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Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome

Doi, H., Arimura, K., Ohyagi, Y. & Kira, J. I., Jun 1 2011, In : Internal Medicine. 50, 10, p. 1113-1115 3 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Frostbite
Muscle Rigidity
Voltage-Gated Potassium Channels
Skin
2 Citations (Scopus)
Gyrus Cinguli
Alzheimer Disease
Temporal Lobe
Brain
Frontal Lobe
6 Citations (Scopus)

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., Feb 1 2015, In : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

Research output: Contribution to journalArticle

Galectin 1
Motor Neurons
Transgenic Mice
Amyotrophic Lateral Sclerosis
Axons
7 Citations (Scopus)
Multiple Sclerosis
Phenotype
MHC Class II Genes
Disease Susceptibility
Helicobacter Infections
7 Citations (Scopus)
Neuromyelitis Optica
Multiple Sclerosis
Aquaporin 4
Sanitation
Age of Onset
8 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Apr 15 2014, In : PloS one. 9, 4, e95367.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
sclerosis
cerebrospinal fluid
Multiple Sclerosis
Cerebrospinal Fluid
12 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Jan 1 2014, In : PloS one. 9, 4, p. e95367

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
sclerosis
cerebrospinal fluid
Multiple Sclerosis
Cerebrospinal Fluid
45 Citations (Scopus)

Genetic and Infectious Profiles of Japanese Multiple Sclerosis Patients

Yoshimura, S., Isobe, N., Yonekawa, T., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Yamamoto, K. & Kira, J. I., Nov 9 2012, In : PloS one. 7, 11, e48592.

Research output: Contribution to journalArticle

sclerosis
Multiple Sclerosis
Epstein-Barr Virus Nuclear Antigens
Viruses
HLA-DRB1 Chains
2 Citations (Scopus)

Grand Total EEG score can differentiate Parkinson's disease from Parkinson-related disorders

Barcelon, E. A., Mukaino, T., Yokoyama, J., Uehara, T., Ogata, K., Kira, J. I. & Tobimatsu, S., Jan 1 2019, In : Frontiers in Neurology. 10, APR, 398.

Research output: Contribution to journalArticle

Open Access
Parkinson Disease
Electroencephalography
Parkinsonian Disorders
Multiple System Atrophy
Paralysis
2 Citations (Scopus)

Helicobacter pylori infection and demyelinating disease of the central nervous system

Kira, J. I. & Isobe, N., Apr 15 2019, In : Journal of Neuroimmunology. 329, p. 14-19 6 p.

Research output: Contribution to journalReview article

Helicobacter Infections
Demyelinating Diseases
Helicobacter pylori
Central Nervous System
Neuromyelitis Optica
4 Citations (Scopus)

Helicobacter pylori infection might prove the hygiene hypothesis in multiple sclerosis

Kira, J. I., Jun 1 2015, In : Journal of Neurology, Neurosurgery and Psychiatry. 86, 6, p. 591-592 2 p.

Research output: Contribution to journalComment/debate

Infection
Hygiene
Multiple Sclerosis

Hemicape-like sensory disturbance caused by cortical infarction in the postcentral gyrus

Yamashita, C., Kawamura, N., Torii, T., Ohyagi, Y. & Kira, J-I., Mar 1 2012, In : Clinical Neurology. 52, 3, p. 178-181 4 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Infarction
Hypesthesia
Cerebral Infarction
Arm

Higher postictal parasympathetic activity following greater ictal heart rate increase in right- than left-sided seizures

Shimmura, M., Uehara, T., Ogata, K., Shigeto, H., Maeda, T., Sakata, A., Yamasaki, R. & Kira, J. I., Aug 2019, In : Epilepsy and Behavior. 97, p. 161-168 8 p.

