Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2011

Author

  • Keiichi Nakayama

Identification and characterization of a neuron-specific isoform of protrudin

Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S. & Nakayama, K. I., Feb 1 2014, In : Genes to Cells. 19, 2, p. 97-111 15 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy

Yaguchi, H., Yabe, I., Takahashi, H., Okumura, F., Takeuchi, A., Horiuchi, K., Kano, T., Kanda, A., Saito, W., Matsumoto, M., Nakayama, K. I., Hatakeyama, S. & Sasaki, H., Jan 2014, In : Journal of Neurology. 261, 1, p. 224-226 3 p.

Research output: Contribution to journalLetter

10 Citations (Scopus)

Identification of low-abundance proteins in serum via the isolation of HSP72 complexes

Tanaka, M., Shiota, M., Nakao, T., Uemura, R., Nishi, S., Ohkawa, Y., Matsumoto, M., Yamaguchi, M., Osada-Oka, M., Inagaki, A., Takahashi, K., Nakayama, K. I., Gi, M., Izumi, Y., Miura, K. & Iwao, H., Mar 16 2016, In : Journal of Proteomics. 136, p. 214-221 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Impaired ovarian development and reduced fertility in female mice deficient in Skp2

Fotovati, A., Abu-Ali, S., Nakayama, K. & Nakayama, K. I., Jun 1 2011, In : Journal of Anatomy. 218, 6, p. 668-677 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

Laukoter, S., Beattie, R., Pauler, F. M., Amberg, N., Nakayama, K. I. & Hippenmeyer, S., Dec 1 2020, In : Nature communications. 11, 1, 195.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., Feb 6 2018, In : International journal of molecular sciences. 19, 2, 474.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Integrated view of the human chromosome x-centric proteome project

Yamamoto, T., Nakayama, K., Hirano, H., Tomonaga, T., Ishihama, Y., Yamada, T., Kondo, T., Kodera, Y., Sato, Y., Araki, N., Mamitsuka, H. & Goshima, N., Jan 4 2013, In : Journal of Proteome Research. 12, 1, p. 58-61 4 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components

Nakagawa, T., Nakayama, K. & Nakayama, K. I., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 147-171 25 p. (Advances in Experimental Medicine and Biology; vol. 1217).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner

Yanagida, A., Chikada, H., Ito, K., Umino, A., Kato-Itoh, M., Yamazaki, Y., Sato, H., Kobayashi, T., Yamaguchi, T., Nakayama, K. I., Nakauchi, H. & Kamiya, A., Nov 15 2015, In : Developmental Biology. 407, 2, p. 331-343 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Loss of Protein Kinase C-δ Protects against LPS-Induced Osteolysis Owing to an Intrinsic Defect in Osteoclastic Bone Resorption

Khor, E. C., Abel, T., Tickner, J., Chim, S. M., Wang, C., Cheng, T., Ng, B., Ng, P. Y., Teguh, D. A., Kenny, J., Yang, X., Chen, H., Nakayama, K. I., Nakayama, K., Pavlos, N., Zheng, M. H. & Xu, J., Aug 8 2013, In : PloS one. 8, 8, e70815.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., Oct 28 2015, In : Scientific reports. 5, 15876.

Research output: Contribution to journalArticle

20 Citations (Scopus)

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24

Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K. & Nakayama, K. I., Jan 1 2014, In : Molecular and cellular biology. 34, 17, p. 3321-3340 20 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Nakayama, T., May 22 2015, In : Journal of Biological Chemistry. 290, 21, p. 13095-13103 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27 kip1, KPC1, and SOCS-1

Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K. I., Blazar, B. R., Zeng, Y. & Zhou, X., Apr 21 2011, In : Blood. 117, 16, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

199 Citations (Scopus)

Mitochondria: FKBP38 and mitochondrial degradation

Shirane, M. & Nakayama, K., Jan 1 2014, In : International Journal of Biochemistry and Cell Biology. 51, 1, p. 19-22 4 p.

Research output: Contribution to journalShort survey

11 Citations (Scopus)

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., Jan 12 2017, In : Nature. 541, 7636, p. 228-232 5 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, In : Nature. 541, 7636, p. 228 5 p., 541.

Research output: Contribution to journalArticle

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K. I., Nov 28 2017, In : Cell Reports. 21, 9, p. 2471-2486 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K. I., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., Nov 16 2017, In : Molecular Cell. 68, 4, p. 645-658.e5

Research output: Contribution to journalArticle

13 Citations (Scopus)

Nuclear–cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1

Nakatsumi, H., Oka, T., Higa, T., Shirane, M. & Nakayama, K. I., Jul 2018, In : Genes to Cells. 23, 7, p. 599-605 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice

Kawamura, A., Katayama, Y., Nishiyama, M., Shoji, H., Tokuoka, K., Ueta, Y., Miyata, M., Isa, T., Miyakawa, T., Hayashi-Takagi, A. & Nakayama, K. I., May 28 2020, In : Human molecular genetics. 29, 8, p. 1274-1291 18 p.

