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2019
2 Citations (Scopus)
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetic Retinopathy
Hypercholesterolemia
LDL Cholesterol
Therapeutics

Architecture of the Japan ischemic heart disease multimodal prospective data acquisition for precision treatment (J-IMPACT) system

Matoba, T., Kohro, T., Fujita, H., Nakayama, M., Kiyosue, A., Miyamoto, Y., Nishimura, K., Hashimoto, H., Antoku, Y., Nakashima, N., Ohe, K., Ogawa, H., Tsutsui, H. & Nagai, R., Jan 1 2019, In : International heart journal. 60, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

Open Access
Percutaneous Coronary Intervention
Myocardial Ischemia
Japan
Coronary Angiography
Information Systems

Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T: Comparison with 15O-labeled water positron emission tomography

Kikuchi, Y., Naya, M., Manabe, N. O., Manabe, O., Sugimori, H., Kudo, K., Kato, F., Aikawa, T., Tsutsui, H., Tamaki, N. & Shirato, H., Jan 1 2019, In : Magnetic Resonance in Medical Sciences. 18, 2, p. 134-141 8 p.

Research output: Contribution to journalArticle

Open Access
Positron-Emission Tomography
Coronary Artery Disease
Water
Arteries
Contrast Media
2 Citations (Scopus)

Baseline demographics and clinical characteristics in the all nippon af in the elderly (ANAFIE) registry

Koretsune, Y., Yamashita, T., Akao, M., Atarashi, H., Ikeda, T., Okumura, K., Shimizu, W., Tsutsui, H., Toyoda, K., Hirayama, A., Yasaka, M., Yamaguchi, T., Teramukai, S., Kimura, T., Kaburagi, J., Takita, A. & Inoue, H., Jan 1 2019, In : Circulation Journal. 83, 7, p. 1538-1545 8 p.

Research output: Contribution to journalArticle

Open Access
Registries
Demography
Anticoagulants
Atrial Fibrillation
Prospective Studies
1 Citation (Scopus)

Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation

Iyonaga, T., Shinohara, K., Mastuura, T., Hirooka, Y. & Tsutsui, H., Jan 1 2019, (Accepted/In press) In : Hypertension Research.

Research output: Contribution to journalArticle

Inbred SHR Rats
Stroke
Macrophages
Hypertension
Clodronic Acid
1 Citation (Scopus)

Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity

Ohtani, K., Ide, T., Hiasa, K. I., Sakamoto, I., Yamashita, N., Kubo, M. & Tsutsui, H., Oct 1 2019, In : Clinical Research in Cardiology. 108, 10, p. 1128-1139 12 p.

Research output: Contribution to journalArticle

Anthracyclines
Left Ventricular Dysfunction
Breast Neoplasms
Heart Failure
Cardiotoxicity
Purkinje Fibers
Catheter Ablation
Ventricular Tachycardia
Verapamil
Electrodes

Cilostazol is useful for the treatment of sinus bradycardia and associated hemodynamic deterioration following heart transplantation

Uchikawa, T., Fujino, T., Higo, T., Ohtani, K., Shiose, A. & Tsutsui, H., Jan 1 2019, In : International heart journal. 60, 5, p. 1222-1225 4 p.

Research output: Contribution to journalArticle

Open Access
Heart Transplantation
Bradycardia
Hemodynamics
Heart Rate
Isoproterenol
Mandibular Advancement
Obstructive Sleep Apnea
Blood Pressure
Equipment and Supplies
Sleep

Diabetes mellitus attenuates the pressure response against hypotensive stress by impairing the sympathetic regulation of the baroreflex afferent arc

Kamada, K., Saku, K., Tohyama, T., Kawada, T., Mannoji, H., Abe, K., Nishikawa, T., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Jan 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H35-H44

Research output: Contribution to journalArticle

Baroreflex
Diabetes Mellitus
Arterial Pressure
Pressure
Type 2 Diabetes Mellitus
Heart-Assist Devices
Suction
Transplants
2 Citations (Scopus)

Early therapeutic effects of adaptive servo-ventilation on cardiac sympathetic nervous function in patients with heart failure evaluated using a combination of 11C-HED PET and 123I-MIBG SPECT

Tokuda, Y., Sakakibara, M., Yoshinaga, K., Yamada, S., Kamiya, K., Asakawa, N., Yoshitani, T., Noguchi, K., Manabe, O., Tamaki, N. & Tsutsui, H., Aug 15 2019, In : Journal of Nuclear Cardiology. 26, 4, p. 1079-1089 11 p.

