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2019

Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study

Tanaka, S., Ninomiya, T., Hiyamuta, H., Taniguchi, M., Tokumoto, M., Masutani, K., Ooboshi, H., Nakano, T., Tsuruya, K. & Kitazono, T., Dec 1 2019, In : Scientific reports. 9, 1, 1043.

Research output: Contribution to journal › Article

Renal Dialysis
Cohort Studies
Hypertension
Confidence Intervals
Peripheral Arterial Disease

Association between Axial Length and Myopic Maculopathy: The Hisayama Study

Hashimoto, S., Yasuda, M., Fujiwara, K., Ueda, E., Hata, J., Hirakawa, Y., Ninomiya, T. & Sonoda, K. H., Oct 2019, In : Ophthalmology Retina. 3, 10, p. 867-873 7 p.

Research output: Contribution to journal › Article

Open Access
Odds Ratio
Confidence Intervals
Atrophy
Macular Degeneration
ROC Curve
2 Citations (Scopus)

Association between Genetic Risk and Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study

Inaishi, J., Hirakawa, Y., Horikoshi, M., Akiyama, M., Higashioka, M., Yoshinari, M., Hata, J., Mukai, N., Kamatani, Y., Momozawa, Y., Kubo, M. & Ninomiya, T., Jun 19 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 8, p. 3213-3222 10 p.

Research output: Contribution to journal › Article

Medical problems
Type 2 Diabetes Mellitus
Population
Hazards
Precision Medicine

Association between Serum β-Alanine and Risk of Dementia

Hata, J., Ohara, T., Katakura, Y., Shimizu, K., Yamashita, S., Yoshida, D., Honda, T., Hirakawa, Y., Shibata, M., Sakata, S., Kitazono, T., Kuhara, S. & Ninomiya, T., Sep 1 2019, In : American journal of epidemiology. 188, 9, p. 1637-1645 9 p.

Research output: Contribution to journal › Article

Alanine
Dementia
Anserine
Carnosine
Confidence Intervals
13 Citations (Scopus)

Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies

Marklund, M., Wu, J. H. Y., Imamura, F., Del Gobbo, L. C., Fretts, A., De Goede, J., Shi, P., Tintle, N., Wennberg, M., Aslibekyan, S., Chen, T. A., De Oliveira Otto, M. C., Hirakawa, Y., Eriksen, H. H., Kröger, J., Laguzzi, F., Lankinen, M., Murphy, R. A., Prem, K., Samieri, C. & 67 others, Virtanen, J., Wood, A. C., Wong, K., Yang, W. S., Zhou, X., Baylin, A., Boer, J. M. A., Brouwer, I. A., Campos, H., Chaves, P. H. M., Chien, K. L., De Faire, U., Djoussé, L., Eiriksdottir, G., El-Abbadi, N., Forouhi, N. G., Michael Gaziano, J., Geleijnse, J. M., Gigante, B., Giles, G., Guallar, E., Gudnason, V., Harris, T., Harris, W. S., Helmer, C., Hellenius, M. L., Hodge, A., Hu, F. B., Jacques, P. F., Jansson, J. H., Kalsbeek, A., Khaw, K. T., Koh, W. P., Laakso, M., Leander, K., Lin, H. J., Lind, L., Luben, R., Luo, J., Mcknight, B., Mursu, J., Ninomiya, T., Overvad, K., Psaty, B. M., Rimm, E., Schulze, M. B., Siscovick, D., Skjelbo Nielsen, M., Smith, A. V., Steffen, B. T., Steffen, L., Sun, Q., Sundström, J., Tsai, M. Y., Tunstall-Pedoe, H., Uusitupa, M. I. J., Van Dam, R. M., Veenstra, J., Monique Verschuren, W. M., Wareham, N., Willett, W., Woodward, M., Yuan, J. M., Micha, R., Lemaitre, R. N., Mozaffarian, D. & Risérus, U., May 21 2019, In : Circulation. 139, 21, p. 2422-2436 15 p.

Research output: Contribution to journal › Article

Omega-6 Fatty Acids
Linoleic Acid
Cohort Studies
Cardiovascular Diseases
Biomarkers
9 Citations (Scopus)

Cardiovascular Risk Factors Associated with Venous Thromboembolism

Gregson, J., Kaptoge, S., Bolton, T., Pennells, L., Willeit, P., Burgess, S., Bell, S., Sweeting, M., Rimm, E. B., Kabrhel, C., Zöller, B., Assmann, G., Gudnason, V., Folsom, A. R., Arndt, V., Fletcher, A., Norman, P. E., Nordestgaard, B. G., Kitamura, A., Mahmoodi, B. K. & 54 others, Whincup, P. H., Knuiman, M., Salomaa, V., Meisinger, C., Koenig, W., Kavousi, M., Völzke, H., Cooper, J. A., Ninomiya, T., Casiglia, E., Rodriguez, B., Ben-Shlomo, Y., Després, J. P., Simons, L., Barrett-Connor, E., Björkelund, C., Notdurfter, M., Kromhout, D., Price, J., Sutherland, S. E., Sundström, J., Kauhanen, J., Gallacher, J., Beulens, J. W. J., Dankner, R., Cooper, C., Giampaoli, S., Deen, J. F., Gómez De La Cámara, A., Kuller, L. H., Rosengren, A., Svensson, P. J., Nagel, D., Crespo, C. J., Brenner, H., Albertorio-Diaz, J. R., Atkins, R., Brunner, E. J., Shipley, M., Njølstad, I., Lawlor, D. A., Van Der Schouw, Y. T., Selmer, R. M., Trevisan, M., Verschuren, W. M. M., Greenland, P., Wassertheil-Smoller, S., Lowe, G. D. O., Wood, A. M., Butterworth, A. S., Thompson, S. G., Danesh, J., Di Angelantonio, E. & Meade, T., Feb 2019, In : JAMA Cardiology. 4, 2, p. 163-173 11 p.

