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Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma

Jinno, T., Kawano, S., Maruse, Y., Matsubara, R., Goto, Y., Sakamoto, T., Hashiguchi, Y., Kaneko, N., Tanaka, H., Kitamura, R., Toyoshima, T., Jinno, A., Moriyama, M., Oobu, K., Kiyoshima, T. & Nakamura, S., May 1 2015, In : Oncology reports. 33, 5, p. 2161-2168 8 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Increased expression of kisspeptin and GnRH forms in the brain of scombroid fish during final ovarian maturation and ovulation

Selvaraj, S., Kitano, H., Amano, M., Ohga, H., Yoneda, M., Yamaguchi, A., Shimizu, A. & Matsuyama, M., Aug 27 2012, In : Reproductive Biology and Endocrinology. 10, 64.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm

Kuga, T., Shimokawa, H., Hirakawa, Y., Kadokami, Y., Arai, Y., Fukumoto, Y., Kuwata, K., Kozai, T., Egashira, K. & Takeshita, A., May 22 2000, In : Journal of Cardiovascular Pharmacology. 35, 5, p. 822-828 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans

Ichioka, M., Suganami, T., Tsuda, N., Shirakawa, I., Hirata, Y., Satoh-Asahara, N., Shimoda, Y., Tanaka, M., Kim-Saijo, M., Miyamoto, Y., Kamei, Y., Sata, M. & Ogawa, Y., Mar 2011, In : Diabetes. 60, 3, p. 819-826 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles

Tsuruta, Y., Furuta, A., Taniguchi, N., Yamada, T., Kira, J. I. & Iwaki, T., 2002, In : Acta neuropathologica. 103, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: Implications for M2 macrophage-involving fibrovascular membrane formation

Yoshida, S., Kobayashi, Y., Nakama, T., Zhou, Y., Ishikawa, K., Arita, R., Nakao, S., Miyazaki, M., Sassa, Y., Oshima, Y., Izuhara, K., Kono, T. & Ishibashi, T., May 1 2015, In : British Journal of Ophthalmology. 99, 5, p. 629-634 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus

Horiuchi, T., Morita, C., Tsukamoto, H., Mitoma, H., Sawabe, T., Harashima, S. I., Kashiwagi, Y. & Okamura, S., May 2006, In : International journal of molecular medicine. 17, 5, p. 875-879 5 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin

Tada, Y., Wada, M., Migita, T., Nagayama, J., Hinoshita, E., Mochida, Y., Maehara, Y., Tsuneyoshi, M., Kuwano, M. & Naito, S., Apr 1 2002, In : International Journal of Cancer. 98, 4, p. 630-635 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist

Nakayama, M., Inoguchi, T., Sonta, T., Maeda, Y., Sasaki, S., Sawada, F., Tsubouchi, H., Sonoda, N., Kobayashi, K., Sumimoto, H. & Nawata, H., Jul 15 2005, In : Biochemical and Biophysical Research Communications. 332, 4, p. 927-933 7 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

Etoh, T., Inoguchi, T., Kakimoto, M., Sonoda, N., Kobayashi, K., Kuroda, J., Sumimoto, H. & Nawata, H., Oct 2003, In : Diabetologia. 46, 10, p. 1428-1437 10 p.

Research output: Contribution to journalArticle

206 Citations (Scopus)

Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis

Nakamura, M., Takii, Y., Ito, M., Komori, A., Yokoyama, T., Shimizu-Yoshida, Y., Koyabu, M., Matsuyama, M., Mori, T., Kamihira, T., Daikoku, M., Migita, K., Yatsuhashi, H., Nozaki, N., Shimoda, S. & Ishibashi, H., Mar 2006, In : Journal of Autoimmunity. 26, 2, p. 138-145 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Increased expression of ornithine decarboxylase messenger RNA in human esophageal carcinoma

Mafune, K. I., Tanaka, Y., Mimori, K., Mori, M., Takubo, K. & Makuuchi, M., Dec 1999, In : Clinical Cancer Research. 5, 12, p. 4073-4078 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Increased expression of periostin and tenascin-C in eyes with neovascular glaucoma secondary to PDR

Ishikawa, K., Kohno, R. I., Mori, K., Murakami, Y., Nakao, S., Akiyama, M., Yoshida, S. & Sonoda, K. H., Mar 1 2020, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 258, 3, p. 621-628 8 p.

