle

Tauopathies
Neurology
Neurodegenerative Diseases
Autopsy
2018

Le hazard ou la nécessité? Comorbid pathologies of neurodegenerative diseases

Uchihara, T. & Iwaki, T., Feb 1 2018, In : Neuropathology. 38, 1, p. 62-63 2 p.

Research output: Contribution to journalEditorial

Neurodegenerative Diseases
Pathology
2019
Mitochondrial DNA
Mitochondria
Pharmaceutical Preparations
2017

Dura mater graft-associated Creutzfeldt-Jakob disease with 30-year incubation period

Shijo, M., Honda, H., Koyama, S., Ishitsuka, K., Maeda, K., Kuroda, J., Tanii, M., Kitazono, T. & Iwaki, T., Jun 2017, In : Neuropathology. 37, 3, p. 275-281 7 p.

Research output: Contribution to journalArticle

Dura Mater
Creutzfeldt-Jakob Syndrome
Parietal Lobe
Transplants
Pathology
2019

Differences between primary central nervous system lymphoma and glioblastoma: topographic analysis using voxel-based morphometry

Yamashita, K., Hiwatashi, A., Togao, O., Kikuchi, K., Momosaka, D., Hata, N., Akagi, Y., Suzuki, S. O., Iwaki, T., Iihara, K. & Honda, H., Oct 2019, In : Clinical Radiology. 74, 10, p. 816.e1-816.e8

Research output: Contribution to journalArticle

Glioblastoma
Lymphoma
Central Nervous System
Software
Corpus Callosum
2017
16 Citations (Scopus)

Discrepancy in programmed cell death-ligand 1 between primary and metastatic non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Katsura, M., Mukae, N., Shoji, F., Okamoto, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Aug 2017, In : Anticancer research. 37, 8, p. 4223-4228 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Ligands
Radiotherapy
Brain

A case of suprasellar ganglioglioma arising from the genu‒rostrum of the corpus callosum composed of tumor cells in various stages of neuronal differentiation

Funakoshi, Y., Natori, Y., Suzuki, S., Iwaki, T., Imamoto, N., Yamada, T., Inoue, D., Mori, M., Matsuo, S. & Iwaki, K., Jan 1 2017, In : Japanese Journal of Neurosurgery. 26, 5, p. 362-368 7 p.

Research output: Contribution to journalArticle

Ganglioglioma
Corpus Callosum
Septum Pellucidum
Optic Chiasm
Neoplasms
2019
Isocitrate Dehydrogenase
Gadolinium
Glioma
Survival
Glioblastoma

Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)-binding protein 1 in Huntington's disease

Mori, S., Honda, H., Ishii, T., Yoshimura, M., Sasagasako, N., Suzuki, S. O., Taniwaki, T. & Iwaki, T., Oct 1 2019, In : Neuropathology. 39, 5, p. 358-367 10 p.

Research output: Contribution to journalArticle

Intranuclear Inclusion Bodies
Normal Distribution
Huntington Disease
Sarcoma
Carrier Proteins
3 Citations (Scopus)
Myelin-Oligodendrocyte Glycoprotein
Central Nervous System Vasculitis
Immunotherapy
Antibodies
Cerebrum
2018

Four-repeat tau dominant pathology in a congenital myotonic dystrophy type 1 patient with mental retardation

Mizuno, Y., Maeda, N., Hamasaki, H., Arahata, H., Sasagasako, N., Honda, H., Fujii, N. & Iwaki, T., May 2018, In : Brain Pathology. 28, 3, p. 431-433 3 p.

Research output: Contribution to journalLetter

Myotonic Dystrophy
Intellectual Disability
Pathology

Dynactin is involved in Lewy body pathology

Shen, C., Honda, H., Suzuki, S. O., Maeda, N., Shijo, M., Hamasaki, H., Sasagasako, N., Fujii, N. & Iwaki, T., Dec 2018, In : Neuropathology. 38, 6, p. 583-590 8 p.