Research output: Contribution to journalArticle

Therapeutic Uses
Single-Photon Emission-Computed Tomography
Ventilation
Heart Failure
Brain Natriuretic Peptide
Vasodilator Agents
Nitrates
Heart Failure
Databases
Hospitalization
1 Citation (Scopus)

Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease

Aikawa, T., Naya, M., Obara, M., Manabe, O., Magota, K., Koyanagawa, K., Asakawa, N., Ito, Y. M., Shiga, T., Katoh, C., Anzai, T., Tsutsui, H., Murthy, V. L. & Tamaki, N., Jan 1 2019, In : Cardiovascular research. 115, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Coronary Artery Bypass
Percutaneous Coronary Intervention
Coronary Artery Disease
Positron-Emission Tomography
Multicenter Studies
1 Citation (Scopus)

Efficacy and safety of ivabradine in Japanese patients with chronic heart failure ― J-SHIFT study ―

behalf of the J-SHIFT Study Investigators, Jan 1 2019, In : Circulation Journal. 83, 10, p. 2049-2060 12 p.

Research output: Contribution to journalArticle

Open Access
ivabradine
Heart Failure
Safety
Placebos
Heart Rate

Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot

Yamamura, K., Sakamoto, I., Morihana, E., Hirata, Y., Nagata, H., Yamasaki, Y., Okumura, Y., Kouhashi, K., Koto, K., Tsutsui, H. & Ohga, S., Jul 15 2019, In : International Journal of Cardiology. 287, p. 121-126 6 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Liver Cirrhosis
Carcinoma
Liver
Hyaluronic Acid
1 Citation (Scopus)

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings

Mannoji, H., Saku, K., Nishikawa, T., Tohyama, T., Kamada, K., Abe, K., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Apr 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 4, p. H828-H839

Research output: Contribution to journalArticle

Baroreflex
Arterial Pressure
Denervation
Pressure
Carotid Sinus
Open Access
Heart-Assist Devices
Thrombosis
Transplants
Architectural Accessibility
Heart Failure

Heart Failure Practice in Japan: Successful at Present, but Challenging in the Future

Tsutsui, H., Mar 1 2019, In : Journal of Cardiac Failure. 25, 3, p. 145-146 2 p.

Research output: Contribution to journalEditorial

Japan
Heart Failure
6 Citations (Scopus)

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Dewan, P., Jhund, P. S., Shen, L., Petrie, M. C., Abraham, W. T., Atif Ali, M., Chen, C. H., Desai, A. S., Dickstein, K., Huang, J., Kiatchoosakun, S., Kim, K. S., Køber, L., Lai, W. T., Liao, Y., Mogensen, U. M., Oh, B. H., Packer, M., Rouleau, J. L., Shi, V. & 7 others, Sibulo, A. S., Solomon, S. D., Sritara, P., Swedberg, K., Tsutsui, H., Zile, M. R. & McMurray, J. J. V., May 2019, In : European Journal of Heart Failure. 21, 5, p. 577-587 11 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
North America
Philippines
China
Taiwan
1 Citation (Scopus)

Hospitalization costs for patients with acute congestive heart failure in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., Jan 1 2019, In : Circulation Journal. 83, 5, p. 1025-1031 7 p.

Research output: Contribution to journalArticle

Open Access
Japan
Hospitalization
Heart Failure
Costs and Cost Analysis
Acute Disease

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., Apr 1 2019, In : Physiological Reports. 7, 7, e14025.

Research output: Contribution to journalArticle

Open Access
Hypoxia-Inducible Factor 1
Pulmonary Hypertension
Knockout Mice
Lung
Macrophages

Impact of population density on mortality in patients hospitalized for heart failure – JROAD-DPC Registry Analysis –

Konishi, M., Matsuzawa, Y., Ebina, T., Kosuge, M., Gohbara, M., Nishimura, K., Nakai, M., Miyamoto, Y., Saito, Y., Tsutsui, H., Komuro, I., Ogawa, H., Tamura, K. & Kimura, K., Jan 1 2019, (Accepted/In press) In : Journal of Cardiology.

Research output: Contribution to journalArticle

Population Density
Hospital Mortality
Vascular Diseases
Registries
Heart Diseases
1 Citation (Scopus)

Inhibition of TLR9-NF-κB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats

Yoshida, K., Abe, K., Ishikawa, M., Saku, K., Shinoda-Sakamoto, M., Ishikawa, T., Watanabe, T., Oka, M., Sunagawa, K. & Tsutsui, H., Mar 1 2019, In : Cardiovascular research. 115, 3, p. 658-668 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Right Ventricular Dysfunction
Pulmonary Artery
Inflammation
Pressure
3 Citations (Scopus)

Ivabradine for the treatment of cardiovascular diseases

Ide, T., Ohtani, K., Higo, T., Tanaka, M., Kawasaki, Y. & Tsutsui, H., Feb 2019, In : Circulation Journal. 83, 2, p. 252-260 9 p.

