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Author

  • Keiichi Nakayama

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., Mar 12 2018, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

32 Citations (Scopus)

Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin

Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K. I., Okumura, F., Hatakeyama, S. & Koike, T., Jan 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K. I., Jul 2019, In : Cancer Science. 110, 7, p. 2090-2099 10 p.

Research output: Contribution to journalReview article

Open Access
7 Citations (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., Jan 1 2019, In : JCI Insight. 4, 4, e125138.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis

Matsuhisa, K., Saito, A., Cai, L., Kaneko, M., Okamoto, T., Sakaue, F., Asada, R., Urano, F., Yanagida, K., Okochi, M., Kudo, Y., Matsumoto, M., Nakayama, K. I. & Imaizumi, K., Jan 1 2020, In : FASEB Journal. 34, 1, p. 865-880 16 p.

Research output: Contribution to journalArticle

Open Access

Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells

Takahashi, K., Tanaka, M., Yashiro, M., Matsumoto, M., Ohtsuka, A., Nakayama, K. I., Izumi, Y., Nagayama, K., Miura, K., Iwao, H. & Shiota, M., Aug 1 2016, In : Cancer Letters. 378, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts

Cremasco, V., Decker, C. E., Stumpo, D., Blackshear, P. J., Nakayama, K., Nakayama, K., Lupu, T. S., Graham, D. B., Novack, D. V. & Faccio, R., Dec 1 2012, In : Journal of Bone and Mineral Research. 27, 12, p. 2452-2463 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Proteome of ubiquitin/MVB pathway: Possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

Tachiyama, R., Ishikawa, D., Matsumoto, M., Nakayama, K. I., Yoshimori, T., Yokota, S., Himeno, M., Tanaka, Y. & Fujita, H., Apr 1 2011, In : Genes to Cells. 16, 4, p. 448-466 19 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin

Oshikawa, K., Matsumoto, M., Oyamada, K. & Nakayama, K. I., Feb 3 2012, In : Journal of Proteome Research. 11, 2, p. 796-807 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia

Hashimoto, Y., Shirane, M., Matsuzaki, F., Saita, S., Ohnishi, T. & Nakayama, K. I., Jan 1 2014, In : Journal of Biological Chemistry. 289, 19, p. 12946-12961 16 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

Matsuzaki, F., Shirane, M., Matsumoto, M. & Nakayama, K. I., Dec 1 2011, In : Molecular biology of the cell. 22, 23, p. 4602-4620 19 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Recent insight into the role of FBXW7 as a tumor suppressor

Yumimoto, K. & Nakayama, K. I., Jan 1 2020, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., Jan 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Reconstruction of insulin signal flow from phosphoproteome and metabolome data

Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K. I., Kashikura, K., Endo, K., Ikeda, K., Soga, T. & Kuroda, S., Aug 21 2014, In : Cell Reports. 8, 4, p. 1171-1183 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Regulation of APC/C Cdc20 activity by RASSF1A-APC/C Cdc20 circuitry

Chow, C., Wong, N., Pagano, M., Lun, S. W. M., Nakayama, K. I., Nakayama, K. & Lo, K. W., Apr 12 2012, In : Oncogene. 31, 15, p. 1975-1987 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression

Reavie, L., Buckley, S. M., Loizou, E., Takeishi, S., Aranda-Orgilles, B., Ndiaye-Lobry, D., Abdel-Wahab, O., Ibrahim, S., Nakayama, K. I. & Aifantis, I., Mar 18 2013, In : Cancer Cell. 23, 3, p. 362-375 14 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., Apr 17 2015, In : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Ribophorin ii is involved in the tissue factor expression mediated by phosphatidylserinedependent antiprothrombin antibody on monocytes

