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2018
3 Citations (Scopus)

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Bharti, S. K., Sommers, J. A., Awate, S., Bellani, M. A., Khan, I., Bradley, L., King, G. A., Seol, Y., Vidhyasagar, V., Wu, Y., Abe, T., Kobayashi, K., Shin-Ya, K., Kitao, H., Wold, M. S., Branzei, D., Neuman, K. C. & Brosh, R. M., Jul 6 2018, In : Nucleic acids research. 46, 12, p. 6238-6256 19 p.

Research output: Contribution to journalArticle

Fanconi Anemia
DNA
Aphidicolin
Bleomycin
G-Quadruplexes
1 Citation (Scopus)

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer

Inoue, Y., Yamashita, N., Kitao, H., Tanaka, K., Saeki, H., Oki, E., Oda, Y., Tokunaga, E. & Maehara, Y., Aug 2018, In : Clinical Breast Cancer. 18, 4, p. e643-e650

Research output: Contribution to journalArticle

Protein Phosphatase 1
Phosphoric Monoester Hydrolases
Phosphoprotein Phosphatases
Magnesium
Breast Neoplasms
9 Citations (Scopus)

DNA replication stress and cancer chemotherapy

Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., Feb 1 2018, In : Cancer Science. 109, 2, p. 264-271 8 p.

Research output: Contribution to journalReview article

DNA Replication
Drug Therapy
Neoplasms
Biological Phenomena
Genomic Instability
11 Citations (Scopus)

Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer

Yamashita, N., Tokunaga, E., Iimori, M., Inoue, Y., Tanaka, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., Oct 2018, In : Clinical Breast Cancer. 18, 5, p. e1003-e1009

Research output: Contribution to journalArticle

Vimentin
Cadherins
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
4 Citations (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., Dec 1 2018, In : Scientific reports. 8, 1, 10888.

Research output: Contribution to journalArticle

Histone-Lysine N-Methyltransferase
Methyltransferases
Methylation
Lysine
DNA Damage
3 Citations (Scopus)

Thymidine kinase 1 loss confers trifluridine resistance without affecting 5-fluorouracil metabolism and cytotoxicity

Edahiro, K., Iimori, M., Kobunai, T., Morikawa-Ichinose, T., Miura, D., Kataoka, Y., Niimi, S., Wakasa, T., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Oct 2018, In : Molecular Cancer Research. 16, 10, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

Trifluridine
Fluorouracil
Pyrimidine Nucleotides
Pharmaceutical Preparations
Cell Line
2017
6 Citations (Scopus)

Activation of the FA pathway mediated by phosphorylation and ubiquitination

Ishiai, M., Sato, K., Tomida, J., Kitao, H., Kurumizaka, H. & Takata, M., Oct 2017, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 803-805, p. 89-95 7 p.

Research output: Contribution to journalReview article

Fanconi Anemia
Ubiquitination
Phosphorylation
Fanconi Anemia Complementation Group D2 Protein
Bone Marrow Cells
9 Citations (Scopus)

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest

Tsuda, Y., Iimori, M., Nakashima, Y., Nakanishi, R., Ando, K., Ohgaki, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., Dec 1 2017, In : Scientific reports. 7, 1, 16762.

Research output: Contribution to journalArticle

Tubulin
Microtubules
eribulin
Aurora Kinase B
Endoreduplication
1 Citation (Scopus)

Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Nakanishi, R., Kitao, H., Kiniwa, M., Morodomi, Y., Iimori, M., Kurashige, J., Sugiyama, M., Nakashima, Y., Saeki, H., Oki, E. & Maehara, Y., Dec 1 2017, In : Scientific reports. 7, 1, 16969.

Research output: Contribution to journalArticle

Trifluridine
Colorectal Neoplasms
Blood Cells
Antibodies
DNA
11 Citations (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., Jan 1 2017, In : Cancer Medicine. 6, 1, p. 258-266 9 p.

Research output: Contribution to journalArticle

Neoplasms
Survival
Pyrophosphatases
Messenger RNA
Neoadjuvant Therapy
2016

Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)

Kitao, H., Matsuoka, K., Iimori, M., Tokunaga, E., Saeki, H., Oki, E., Miyamoto, Y., Baba, H. & Maehara, Y., Jan 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 1, p. 8-14 7 p.

