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  • Hiroyuki Tsutsui
2016

Bedside teaching serelaxin

Tsutsui, H., Jul 1 2016, In : Respiration and Circulation. 64, 7, p. 725-730 6 p.

Research output: Contribution to journalArticle

Relationship between uric acid and coronary artery disease

Sakakibara, M. & Tsutsui, H., Jun 20 2016, In : Nippon rinsho. Japanese journal of clinical medicine. 74 Pt 1, p. 165-171 7 p.

Research output: Contribution to journalArticle

2019

Unexpected, but reasonable association between anderson-fabry disease and coronary vasospasm

Matoba, T., Nakano, Y. & Tsutsui, H., Feb 2019, In : Circulation Journal. 83, 2, p. 283-284 2 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., Apr 2019, In : Physiological Reports. 7, 7, e14025.

Research output: Contribution to journalArticle

Open Access

Prior exposure to placental ischemia causes increased salt sensitivity of blood pressure via vasopressin production and secretion in postpartum rats

Matsuura, T., Shinohara, K., Iyonaga, T., Hirooka, Y. & Tsutsui, H., Aug 1 2019, In : Journal of hypertension. 37, 8, p. 1657-1667 11 p.

Research output: Contribution to journalArticle

Geographical differences and the national meeting effect in patients with out-of-hospital cardiac arrests: A JCS–ReSS study report

behalf of the Japanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group, Dec 2 2019, In : International journal of environmental research and public health. 16, 24, 5130.

Research output: Contribution to journalArticle

Open Access
2017
2016

Long-term effect of sitagliptin on endothelial function in type 2 diabetes: A sub-analysis of the PROLOGUE study

for the PROLOGUE Study Investigators, Sep 13 2016, In : Cardiovascular Diabetology. 15, 1, 134.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2018

Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy

Tenma, T., Mitsuyama, H., Watanabe, M., Kakutani, N., Otsuka, Y., Mizukami, K., Kamada, R., Takahashi, M., Takada, S., Sabe, H., Tsutsui, H. & Yokoshiki, H., Aug 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H262-H272

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension

Tanaka, M., Abe, K., Oka, M., Saku, K., Yoshida, K., Ishikawa, T., McMurtry, I. F., Sunagawa, K., Hoka, S. & Tsutsui, H., Dec 2017, In : Physiological Reports. 5, 23, e13537.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Impact of anteroinferior transseptal puncture on creation of a complete block at the mitral isthmus in patients with atrial fibrillation

Okubo, K., Kuwahara, T., Takigawa, M., Tanaka, Y., Nakajima, J., Watari, Y., Nakashima, E., Yamao, K., Sagawa, Y., Takagi, K., Fujino, T., Tsutsui, H. & Takahashi, A., Apr 1 2017, In : Journal of Interventional Cardiac Electrophysiology. 48, 3, p. 317-325 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Central chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats

Saku, K., Tohyama, T., Shinoda, M., Kishi, T., Hosokawa, K., Nishikawa, T., Oga, Y., Sakamoto, T., Tsutsui, H., Miyamoto, T. & Sunagawa, K., Sep 12 2017, In : Physiological Reports. 5, 17, e13406.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2019

Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease

Aikawa, T., Naya, M., Obara, M., Manabe, O., Magota, K., Koyanagawa, K., Asakawa, N., Ito, Y. M., Shiga, T., Katoh, C., Anzai, T., Tsutsui, H., Murthy, V. L. & Tamaki, N., Jan 1 2019, In : Cardiovascular research. 115, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings

Mannoji, H., Saku, K., Nishikawa, T., Tohyama, T., Kamada, K., Abe, K., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Apr 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 4, p. H828-H839

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure

Matsumoto, J., Takada, S., Kinugawa, S., Furihata, T., Nambu, H., Kakutani, N., Tsuda, M., Fukushima, A., Yokota, T., Tanaka, S., Takahashi, H., Watanabe, M., Hatakeyama, S., Matsumoto, M., Nakayama, K. I., Otsuka, Y., Sabe, H., Tsutsui, H. & Anzai, T., Jan 1 2018, In : Circulation. 138, 18, p. 2064-2066 3 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

The impact of volume loading–induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats

Oga, Y., Saku, K., Nishikawa, T., Kishi, T., Tobushi, T., Hosokawa, K., Tohyama, T., Sakamoto, T., Sunagawa, K. & Tsutsui, H., Sep 2018, In : Physiological Reports. 6, 19, e13887.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study

Tsutsui, H., Momomura, S., Saito, Y., Ito, H., Yamamoto, K., Ohishi, T., Okino, N. & Guo, W., Sep 2017, In : Journal of Cardiology. 70, 3, p. 225-231 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs

Saku, K., Kakino, T., Arimura, T., Sunagawa, G., Nishikawa, T., Sakamoto, T., Kishi, T., Tsutsui, H. & Sunagawa, K., May 1 2018, In : Circulation. Heart failure. 11, 5, p. e004397

Research output: Contribution to journalArticle

13 Citations (Scopus)
2020

Spironolactone use is associated with improved outcomes in heart failure with mid-range ejection fraction

Enzan, N., Matsushima, S., Ide, T., Kaku, H., Higo, T., Tsuchihashi-Makaya, M. & Tsutsui, H., Jan 1 2020, (Accepted/In press) In : ESC Heart Failure.