Research output: Contribution to journalArticle

Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch

Ishikawa, Y., Hosogane, M., Okuyama, R., Aoyama, S., Onoyama, I., Nakayama, K. I. & Nakayama, K., Apr 11 2013, In : Oncogene. 32, 15, p. 1921-1932 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

P27 is regulated independently of Skp2 in the absence of Cdk2

Kotoshiba, S., Gopinathan, L., Pfeiffenberger, E., Rahim, A., Vardy, L. A., Nakayama, K., Nakayama, K. I. & Kaldis, P., Feb 1 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 2, p. 436-445 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

P57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis

Furutachi, S., Matsumoto, A., Nakayama, K. I. & Gotoh, Y., Apr 3 2013, In : EMBO Journal. 32, 7, p. 970-981 12 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

P57 Is required for quiescence and maintenance of adult hematopoietic stem cells

Matsumoto, A., Takeishi, S., Kanie, T., Susaki, E., Onoyama, I., Tateishi, Y., Nakayama, K. & Nakayama, K. I., Sep 2 2011, In : Cell stem cell. 9, 3, p. 262-271 10 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I. & Suda, T., Sep 2 2011, In : Cell stem cell. 9, 3, p. 247-261 15 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome

Duquesnes, N., Callot, C., Jeannot, P., Daburon, V., Nakayama, K. I., Manenti, S., Davy, A. & Besson, A., Jul 1 2016, In : Journal of Pathology. 239, 3, p. 250-261 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

P57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling

Matsumoto, A., Takeishi, S. & Nakayama, K. I., May 29 2014, In : Blood. 123, 22, p. 3429-3439 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K. I., Yamashita, T. & Fujiki, Y., 2018, In : Life Science Alliance. 1, 6

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer

Masuda, T., Noda, M., Kogawa, T., Kitagawa, D., Hayashi, N., Jomori, T., Nakanishi, Y., Nakayama, K. I., Ohno, S. & Mimori, K., Mar 1 2020, In : Cancer Science. 111, 3, p. 924-931 8 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling

Hatano, A., Matsumoto, M. & Nakayama, K. I., Oct 1 2016, In : Genes to Cells. 21, 10, p. 1095-1112 18 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1

Yamamoto, A., Takeya, R., Matsumoto, M., Nakayama, K. I. & Sumimoto, H., Oct 1 2013, In : FEBS Journal. 280, 20, p. 5145-5159 15 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Phosphorylation of p27Kip1on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K. I., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, 1 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., Mar 1 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

Research output: Contribution to journalArticle

PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment

Shin, E. J., Duong, C. X., Nguyen, X. K. T., Bing, G., Bach, J. H., Park, D. H., Nakayama, K., Ali, S. F., Kanthasamy, A. G., Cadet, J. L., Nabeshima, T. & Kim, H. C., Aug 1 2011, In : Neurochemistry International. 59, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., Mar 12 2018, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

34 Citations (Scopus)

Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin

Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K. I., Okumura, F., Hatakeyama, S. & Koike, T., Jan 2011, In : Journal of Cellular and Molecular Medicine. 15, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K. I., Jul 2019, In : Cancer Science. 110, 7, p. 2090-2099 10 p.

Research output: Contribution to journalReview article

Open Access
7 Citations (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., 2019, In : JCI Insight. 4, 4, e125138.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis

Matsuhisa, K., Saito, A., Cai, L., Kaneko, M., Okamoto, T., Sakaue, F., Asada, R., Urano, F., Yanagida, K., Okochi, M., Kudo, Y., Matsumoto, M., Nakayama, K. I. & Imaizumi, K., Jan 1 2020, In : FASEB Journal. 34, 1, p. 865-880 16 p.

Research output: Contribution to journalArticle

Open Access

Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells

Takahashi, K., Tanaka, M., Yashiro, M., Matsumoto, M., Ohtsuka, A., Nakayama, K. I., Izumi, Y., Nagayama, K., Miura, K., Iwao, H. & Shiota, M., Aug 1 2016, In : Cancer Letters. 378, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Proteome of ubiquitin/MVB pathway: Possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

Tachiyama, R., Ishikawa, D., Matsumoto, M., Nakayama, K. I., Yoshimori, T., Yokota, S., Himeno, M., Tanaka, Y. & Fujita, H., Apr 1 2011, In : Genes to Cells. 16, 4, p. 448-466 19 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia

Hashimoto, Y., Shirane, M., Matsuzaki, F., Saita, S., Ohnishi, T. & Nakayama, K. I., Jan 1 2014, In : Journal of Biological Chemistry. 289, 19, p. 12946-12961 16 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

Matsuzaki, F., Shirane, M., Matsumoto, M. & Nakayama, K. I., Dec 1 2011, In : Molecular biology of the cell. 22, 23, p. 4602-4620 19 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Recent insight into the role of FBXW7 as a tumor suppressor

Yumimoto, K. & Nakayama, K. I., Jan 1 2020, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., Jan 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Reconstruction of insulin signal flow from phosphoproteome and metabolome data

Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K. I., Kashikura, K., Endo, K., Ikeda, K., Soga, T. & Kuroda, S., Aug 21 2014, In : Cell Reports. 8, 4, p. 1171-1183 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression

Reavie, L., Buckley, S. M., Loizou, E., Takeishi, S., Aranda-Orgilles, B., Ndiaye-Lobry, D., Abdel-Wahab, O., Ibrahim, S., Nakayama, K. I. & Aifantis, I., Mar 18 2013, In : Cancer Cell. 23, 3, p. 362-375 14 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., Apr 17 2015, In : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Ribophorin ii is involved in the tissue factor expression mediated by phosphatidylserinedependent antiprothrombin antibody on monocytes

Fujieda, Y., Amengual, O., Matsumoto, M., Kuroki, K., Takahashi, H., Kono, M., Kurita, T., Otomo, K., Kato, M., Oku, K., Bohgaki, T., Horita, T., Yasuda, S., Maenaka, K., Hatakeyama, S., Nakayama, K. I. & Atsumi, T., Jun 1 2016, In : Rheumatology (United Kingdom). 55, 6, p. 1117-1126 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)