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  • Isamu Okamoto
2019

Immune checkpoint protein and cytokine expression by T lymphocytes in pleural effusion of cancer patients receiving anti–PD-1 therapy

Ikematsu, Y., Tanaka, K., Yanagihara, T., Liu, R., Inoue, H., Yoneshima, Y., Ota, K., Iwama, E., Takata, S., Hata, K., Takahata, Y., Wataya, H., Nakanishi, Y. & Okamoto, I., Dec 2019, In : Lung Cancer. 138, p. 58-64 7 p.

Research output: Contribution to journalArticle

Heregulin expression and its clinical implication for patients with EGFR-mutant non-small cell lung cancer treated with EGFR-tyrosine kinase inhibitors

Yonesaka, K., Iwama, E., Hayashi, H., Suzuki, S., Kato, R., Watanabe, S., Takahama, T., Tanizaki, J., Tanaka, K., Takeda, M., Sakai, K., Azuma, K., Chiba, Y., Atagi, S., Nishio, K., Okamoto, I. & Nakagawa, K., Dec 1 2019, In : Scientific reports. 9, 1, 19501.

Research output: Contribution to journalArticle

Open Access
2016

Characteristics and overall survival of EGFR mutation-positive non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors: A retrospective analysis for 1660 Japanese patients

Inoue, A., Yoshida, K., Morita, S., Imamura, F., Seto, T., Okamoto, I., Nakagawa, K., Yamamoto, N., Muto, S. & Fukuoka, M., Jan 1 2016, In : Japanese journal of clinical oncology. 46, 5, p. 462-467 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy

Kawakami, H. & Okamoto, I., Jul 1 2016, In : Gastric Cancer. 19, 3, p. 687-695 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2018

Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix-assisted laser desorption ionization mass spectrometry imaging: a pilot study

Ryu, S., Hayashi, M., Aikawa, H., Okamoto, I., Fujiwara, Y. & Hamada, A., Jan 2018, In : British Journal of Pharmacology. 175, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Dec 2018, In : Cancer Science. 109, 12, p. 3921-3933 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Treatment Rationale and Design for J-AXEL: A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

Yoneshima, Y., Morita, S., Ando, M., Miura, S., Yoshioka, H., Abe, T., Kato, T., Kondo, M., Hosomi, Y., Hotta, K., Yamamoto, N., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Jan 1 2017, In : Clinical Lung Cancer. 18, 1, p. 100-103 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma

Matsubara, T., Takada, K., Azuma, K., Takamori, S., Toyokawa, G., Haro, A., Osoegawa, A., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2018

Treatment Rationale and Design for J-SONIC: A Randomized Study of Carboplatin Plus Nab-paclitaxel With or Without Nintedanib for Advanced Non–Small-cell Lung Cancer With Idiopathic Pulmonary Fibrosis

Otsubo, K., Kishimoto, J., Kenmotsu, H., Minegishi, Y., Ichihara, E., Shiraki, A., Kato, T., Atagi, S., Horinouchi, H., Ando, M., Kondoh, Y., Kusumoto, M., Ichikado, K., Yamamoto, N., Nakanishi, Y. & Okamoto, I., Jan 2018, In : Clinical Lung Cancer. 19, 1, p. e5-e9

Research output: Contribution to journalArticle

18 Citations (Scopus)

Sensitivity of epidermal growth factor receptor with single or double uncommon mutations to afatinib confirmed by a visual assay

Kimura, S., Tanaka, K., Harada, T., Liu, R., Shibahara, D., Kawano, Y., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Cancer Science. 109, 11, p. 3657-3661 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Osimertinib in Japanese patients with EGFR T790M mutation-positive advanced non-small-cell lung cancer: AURA3 trial

Akamatsu, H., Katakami, N., Okamoto, I., Kato, T., Kim, Y. H., Imamura, F., Shinkai, M., Hodge, R. A., Uchida, H. & Hida, T., Jun 2018, In : Cancer Science. 109, 6, p. 1930-1938 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2019
Open Access

Molecularly-targeted therapies for advanced non-small-cell lung cancer

Okamoto, I., Nov 25 2019, In : Japanese Journal of Lung Cancer. 59, p. 1115-1118 4 p.

