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  • Kazuhide Inoue
2019

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori-Hayashi, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Kido-Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Tsuda, M., Mar 2019, In : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

Research output: Contribution to journalArticle

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Tozaki-Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Tsuda, M., Apr 2019, In : GLIA. 67, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori-Hayashi, M., Yamashita, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Mar 23 2016, In : Scientific reports. 6, 23701.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2019

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2012

P2X4R and P2X7R in neuropathic pain

Makoto, T., Hidetoshi, T. S. & Kazuhide, I., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 513-521 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2011
58 Citations (Scopus)

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases

Kuboyama, K., Tsuda, M., Tsutsui, M., Toyohara, Y., Tozaki-Saitoh, H., Shimokawa, H., Yanagihara, N. & Inoue, K., Jul 14 2011, In : Molecular Pain. 7, 50.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2016

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Wu, Z., Kohsaka, S., Inoue, K. & Nakanishi, H., May 31 2016, In : Nature communications. 7, 11697.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Transcriptional regulation in microglia and neuropathic pain

Masuda, T., Tsuda, M. & Inoue, K., Apr 1 2016, In : Pain management. 6, 2, p. 91-94 4 p.

Research output: Contribution to journalEditorial

Open Access
3 Citations (Scopus)
2013

Microglia and intractable chronic pain

Tsuda, M., Beggs, S., Salter, M. W. & Inoue, K., Jan 1 2013, In : GLIA. 61, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2015

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Masuda, T., Iwamoto, S., Mikuriya, S., Tozaki-Saitoh, H., Tamura, T., Tsuda, M. & Inoue, K., Sep 4 2015, In : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2013

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Nakaya, M., Tajima, M., Kosako, H., Nakaya, T., Hashimoto, A., Watari, K., Nishihara, H., Ohba, M., Komiya, S., Tani, N., Nishida, M., Taniguchi, H., Sato, Y., Matsumoto, M., Tsuda, M., Kuroda, M., Inoue, K. & Kurose, H., Mar 11 2013, In : Nature communications. 4, 1532.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2012

Purinergic system, microglia and neuropathic pain

Makoto, T., Saitoh, H. & Inoue, K., Feb 1 2012, In : Current Opinion in Pharmacology. 12, 1, p. 74-79 6 p.

Research output: Contribution to journalReview article

41 Citations (Scopus)
2016

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Oct 2016, In : PloS one. 11, 10, e0165189.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

Koizumi, S., Ohsawa, K., Inoue, K. & Kohsaka, S., Jan 1 2013, In : GLIA. 61, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

The Neuropharmacological study for ATP receptors especially in pain

Inoue, K., Jan 1 2013, In : Yakugaku Zasshi. 133, 10, p. 1035-1039 5 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2019

Role of the P2X4 receptor in neuropathic pain

Inoue, K., Aug 2019, In : Current Opinion in Pharmacology. 47, p. 33-39 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2011

Role of Purinergic Receptors in CNS Function and Neuroprotection

Saitoh, H., Makoto, T. & Inoue, K., Jan 1 2011, Advances in Pharmacology. Academic Press Inc., p. 495-528 34 p. (Advances in Pharmacology; vol. 61).

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)
2012

Purinergic systems, neuropathic pain and the role of microglia

Inoue, K. & Tsuda, M., Apr 1 2012, In : Experimental Neurology. 234, 2, p. 293-301 9 p.

Research output: Contribution to journalReview article

49 Citations (Scopus)
2014
43 Citations (Scopus)
2012

Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain

Sun, L., Wu, Z., Hayashi, Y., Peters, C., Tsuda, M., Inoue, K. & Nakanishi, H., Aug 15 2012, In : Journal of Neuroscience. 32, 33, p. 11330-11342 13 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2019

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., Mar 15 2019, In : Purinergic Signalling. 15, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017
16 Citations (Scopus)
2019

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., Mar 30 2019, In : Journal of neuroinflammation. 16, 1, 67.