Research output: Contribution to journalReview article

Trifluridine
Colorectal Neoplasms
Drug Therapy
Salvage Therapy
Japan
5 Citations (Scopus)

Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer

Tokunaga, E., Yamashita, N., Kitao, H., Tanaka, K., Taketani, K., Inoue, Y., Saeki, H., Oki, E., Oda, Y. & Maehara, Y., Feb 1 2016, In : Breast. 25, p. 62-68 7 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Breast Neoplasms
Genes
Neoplasms
Survival

Evolving 5-fluorouracil therapy to achieve enhanced efficacy-past and current efforts of researchers

Maehara, Y., Oki, E., Saeki, H., Tokunaga, E., Kitao, H., Iimori, M., Niimi, S., Kataoka, Y., Emi, Y., Kakeji, Y., Baba, H. & Shirasaka, T., Jul 2016, In : Japanese Journal of Cancer and Chemotherapy. 43, 7, p. 845-854 10 p.

Research output: Contribution to journalReview article

Fluorouracil
Research Personnel
Tegafur
Prodrugs
Pharmaceutical Preparations
5 Citations (Scopus)

Expression of APOBEC3B mRNA in primary breast cancer of Japanese women

Tokunaga, E., Yamashita, N., Tanaka, K., Inoue, Y., Akiyoshi, S., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Dec 2016, In : PloS one. 11, 12, e0168090.

Research output: Contribution to journalArticle

apolipoprotein B
Apolipoproteins B
breast neoplasms
polypeptides
Breast Neoplasms
21 Citations (Scopus)

Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome

Ito, S., Okano, S., Morita, M., Saeki, H., Tsutsumi, S., Tsukihara, H., Nakashima, Y., Ando, K., Imamura, Y., Ohgaki, K., Oki, E., Kitao, H., Mimori, K. & Maehara, Y., Aug 1 2016, In : Annals of Surgical Oncology. 23, p. 508-515 8 p.

Research output: Contribution to journalArticle

CD274 Antigen
HLA Antigens
Survival
Recurrence
Confidence Intervals
14 Citations (Scopus)

Gastric Cancer Patients with High PLK1 Expression and DNA Aneuploidy Correlate with Poor Prognosis

Otsu, H., Iimori, M., Ando, K., Saeki, H., Aishima, S., Oda, Y., Morita, M., Matsuo, K., Kitao, H., Oki, E. & Maehara, Y., Jul 1 2016, In : Oncology (Switzerland). 91, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Aneuploidy
Stomach Neoplasms
DNA
Ploidies
Neoplasms
12 Citations (Scopus)

High expression of the Notch ligand Jagged-1 is associated with poor prognosis after surgery for colorectal cancer

Sugiyama, M., Oki, E., Nakaji, Y., Tsutsumi, S., Ono, N., Nakanishi, R., Sugiyama, M., Nakashima, Y., Sonoda, H., Ohgaki, K., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Morita, M., Oda, Y. & Maehara, Y., Nov 1 2016, In : Cancer Science. 107, 11, p. 1705-1716 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Ligands
Cadherins
Epithelial-Mesenchymal Transition
Recurrence
11 Citations (Scopus)

Impact of Expression of Vimentin and Axl in Breast Cancer

Tanaka, K., Tokunaga, E., Inoue, Y., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Oki, E., Oda, Y. & Maehara, Y., Dec 1 2016, In : Clinical Breast Cancer. 16, 6, p. 520-526.e2

Research output: Contribution to journalArticle

Vimentin
Breast Neoplasms
Triple Negative Breast Neoplasms
Survival
Neoplasms

Oxaliplatin - A 10-year trajectory

Kanaji, S., Oki, E., Saeki, H., Kitao, H., Maehara, Y. & Kakeji, Y., Jun 2016, In : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 715-722 8 p.

Research output: Contribution to journalReview article

oxaliplatin
antineoplaston A10
Platinum
Japan
Clinical Trials

Oxaliplatin -- A 10-Year Trajectory

Kanaji, S., Oki, E., Saeki, H., Kitao, H., Maehara, Y. & Kakeji, Y., Jun 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 6, p. 715-722 8 p.

Research output: Contribution to journalArticle

oxaliplatin
antineoplaston A10
Platinum
Japan
Clinical Trials
12 Citations (Scopus)

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Iimori, M., Watanabe, S., Kiyonari, S., Matsuoka, K., Sakasai, R., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Mar 31 2016, In : Nature communications. 7, 11117.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
genome
Genomic Instability
progressions
13 Citations (Scopus)

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA

Kitao, H., Morodomi, Y., Niimi, S., Kiniwa, M., Shigeno, K., Matsuoka, K., Kataoka, Y., Iimori, M., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., May 3 2016, In : Scientific reports. 6, 25286.