Research output: Contribution to journalArticle

2018

PD-L2 expression as a potential predictive biomarker for the response to anti-PD-1 drugs in patients with non-small cell lung cancer

Takamori, S., Takada, K., Toyokawa, G., Azuma, K., Shimokawa, M., Jogo, T., Yamada, Y., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5897-5901 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2019

Localized malignant pleural mesothelioma mimicking an anterior mediastinal tumor

Hino, T., Kamitani, T., Sagiyama, K., Yamasaki, Y., Okamoto, I., Tagawa, T., Ijichi, K., Yamamoto, H., Yabuuchi, H. & Honda, H., Jan 1 2019, In : European Journal of Radiology Open. 6, p. 72-77 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Association of preoperative serum CRP with PD-L1 expression in 508 patients with non-small cell lung cancer: A comprehensive analysis of systemic inflammatory markers

Akamine, T., Takada, K., Toyokawa, G., Kinoshita, F., Matsubara, T., Kozuma, Y., Haratake, N., Takamori, S., Hirai, F., Tagawa, T., Okamoto, T., Yoneshima, Y., Okamoto, I., Shimokawa, M., Oda, Y., Nakanishi, Y. & Maehara, Y., Mar 2018, In : Surgical Oncology. 27, 1, p. 88-94 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2019

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies

Yoneshima, Y., Tanaka, K., Shiraishi, Y., Hata, K., Watanabe, H., Harada, T., Otsubo, K., Iwama, E., Inoue, H., Masuda, S., Nakanishi, Y. & Okamoto, I., Apr 2019, In : Lung Cancer. 130, p. 5-9 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Phase II trial of weekly nab-paclitaxel for previously treated advanced non–small cell lung cancer: Kumamoto thoracic oncology study group (KTOSG) trial 1301

Sakata, S., Saeki, S., Okamoto, I., Otsubo, K., Komiya, K., Morinaga, R., Yoneshima, Y., Koga, Y., Enokizu, A., Kishi, H., Hirosako, S., Yamaguchi, E., Aragane, N., Fujii, S., Harada, T., Iwama, E., Semba, H., Nakanishi, Y. & Kohrogi, H., Sep 1 2016, In : Lung Cancer. 99, p. 41-45 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2019

Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma

Takada, K., Shimokawa, M., Tanaka, K., Kohashi, K., Haro, A., Osoegawa, A., Tagawa, T., Azuma, K., Okamoto, I., Oda, Y. & Mori, M., Jun 2019, In : PloS one. 14, 6, e0217991.

Research output: Contribution to journalArticle

Open Access
2016

Phase II study of erlotinib plus tivantinib (ARQ 197) in patients with locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer just after progression on EGFR-TKI, gefitinib or erlotinib

Azuma, K., Hirashima, T., Yamamoto, N., Okamoto, I., Takahashi, T., Nishio, M., Hirata, T., Kubota, K., Kasahara, K., Hida, T., Yoshioka, H., Nakanishi, K., Akinaga, S., Nishio, K., Mitsudomi, T. & Nakagawa, K., Jul 2016, In : ESMO Open. 1, 4, e000063.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2018

Osimertinib in untreated EGFR-Mutated advanced non-small-cell lung cancer

Soria, J. C., Ohe, Y., Vansteenkiste, J., Reungwetwattana, T., Chewaskulyong, B., Lee, K. H., Dechaphunkul, A., Imamura, F., Nogami, N., Kurata, T., Okamoto, I., Zhou, C., Cho, B. C., Cheng, Y., Cho, E. K., Voon, P. J., Planchard, D., Su, W. C., Gray, J. E., Lee, S. M. & 4 others, Hodge, R., Marotti, M., Rukazenkov, Y. & Ramalingam, S. S., Jan 11 2018, In : New England Journal of Medicine. 378, 2, p. 113-125 13 p.