Research output: Contribution to journalArticle

Lewy Bodies
Cytoplasmic Dyneins
Pathology
Microtubules
Dyneins
2019
Open Access
Tauopathies
Basal Ganglia
Microtubule-Associated Proteins
Alzheimer Disease
Parkinsonian Disorders

Clinicopathological review of solitary fibrous tumors: dedifferentiation is a major cause of patient death

Yamada, Y., Kohashi, K., Kinoshita, I., Yamamoto, H., Iwasaki, T., Yoshimoto, M., Ishihara, S., Toda, Y., Itou, Y., Koga, Y., Hashisako, M., Nozaki, Y., Kiyozawa, D., Kitahara, D., Inoue, T., Mukai, M., Honda, Y., Toyokawa, G., Tsuchihashi, K., Matsushita, Y. & 9 others, Fushimi, F., Taguchi, K., Tamiya, S., Oshiro, Y., Furue, M., Nakashima, Y., Suzuki, S., Iwaki, T. & Oda, Y., Oct 1 2019, In : Virchows Archiv. 475, 4, p. 467-477 11 p.

Research output: Contribution to journalArticle

Solitary Fibrous Tumors
Cause of Death
Hypoglycemia
Neoplasms
Central Nervous System
2016
11 Citations (Scopus)

Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 are Identical in Transmission Properties

Kobayashi, A., Matsuura, Y., Iwaki, T., Iwasaki, Y., Yoshida, M., Takahashi, H., Murayama, S., Takao, M., Kato, S., Yamada, M., Mohri, S. & Kitamoto, T., Jan 1 2016, In : Brain Pathology. 26, 1, p. 95-101 7 p.

Research output: Contribution to journalArticle

Prions
Creutzfeldt-Jakob Syndrome
Dura Mater
Valine
Codon
4 Citations (Scopus)

'PrP systemic deposition disease': Clinical and pathological characteristics of novel familial prion disease with 2-bp deletion in codon 178

Matsuzono, K., Honda, H., Sato, K., Morihara, R., Deguchi, K., Hishikawa, N., Yamashita, T., Kono, S., Ohta, Y., Iwaki, T. & Abe, K., Jan 1 2016, In : European Journal of Neurology. 23, 1, p. 196-200 5 p.

Research output: Contribution to journalArticle

Prion Diseases
Codon
Fathers
Restriction Fragment Length Polymorphisms
Siblings
2019
2 Citations (Scopus)

Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study

Fujii, T., Takase, K. I., Honda, H., Kawamura, N., Yamasaki, R., Urata, M., Uchiumi, T., Iwaki, T. & Kira, J. I., Apr 2019, In : Neuropathology. 39, 2, p. 162-167 6 p.

Research output: Contribution to journalArticle

Poisons
Muscular Diseases
Hepatitis B
Mitochondrial DNA
Nucleosides
2018
1 Citation (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., Jun 2018, In : Neuropathology. 38, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Amyotrophic Lateral Sclerosis
Pyramidal Cells
Kidney
Cerebral Cortex
3 Citations (Scopus)

DCTN1 F52L mutation case of Perry syndrome with progressive supranuclear palsy-like tauopathy

Honda, H., Sasagasako, N., Shen, C., Shijo, M., Hamasaki, H., Suzuki, S. O., Tsuboi, Y., Fujii, N. & Iwaki, T., Jun 2018, In : Parkinsonism and Related Disorders. 51, p. 105-110 6 p.

Research output: Contribution to journalArticle

Tauopathies
Progressive Supranuclear Palsy
Parkinsonian Disorders
Hypoventilation
Mutation
2019

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

Prion Diseases
Human Growth Hormone
Pituitary Gland
Molecular Weight
Dura Mater
2017
38 Citations (Scopus)

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., Jan 15 2017, In : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.

