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  • Keiichi Nakayama

Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence

Takeishi, S., Matsumoto, A., Onoyama, I., Naka, K., Hirao, A. & Nakayama, K. I., Mar 18 2013, In : Cancer Cell. 23, 3, p. 347-361 15 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., Oct 15 2018, In : Neuroscience Letters. 685, p. 50-54 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle

Wakabayashi, Y., Tamura, Y., Kouzaki, K., Kikuchi, N., Hiranuma, K., Menuki, K., Tajima, T., Yamanaka, Y., Sakai, A., Nakayama, K. I., Kawamoto, T., Kitagawa, K. & Nakazato, K., Apr 1 2020, In : American journal of physiology. Regulatory, integrative and comparative physiology. 318, 4, p. R677-R690

Research output: Contribution to journalArticle

A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen

Oshikawa, K., Matsumoto, M., Kodama, M., Shimizu, H. & Nakayama, K. I., Mar 5 2020, In : Oncogene. 39, 10, p. 2170-2186 17 p.

Research output: Contribution to journalArticle

Akt1-mediated Gata3 phosphorylation controls the repression of IFNÎ 3 in memory-type Th2 cells

Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I. & Nakayama, T., Apr 7 2016, In : Nature communications. 7, 11289.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A large-scale targeted proteomics assay resource based on an in vitro human proteome

Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura, Y., Ogawa, K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K., Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K. & Nakayama, K. I., Feb 28 2017, In : Nature Methods. 14, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis

Hoshi, H., Hao, W., Fujita, Y., Funayama, A., Miyauchi, Y., Hashimoto, K., Miyamoto, K., Iwasaki, R., Sato, Y., Kobayashi, T., Miyamoto, H., Yoshida, S., Mori, T., Kanagawa, H., Katsuyama, E., Fujie, A., Kitagawa, K., Nakayama, K. I., Kawamoto, T., Sano, M. & 8 others, Fukuda, K., Ohsawa, I., Ohta, S., Morioka, H., Matsumoto, M., Chiba, K., Toyama, Y. & Miyamoto, T., Sep 2012, In : Journal of Bone and Mineral Research. 27, 9, p. 2015-2023 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Artificial intelligence in oncology

Shimizu, H. & Nakayama, K. I., May 1 2020, In : Cancer Science. 111, 5, p. 1452-1460 9 p.

Research output: Contribution to journalArticle

Open Access

A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer

Kodama, M., Oshikawa, K., Shimizu, H., Yoshioka, S., Takahashi, M., Izumi, Y., Bamba, T., Tateishi, C., Tomonaga, T., Matsumoto, M. & Nakayama, K. I., Dec 1 2020, In : Nature communications. 11, 1, 1320.

Research output: Contribution to journalArticle

Open Access

A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples

Narumi, R., Murakami, T., Kuga, T., Adachi, J., Shiromizu, T., Muraoka, S., Kume, H., Kodera, Y., Matsumoto, M., Nakayama, K., Miyamoto, Y., Ishitobi, M., Inaji, H., Kato, K. & Tomonaga, T., Nov 2 2012, In : Journal of Proteome Research. 11, 11, p. 5311-5322 12 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Rothenberg, E. V., Dec 1 2018, In : Nature Immunology. 19, 12, p. 1427-1440 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure

Matsumoto, J., Takada, S., Kinugawa, S., Furihata, T., Nambu, H., Kakutani, N., Tsuda, M., Fukushima, A., Yokota, T., Tanaka, S., Takahashi, H., Watanabe, M., Hatakeyama, S., Matsumoto, M., Nakayama, K. I., Otsuka, Y., Sabe, H., Tsutsui, H. & Anzai, T., Jan 1 2018, In : Circulation. 138, 18, p. 2064-2066 3 p.