Research output: Contribution to journalArticle

731 Citations (Scopus)

Radiological features of programmed cell death-ligand 2-positive lung adenocarcinoma: A single-institution retrospective study

Takada, K., Toyokawa, G., Azuma, K., Takamori, S., Jogo, T., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Nov 1 2018, In : In Vivo. 32, 6, p. 1541-1550 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Osimertinib versus Standard of Care EGFR TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset

Cho, B. C., Chewaskulyong, B., Lee, K. H., Dechaphunkul, A., Sriuranpong, V., Imamura, F., Nogami, N., Kurata, T., Okamoto, I., Zhou, C., Cheng, Y., Cho, E. K., Voon, P. J., Lee, J. S., Mann, H., Saggese, M., Reungwetwattana, T., Ramalingam, S. S. & Ohe, Y., Jan 2019, In : Journal of Thoracic Oncology. 14, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Osimertinib for Japanese patients with T790M-positive advanced non-small-cell lung cancer: A pooled subgroup analysis

Hirashima, T., Satouchi, M., Hida, T., Nishio, M., Kato, T., Sakai, H., Imamura, F., Kiura, K., Okamoto, I., Kasahara, K., Uchida, H., Vowler, S. L. & Mitsudomi, T., Sep 1 2019, In : Cancer Science. 110, 9, p. 2884-2893 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Japanese subgroup analysis of a phase III study of S-1 versus docetaxel in non-small cell lung cancer patients after platinum-based treatment: EAST-LC

Sugawara, S., Nakagawa, K., Yamamoto, N., Nokihara, H., Ohe, Y., Nishio, M., Takahashi, T., Goto, K., Maemondo, M., Ichinose, Y., Seto, T., Sakai, H., Gemma, A., Imamura, F., Shingyoji, M., Saka, H., Inoue, A., Takeda, K., Okamoto, I., Kiura, K. & 2 others, Morita, S. & Tamura, T., May 15 2019, In : International Journal of Clinical Oncology. 24, 5, p. 485-493 9 p.

Research output: Contribution to journalArticle

Open Access
2020

Multiclonality and Radiosensitivity of Granulocyte-colony Stimulating Factor-Producing Lung Adenocarcinoma Positive for an Activating EGFR Mutation

Tsutsumi, H., Yoneshima, Y., Ota, K., Otsubo, K., Iwama, E., Inoue, H., Tanaka, K., Nakanishi, Y. & Okamoto, I., Jan 2020, In : Clinical Lung Cancer. 21, 1, p. e21-e24

Research output: Contribution to journalArticle

2019

18F-FDG uptake in PET/CT is a potential predictive biomarker of response to anti-PD-1 antibody therapy in non-small cell lung cancer

Takada, K., Toyokawa, G., Yoneshima, Y., Tanaka, K., Okamoto, I., Shimokawa, M., Wakasu, S., Haro, A., Osoegawa, A., Tagawa, T., Oda, Y., Nakanishi, Y. & Mori, M., Dec 1 2019, In : Scientific reports. 9, 1, 13362.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Updated Survival Data for a Phase I/II Study of Carboplatin plus Nab-Paclitaxel and Concurrent Radiotherapy in Patients with Locally Advanced Non-Small Cell Lung Cancer

Tsuchiya-Kawano, Y., Sasaki, T., Yamaguchi, H., Hirano, K., Horiike, A., Satouchi, M., Hosokawa, S., Morinaga, R., Komiya, K., Inoue, K., Fujita, Y., Toyozawa, R., Kimura, T., Takahashi, K., Nishikawa, K., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access

Phase I safety and pharmacokinetics study of rovalpituzumab tesirine in Japanese patients with advanced, recurrent small cell lung cancer

Udagawa, H., Akamatsu, H., Tanaka, K., Takeda, M., Kanda, S., Kirita, K., Teraoka, S., Nakagawa, K., Fujiwara, Y., Yasuda, I., Okubo, S., Shintani, M., Kosloski, M. P., Scripture, C., Tamura, T. & Okamoto, I., Sep 2019, In : Lung Cancer. 135, p. 145-150 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2020

Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors

Takada, K., Yoneshima, Y., Tanaka, K., Okamoto, I., Shimokawa, M., Wakasu, S., Takamori, S., Toyokawa, G., Oba, T., Osoegawa, A., Tagawa, T., Oda, Y., Nakanishi, Y. & Mori, M., Jan 1 2020, (Accepted/In press) In : Journal of Cancer Research and Clinical Oncology.