Research output: Contribution to journalArticle

Seizures
Heart Rate
Stroke
ROC Curve
Partial Epilepsy
45 Citations (Scopus)

Histopathologic Analysis of Retrieved Thrombi Associated with Successful Reperfusion after Acute Stroke Thrombectomy

Hashimoto, T., Hayakawa, M., Funatsu, N., Yamagami, H., Satow, T., Takahashi, J. C., Nagatsuka, K., Ishibashi-Ueda, H., Kira, J. I. & Toyoda, K., Dec 1 2016, In : Stroke. 47, 12, p. 3035-3037 3 p.

Research output: Contribution to journalArticle

Thrombectomy
Reperfusion
Thrombosis
Stroke
Erythrocytes
6 Citations (Scopus)

HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese

Sato, S., Isobe, N., Yoshimura, S., Kanamori, Y., Masaki, K., Matsushita, T. & Kira, J. I., Oct 15 2012, In : Journal of Neuroimmunology. 251, 1-2, p. 110-113 4 p.

Research output: Contribution to journalArticle

Myelitis
HLA Antigens
Alleles
Neuromyelitis Optica
Immunogenetics
5 Citations (Scopus)

HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis

Shinoda, K., Matsushita, T., Nakamura, Y., Masaki, K., Yamasaki, R., Yamaguchi, H., Togao, O., Hiwatashi, A. & Kira, J-I., May 1 2017, In : Multiple Sclerosis. p. 1352458517707067

Research output: Contribution to journalArticle

Multiple Sclerosis
Alleles
HLA-DRB1 Chains
HLA-DRB1*04 antigen
Logistic Models

HLA genotype and cortical lesions: Response to the letter from Spencer et al.

Shinoda, K., Matsushita, T., Nakamura, Y., Masaki, K., Yamasaki, R. & Kira, J. I., May 1 2018, In : Multiple Sclerosis Journal. 24, 6, p. 819-820 2 p.

Research output: Contribution to journalLetter

Genotype
Neuromyelitis Optica
Spinal Cord
White Matter

Hopkins syndrome following the first episode of bronchial asthma associated with enterovirus D68: A case report

Hayashi, F., Hayashi, S., Matsuse, D., Yamasaki, R., Yonekura, K. & Kira, J. I., May 23 2018, In : BMC neurology. 18, 1, 71.

Research output: Contribution to journalArticle

Enterovirus
Asthma
Respiratory Hypersensitivity
Lower Extremity
Adult Respiratory Distress Syndrome
68 Citations (Scopus)

Human umbilical cord-derived mesenchymal stromal cells differentiate into functional schwann cells that sustain peripheral nerve regeneration

Matsuse, D., Kitada, M., Kohama, M., Nishikawa, K., Makinoshima, H., Wakao, S., Fujiyoshi, Y., Heike, T., Nakahata, T., Akutsu, H., Umezawa, A., Harigae, H., Kira, J. I. & Dezawa, M., Sep 2010, In : Journal of neuropathology and experimental neurology. 69, 9, p. 973-985 13 p.

Research output: Contribution to journalArticle

Nerve Regeneration
Umbilical Cord
Schwann Cells
Mesenchymal Stromal Cells
Peripheral Nerves
1 Citation (Scopus)

Hyperexcitability restricted to the lower limb motor system in a patient with stiff-leg syndrome

Iwata, T., Shigeto, H., Ogata, K., Hagiwara, K. I., Kanamori, Y., Uehara, T., Ohyagi, Y., Tobimatsu, S. & Kira, J. I., Dec 1 2011, In : Journal of Clinical Neuroscience. 18, 12, p. 1720-1722 3 p.