Fujieda, Y., Amengual, O., Matsumoto, M., Kuroki, K., Takahashi, H., Kono, M., Kurita, T., Otomo, K., Kato, M., Oku, K., Bohgaki, T., Horita, T., Yasuda, S., Maenaka, K., Hatakeyama, S., Nakayama, K. & Atsumi, T., Jun 1 2016, In : Rheumatology (United Kingdom). 55, 6, p. 1117-1126 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-β2 glycoprotein i antibodies

Otomo, K., Amengual, O., Fujieda, Y., Nakagawa, H., Kato, M., Oku, K., Horita, T., Yasuda, S., Matsumoto, M., Nakayama, K. I., Hatakeyama, S., Koike, T. & Atsumi, T., Oct 1 2016, In : Lupus. 25, 12, p. 1288-1298 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.

Takeishi, S. & Nakayama, K. I., Sep 9 2014, In : British journal of cancer. 111, 6, p. 1054-1059 6 p.

Research output: Contribution to journalReview article

40 Citations (Scopus)

Role of key regulators of the cell cycle in maintenance of hematopoietic stem cells

Matsumoto, A. & Nakayama, K. I., Feb 1 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2335-2344 10 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ

Shin, E. J., Duong, C. X., Nguyen, X. K. T., Li, Z., Bing, G., Bach, J. H., Park, D. H., Nakayama, K., Ali, S. F., Kanthasamy, A. G., Cadet, J. L., Nabeshima, T. & Kim, H. C., Jun 15 2012, In : Behavioural Brain Research. 232, 1, p. 98-113 16 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Role of the ANKMY2-FKBP38 axis in regulation of the sonic hedgehog (Shh) signaling pathway

Saita, S., Shirane, M., Ishitani, T., Shimizu, N. & Nakayama, K. I., Sep 12 2014, In : Journal of Biological Chemistry. 289, 37, p. 25639-25654 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Role of the Atg9a gene in intrauterine growth and survival of fetal mice

Kojima, T., Yamada, T., Akaishi, R., Furuta, I., Saitoh, T., Nakabayashi, K., Nakayama, K. I., Nakayama, K., Akira, S. & Minakami, H., Sep 1 2015, In : Reproductive Biology. 15, 3, p. 131-138 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction

Fukushima, H., Matsumoto, A., Inuzuka, H., Zhai, B., Lau, A. W., Wan, L., Gao, D., Shaik, S., Yuan, M., Gygi, S. P., Jimi, E., Asara, J. M., Nakayama, K., Nakayama, K. I. & Wei, W., May 31 2012, In : Cell Reports. 1, 5, p. 434-443 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Inuzuka, H., Shaik, S., Onoyama, I., Gao, D., Tseng, A., Maser, R. S., Zhai, B., Wan, L., Gutierrez, A., Lau, A. W., Xiao, Y., Christie, A. L., Aster, J., Settleman, J., Gygi, S. P., Kung, A. L., Look, T., Nakayama, K. I., Depinho, R. A. & Wei, W., Mar 3 2011, In : Nature. 471, 7336, p. 104-109 6 p.

Research output: Contribution to journalArticle

400 Citations (Scopus)

SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K. I., May 2019, In : Genes to Cells. 24, 5, p. 354-365 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Selective escape of proteins from the mitochondria during mitophagy

Saita, S., Shirane, M. & Nakayama, K. I., Oct 28 2013, In : Nature communications. 4, 1410.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Sez6l2 regulates phosphorylation of ADD and neuritogenesis

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K. I., Watanabe, M. & Hatakeyama, S., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 234-241 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
40 Citations (Scopus)

Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development

Yamauchi, Y., Nita, A., Nishiyama, M., Muto, Y., Shimizu, H., Nakatsumi, H. & Nakayama, K. I., Jun 1 2020, In : Genes to Cells. 25, 6, p. 427-438 12 p.