Research output: Contribution to journalArticle

2019

Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial

Nakagawa, K., Garon, E. B., Seto, T., Nishio, M., Ponce Aix, S., Paz-Ares, L., Chiu, C. H., Park, K., Novello, S., Nadal, E., Imamura, F., Yoh, K., Shih, J. Y., Au, K. H., Moro-Sibilot, D., Enatsu, S., Zimmermann, A., Frimodt-Moller, B., Visseren-Grul, C., Reck, M. & 96 others, Chu, Q., Cortot, A., Pujol, J. L., Fabre, E., Lamour, C., Bischoff, H., Kollmeier, J., Kimmich, M., Engel-Riedel, W., Hammerschmidt, S., Schütte, W., Syrigos, K., Ho, J. C. M., Au, K. H., Ardizzoni, A., Pasello, G., Gregorc, V., Del Conte, A., Galetta, D., Takahashi, T., Kumagai, T., Hotta, K., Goto, Y., Hosomi, Y., Sakai, H., Takiguchi, Y., Kim, Y. H., Kurata, T., Yamaguchi, H., Daga, H., Okamoto, I., Satouchi, M., Ikeda, S., Kasahara, K., Atagi, S., Azuma, K., Aoe, K., Horio, Y., Yamamoto, N., Tanaka, H., Watanabe, S., Nogami, N., Ozaki, T., Koyama, R., Hirashima, T., Kaneda, H., Tomii, K., Fujita, Y., Seike, M., Nishimura, N., Kato, T., Ichiki, M., Saka, H., Hirano, K., Nakahara, Y., Sugawara, S., Kim, S. W., Min, Y. J., Lee, H. W., Kang, J. H., An, H. J., Lee, K. H., Kim, J. S., Lee, G. W., Lee, S. Y., Alexandru, A., Udrea, A. A., Juan-Vidal, Ó., Nadal-Alforja, E., Gil-Bazo, I., Ponce-Aix, S., Rubio-Viqueira, B., Alonso Garcia, M., Felip Font, E., Fuentes Pradera, J., Coves Sarto, J., Lin, M. C., Su, W. C., Hsia, T. C., Chang, G. C., Wei, Y. F., Su, J., Cicin, I., Goksel, T., Harputluoglu, H., Ozyilkan, O., Henning, I., Popat, S., Hatcher, O., Mileham, K., Acoba, J., Garon, E., Jung, G., Raj, M., Martin, W. & Dakhil, S., Dec 2019, In : The Lancet Oncology. 20, 12, p. 1655-1669 15 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (West Japan Oncology Group 5910L): An open-label, randomized, phase 2 trial

Takeda, M., Yamanaka, T., Seto, T., Hayashi, H., Azuma, K., Okada, M., Sugawara, S., Daga, H., Hirashima, T., Yonesaka, K., Urata, Y., Murakami, H., Saito, H., Kubo, A., Sawa, T., Miyahara, E., Nogami, N., Nakagawa, K., Nakanishi, Y. & Okamoto, I., Apr 1 2016, In : Cancer. 122, 7, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2019

Osimertinib versus standard-of-care EGFR-TKI as first-line treatment for EGFRm advanced NSCLC: FLAURA Japanese subset

Ohe, Y., Imamura, F., Nogami, N., Okamoto, I., Kurata, T., Kato, T., Sugawara, S., Ramalingam, S. S., Uchida, H., Hodge, R., Vowler, S. L., Walding, A. & Nakagawa, K., Jan 1 2019, In : Japanese journal of clinical oncology. 49, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