Research output: Contribution to journalReview article

ivabradine
Cardiovascular Diseases
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Sinoatrial Node
Heart Failure
3 Citations (Scopus)

JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

on behalf of the Japanese Circulation Society Joint Working Group, Jan 1 2019, In : Circulation Journal. 83, 5, p. 1085-1196 112 p.

Research output: Contribution to journalArticle

Open Access
Acute Coronary Syndrome
Guidelines
1 Citation (Scopus)

Left atrial involvement of cardiac sarcoidosis manifesting as left atrial re-entrant tachycardia

Enzan, N., Ohtani, K., Nagaoka, K., Sakamoto, I. & Tsutsui, H., Aug 1 2019, In : European heart journal cardiovascular Imaging. 20, 8, 1 p., jez051.

Research output: Contribution to journalComment/debate

Sarcoidosis
Tachycardia
3 Citations (Scopus)

Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption

Sunagawa, G., Saku, K., Arimura, T., Nishikawa, T., Mannoji, H., Kamada, K., Abe, K., Kishi, T., Tsutsui, H. & Sunagawa, K., Apr 15 2019, In : Journal of Cardiovascular Translational Research. 12, 2, p. 124-134 11 p.

Research output: Contribution to journalArticle

ivabradine
Oxygen Consumption
Myocardial Infarction
Ischemia
Reperfusion
1 Citation (Scopus)

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Open Access
Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia

Nationwide survey of multidisciplinary care and cardiac rehabilitation for patients with heart failure in Japan ― An analysis of the AMED-CHF study ―

Kamiya, K., Yamamoto, T., Tsuchihashi-Makaya, M., Ikegame, T., Takahashi, T., Sato, Y., Kotooka, N., Saito, Y., Tsutsui, H., Miyata, H. & Isobe, M., Jan 1 2019, In : Circulation Journal. 83, 7, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

Open Access
Japan
Heart Failure
Outpatients
Inpatients
Cardiac Rehabilitation

Non-Pulmonary Vein Triggers of Atrial Fibrillation Are Likely to Arise from Low-Voltage Areas in the Left Atrium

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Dec 1 2019, In : Scientific reports. 9, 1, 12271.

Research output: Contribution to journalArticle

Open Access
Heart Atria
Atrial Fibrillation
Veins
Catheter Ablation
Open Access
Brain Natriuretic Peptide
Dementia
Population
Serum
Alzheimer Disease

Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Onoue, K., Soeda, T., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., Sep 17 2019, In : Journal of the American Heart Association. 8, 18, p. e012282

Research output: Contribution to journalArticle

Open Access
Hospital Mortality
Japan
Heart Failure
Emergencies
Odds Ratio

Outcome of patients with functional single ventricular heart after pacemaker implantation: What makes it poor, and what can we do?

Kodama, Y., Kuraoka, A., Ishikawa, Y., Nakamura, M., Ushinohama, H., Sagawa, K., Umemoto, S., Hashimoto, T., Sakamoto, I., Ohtani, K., Ide, T., Tsutsui, H. & Ishikawa, S., Dec 2019, In : Heart Rhythm. 16, 12, p. 1870-1874 5 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Pericardium
Survival Rate

Peripartum management of pregnant women with congenital heart disease

Yamasaki, K., Sawatari, H., Konagai, N., Kamiya, C. A., Yoshimatsu, J., Muneuchi, J., Watanabe, M., Fukuda, T., Mizuno, A., Sakamoto, I., Yamamura, K., Ohkusa, T., Tsutsui, H., Niwa, K. & Chishaki, A., Jan 1 2019, In : Circulation Journal. 83, 11, p. 2257-2264 8 p.

Research output: Contribution to journalArticle

Open Access
Peripartum Period
Pregnant Women
Heart Diseases
Maternal Age
Parity
3 Citations (Scopus)

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Tokutome, M., Matoba, T., Nakano, Y., Okahara, A., Fujiwara, M., Koga, J. I., Nakano, K., Tsutsui, H. & Egashira, K., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 419-431 13 p.

Research output: Contribution to journalArticle

pioglitazone
Nanomedicine
PPAR gamma
Monocytes
Animal Models

Predictive value of the induction test with atrial burst pacing with regard to long-term recurrence after ablation in persistent atrial fibrillation

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Jan 1 2019, (Accepted/In press) In : journal of arrhythmia.