Research output: Contribution to journalLetter

6 Citations (Scopus)

CDK inhibitors, p21Cip1 and p27Kip1, participate in cell cycle exit of mammalian cardiomyocytes

Tane, S., Ikenishi, A., Okayama, H., Iwamoto, N., Nakayama, K. I. & Takeuchi, T., Jan 17 2014, In : Biochemical and Biophysical Research Communications. 443, 3, p. 1105-1109 5 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Cell cycle–dependent localization of the proteasome to chromatin

Kito, Y., Matsumoto, M., Hatano, A., Takami, T., Oshikawa, K., Matsumoto, A. & Nakayama, K. I., Dec 1 2020, In : Scientific reports. 10, 1, 5801.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T. & Nakayama, K. I., Jan 1 2016, In : Nature. 537, 7622, p. 675-679 5 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling

Liu, N., Matsumoto, M., Kitagawa, K., Kotake, Y., Suzuki, S., Shirasawa, S., Nakayama, K. I., Nakanishi, M., Niida, H. & Kitagawa, M., May 16 2012, In : EMBO Journal. 31, 10, p. 2365-2377 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., Mar 1 2018, In : Cancer Research. 78, 5, p. 1334-1346 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Comprehensive identification of substrates for f-box proteins by differential proteomics analysis

Yumimoto, K., Matsumoto, M., Oyamada, K., Moroishi, T. & Nakayama, K. I., Jun 1 2012, In : Journal of Proteome Research. 11, 6, p. 3175-3185 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Comprehensive study of protein ubiquitylation sites by conjugation of engineered lysine-less ubiquitin

Oshikawa, K., Matsumoto, M. & Nakayama, K. I., Dec 1 2012, In : Seikagaku. 84, 6, p. 479-487 9 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma

Yokobori, T., Mimori, K., Iwatsuki, M., Ishii, H., Tanaka, F., Sato, T., Toh, H., Sudo, T., Iwaya, T., Tanaka, Y., Onoyama, I., Kuwano, H., Nakayama, K. I. & Mori, M., Jul 1 2012, In : International journal of oncology. 41, 1, p. 253-259 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin

Bargagna-Mohan, P., Paranthan, R. R., Hamza, A., Zhan, C. G., Lee, D. M., Kim, K. B., Lau, D. L., Srinivasan, C., Nakayama, K., Nakayama, K., Herrmann, H. & Mohan, R., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 989-1006 18 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Correction: "UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation" [Molecular and Cellular Biology 36, 3, (2016) (394-406)] doi 10.1128/MCB.00809-15

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., Apr 1 2018, In : Molecular and cellular biology. 38, 7, e00572-17.

Research output: Contribution to journalComment/debate

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hagihara, H., Catts, V. S., Katayama, Y., Shoji, H., Takagi, T., Huang, F. L., Nakao, A., Mori, Y., Huang, K. P., Ishii, S., Graef, I. A., Nakayama, K. I., Shannon Weickert, C. & Miyakawa, T., Feb 1 2018, In : Neuropsychopharmacology. 43, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Deficiency of Rap1-Binding Protein RAPL Causes Lymphoproliferative Disorders through Mislocalization of p27kip1

Katagiri, K., Ueda, Y., Tomiyama, T., Yasuda, K., Toda, Y., Ikehara, S., Nakayama, K. I. & Kinashi, T., Jan 28 2011, In : Immunity. 34, 1, p. 24-38 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism

Fuster, J. J., González-Navarro, H., Vinué, A., Molina-Sànchez, P., Andrés-Manzano, M. J., Nakayama, K. I., Nakayama, K., Díez-Juan, A., Bernad, A., Rodríguez, C., Martínez-González, J. & Andrés, V., Nov 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 11, p. 2455-2463 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3

Nakayama, S., Yumimoto, K., Kawamura, A. & Nakayama, K. I., Apr 13 2018, In : Journal of Biological Chemistry. 293, 15, p. 5705-5714 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice

Matsumoto, A., Susaki, E., Onoyama, I., Nakayama, K., Hoshino, M. & Nakayama, K. I., Oct 1 2011, In : Molecular and cellular biology. 31, 20, p. 4176-4192 17 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Development of mice without Cip/Kip CDK inhibitors

Tateishi, Y., Matsumoto, A., Kanie, T., Hara, E., Nakayama, K. & Nakayama, K. I., Oct 19 2012, In : Biochemical and Biophysical Research Communications. 427, 2, p. 285-292 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Drug repositioning in cancer: The current situation in Japan

Masuda, T., Tsuruda, Y., Matsumoto, Y., Uchida, H., Nakayama, K. I. & Mimori, K., Apr 1 2020, In : Cancer Science. 111, 4, p. 1039-1046 8 p.

