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Author

  • Yusaku Nakabeppu
2014

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells

Guikema, J. E. J., Linehan, E. K., Esa, N., Tsuchimoto, D., Nakabeppu, Y., Woodland, R. T. & Schrader, C. E., Jul 15 2014, In : Journal of Immunology. 193, 2, p. 931-939 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
85 Citations (Scopus)

Characterization of galectin-1-positive cells in the mouse hippocampus

Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H. & Nakabeppu, Y., Feb 12 2014, In : NeuroReport. 25, 3, p. 171-176 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., Jun 1 2014, In : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Stavnezer, J., Linehan, E. K., Thompson, M. R., Habboub, G., Ucher, A. J., Kadungure, T., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9217-9222 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains

Hamasaki, H., Honda, H., Suzuki, S. O., Hokama, M., Kiyohara, Y., Nakabeppu, Y. & Iwaki, T., Jun 2014, In : Neuropathology. 34, 3, p. 284-290 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J. & Nakabeppu, Y., Aug 2014, In : GLIA. 62, 8, p. 1284-1298 15 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y. & Nishigori, C., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2610-2619 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

International symposium on “germline mutagenesis and Biodiversification”

Uchimura, A., Hara, Y., Gondo, Y. & Nakabeppu, Y., Sep 1 2014, In : Genes and Genetic Systems. 89, 2, p. 93-95 3 p.

Research output: Contribution to journalEditorial

Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes

Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K. & Kitazono, T., Jan 1 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

Oka, S., Leon, J., Tsuchimoto, D., Sakumi, K. & Nakabeppu, Y., Jan 1 2014, In : Oncogenesis. 3, 10, e121.

Research output: Contribution to journalArticle

24 Citations (Scopus)

What have we learned from cultured adult dorsal root ganglion neurons?

Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T. & Horie, H., Jan 1 2014, Ganglion Cells: Morphology, Functional Development and Role in Disease. Nova Science Publishers, Inc., p. 125-148 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus

Koga, Y., Inazato, M., Nakamura, T., Hashikawa, C., Chirifu, M., Michi, A., Yamashita, T., Toma, S., Kuniyasu, A., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., Jan 1 2013, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 1, p. 45-48 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Erratum: FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56)

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., Jun 1 2013, In : Neuropsychopharmacology. 38, 7, p. 1374-1375 2 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., Apr 1 2013, In : Neuropsychopharmacology. 38, 5, p. 895-906 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

Takaku, S., Yanagisawa, H., Watabe, K., Horie, H., Kadoya, T., Sakumi, K., Nakabeppu, Y., Poirier, F. & Sango, K., Feb 1 2013, In : Neurochemistry International. 62, 3, p. 330-339 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice

Tsuji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M. & Sado, T., May 1 2013, In : Journal of radiation research. 54, 3, p. 453-466 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus

Sakai, Y., Ohkubo, K., Matsushita, Y., Akamine, S., Ishizaki, Y., Torisu, H., Ihara, K., Sanefuji, M., Kim, M. S., Lee, K. U., Shaw, C. A., Lim, J., Nakabeppu, Y. & Hara, T., Sep 1 2013, In : European Journal of Medical Genetics. 56, 9, p. 475-483 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M. & Nakaya, H., Nov 29 2013, In : Scientific reports. 3, 3273.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2012

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., Dec 17 2012, In : PloS one. 7, 12, e51697.

Research output: Contribution to journalArticle

66 Citations (Scopus)

MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration

Murakami, Y., Ikeda, Y., Yoshida, N., Notomi, S., Hisatomi, T., Oka, S., De Luca, G., Yonemitsu, Y., Bignami, M., Nakabeppu, Y. & Ishibashi, T., Oct 1 2012, In : American Journal of Pathology. 181, 4, p. 1378-1386 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines

Nishimura, Y., Takiguchi, S., Yoshioka, K., Nakabeppu, Y. & Itoh, K., Oct 1 2012, In : International journal of oncology. 41, 4, p. 1520-1530 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype

Yogianti, F., Kunisada, M., Ono, R., Sakumi, K., Nakabeppu, Y. & Nishigori, C., Nov 1 2012, In : Mutagenesis. 27, 6, p. 637-643 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
29 Citations (Scopus)
2011

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

Guikema, J. E. J., Gerstein, R. M., Linehan, E. K., Cloherty, E. K., Evan-Browning, E., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 1943-1950 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A role for SNX1 in the regulation of EGF-dependent phosphorylated EGFR endocytosis via the early/late endocytic pathway in a gefitinib-sensitive human lung cancer cells

Nishimura, Y., Yoshioka, K., Takiguchi, S., Bereczky, B., Nakabeppu, Y. & Itoh, K., Sep 1 2011, In : Current Signal Transduction Therapy. 6, 3, p. 383-395 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., Jun 1 2011, In : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

Oka, S. & Nakabeppu, Y., Apr 1 2011, In : Cancer Science. 102, 4, p. 677-682 6 p.

Research output: Contribution to journalReview article

45 Citations (Scopus)

FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔfosB

Ohnishi, Y. N., Ohnishi, Y. H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Kunihiko, S., Nestler, E. J. & Nakabeppu, Y., Sep 1 2011, In : Biological Psychiatry. 70, 5, p. 487-495 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis

Kunisada, M., Yogianti, F., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., Dec 1 2011, In : American Journal of Pathology. 179, 6, p. 3056-3065 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Nucleotides function as endogenous chemical sensors for oxidative stress signaling

Ihara, H., Sawa, T., Nakabeppu, Y. & Akaike, T., Jan 1 2011, In : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 33-39 7 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice.

Tsuzuki, T., Piao, J. S., Isoda, T., Sakumi, K., Nakabeppu, Y. & Nakatsu, Y., Mar 1 2011, In : Health physics. 100, 3, p. 293-294 2 p.

Research output: Contribution to journalConference article

1 Citation (Scopus)

Therapeutic effects of hydrogen in animal models of Parkinson's disease

Fujita, K., Nakabeppu, Y. & Noda, M., Sep 19 2011, In : Parkinson's Disease. 307875.

Research output: Contribution to journalReview article

11 Citations (Scopus)