Research output: Contribution to journalArticle

Predictive Value of Tests
Atrial Fibrillation
Tachycardia
Recurrence
Catheter Ablation

Prescription rates of guideline-directed medications are associated with in-hospital mortality among Japanese patients with acute myocardial infarction: A report from JROAD-DPC study

Nakao, K., Yasuda, S., Nishimura, K., Noguchi, T., Nakai, M., Miyamoto, Y., Sumita, Y., Shishido, T., Anzai, T., Ito, H., Tsutsui, H., Saito, Y., Komuro, I. & Ogawa, H., Jan 1 2019, In : Journal of the American Heart Association. 8, 7, e009692.

Research output: Contribution to journalArticle

Open Access
Hospital Mortality
Prescriptions
Myocardial Infarction
Guidelines
Peptidyl-Dipeptidase A

Primary percutaneous coronary intervention in elderly patients with acute myocardial infarction — An analysis from a Japanese nationwide claim-based database

Uemura, S., Okamoto, H., Nakai, M., Nishimura, K., Miyamoto, Y., Yasuda, S., Tanaka, N., Kohsaka, S., Kadota, K., Saito, Y., Tsutsui, H., Komuro, I., Ikari, Y., Ogawa, H. & Nakamura, M., Jan 1 2019, In : Circulation Journal. 83, 6, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

Open Access
Percutaneous Coronary Intervention
Myocardial Infarction
Databases
Mortality
Propensity Score

Primary pericardial mesothelioma presenting as constrictive pericarditis

Yamamoto, T., Ohtani, K., Tanoue, Y., Shiose, A. & Tsutsui, H., May 1 2019, In : European heart journal cardiovascular Imaging. 20, 5, 1 p.

Research output: Contribution to journalArticle

Constrictive Pericarditis
Mesothelioma
2 Citations (Scopus)

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., Jul 1 2019, In : Cardiovascular research. 115, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
PAR-1 Receptor
Pulmonary Hypertension
Monocrotaline
Pulmonary Artery
Right Ventricular Hypertrophy
2 Citations (Scopus)
Anthracyclines
Left Ventricular Dysfunction
Heart Failure
Treatment Failure
Neoplasms

Simple risk score to predict survival in acute decompensated heart failure: A2B score

Nakada, Y., Kawakami, R., Matsushima, S., Ide, T., Kanaoka, K., Ueda, T., Ishihara, S., Nishida, T., Onoue, K., Soeda, T., Okayama, S., Watanabe, M., Okura, H., Tsuchihashi-Makaya, M., Tsutsui, H. & Saito, Y., Jan 1 2019, In : Circulation Journal. 83, 5, p. 1019-1024 6 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
Survival
Patient Discharge
Brain Natriuretic Peptide
Hemoglobins

Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in rats with pulmonary arterial hypertension

Shinoda, M., Saku, K., Oga, Y., Tohyama, T., Nishikawa, T., Abe, K., Yoshida, K., Kuwabara, Y., Fujii, K., Ishikawa, T., Kishi, T., Sunagawa, K. & Tsutsui, H., Jan 1 2019, In : Experimental Physiology.

Research output: Contribution to journalArticle

Baroreflex
Pulmonary Hypertension
Monocrotaline
Arterial Pressure
Pressure

Tolerability, efficacy, and safety of bisoprolol vs. Carvedilol in japanese patients with heart failure and reduced ejection fraction: The CIBIS-J trial

CIBIS-J Investigators, Jan 1 2019, In : Circulation Journal. 83, 6, p. 1269-1277 9 p.

Research output: Contribution to journalArticle

Open Access
Bisoprolol
Heart Failure
Safety
Brain Natriuretic Peptide
Heart Rate
Right Ventricular Dysfunction
Pulmonary Hypertension
Electrocardiography

Unexpected, but reasonable association between anderson-fabry disease and coronary vasospasm

Matoba, T., Nakano, Y. & Tsutsui, H., Feb 2019, In : Circulation Journal. 83, 2, p. 283-284 2 p.

Research output: Contribution to journalArticle

Coronary Vasospasm
Fabry Disease
Pulmonary Hypertension
Vascular Resistance
Anticoagulants
Incidence
2018
3 Citations (Scopus)

Angiotensin receptor neprilysin inhibitor in Japanese patients with heart failure and reduced ejection fraction: Baseline characteristics and treatment of PARALLEL-HF trial

Tsutsui, H., Momomura, S. I., Saito, Y., Ito, H., Yamamoto, K., Ohishi, T., Okino, N., Kitamura, T. & Guo, W., Jan 1 2018, In : Circulation Journal. 82, 10, p. 2575-2583 9 p.

Research output: Contribution to journalArticle

Neprilysin
Angiotensin Receptors
Heart Failure
Therapeutics
Registries