Research output: Contribution to journalArticle

Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors

Zhao, H., Bauzon, F., Fu, H., Lu, Z., Cui, J., Nakayama, K., Nakayama, K. I., Locker, J. & Zhu, L., Nov 11 2013, In : Cancer Cell. 24, 5, p. 645-659 15 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B. R., Nakayama, K. I., Matusik, R. J. & Chen, Z., Jan 1 2015, In : Oncotarget. 6, 2, p. 771-788 18 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium

Sistrunk, C., MacIas, E., Nakayama, K., Kim, Y. & Rodriguez-Puebla, M. L., Jun 2011, In : American Journal of Pathology. 178, 6, p. 2470-2477 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity

Lu, Z., Bauzon, F., Fu, H., Cui, J., Zhao, H., Nakayama, K., Nakayama, K. I. & Zhu, L., Mar 17 2014, In : Nature communications. 5, 3463.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y. & Gotoh, Y., Apr 28 2015, In : Nature Neuroscience. 18, 5, p. 657-665 9 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., Jan 20 2017, In : Scientific reports. 7, 41130.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., Dec 1 2017, In : Nature communications. 8, 1, 1625.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF Fbxl3) protein complex

Yumimoto, K., Muneoka, T., Tsuboi, T. & Nakayama, K. I., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32766-32776 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The amelioration of renal damage in Skp2-deficient mice canceled by p27Kip1 deficiency in Skp2-/- p27-/- mice

Suzuki, S., Fukasawa, H., Misaki, T., Togawa, A., Ohashi, N., Kitagawa, K., Kotake, Y., Liu, N., Niida, H., Nakayama, K., Nakayama, K. I., Yamamoto, T. & Kitagawa, M., Apr 27 2012, In : PloS one. 7, 4, e36249.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., May 15 2018, In : Cell Reports. 23, 7, p. 1988-2000 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression

Nakagawa, T., Hattori, S., Nobuta, R., Kimura, R., Nakagawa, M., Matsumoto, M., Nagasawa, Y., Funayama, R., Miyakawa, T., Inada, T., Osumi, N., Nakayama, K. I. & Nakayama, K., Apr 24 2020, In : iScience. 23, 4, 101030.

Research output: Contribution to journalArticle

Open Access

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I., Sep 7 2011, In : Cell metabolism. 14, 3, p. 339-351 13 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K. I., Tsutsui, H. & Hatakeyama, S., Nov 1 2016, In : Journal of Molecular and Cellular Cardiology. 100, p. 43-53 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: In vitro, ex vivo, and in vivo studies

Ellman, M. B., Kim, J. S., An, H. S., Kroin, J. S., Li, X., Chen, D., Yan, D., Buechter, D. D., Nakayama, K., Liu, B., Morgan, S. & Im, H. J., Jun 1 2012, In : Arthritis and rheumatism. 64, 6, p. 1950-1959 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., Dec 16 2019, In : EMBO Journal. 38, 24, e102566.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The promise of targeted proteomics for quantitative network biology

Matsumoto, M. & Nakayama, K., Dec 1 2018, In : Current Opinion in Biotechnology. 54, p. 88-97 10 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

The role of Mediator and Little Elongation Complex in transcription termination

Takahashi, H., Ranjan, A., Chen, S., Suzuki, H., Shibata, M., Hirose, T., Hirose, H., Sasaki, K., Abe, R., Chen, K., He, Y., Zhang, Y., Takigawa, I., Tsukiyama, T., Watanabe, M., Fujii, S., Iida, M., Yamamoto, J., Yamaguchi, Y., Suzuki, Y. & 10 others, Matsumoto, M., Nakayama, K. I., Washburn, M. P., Saraf, A., Florens, L., Sato, S., Tomomori-Sato, C., Conaway, R. C., Conaway, J. W. & Hatakeyama, S., Dec 1 2020, In : Nature communications. 11, 1, 1063.

Research output: Contribution to journalArticle

Open Access

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. & 1 others, Wei, W., Jan 3 2017, In : Science Signaling. 10, 460

Research output: Contribution to journalArticle

18 Citations (Scopus)

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., Jun 16 2011, In : Blood. 117, 24, p. 6509-6519 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)