Research output: Contribution to journalArticle

Lower Extremity
Leg
Stretch Reflex
Glutamate Decarboxylase
Transcranial Magnetic Stimulation
28 Citations (Scopus)

IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay

Kadoya, M., Kaida, K., Koike, H., Takazaki, H., Ogata, H., Moriguchi, K., Shimizu, J., Nagata, E., Takizawa, S., Chiba, A., Yamasaki, R., Kira, J. I., Sobue, G. & Ikewaki, K., Dec 15 2016, In : Journal of Neuroimmunology. 301, p. 16-22 7 p.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Anti-Idiotypic Antibodies
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antibodies
1 Citation (Scopus)

Immune-mediated spastic paraparesis accompanied with high titres of voltage-gated potassium channel complex antibodies and myokymia/fasciculation

Saitoh, B. Y., Hayashi, S., Ogata, K., Uehara, T., Doi, H., Watanabe, O., Yamasaki, R., Murai, H. & Kira, J. I., May 15 2016, In : Journal of the Neurological Sciences. 364, p. 133-135 3 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)

Impact and characteristics of quality of life in Japanese patients with multiple sclerosis

Kikuchi, H., Mifune, N., Niino, M., Ohbu, S., Kira, J. I., Kohriyama, T., Ota, K., Tanaka, M., Ochi, H., Nakane, S., Maezawa, M. & Kikuchi, S., Feb 1 2011, In : Quality of Life Research. 20, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Quality of Life
Social Adjustment
Medical Staff
Focus Groups
28 Citations (Scopus)

Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1α in amyotrophic lateral sclerosis

Nagara, Y., Tateishi, T., Yamasaki, R., Hayashi, S., Kawamura, M., Kikuchi, H., Iinuma, K. M., Tanaka, M., Iwaki, T., Matsushita, T., Ohyagi, Y. & Kira, J. I., Sep 1 2013, In : Brain Pathology. 23, 5, p. 534-546 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Cell Nucleus Active Transport
Amyotrophic Lateral Sclerosis
Karyopherins
Anterior Horn Cells
9 Citations (Scopus)

Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model

Kawamura, M. F., Yamasaki, R., Kawamura, N., Tateishi, T., Nagara, Y., Matsushita, T., Ohyagi, Y. & Kira, J-I., Apr 1 2012, In : Experimental Neurology. 234, 2, p. 437-445 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Microglia
T-Lymphocytes
Wounds and Injuries
Axotomy
3 Citations (Scopus)

Improving treatment times for patients with in-hospital stroke using a standardized protocol

Koge, J., Matsumoto, S., Nakahara, I., Ishii, A., Hatano, T., Sadamasa, N., Kai, Y., Ando, M., Saka, M., Chihara, H., Takita, W., Tokunaga, K., Kamata, T., Nishi, H., Hashimoto, T., Tsujimoto, A., Kira, J. I. & Nagata, I., Oct 15 2017, In : Journal of the Neurological Sciences. 381, p. 68-73 6 p.

Research output: Contribution to journalArticle

Stroke
Neuroimaging
Therapeutics
Intracranial Hemorrhages
Clinical Protocols
7 Citations (Scopus)

Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNA-binding protein from starved cells (C-Dps) in myelinated nerve fibers

Piao, H., Minohara, M., Kawamura, N., Li, W., Mizunoe, Y., Umehara, F., Goto, Y., Kusunoki, S., Matsushita, T., Ikenaka, K., Maejima, T., Nabekura, J. I., Yamasaki, R. & Kira, J. I., Jan 15 2010, In : Journal of the Neurological Sciences. 288, 1-2, p. 54-62 9 p.

Research output: Contribution to journalArticle

Sulfoglycosphingolipids
Myelinated Nerve Fibers
Campylobacter jejuni
Sodium Channels
DNA-Binding Proteins
3 Citations (Scopus)

Inflammatory radiculoneuropathy in an ALS4 patient with a novel SETX mutation

Saiga, T., Tateishi, T., Torii, T., Kawamura, N., Nagara, Y., Shigeto, H., Hashiguchi, A., Takashima, H., Honda, H., Ohyagi, Y. & Kira, J. I., Jul 2012, In : Journal of Neurology, Neurosurgery and Psychiatry. 83, 7, p. 763-764 2 p.