Research output: Contribution to journalArticle

DNA Damage
Alzheimer Disease
Glucose
DNA Glycosylases
Brain
2016
15 Citations (Scopus)

Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study

Honda, H., Sasaki, K., Hamasaki, H., Shijo, M., Koyama, S., Ohara, T., Ninomiya, T., Kiyohara, Y., Suzuki, S. O. & Iwaki, T., Aug 1 2016, In : Neuropathology. 36, 4, p. 383-387 5 p.

Research output: Contribution to journalArticle

Dementia
Autopsy
Alzheimer Disease
Pathology
Life Style
2017
14 Citations (Scopus)

A comprehensive analysis identifies BRAF hotspot mutations associated with gliomas with peculiar epithelial morphology

Hatae, R., Hata, N., Suzuki, S. O., Yoshimoto, K., Kuga, D., Murata, H., Akagi, Y., Sangatsuda, Y., Iwaki, T., Mizoguchi, M. & Iihara, K., Jun 2017, In : Neuropathology. 37, 3, p. 191-199 9 p.

Research output: Contribution to journalArticle

Glioma
Mutation
Glioblastoma
Ganglioglioma
Neuroepithelial Neoplasms
2018
3 Citations (Scopus)
Craniopharyngioma
Freezing
Mutation
Staining and Labeling
Central Nervous System Cysts
2016
46 Citations (Scopus)

Differentiation of high-grade and low-grade diffuse gliomas by intravoxel incoherent motion MR imaging

Togao, O., Hiwatashi, A., Yamashita, K., Kikuchi, K., Mizoguchi, M., Yoshimoto, K., Suzuki, S. O., Iwaki, T., Obara, M., Van Cauteren, M. & Honda, H., Jan 1 2016, In : Neuro-Oncology. 18, 1, p. 132-141 10 p.

Research output: Contribution to journalArticle

Glioma
ROC Curve
Area Under Curve
Perfusion
2017
19 Citations (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.

Research output: Contribution to journalArticle

Gene Expression Profiling
Amyloidosis
Alzheimer Disease
Genes
Neurofibrillary Tangles
4 Citations (Scopus)

Insular primary glioblastomas with IDH mutations: Clinical and biological specificities

Hata, N., Hatae, R., Yoshimoto, K., Murata, H., Kuga, D., Akagi, Y., Sangatsuda, Y., Suzuki, S. O., Iwaki, T., Mizoguchi, M. & Iihara, K., Jun 2017, In : Neuropathology. 37, 3, p. 200-206 7 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Glioblastoma
Mutation
Neoplasms
Phenotype
2016
8 Citations (Scopus)
Nimustine
Procarbazine
Vincristine
Radiotherapy
Survival
4 Citations (Scopus)
Inborn Genetic Diseases
Prion Diseases
Codon
Glycosylphosphatidylinositols
Autopsy
2018
4 Citations (Scopus)

Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation

Takamori, S., Toyokawa, G., Shimokawa, M., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Mukae, N., Hirai, F., Tagawa, T., Oda, Y., Iwaki, T., Iihara, K., Honda, H. & Maehara, Y., Jun 2018, In : Anticancer research. 38, 6, p. 3731-3734 4 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Mutation
Brain
2019

Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 glioblastoma

Yamashita, K., Hatae, R., Hiwatashi, A., Togao, O., Kikuchi, K., Momosaka, D., Yamashita, Y., Kuga, D., Hata, N., Yoshimoto, K., Suzuki, S. O., Iwaki, T., Iihara, K. & Honda, H., Jul 1 2019, In : Diagnostic and Interventional Imaging. 100, 7-8, p. 411-419 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Telomerase
Mutation
Confidence Intervals
Necrosis
2017
43 Citations (Scopus)

Trends in dementia prevalence, incidence, and survival rate in a Japanese community

Ohara, T., Hata, J., Yoshida, D., Mukai, N., Nagata, M., Iwaki, T., Kitazono, T., Kanba, S., Kiyohara, Y. & Ninomiya, T., May 16 2017, In : Neurology. 88, 20, p. 1925-1932 8 p.