Research output: Contribution to journalArticle

Increased expression of periostin in vitreous and fibrovascular membranes obtained from patients with proliferative diabetic retinopathy

Yoshida, S., Ishikawa, K., Asato, R., Arima, M., Sassa, Y., Yoshida, A., Yoshikawa, H., Narukawa, K., Obika, S., Ono, J., Ohta, S., Izuhara, K., Kono, T. & Ishibashi, T., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5670-5678 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues

Hassan, N. M. M., Hamada, J. I., Kameyama, T., Tada, M., Nakagawa, K., Yoshida, S., Kashiwazaki, H., Yamazaki, Y., Suzuki, Y., Sasaki, A., Nagatsuka, H., Inoue, N. & Moriuchi, T., 2011, In : Asian Pacific Journal of Cancer Prevention. 12, 4, p. 947-951 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis

Kunisada, M., Yogianti, F., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., Dec 1 2011, In : American Journal of Pathology. 179, 6, p. 3056-3065 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Increased Fas antigen expression in murine retrovirus‐induced immunodeficiency syndrome, MAIDS

Hiromatsu, K., Aoki, Y., Makino, M., Matsumoto, Y., Mizuochi, T., Gotoh, Y., Nomoto, K., Ogasawara, J., Nagata, S. & Yoshikai, Y., Jan 1 1994, In : European Journal of Immunology. 24, 10, p. 2446-2451 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Increased food intake leads to obesity and insulin resistance in the Tg2576 Alzheimer's disease mouse model

Kohjima, M., Sun, Y. & Chan, L., Apr 2010, In : Endocrinology. 151, 4, p. 1532-1540 9 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Increased formation of hepatic N2 -ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol

Matsuda, T., Matsumoto, A., Uchida, M., Kanaly, R. A., Misaki, K., Shibutani, S., Kawamoto, T., Kitagawa, K., Nakayama, K. I., Tomokuni, K. & Ichiba, M., Nov 2007, In : Carcinogenesis. 28, 11, p. 2363-2366 4 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Increased frequency of antigen-specific CD8+ cytotoxic T lymphocytes infiltrating an epstein-barr virus-associated gastric carcinoma

Kuzushima, K., Nakamura, S., Nakamura, T., Yamamura, Y., Yokoyama, N., Fujita, M., Kiyono, T. & Tsurumi, T., Jul 1999, In : Journal of Clinical Investigation. 104, 2, p. 163-171 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Increased frequency of CD27- (Naive) B cells and their phenotypic alteration in HIV type 1-infected patients

Chong, Y., Ikematsu, H., Yamamoto, M., Murata, M., Yamaji, K., Nishimura, M., Nabeshima, S., Kashiwagi, S. & Hayashi, J., Jun 1 2004, In : AIDS Research and Human Retroviruses. 20, 6, p. 621-629 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

McMichael, A. J., Sasazuki, T., McDevitt, H. O. & Payne, R. O., Jun 1977, In : Arthritis & Rheumatism. 20, 5, p. 1037-1042 6 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Increased frequency of IFN-γ-producing peripheral CD8+ T cells with memory-phenotype in patients with chronic hepatitis C

Murata, M., Nabeshima, S., Maeda, N., Nakashima, H., Kashiwagi, S. & Hayashi, J., May 20 2002, In : Journal of Medical Virology. 67, 2, p. 162-170 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Increased frequency of interferon-γ-producing peripheral blood CD4+ T cells in chronic hepatitis C virus infection

Kawakami, Y., Nabeshima, S., Furusyo, N., Sawayama, Y., Hayashi, J. & Kashiwagi, S., Jan 1 2000, In : American Journal of Gastroenterology. 95, 1, p. 227-232 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin

Ogawa, Y., Masuzaki, H., Hosoda, K., Aizawa-Abe, M., Suga, J., Suda, M., Ebihara, K., Iwai, H., Matsuoka, N., Satoh, N., Odaka, H., Kasuga, H., Fujisawa, Y., Inoue, G., Nishimura, H., Yoshimasa, Y. & Nakao, K., Sep 11 1999, In : Diabetes. 48, 9, p. 1822-1829 8 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Increased grey matter volume of the right superior temporal gyrus in healthy children with autistic cognitive style: A VBM study

Kobayashi, A., Yokota, S., Takeuchi, H., Asano, K., Asano, M., Sassa, Y., Taki, Y. & Kawashima, R., Mar 2020, In : Brain and Cognition. 139, 105514.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism

Miyazaki, M., Kato, M., Tanaka, K., Tanaka, M., Kohjima, M., Nakamura, K., Enjoji, M., Nakamuta, M., Kotoh, K. & Takayanagi, R., Mar 2012, In : Molecular medicine reports. 5, 3, p. 729-733 5 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Increased hepatic inflammation in a normal-weight mouse after long-term high-fat diet feeding

Toita, R., Kawano, T., Fujita, S., Murata, M. & Kang, J. H., 2018, In : Journal of Toxicologic Pathology. 31, 1, p. 43-47 5 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Increased HTLV‐I proviral DNA in HTLV‐I–associated myelopathy: A quantitative polymerase chain reaction study

Kira, J. ., Koyanagi, Y., Yamada, T., Itoyama, Y., Goto, I., Yamamoto, N., Sasaki, H. & Sakaki, Y., Jan 1 1991, In : Annals of Neurology. 29, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Increased hyperthermic response with prostaglandin e1 in VX2 liver carcinoma in rabbits

Morita, M., Kuwano, H., Matsuda, H., Mori, M. & Sugimachi, K., Oct 2 1991, In : Journal of the National Cancer Institute. 83, 19, p. 1395-1400 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Increased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase

Ochi, H., Osoegawa, M., Wu, X. M., Minohara, M., Horiuchi, I., Murai, H., Furuya, H. & Kira, J. I., Sep 15 2002, In : Journal of the Neurological Sciences. 201, 1-2, p. 45-51 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Increased IL-13-producing T cells in ALS: Positive correlations with disease severity and progression rate

Shi, N., Kawano, Y., Tateishi, T., Kikuchi, H., Osoegawa, M., Ohyagi, Y. & Kira, J. I., Jan 1 2007, In : Journal of Neuroimmunology. 182, 1-2, p. 232-235 4 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Increased IL-16 levels in hemophagocytic lymphohistiocytosis

Takada, H., Ohga, S., Mizuno, Y., Nomura, A. & Hara, T., Sep 2004, In : Journal of Pediatric Hematology/Oncology. 26, 9, p. 567-573 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Increased IL-17A/IL-17F expression ratio represents the key mucosal T helper/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis

Iboshi, Y., Nakamura, K., Fukaura, K., Iwasa, T., Ogino, H., Sumida, Y., Ihara, E., Akiho, H., Harada, N. & Nakamuta, M., Mar 1 2017, In : Journal of gastroenterology. 52, 3, p. 315-326 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Increased immunogenicity of tumor-associated antigen, mucin 1, engineered to express α-Gal epitopes: A novel approach to immunotherapy in pancreatic cancer

Deguchi, T., Tanemura, M., Miyoshi, E., Nagano, H., Machida, T., Ohmura, Y., Kobayashi, S., Marubashi, S., Eguchi, H., Takeda, Y., Ito, T., Mori, M., Doki, Y. & Sawa, Y., Jul 1 2010, In : Cancer Research. 70, 13, p. 5259-5269 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure

Akimura, K., Egashira, K., Nakamura, R., Ide, T., Tsutsui, H., Shimokawa, H. & Takeshita, A., 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 280, 1 49-1, p. H68-H75

Research output: Contribution to journalArticle

49 Citations (Scopus)

Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure

Nakamura, R. Y. O., Egashira, K., Arimura, K., Machida, Y., Tomomi, I. D. E., Tsutsui, H., Shimokawa, H. & Takeshita, A., 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 281, 6 50-6, p. H2619-H2625