First-line afatinib for the treatment of EGFR mutation-positive non-small-cell lung cancer in the ‘real-world’ clinical setting

Park, K., Wan-Teck Lim, D., Okamoto, I. & Yang, J. C. H., Apr 1 2019, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)
2018

Osimertinib in patients with epidermal growth factor receptor T790M advanced non-small cell lung cancer selected using cytology samples

Kiura, K., Yoh, K., Katakami, N., Nogami, N., Kasahara, K., Takahashi, T., Okamoto, I., Cantarini, M., Hodge, R. & Uchida, H., Apr 2018, In : Cancer Science. 109, 4, p. 1177-1184 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Ogata, H., Okamoto, I., Yoshimoto, G., Obara, T., Ijichi, K., Iwama, E., Harada, T., Akashi, K. & Nakanishi, Y., Mar 1 2017, In : Respiratory Investigation. 55, 2, p. 181-183 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis

Ide, M., Tanaka, K., Sunami, S., Asoh, T., Maeyama, T., Tsuruta, N., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Thoracic Cancer. 9, 11, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., Nov 2017, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Alectinib for Patients with ALK Rearrangement–Positive Non–Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401)

Iwama, E., Goto, Y., Murakami, H., Harada, T., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Okazaki, A., Akamatsu, H., Morinaga, R., Ushijima, S., Shimose, T., Tokunaga, S., Hamada, A., Yamamoto, N. & 3 others, Nakanishi, Y., Sugio, K. & Okamoto, I., Jul 2017, In : Journal of Thoracic Oncology. 12, 7, p. 1161-1166 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Meta-analysis of pemetrexed plus carboplatin doublet safety profile in first-line non-squamous non-small cell lung cancer studies

Okamoto, I., Schuette, W. H. W., Stinchcombe, T. E., Rodrigues-Pereira, J., San Antonio, B., Chen, J., Liu, J., John, W. J. & Zinner, R. G., May 4 2017, In : Current Medical Research and Opinion. 33, 5, p. 937-941 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
4 Citations (Scopus)
2018
1 Citation (Scopus)

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Development of leptomeningeal carcinomatosis during a marked response of brain metastases to pembrolizumab in a patient with non-small-cell lung cancer

Otsubo, K., Seki, N., Nakanishi, Y. & Okamoto, I., Mar 1 2018, In : Annals of Oncology. 29, 3, p. 780-781 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)
2017

Discrepancy in programmed cell death-ligand 1 between primary and metastatic non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Katsura, M., Mukae, N., Shoji, F., Okamoto, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Aug 2017, In : Anticancer research. 37, 8, p. 4223-4228 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2016

Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma: Post hoc analyses of the randomized LUX-Lung 3 and 6 trials

Yang, J. C. H., Sequist, L. V., Zhou, C., Schuler, M., Geater, S. L., Mok, T., Hu, C. P., Yamamoto, N., Feng, J., O'Byrne, K., Lu, S., Hirsh, V., Huang, Y., Sebastian, M., Okamoto, I., Dickgreber, N., Shah, R., Märten, A., Massey, D., Wind, S. & 1 others, Wu, Y. L., Jan 1 2016, In : Annals of Oncology. 27, 11, p. 2103-2110 8 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
2017

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y., Jun 1 2017, In : Lung Cancer. 108, p. 75-82 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Combination therapy with molecularly targeted agents in lung cancer

Okamoto, I., Oct 2017, In : Annals of Oncology. 28, p. ix5

Research output: Contribution to journalArticle

Open Access
2016

Anti-HER3 monoclonal antibody patritumab sensitizes refractory non-small cell lung cancer to the epidermal growth factor receptor inhibitor erlotinib

Yonesaka, K., Hirotani, K., Kawakami, H., Takeda, M., Kaneda, H., Sakai, K., Okamoto, I., Nishio, K., Jänne, P. A. & Nakagawa, K., Feb 18 2016, In : Oncogene. 35, 7, p. 878-886 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2018

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., Ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., Jul 2018, In : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)