Research output: Contribution to journalArticle

Open Access
2012

Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures

Kumamaru, H., Saiwai, H., Kobayakawa, K., Kubota, K., van Rooijen, N., Inoue, K., Iwamoto, Y. & Okada, S., May 31 2012, In : Journal of neuroinflammation. 9, 116.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2013

Reply to: 'The discovery of a new class of synaptic transmitters in smooth muscle fifty years ago and amelioration of coronary artery thrombosis'

Abbracchio, M. P., Boeynaems, J. M., Cattaneo, M., Virgilio, F. D., Illes, P., Inoue, K., Jacobson, K. A., Teresa Miras-Portugal, M., Ralevic, V., Robson, S. C., Verkhratsky, A. & Zimmermann, H., Jun 1 2013, In : Acta Physiologica. 208, 2, p. 139-140 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)
2016

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., Aug 12 2016, In : Nature communications. 7, 12529.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2011

Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways

Kataoka, A., Koga, Y., Uesugi, A., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., Dec 1 2011, In : Purinergic Signalling. 7, 4, p. 403-411 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2013

Intrathecal infusion of microglia cells

Masuda, T., Tsuda, M., Tozaki-Saitoh, H. & Inoue, K., Jul 18 2013, Microglia: Methods and Protocols. p. 291-294 4 p. (Methods in Molecular Biology; vol. 1041).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2015

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding

Igawa, T., Abe, Y., Tsuda, M., Inoue, K. & Ueda, T., Mar 12 2015, In : FEBS Letters. 589, 6, p. 680-686 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Matsunaga, N., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. & 7 others, Amamoto, T., Aramaki, H., Tsuda, M., Inoue, K., Ojida, A., Koyanagi, S. & Ohdo, S., Nov 1 2016, In : EBioMedicine. 13, p. 262-273 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Ochi-ishi, R., Nagata, K., Inoue, T., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., Aug 15 2014, In : Molecular Pain. 10, 1, 53.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2018

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015

Effect of adenosine system in the action of oseltamivir on behavior in mice

Uchiyama, H., Hiromura, M., Shiratani, T., Kuroki, H., Honda, S., Kosako, K., Soeda, S., Inoue, K. & Toda, A., Jul 1 2015, In : Neuroscience Letters. 599, p. 7-11 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells

Ohgidani, M., Kato, T. A., Hosoi, M., Tsuda, M., Hayakawa, K., Hayaki, C., Iwaki, R., Sagata, N., Hashimoto, R., Inoue, K., Sudo, N. & Kanba, S., Dec 1 2017, In : Scientific reports. 7, 1, 11882.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2018

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., May 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2012

P2Y receptors in microglia and neuroinflammation

Saitoh, H., Makoto, T. & Inoue, K., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 493-501 9 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)
2017
5 Citations (Scopus)
2016

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Tsuda, M. & Inoue, K., May 1 2016, In : Neuropharmacology. 104, p. 76-81 6 p.

Research output: Contribution to journalReview article

43 Citations (Scopus)
2012

Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis

Uesugi, A., Kataoka, A., Tozaki-Saitoh, H., Koga, Y., Tsuda, M., Robaye, B., Boeynaems, J. M. & Inoue, K., Jul 1 2012, In : GLIA. 60, 7, p. 1094-1105 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

P2X4 receptors of microglia in neuropathic pain

Inoue, K. & Makoto, T., Nov 19 2012, In : CNS and Neurological Disorders - Drug Targets. 11, 6, p. 699-704 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2017

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Koga, K., Kanehisa, K., Kohro, Y., Shiratori-Hayashi, M., Tozaki-Saitoh, H., Inoue, K., Furue, H. & Tsuda, M., Dec 1 2017, In : Scientific reports. 7, 1, 4739.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2013

Microglial regulation of neuropathic pain

Tsuda, M., Masuda, T., Tozaki-Saitoh, H. & Inoue, K., Feb 26 2013, In : Journal of Pharmacological Sciences. 121, 2, p. 89-94 6 p.

Research output: Contribution to journalReview article

81 Citations (Scopus)
2011

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

Tsuda, M., Kohro, Y., Yano, T., Tsujikawa, T., Kitano, J., Tozaki-Saitoh, H., Koyanagi, S., Ohdo, S., Ji, R. R., Salter, M. W. & Inoue, K., Apr 1 2011, In : Brain. 134, 4, p. 1127-1139 13 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)
2018

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., Dec 1 2018, In : Nature communications. 9, 1, 1886.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2011

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

Biber, K., Tsuda, M., Tozaki-Saitoh, H., Tsukamoto, K., Toyomitsu, E., Masuda, T., Boddeke, H. & Inoue, K., May 4 2011, In : EMBO Journal. 30, 9, p. 1864-1873 10 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Microglial Ca 2+-activated K + channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain

Hayashi, Y., Kawaji, K., Sun, L., Zhang, X., Koyano, K., Yokoyama, T., Kohsaka, S., Inoue, K. & Nakanishi, H., Nov 30 2011, In : Journal of Neuroscience. 31, 48, p. 17370-17382 13 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2018

A state-of-the-art perspective on microgliopathic pain

Inoue, K., Nov 1 2018, In : Open Biology. 8, 11, 180154.

Research output: Contribution to journalReview article

3 Citations (Scopus)