Research output: Contribution to journalArticle

Open Access
2016
11 Citations (Scopus)
2018

Association of peripartum troponin i levels with left ventricular relaxation in women with hypertensive disorders of pregnancy

Umazume, T., Yamada, S., Yamada, T., Ishikawa, S., Furuta, I., Iwano, H., Murai, D., Hayashi, T., Okada, K., Morikawa, M., Tsutsui, H. & Minakami, H., Jan 1 2018, In : Open Heart. 5, 2, e000829.

Research output: Contribution to journalArticle

2017

Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome

Yokota, T., Kinugawa, S., Hirabayashi, K., Suga, T., Takada, S., Omokawa, M., Kadoguchi, T., Takahashi, M., Fukushima, A., Matsushima, S., Yamato, M., Okita, K. & Tsutsui, H., Jul 2017, In : Journal of Diabetes Investigation. 8, 4, p. 535-541 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Usefulness of the Continuous-Wave Doppler-Derived Pulmonary Arterial–Right Ventricular Pressure Gradient Just before Atrial Contraction for the Estimation of Pulmonary Arterial Diastolic and Wedge Pressures

Murayama, M., Mikami, T., Kaga, S., Okada, K., Hioka, T., Masauzi, N., Nakabachi, M., Nishino, H., Yokoyama, S., Nishida, M., Iwano, H., Sakakibara, M., Yamada, S. & Tsutsui, H., May 1 2017, In : Ultrasound in Medicine and Biology. 43, 5, p. 958-966 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice

Fukushima, A., Kinugawa, S., Takada, S., Matsumoto, J., Furihata, T., Mizushima, W., Tsuda, M., Yokota, T., Matsushima, S., Okita, K. & Tsutsui, H., May 15 2016, In : European Journal of Pharmacology. 779, p. 147-156 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2020

The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice

Takahashi, M., Kinugawa, S., Takada, S., Kakutani, N., Furihata, T., Sobirin, M. A., Fukushima, A., Obata, Y., Saito, A., Ishimori, N., Iwabuchi, K. & Tsutsui, H., Jan 1 2020, (Accepted/In press) In : Experimental Physiology.

Research output: Contribution to journalArticle

2017

Association of contrast-induced nephropathy with risk of adverse clinical outcomes in patients with cardiac catheterization: From the CINC-J study

on behalf of the CINC-J study investigators, Jan 15 2017, In : International Journal of Cardiology. 227, p. 424-429 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2016

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Furihata, T., Kinugawa, S., Fukushima, A., Takada, S., Homma, T., Masaki, Y., Abe, T., Yokota, T., Oba, K., Okita, K. & Tsutsui, H., Oct 1 2016, In : International Journal of Cardiology. 220, p. 483-487 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica

Translated title of the contribution: 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failurePonikowski, AM. D. G. D. T. P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V. P., Jankowska, E. A., Jessup, M., Linde, C., Nihoyannopoulos, P., Parissis, J. T., Pieske, B., Riley, J. P., Rosano, G. M. C., Ruilope, L. M., Ruschitzka, F., Rutten, F. H. & 43 others, van der Meer, P., Filippatos, R. D. D. G., McMurray, J. J. V., Aboyans, V., Achenbach, S., Agewall, S., Al-Attar, N., James Atherton, J., Bauersachs, J., Camm, A. J., Carerj, S., Ceconi, C., Coca, A., Elliott, P., Erol, Ç., Ezekowitz, J., Fernández-Golfín, C., Fitzsimons, D., Guazzi, M., Guenoun, M., Hasenfuss, G., Hindricks, G., Hoes, A. W., Iung, B., Jaarsma, T., Kirchhof, P., Knuuti, J., Kolh, P., Konstantinides, S., Lainscak, M., Lancellotti, P., Lip, G. Y. H., Maisano, F., Mueller, C., Petrie, M. C., Piepoli, M. F., Priori, S. G., Torbicki, A., Tsutsui, H., van Veldhuisen, D. J., Windecker, S., Yancy, C. & Zamorano, J. L., Dec 1 2016, In : Revista Espanola de Cardiologia. 69, 12, p. 1167.-1167.