Research output: Contribution to journalReview article

Open Access

Erratum: Regulation of SV40 large T-Antigen stability by reversible acetylation (Oncogene (2006) 25 (7391-7400) DOI: 10.1038/sj.onc.1209731)

Shimazu, T., Komatsu, Y., Nakayama, K. I., Fukazawa, H., Horinouchi, S. & Yoshida, M., Jul 17 2014, In : Oncogene. 33, 29, 1 p.

Research output: Contribution to journalComment/debate

Erratum: The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis (Cell (2012) 149 (1098-1111))

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., Nov 9 2012, In : Cell. 151, 4, p. 913-914 2 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Erratum: Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding (Immunity (2018) 48(6) (1119–1134.e7), (S1074761318301936) (10.1016/j.immuni.2018.04.024))

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Oct 16 2018, In : Immunity. 49, 4, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., Jul 17 2017, In : Nature communications. 8, 16114.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., Feb 24 2011, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Yumimoto, K., Matsumoto, M., Onoyama, I., Imaizumi, K. & Nakayama, K. I., Oct 4 2013, In : Journal of Biological Chemistry. 288, 40, p. 28488-28502 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

F-box proteins and cancer

Yumimoto, K., Yamauchi, Y. & Nakayama, K. I., May 2020, In : Cancers. 12, 5, 1249.

Research output: Contribution to journalReview article

Open Access

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer

Grim, J. E., Knoblaugh, S. E., Guthrie, K. A., Hagar, A., Swanger, J., Hespelt, J., Delrow, J. J., Small, T., Grady, W. M., Nakayama, K. I. & Clurman, B. E., Jun 1 2012, In : Molecular and cellular biology. 32, 11, p. 2160-2167 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development

Kitagawa, K., Shibat, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H. & Kitagawa, M., Jul 2014, In : Molecular and cellular biology. 34, 14, p. 2732-2744 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., Nov 2015, In : STEM CELLS. 33, 11, p. 3327-3340 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

FBXL12 regulates T-cell differentiation in a cell-autonomous manner

Nita, A., Nishiyama, M., Muto, Y. & Nakayama, K., May 1 2016, In : Genes to Cells. 21, 5, p. 517-524 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes

Hirano, A., Yumimoto, K., Tsunematsu, R., Matsumoto, M., Oyama, M., Kozuka-Hata, H., Nakagawa, T., Lanjakornsiripan, D., Nakayama, K. I. & Fukada, Y., Feb 28 2013, In : Cell. 152, 5, p. 1106-1118 13 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., Apr 1 2017, In : Molecular and cellular biology. 37, 8, e00470-16.

Research output: Contribution to journalArticle

7 Citations (Scopus)

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., Aug 1 2015, In : Genes to Cells. 20, 8, p. 667-674 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Fbxw7-dependent degradation of notch is required for control of "Stemness" and neuronal-glial differentiation in neural stem cells

Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H. & Nakayama, K. I., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13754-13764 11 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

Kitade, S., Onoyama, I., Kobayashi, H., Yagi, H., Yoshida, S., Kato, M., Tsunematsu, R., Asanoma, K., Sonoda, K., Wake, N., Hata, K., Nakayama, K. I. & Kato, K., Oct 1 2016, In : Cancer Science. 107, 10, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K. & Nakayama, K. I., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 342-354 13 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

5 Citations (Scopus)

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

Matsumoto, A., Tateishi, Y., Onoyama, I., Okita, Y., Nakayama, K. & Nakayama, K., Apr 1 2011, In : Cancer Science. 102, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)