Research output: Contribution to journalArticle

Trifluridine
Bromodeoxyuridine
Antibodies
DNA
Nucleoside Transport Proteins
1 Citation (Scopus)

The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Kitao, H., Kiyonari, S., Limori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., Jun 2016, In : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 707-714 8 p.

Research output: Contribution to journalReview article

oxaliplatin
Platinum
Fluorouracil
Leucovorin
Combination Drug Therapy

The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU

Kitao, H., Kiyonari, S., Iimori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., Jun 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 6, p. 707-714 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Platinum
Fluorouracil
Leucovorin
Combination Drug Therapy
2015
22 Citations (Scopus)

Discrimination of p53 immunohistochemistry-positive tumors by its staining pattern in gastric cancer

Ando, K., Oki, E., Saeki, H., Yan, Z., Tsuda, Y., Hidaka, G., Kasagi, Y., Otsu, H., Kawano, H., Kitao, H., Morita, M. & Maehara, Y., Jan 1 2015, In : Cancer Medicine. 4, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Immunohistochemistry
Staining and Labeling
p53 Genes
Neoplasms
23 Citations (Scopus)

Epigenetic inactivation of BRCA1 through promoter hypermethylation and its clinical importance in triple-negative breast cancer

Yamashita, N., Tokunaga, E., Kitao, H., Hitchins, M., Inoue, Y., Tanaka, K., Hisamatsu, Y., Taketani, K., Akiyoshi, S., Okada, S., Oda, Y., Saeki, H., Oki, E. & Maehara, Y., Dec 2015, In : Clinical Breast Cancer. 15, 6, p. 498-504 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Epigenomics
Methylation
Breast Neoplasms
BRCA1 Protein
3 Citations (Scopus)

Intensive immunofluorescence staining methods for low expression protein: Detection of intestinal stem cell marker LGR5

Yamazaki, M., Kato, A., Zaitsu, Y., Watanabe, T., Iimori, M., Funahashi, S., Kitao, H., Saeki, H., Oki, E. & Suzuki, M., Oct 29 2015, In : Acta Histochemica et Cytochemica. 48, 5, p. 159-164 6 p.

Research output: Contribution to journalComment/debate

Stem cells
Fluorescent Antibody Technique
Stem Cells
Staining and Labeling
Proteins
15 Citations (Scopus)

The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis

Kiyonari, S., Iimori, M., Matsuoka, K., Watanabe, S., Morikawa-Ichinose, T., Miura, D., Niimi, S., Saeki, H., Tokunaga, E., Oki, E., Morita, M., Kadomatsu, K., Maehara, Y. & Kitao, H., Oct 1 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2332-2342 11 p.

Research output: Contribution to journalArticle

oxaliplatin
Ligands
Deoxyuridine
Fluorouracil
Platinum
34 Citations (Scopus)

Trifluridine induces p53-dependent sustained G2 phase arrest with its massive misincorporation into DNA and few DNA strand breaks

Matsuoka, K., Iimori, M., Niimi, S., Tsukihara, H., Watanabe, S., Kiyonari, S., Kiniwa, M., Ando, K., Tokunaga, E., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 4, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Trifluridine
DNA Breaks
G2 Phase
Cyclin B1
Deoxyuridine
2014
12 Citations (Scopus)

Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer

Zhao, Y., Ando, K., Oki, E., Ikawa-Yoshida, A., Ida, S., Kimura, Y., Saeki, H., Kitao, H., Morita, M. & Maehara, Y., Oct 1 2014, In : Anticancer research. 34, 10, p. 5421-5427 7 p.

Research output: Contribution to journalArticle

Chromosomal Instability
p53 Genes
Colorectal Neoplasms
Aneuploidy
Mutation
30 Citations (Scopus)

Chromosomal Instability Associated with Global DNA Hypomethylation is Associated with the Initiation and Progression of Esophageal Squamous Cell Carcinoma

Kawano, H., Saeki, H., Kitao, H., Tsuda, Y., Otsu, H., Ando, K., Ito, S., Egashira, A., Oki, E., Morita, M., Oda, Y. & Maehara, Y., Jan 1 2014, In : Annals of Surgical Oncology. 21, 4, p. 696-702 7 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Methylation
DNA
Carcinogenesis
Genome
10 Citations (Scopus)

Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers

Honma, K., Nakanishi, R., Nakanoko, T., Ando, K., Saeki, H., Oki, E., Iimori, M., Kitao, H., Kakeji, Y. & Maehara, Y., Mar 1 2014, In : Surgery today. 44, 3, p. 454-461 8 p.