Research output: Contribution to journalLetter

Mutation
21 Citations (Scopus)

Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status

Isobe, N., Matsushita, T., Yamasaki, R., Ramagopalan, S. V., Kawano, Y., Nishimura, Y., Ebers, G. C. & Kira, J., Feb 1 2010, In : Multiple Sclerosis. 16, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

Aquaporin 4
HLA Antigens
Multiple Sclerosis
Alleles
Antibodies
11 Citations (Scopus)

Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

Ainiding, G., Kawano, Y., Sato, S., Isobe, N., Matsushita, T., Yoshimura, S., Yonekawa, T., Yamasaki, R., Murai, H. & Kira, J. I., Feb 15 2014, In : Journal of the Neurological Sciences. 337, 1-2, p. 147-150 4 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Interleukin-2 Receptors
Multiple Sclerosis
Genes
Genotype
21 Citations (Scopus)

Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians

Fang, L., Isobe, N., Yoshimura, S., Yonekawa, T., Matsushita, T., Masaki, K., Doi, H., Ochi, K., Miyamoto, K., Kawano, Y. & Kira, J., Jun 14 2011, In : Neurology. 76, 24, p. 2125-2127 3 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
Neuromyelitis Optica
Genetic Predisposition to Disease
Gene Frequency
Multiple Sclerosis
40 Citations (Scopus)

Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease

Soejima, N., Ohyagi, Y., Nakamura, N., Himeno, E., Iinuma, K. M., Sakae, N., Yamasaki, R., Tabira, T., Murakami, K., Irie, K., Kinoshita, N., LaFerla, F. M., Kiyohara, Y., Iwaki, T. & Kira, J. I., Nov 29 2013, In : Current Alzheimer Research. 10, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Endoplasmic Reticulum Stress
Poisons
Amyloid
Alzheimer Disease
1 Citation (Scopus)

Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: A case report

Mizuno, Y., Shinoda, K., Watanabe, M., Ogata, H., Isobe, N., Matsushita, T., Yamasaki, R., Tanaka, K., Koike, H., Katsuno, M. & Kira, J. I., Oct 2019, In : Multiple Sclerosis and Related Disorders. 35, p. 16-18 3 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Peripheral Nerves
Upper Extremity
Aquaporin 4
Magnetic Resonance Spectroscopy
7 Citations (Scopus)
Relapsing-Remitting Multiple Sclerosis
Gadolinium
Brain
Interferon-beta
Therapeutics

Intrathecal cytokine profile in neuropathy with anti-neurofascin 155 antibody

Ogata, H., Zhang, X., Yamasaki, R., Fujii, T., Machida, A., Morimoto, N., Kaida, K., Masuda, T., Ando, Y., Kuwahara, M., Kusunoki, S., Nakamura, Y., Matsushita, T., Isobe, N. & Kira, J. I., Nov 1 2019, In : Annals of Clinical and Translational Neurology. 6, 11, p. 2304-2316 13 p.

Research output: Contribution to journalArticle

Open Access
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Cytokines
Antibodies
Interleukin-13
Interleukin-8
3 Citations (Scopus)

Japanese guidelines for fingolimod in multiple sclerosis: Putting into practice

Matsui, M., Shimizu, Y., Doi, H., Tomioka, R., Nakashima, I., Niino, M. & Kira, J-I., Jan 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 34-48 15 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Guidelines
Lysosphingolipid Receptors
Aquaporin 4
Neuromyelitis Optica
11 Citations (Scopus)

Japanese POEMS syndrome with thalidomide ( J-POST) trial: Study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial

Katayama, K., Misawa, S., Sato, Y., Sobue, G., Yabe, I., Watanabe, O., Nishizawa, M., Kusunoki, S., Kikuchi, S., Nakashima, I., Ikeda, S. I., Kohara, N., Kanda, T., Kira, J. I., Hanaoka, H. & Kuwabara, S., 2015, In : BMJ open. 5, 1, e007330.

Research output: Contribution to journalArticle

POEMS Syndrome
Thalidomide
Clinical Protocols
Placebos
Safety

Japan MG Registry Study: A Sophisti- cated Multi-center Study of Myasthe- nia Gravis A sophisticated multi-center Study of Myasthenia Gravis

Murai, H., Utsugisawa, K., Suzuki, S., Nagane, Y., Imai, T., Motomura, M. & Kira, J. I., Dec 1 2015, In : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 12, p. 309-315 7 p.