Research output: Contribution to journalArticle

170 Citations (Scopus)
2019

Left atrial involvement of cardiac sarcoidosis manifesting as left atrial re-entrant tachycardia

Enzan, N., Ohtani, K., Nagaoka, K., Sakamoto, I. & Tsutsui, H., Aug 1 2019, In : European heart journal cardiovascular Imaging. 20, 8, 1 p., jez051.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)
Open Access
1 Citation (Scopus)
2017
1 Citation (Scopus)
23 Citations (Scopus)
2019

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Tokutome, M., Matoba, T., Nakano, Y., Okahara, A., Fujiwara, M., Koga, J. I., Nakano, K., Tsutsui, H. & Egashira, K., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 419-431 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Predictive value of the induction test with atrial burst pacing with regard to long-term recurrence after ablation in persistent atrial fibrillation

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Apr 1 2019, In : journal of arrhythmia. 35, 2, p. 223-229 7 p.

Research output: Contribution to journalArticle

Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption

Sunagawa, G., Saku, K., Arimura, T., Nishikawa, T., Mannoji, H., Kamada, K., Abe, K., Kishi, T., Tsutsui, H. & Sunagawa, K., Apr 15 2019, In : Journal of Cardiovascular Translational Research. 12, 2, p. 124-134 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

The challenge of magnetic vagal nerve stimulation for myocardial infarction -preliminary clinical trial

Nishikawa, T., Saku, K., Todaka, K., Kuwabara, Y., Arai, S., Kishi, T., Ide, T., Tsutsui, H. & Sunagawa, K., Jul 2017, In : Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2017, p. 4321-4324 4 p.

Research output: Contribution to journalArticle

The challenge of magnetic vagal nerve stimulation for myocardial infarction -preliminary clinical trial

Nishikawa, T., Saku, K., Todaka, K., Kuwabara, Y., Arai, S., Kishi, T., Ide, T., Tsutsui, H. & Sunagawa, K., Sep 13 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., p. 4321-4324 4 p. 8037812. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2016

Incidental focal myocardial 18F-FDG uptake indicating asymptomatic coronary artery disease

Aikawa, T., Naya, M., Manabe, O., Obara, M., Matsushima, S., Tamaki, N. & Tsutsui, H., Jun 1 2016, In : Journal of Nuclear Cardiology. 23, 3, p. 596-598 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in rats with pulmonary arterial hypertension

Shinoda, M., Saku, K., Oga, Y., Tohyama, T., Nishikawa, T., Abe, K., Yoshida, K., Kuwabara, Y., Fujii, K., Ishikawa, T., Kishi, T., Sunagawa, K. & Tsutsui, H., Aug 1 2019, In : Experimental Physiology. 104, 8, p. 1164-1178 15 p.

Research output: Contribution to journalArticle

2016

Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome

Masuda, A., Yoshinaga, K., Naya, M., Manabe, O., Yamada, S., Iwano, H., Okada, T., Katoh, C., Takeishi, Y., Tsutsui, H. & Tamaki, N., Jan 1 2016, In : EJNMMI Research. 6, 1, 41.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency

Murai, D., Yamada, S., Hayashi, T., Okada, K., Nishino, H., Nakabachi, M., Yokoyama, S., Abe, A., Ichikawa, A., Ono, K., Kaga, S., Iwano, H., Mikami, T. & Tsutsui, H., May 1 2017, In : Heart and Vessels. 32, 5, p. 574-583 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019

Nationwide survey of multidisciplinary care and cardiac rehabilitation for patients with heart failure in Japan ― An analysis of the AMED-CHF study ―

Kamiya, K., Yamamoto, T., Tsuchihashi-Makaya, M., Ikegame, T., Takahashi, T., Sato, Y., Kotooka, N., Saito, Y., Tsutsui, H., Miyata, H. & Isobe, M., Jan 1 2019, In : Circulation Journal. 83, 7, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

Open Access
2018
5 Citations (Scopus)
2017

Influence of myopotential interference on the Wavelet discrimination algorithm in implantable cardioverter-defibrillator

Mizukami, K., Yokoshiki, H., Mitsuyama, H., Watanabe, M., Tenma, T., Kamada, R., Takahashi, M., Sasaki, R., Maeno, M. & Tsutsui, H., Jun 2017, In : journal of arrhythmia. 33, 3, p. 214-219 6 p.

Research output: Contribution to journalArticle

2019
Open Access
2016

Myocardial immunocompetent cells and macrophage phenotypes as histopathological surrogates for diagnosis of cardiac sarcoidosis in Japanese

Honda, Y., Nagai, T., Ikeda, Y., Sakakibara, M., Asakawa, N., Nagano, N., Nakai, M., Nishimura, K., Sugano, Y., Ohta-Ogo, K., Asaumi, Y., Aiba, T., Kanzaki, H., Kusano, K., Noguchi, T., Yasuda, S., Tsutsui, H., Ishibashi-Ueda, H. & Anzai, T., Nov 2016, In : Journal of the American Heart Association. 5, 11, e004019.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2019