Research output: Contribution to journalArticle

16 Citations (Scopus)

Increased incidence of cytomegalovirus (CMV) infection and CMV-associated disease after allogeneic bone marrow transplantation from unrelated donors

Takenaka, K., Gondo, H., Tanimoto, K., Nagafuji, K., Fujisaki, T., Mizuno, S., Miyamoto, T., Okamura, T., Hayashi, S., Eto, T., Osaki, K., Yamasaki, K., Shibuya, T., Harada, N., Teshima, T., Matsuishi, E., Minematsu, T., Minamishima, Y., Harada, M. & Niho, Y., Feb 1 1997, In : Bone Marrow Transplantation. 19, 3, p. 241-248 8 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Increased incidence of proximal colon cancer in the elderly

Ikeda, Y., Koyanagi, N., Mori, M., Ezaki, T., Toyomasu, T., Minagawa, S., Tateishi, H. & Sugimachi, K., Sep 1 1996, In : Journal of Clinical Gastroenterology. 23, 2, p. 105-108 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Increased incidence of undifferentiated type of gastric cancer with tumor progression in 912 patients with early gastric cancer and 1245 with advanced gastric cancer

Ikeda, Y., Mori, M., Kamakura, T., Haraguchi, Y., Saku, M. & Sugimachi, K., May 15 1994, In : Cancer. 73, 10, p. 2459-2463 5 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Increased interleukin-18 levels in patients with hemophagocytic lymphohistiocytosis

Takada, H., Ohga, S., Mizuno, Y., Honda, K., Kohno, K., Kurimoto, M. & Hara, T., 1999, In : Medical and Pediatric Oncology. 32, 3, 1 p.

Research output: Contribution to journalArticle

Increased intestinal permeability correlates with gastrointestinal toxicity among formulations of the fluorouracil analogue tegafur in rats

Korenaga, D., Honda, M., Yasuda, M., Inutsuka, S., Nozoe, T. & Tashiro, H., Oct 17 2002, In : European Surgical Research. 34, 5, p. 351-356 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Increased intracranial pressure caused by obstruction of torcular herophili with hemangopericytoma: A case report

Hashiguchi, K., Inamura, T., Iwaki, T., Matsushima, T., Takeno, Y., Abe, H. & Fukui, M., 2001, In : Neurological Surgery. 29, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
77 Citations (Scopus)

Increased light outcoupling efficiency in dye-doped small molecule organic light-emitting diodes with horizontally oriented emitters

Frischeisen, J., Yokoyama, D., Endo, A., Adachi, C. & Brütting, W., May 2011, In : Organic Electronics. 12, 5, p. 809-817 9 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Increased lipid absorption and transport in the small intestine of Zucker obese rats

Anzai, K., Fukagawa, K., Iwakiri, R., Fujimoto, K., Akashi, K. & Tso, P., Jul 2009, In : Journal of Clinical Biochemistry and Nutrition. 45, 1, p. 82-85 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Increased local cerebral glucose utilization in the basal ganglia of the rolling mouse Nagoya

Kato, M., Hosokawa, S., Tobimatsu, S. & Kuroiwa, Y., 1982, In : Journal of Cerebral Blood Flow and Metabolism. 2, 4, p. 385-393 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Increased mRNA expression of a novel prostacyclin-stimulating factor in human colon cancer

Umeda, F., Ono, Y., Sekiguchi, N., Hashimoto, T., Masakado, M., Nakamura, K., Chijiiwa, Y. & Nawata, H., Apr 1 1998, In : Journal of gastroenterology. 33, 2, p. 213-217 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
37 Citations (Scopus)

Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure With Preserved Ejection Fraction

Hieda, M., Sarma, S., Hearon, C. M., Dias, K. A., Martinez, J., Samels, M., Everding, B., Palmer, D., Livingston, S., Morris, M., Howden, E. & Levine, B. D., Jan 14 2020, In : Circulation. 141, 2, p. 115-123 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)