Research output: Contribution to journalArticle

Dementia
Survival Rate
Alzheimer Disease
Incidence
Vascular Dementia

Different complicated brain pathologies in monozygotic twins with Gerstmann-Sträussler-Scheinker disease

Honda, H., Sasaki, K., Takashima, H., Mori, D., Koyama, S., Suzuki, S. O. & Iwaki, T., Jan 1 2017, In : Journal of neuropathology and experimental neurology. 76, 10, p. 854-863 10 p.

Research output: Contribution to journalArticle

Monozygotic Twins
Pathology
Amyloid Plaques
Brain
Tauopathies
28 Citations (Scopus)

Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging

Togao, O., Hiwatashi, A., Yamashita, K., Kikuchi, K., Keupp, J., Yoshimoto, K., Kuga, D., Yoneyama, M., Suzuki, S. O., Iwaki, T., Takahashi, M., Iihara, K. & Honda, H., Feb 1 2017, In : European Radiology. 27, 2, p. 578-588 11 p.

Research output: Contribution to journalArticle

Perfusion Imaging
Amides
Glioma
Protons
2020

A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement

Yamasaki, R., Yonekawa, T., Inamizu, S., Shinoda, K., Ochi, H., Matsushita, T., Isobe, N., Tsuji, G., Sadashima, S., Kuma, Y., Oda, Y., Iwaki, T., Furue, M. & Kira, J. I., Feb 1 2020, In : Neuropathology. 40, 1, p. 109-115 7 p.

Research output: Contribution to journalArticle

Facial Hemiatrophy
Localized Scleroderma
Extremities
Atrophy
Blepharoptosis
2019
1 Citation (Scopus)

A Novel Combination of Prion Strain Co-Occurrence in Patients with Sporadic Creutzfeldt-Jakob Disease

Kobayashi, A., Iwasaki, Y., Takao, M., Saito, Y., Iwaki, T., Qi, Z., Torimoto, R., Shimazaki, T., Munesue, Y., Isoda, N., Sawa, H., Aoshima, K., Kimura, T., Kondo, H., Mohri, S. & Kitamoto, T., Jun 2019, In : American Journal of Pathology. 189, 6, p. 1276-1283 8 p.

Research output: Contribution to journalArticle

Prions
Olivary Nucleus
Brain
Valine
Codon
2018
Astrocytoma
Glioma
Hemorrhage
Neoplasms
Neuroglia
2019

Intravoxel incoherent motion MR imaging of pediatric intracranial tumors: Correlation with histology and diagnostic utility

Kikuchi, K., Hiwatashi, A., Togao, O., Yamashita, K., Kamei, R., Momosaka, D., Hata, N., Iihara, K., Suzuki, S. O., Iwaki, T. & Honda, H., Jan 1 2019, In : American Journal of Neuroradiology. 40, 5, p. 878-884 7 p.

Research output: Contribution to journalArticle

Open Access
Histology
Perfusion
Pediatrics
Neoplasm Grading
Neoplasms
2017
9 Citations (Scopus)

Early and extensive spinal white matter involvement in neuromyelitis optica

Hayashida, S., Masaki, K., Yonekawa, T., Suzuki, S. O., Hiwatashi, A., Matsushita, T., Watanabe, M., Yamasaki, R., Suenaga, T., Iwaki, T., Murai, H. & Kira, J. I., May 2017, In : Brain Pathology. 27, 3, p. 249-265 17 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Aquaporin 4
Spinal Cord
Horns
Antibodies
7 Citations (Scopus)
Glioma
Retrospective Studies
Neuroepithelial Neoplasms
Histones
Mutation
2018
7 Citations (Scopus)

Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Mukae, N., Hirai, F., Tagawa, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Jan 2018, In : Anticancer research. 38, 1, p. 553-557 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Neoplasm Metastasis
Ligands
Brain
5 Citations (Scopus)

Reclassification of 400 consecutive glioma cases based on the revised 2016WHO classification

Akagi, Y., Yoshimoto, K., Hata, N., Kuga, D., Hatae, R., Amemiya, T., Sangatsuda, Y., Suzuki, S. O., Iwaki, T., Mizoguchi, M. & Iihara, K., Apr 1 2018, In : Brain tumor pathology. 35, 2, p. 81-89 9 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Glioma
Nucleic Acid Denaturation
Chromosomes, Human, Pair 10
Loss of Heterozygosity
5 Citations (Scopus)
Meningioma
Brain Neoplasms
Blood Vessels
Perfusion
Neoplasms
2019

Predictors of recurrence and postoperative outcomes in patients with non-skull base meningiomas based on modern neurosurgical standards

Michiwaki, Y., Hata, N., Amano, T., Suzuki, S. O., Akagi, Y., Kuga, D., Onozuka, D., Momosaki, S., Nakamizo, A., Yoshimoto, K., Iwaki, T. & Iihara, K., Mar 1 2019, In : Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 15, p. 30-37 8 p.

Research output: Contribution to journalArticle

Meningioma
Recurrence
Survival
Neoplasms
Multivariate Analysis
2017
11 Citations (Scopus)

Correlation between arterial spin-labeling perfusion and histopathological vascular density of pediatric intracranial tumors

Kikuchi, K., Hiwatashi, A., Togao, O., Yamashita, K., Yoshimoto, K., Mizoguchi, M., Suzuki, S. O., Iwaki, T., Suzuki, Y. & Honda, H., Dec 1 2017, In : Journal of Neuro-Oncology. 135, 3, p. 561-569 9 p.

Research output: Contribution to journalArticle

Blood Vessels
Perfusion
Pediatrics
Neoplasms
Contrast Media
2018

Mitochondrial dysfunction and altered ribostasis in hippocampal neurons with cytoplasmic inclusions of multiple system atrophy

Maeda, N., Honda, H., Suzuki, S. O., Fujii, N., Kira, J. I. & Iwaki, T., Aug 2018, In : Neuropathology. 38, 4, p. 361-371 11 p.

Research output: Contribution to journalArticle

Multiple System Atrophy
Inclusion Bodies
Neurons
Hippocampus
Heterogeneous-Nuclear Ribonucleoproteins
2 Citations (Scopus)

Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord

Okuda, T., Hata, N., Suzuki, S. O., Yoshimoto, K., Arimura, K., Amemiya, T., Akagi, Y., Kuga, D., Oba, U., Koga, Y., Ohga, S., Iwaki, T. & Iihara, K., Aug 2018, In : Neuropathology. 38, 4, p. 422-427 6 p.

Research output: Contribution to journalArticle

Ganglioglioma
Pediatrics
Mutation
Glioma
Central Nervous System Neoplasms
4 Citations (Scopus)

Arterial spin-labeling is useful for the diagnosis of residual or recurrent meningiomas

Kikuchi, K., Hiwatashi, A., Togao, O., Yamashita, K., Kamei, R., Yoshimoto, K., Iihara, K., Suzuki, S. O., Iwaki, T., Suzuki, Y. & Honda, H., Oct 1 2018, In : European Radiology. 28, 10, p. 4334-4342 9 p.

Research output: Contribution to journalArticle

Meningioma
Radiology
ROC Curve
Reading
Neoplasms
2017
3 Citations (Scopus)
Alzheimer Disease
Pathology
Population
Registries
National Institute on Aging (U.S.)
2018
10 Citations (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., Jan 2018, In : Brain Pathology. 28, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

Adipocytes
Hippocampus
Carrier Proteins
Pathology
Alzheimer Disease