Research output: Contribution to journalArticle

Aneuploidy
Stomach Neoplasms
Microsatellite Instability
DNA
Cell Division
16 Citations (Scopus)

Molecular mechanisms regulating the hormone sensitivity of breast cancer

Tokunaga, E., Hisamatsu, Y., Tanaka, K., Yamashita, N., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Nov 1 2014, In : Cancer Science. 105, 11, p. 1377-1383 7 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinase
Hormones
Breast Neoplasms
Sirolimus
Estrogen Receptors
23 Citations (Scopus)

Mortalin is a prognostic factor of gastric cancer with normal p53 function

Ando, K., Oki, E., Zhao, Y., Ikawa-Yoshida, A., Kitao, H., Saeki, H., Kimura, Y., Ida, S., Morita, M., Kusumoto, T. & Maehara, Y., Apr 2014, In : Gastric Cancer. 17, 2, p. 255-262 8 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Neoplasms
mortalin
HSP70 Heat-Shock Proteins
Hot Temperature
36 Citations (Scopus)

Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer

Tokunaga, E., Nakashima, Y., Yamashita, N., Hisamatsu, Y., Okada, S., Akiyoshi, S., Aishima, S., Kitao, H., Morita, M. & Maehara, Y., May 2014, In : Breast Cancer. 21, 3, p. 341-349 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Phenotype
Disease-Free Survival
Survival Rate
Confidence Intervals
23 Citations (Scopus)

Oxidative DNA damage in human esophageal cancer: Clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme

Kubo, N., Morita, M., Nakashima, Y., Kitao, H., Egashira, A., Saeki, H., Oki, E., Kakeji, Y., Oda, Y. & Maehara, Y., Apr 2014, In : Diseases of the Esophagus. 27, 3, p. 285-293 9 p.

Research output: Contribution to journalArticle

Esophageal Neoplasms
DNA Damage
Carcinogenesis
Epithelium
Enzymes
2013
8 Citations (Scopus)

Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells

Ikawa-Yoshida, A., Ando, K., Oki, E., Saeki, H., Kumashiro, R., Taketani, K., Ida, S., Tokunaga, E., Kitao, H., Morita, M. & Maehara, Y., Aug 2013, In : Cancer Medicine. 2, 4, p. 447-456 10 p.

Research output: Contribution to journalArticle

Aneuploidy
M Phase Cell Cycle Checkpoints
Oxidative Stress
Carcinogenesis
Down-Regulation
6 Citations (Scopus)

Involvement of ribonucleotide reductase-M1 in 5-fluorouracil.-induced DNA damage in esophageal cancer cell lines

Aoki, Y., Sakogawa, K., Hihara, J., Emi, M., Hamai, Y., Kono, K., Shi, L., Sun, J., Kitao, H., Ikura, T., Niida, H., Nakanishi, M., Okada, M. & Tashiro, S., Jun 1 2013, In : International journal of oncology. 42, 6, p. 1951-1960 10 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Esophageal Neoplasms
Fluorouracil
DNA Damage
Cell Line
16 Citations (Scopus)

Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion

Nakashima, Y., Yoshinaga, K., Kitao, H., Ando, K., Kimura, Y., Saeki, H., Oki, E., Morita, M., Kakeji, Y., Hirahashi, M., Oda, Y. & Maehara, Y., Dec 1 2013, In : Cancer Science. 104, 12, p. 1718-1725 8 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Cadherins
Cell Line
Cell Movement
Transfection
37 Citations (Scopus)

Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer

Nakanishi, R., Harada, J., Tuul, M., Zhao, Y., Ando, K., Saeki, H., Oki, E., Ohga, T., Kitao, H., Kakeji, Y. & Maehara, Y., Dec 1 2013, In : International Journal of Clinical Oncology. 18, 6, p. 1042-1048 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Recurrence
Survival
Microsatellite Instability
13 Citations (Scopus)

Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Tuul, M., Kitao, H., Iimori, M., Matsuoka, K., Kiyonari, S., Saeki, H., Oki, E., Morita, M. & Maehara, Y., Feb 1 2013, In : PloS one. 8, 2, e55361.