Research output: Contribution to journalReview article

Early Medical Intervention
Myasthenia Gravis
Registries
Japan
Quality of Life
12 Citations (Scopus)

Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: A cross-sectional study

Nakamura, Y., Matsushita, T., Sato, S., Niino, M., Fukazawa, T., Yoshimura, S., Hisahara, S., Isobe, N., Shimohama, S., Watanabe, M., Yoshida, K., Houzen, H., Miyazaki, Y., Yamasaki, R., Kikuchi, S. & Kira, J. I., Sep 6 2016, In : Journal of neuroinflammation. 13, 1, 239.

Research output: Contribution to journalArticle

HLA Antigens
Multiple Sclerosis
Cross-Sectional Studies
Cerebrospinal Fluid
Immunoglobulin G
8 Citations (Scopus)

Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis

Niino, M., Sato, S., Fukazawa, T., Yoshimura, S., Hisahara, S., Matsushita, T., Isobe, N., Yoshida, K., Houzen, H., Miyazaki, Y., Shimohama, S., Kikuchi, S. & Kira, J. I., Aug 25 2015, In : Multiple Sclerosis. 21, 9, p. 1112-1120 9 p.

Research output: Contribution to journalArticle

Oligoclonal Bands
HLA-DRB1 Chains
Multiple Sclerosis
Cerebrospinal Fluid
Immunoglobulin G

Launch of new review/editing system for Clinical and Experimental Neuroimmunology

Yamamura, T., Kira, J-I., Suzumura, A., Kanda, T. & Murai, H., Jun 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

27 Citations (Scopus)

Longitudinally extensive myelopathy in Caucasians: A West Australian study of 26 cases from the Perth Demyelinating Diseases Database

Qiu, W., Wu, J. S., Zhang, M. N., Matsushita, T., Kira, J. I., Carroll, W. M., Mastaglia, F. L. & Kermode, A. G., Feb 2010, In : Journal of Neurology, Neurosurgery and Psychiatry. 81, 2, p. 209-212 4 p.

Research output: Contribution to journalArticle

Spinal Cord Diseases
Demyelinating Diseases
Databases
Neuromyelitis Optica
Immunoglobulin G
7 Citations (Scopus)

Long-term efficacy and safety of fingolimod in Japanese patients with relapsing multiple sclerosis: 3-year results of the phase 2 extension study

Saida, T., Itoyama, Y., Kikuchi, S., Hao, Q., Kurosawa, T., Ueda, K., Auberson, L. Z., Tsumiyama, I., Nagato, K. & Kira, J. I., Jan 28 2017, In : BMC neurology. 17, 1, 17.

Research output: Contribution to journalArticle

Multiple Sclerosis
Safety
Placebos
Fingolimod Hydrochloride
Recurrence
4 Citations (Scopus)
Relapsing-Remitting Multiple Sclerosis
Human Influenza
Safety
Recurrence
Nasopharyngitis

Long-term use of interferon-β in multiple sclerosis increases Vδ1-Vδ2-Vγ9- γδ T cells that are associated with a better outcome

Maimaitijiang, G., Watanabe, M., Shinoda, K., Isobe, N., Nakamura, Y., Masaki, K., Matsushita, T., Yoshikai, Y. & Kira, J. I., Sep 13 2019, In : Journal of neuroinflammation. 16, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Interferons
Multiple Sclerosis
T-Lymphocytes
B-Lymphocytes
T-Lymphocyte Subsets
10 Citations (Scopus)
Lumbosacral Plexus
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Polyneuropathies
Ganglia
ROC Curve
2 Citations (Scopus)
Lumbosacral Plexus
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Spinal Ganglia
ROC Curve
Research Ethics Committees
Common Carotid Artery
Arteries
Middle Cerebral Artery
Internal Carotid Artery
Ultrasonography