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  • Yusaku Nakabeppu

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 6528.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

8-Oxoguanine causes spontaneous de novo germline mutations in mice

Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., Gondo, Y. & Nakabeppu, Y., Apr 1 2014, In : Scientific reports. 4, 4689.

Research output: Contribution to journalArticle

72 Citations (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., Jul 2017, In : PloS one. 12, 7, e0181687.

Research output: Contribution to journalArticle

11 Citations (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., Dec 17 2012, In : PloS one. 7, 12, e51697.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice

Isoda, T., Nakatsu, Y., Yamauchi, K., Piao, J., Yao, T., Honda, H., Nakabeppu, Y. & Tsuzuki, T., Aug 23 2014, In : International journal of biological sciences. 10, 8, p. 940-947 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage

Jalland, C. M. O., Benestad, S. L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjørås, M. & Tranulis, M. A., Mar 2014, In : Free Radical Biology and Medicine. 68, p. 1-7 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Altered expression of diabetes-related genes in Alzheimer's disease brains: The Hisayama study

Hokama, M., Oka, S., Leon, J., Ninomiya, T., Honda, H., Sasaki, K., Iwaki, T., Ohara, T., Sasaki, T., LaFerla, F. M., Kiyohara, Y. & Nakabeppu, Y., Sep 2014, In : Cerebral Cortex. 24, 9, p. 2476-2488 13 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., Dec 1 2018, In : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

Guikema, J. E. J., Gerstein, R. M., Linehan, E. K., Cloherty, E. K., Evan-Browning, E., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 1943-1950 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells

Guikema, J. E. J., Linehan, E. K., Esa, N., Tsuchimoto, D., Nakabeppu, Y., Woodland, R. T. & Schrader, C. E., Jul 15 2014, In : Journal of Immunology. 193, 2, p. 931-939 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A role for SNX1 in the regulation of EGF-dependent phosphorylated EGFR endocytosis via the early/late endocytic pathway in a gefitinib-sensitive human lung cancer cells

Nishimura, Y., Yoshioka, K., Takiguchi, S., Bereczky, B., Nakabeppu, Y. & Itoh, K., Sep 1 2011, In : Current Signal Transduction Therapy. 6, 3, p. 383-395 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., Jan 2018, In : Brain Pathology. 28, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., Jul 1 2017, In : Lung Cancer. 109, p. 52-57 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., Jun 1 2011, In : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., Jan 1 2017, In : Cancer Science. 108, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
85 Citations (Scopus)

Characterization of galectin-1-positive cells in the mouse hippocampus

Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H. & Nakabeppu, Y., Feb 12 2014, In : NeuroReport. 25, 3, p. 171-176 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., Dec 1 2017, In : Brain Research. 1676, p. 77-82 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., Sep 1 2017, In : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., Feb 1 2017, In : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)
5 Citations (Scopus)

Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus

Koga, Y., Inazato, M., Nakamura, T., Hashikawa, C., Chirifu, M., Michi, A., Yamashita, T., Toma, S., Kuniyasu, A., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., Jan 1 2013, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 1, p. 45-48 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., Torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. & 8 others, Aldhekri, H., Meffre, E., Mizui, M., Tsokos, G. C., Manis, J. P., Al-Herz, W., Wallace, S. S. & Geha, R. S., Nov 1 2016, In : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yoneshima, Y., Abolhassani, N., Iyama, T., Sakumi, K., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., Sep 13 2016, In : Scientific reports. 6, 32849.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (ed.) & Ninomiya, T. (ed.), May 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

Research output: Book/ReportBook

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., Jun 1 2014, In : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Stavnezer, J., Linehan, E. K., Thompson, M. R., Habboub, G., Ucher, A. J., Kadungure, T., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9217-9222 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Kubokura, N., Takahashi-Yanaga, F., Arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., Jan 1 2015, In : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

Oka, S. & Nakabeppu, Y., Apr 1 2011, In : Cancer Science. 102, 4, p. 677-682 6 p.

Research output: Contribution to journalReview article

44 Citations (Scopus)

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains

Hamasaki, H., Honda, H., Suzuki, S. O., Hokama, M., Kiyohara, Y., Nakabeppu, Y. & Iwaki, T., Jun 2014, In : Neuropathology. 34, 3, p. 284-290 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
3 Citations (Scopus)

Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., Jun 10 2016, In : Scientific reports. 6, 27164.

Research output: Contribution to journalComment/debate

Erratum: FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56)

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., Jun 1 2013, In : Neuropsychopharmacology. 38, 7, p. 1374-1375 2 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Erratum: Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria (Nucleic Acids Res. (2000) 28 (1355-64))

Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T. & Nakabeppu, Y., Mar 23 2015, In : Nucleic acids research. 43, 7, p. 3870-3871 2 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., Jun 2018, In : Neuropathology. 38, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. & Toyokuni, S., Nov 2017, In : Pathology International. 67, 11, p. 564-574 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J. & Nakabeppu, Y., Aug 2014, In : GLIA. 62, 8, p. 1284-1298 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔfosB

Ohnishi, Y. N., Ohnishi, Y. H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Kunihiko, S., Nestler, E. J. & Nakabeppu, Y., Sep 1 2011, In : Biological Psychiatry. 70, 5, p. 487-495 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., Apr 1 2013, In : Neuropsychopharmacology. 38, 5, p. 895-906 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., Jun 5 2016, In : AIMS Molecular Science. 3, 3, p. 325-337 13 p.

Research output: Contribution to journalReview article

Open Access

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., Feb 1 2015, In : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

Takaku, S., Yanagisawa, H., Watabe, K., Horie, H., Kadoya, T., Sakumi, K., Nakabeppu, Y., Poirier, F. & Sango, K., Feb 1 2013, In : Neurochemistry International. 62, 3, p. 330-339 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., Nov 29 2016, In : Scientific reports. 6, 37889.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., Mar 10 2016, In : Scientific reports. 6, 22991.

Research output: Contribution to journalArticle

10 Citations (Scopus)