Research output: Contribution to journalArticle

heat tolerance
phosphotransferases (kinases)
Phosphotransferases
Hot Temperature
Chemical activation
59 Citations (Scopus)

Vimentin as a poor prognostic factor for triple-negative breast cancer

Yamashita, N., Tokunaga, E., Kitao, H., Hisamatsu, Y., Taketani, K., Akiyoshi, S., Okada, S., Aishima, S., Morita, M. & Maehara, Y., May 1 2013, In : Journal of Cancer Research and Clinical Oncology. 139, 5, p. 739-746 8 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Vimentin
Survival
Epithelial-Mesenchymal Transition
Recurrence
2012
17 Citations (Scopus)

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

Fujinaka, Y., Matsuoka, K., Iimori, M., Tuul, M., Sakasai, R., Yoshinaga, K., Saeki, H., Morita, M., Kakeji, Y., Gillespie, D. A., Yamamoto, K. I., Takata, M., Kitao, H. & Maehara, Y., Mar 1 2012, In : DNA Repair. 11, 3, p. 247-258 12 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Cytotoxicity
Fluorouracil
Repair
Phosphotransferases
4 Citations (Scopus)

CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication

Sakasai, R., Sakai, A., Iimori, M., Kiyonari, S., Matsuoka, K., Kakeji, Y., Kitao, H. & Maehara, Y., Dec 1 2012, In : Genes to Cells. 17, 12, p. 962-970 9 p.

Research output: Contribution to journalArticle

Camptothecin
DNA Breaks
Double-Stranded DNA Breaks
DNA Replication
S Phase Cell Cycle Checkpoints
10 Citations (Scopus)

FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer

Nakanishi, R., Kitao, H., Fujinaka, Y., Yamashita, N., Iimori, M., Tokunaga, E., Yamashita, N., Morita, M., Kakeji, Y. & Maehara, Y., Oct 1 2012, In : Annals of Surgical Oncology. 19, 11, p. 3627-3635 9 p.

Research output: Contribution to journalArticle

Fluorouracil
Colorectal Neoplasms
Drug Therapy
Neoplasms
DNA Mismatch Repair
10 Citations (Scopus)

High incidence and frequency of LOH are associated with aggressive features of high-grade HER2 and triple-negative breast cancers

Tokunaga, E., Okada, S., Yamashita, N., Akiyoshi, S., Kitao, H., Morita, M., Kakeji, Y. & Maehara, Y., Apr 1 2012, In : Breast Cancer. 19, 2, p. 161-169 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Loss of Heterozygosity
Incidence
Breast Neoplasms
Neoplasms
43 Citations (Scopus)

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

Sato, K., Ishiai, M., Toda, K., Furukoshi, S., Osakabe, A., Tachiwana, H., Takizawa, Y., Kagawa, W., Kitao, H., Dohmae, N., Obuse, C., Kimura, H., Takata, M. & Kurumizaka, H., Aug 29 2012, In : EMBO Journal. 31, 17, p. 3524-3536 13 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group Proteins
Histone Chaperones
Nucleosomes
DNA Repair
Repair
10 Citations (Scopus)

Loss of heterozygosity at BRCA1 locus is significantly associated with aggressiveness and poor prognosis in breast cancer

Okada, S., Tokunaga, E., Kitao, H., Akiyoshi, S., Yamashita, N., Saeki, H., Oki, E., Morita, M., Kakeji, Y. & Maehara, Y., May 1 2012, In : Annals of Surgical Oncology. 19, 5, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Breast Neoplasms
Survival
Progesterone Receptors
Confidence Intervals
11 Citations (Scopus)

PARP and CSB modulate the processing of transcription-mediated DNA strand breaks

Sakai, A., Sakasai, R., Kakeji, Y., Kitao, H. & Maehara, Y., Jan 1 2012, In : Genes and Genetic Systems. 87, 4, p. 265-272 8 p.

Research output: Contribution to journalArticle

DNA Breaks
Poly(ADP-ribose) Polymerases
Camptothecin
DNA Repair
Cockayne Syndrome
23 Citations (Scopus)

The Q motif of fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function

Wu, Y., Sommers, J. A., Loiland, J. A., Kitao, H., Kuper, J., Kisker, C. & Brosh, R. M., Jun 22 2012, In : Journal of Biological Chemistry. 287, 26, p. 21699-21716 18 p.

Research output: Contribution to journalArticle

DNA Helicases
Fanconi Anemia
Dimerization
DNA Repair
Repair