Research output: Contribution to journal › Article

Venous Thromboembolism
Adiposity
Pulmonary Embolism
Coronary Disease
Body Mass Index
1 Citation (Scopus)

Dairy consumption and risk of functional disability in an elderly Japanese population: The Hisayama Study

Yoshida, D., Ohara, T., Hata, J., Shibata, M., Hirakawa, Y., Honda, T., Uchida, K., Takasugi, S., Kitazono, T., Kiyohara, Y. & Ninomiya, T., Jun 1 2019, In : American Journal of Clinical Nutrition. 109, 6, p. 1664-1671 8 p.

Research output: Contribution to journal › Article

Activities of Daily Living
Population
Independent Living
Geriatrics
Mental Competency

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (ed.) & Ninomiya, T. (ed.), May 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

Research output: Book/Report › Book

Diabetes Mellitus
Alzheimer Disease
Insulin
Glucose
Vascular Dementia
1 Citation (Scopus)

Dietary Sodium Reduction Reduces Albuminuria: A Cluster Randomized Trial

Jardine, M. J., Li, N., Ninomiya, T., Feng, X., Zhang, J., Shi, J., Zhang, Y., Zhang, R., Zhang, J., Hao, J., Perkovic, V., Heerspink, H. L., Wu, Y., Yan, L. L. & Neal, B., Jul 2019, In : Journal of Renal Nutrition. 29, 4, p. 276-284 9 p.

Research output: Contribution to journal › Article

Dietary Sodium
Albuminuria
Sodium
Albumins
Creatinine
17 Citations (Scopus)

Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis

Toyama, T., Neuen, B. L., Jun, M., Ohkuma, T., Neal, B., Jardine, M. J., Heerspink, H. L., Wong, M. G., Ninomiya, T., Wada, T. & Perkovic, V., May 1 2019, In : Diabetes, Obesity and Metabolism. 21, 5, p. 1237-1250 14 p.

Research output: Contribution to journal › Article

Sodium-Glucose Transporter 2
Symporters
Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Meta-Analysis
1 Citation (Scopus)

Epidemiological evidence of the relationship between diabetes and dementia

Ninomiya, T., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 13-25 13 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Medical problems
Dementia
Diabetes Mellitus
Independent Living
Vascular Dementia
8 Citations (Scopus)

Equalization of four cardiovascular risk algorithms after systematic recalibration: Individual-participant meta-analysis of 86 prospective studies

Pennells, L., Kaptoge, S., Wood, A., Sweeting, M., Zhao, X., White, I., Burgess, S., Willeit, P., Bolton, T., Moons, K. G. M., Van Der Schouw, Y. T., Selmer, R., Khaw, K. T., Gudnason, V., Assmann, G., Amouyel, P., Salomaa, V., Kivimaki, M., Nordestgaard, B. G., Blaha, M. J. & 200 others, Kuller, L. H., Brenner, H., Gillum, R. F., Meisinger, C., Ford, I., Knuiman, M. W., Rosengren, A., Lawlor, D. A., Völzke, H., Cooper, C., Marín Ibañez, A., Casiglia, E., Kauhanen, J., Cooper, J. A., Rodriguez, B., Sundström, J., Barrett-Connor, E., Dankner, R., Nietert, P. J., Davidson, K. W., Wallace, R. B., Blazer, D. G., Björkelund, C., Donfrancesco, C., Krumholz, H. M., Nissinen, A., Davis, B. R., Coady, S., Whincup, P. H., Jørgensen, T., Ducimetiere, P., Trevisan, M., Engström, G., Crespo, C. J., Meade, T. W., Visser, M., Kromhout, D., Kiechl, S., Daimon, M., Price, J. F., Gómez De La Cámara, A., Wouter Jukema, J., Lamarche, B., Onat, A., Simons, L. A., Kavousi, M., Ben-Shlomo, Y., Gallacher, J., Dekker, J. M., Arima, H., Shara, N., Tipping, R. W., Roussel, R., Brunner, E. J., Koenig, W., Sakurai, M., Pavlovic, J., Gansevoort, R. T., Nagel, D., Goldbourt, U., Barr, E. L. M., Palmieri, L., Njølstad, I., Sato, S., Monique Verschuren, W. M., Varghese, C. V., Graham, I., Onuma, O., Greenland, P., Woodward, M., Ezzati, M., Psaty, B. M., Sattar, N., Jackson, R., Ridker, P. M., Cook, N. R., D'Agostino, R. B., Thompson, S. G., Danesh, J., Di Angelantonio, E., Simpson, L. M., Pressel, S. L., Couper, D. J., Nambi, V., Matsushita, K., Folsom, A. R., Shaw, J. E., Magliano, D. J., Zimmet, P. Z., Wannamethee, S. G., Willeit, J., Santer, P., Egger, G., Casas, J. P., Amuzu, A., Tikhonoff, V., Sutherland, S. E., Cushman, M., Søgaard, A. J., Håheim, L. L., Ariansen, I., Tybjærg-Hansen, A., Jensen, G. B., Schnohr, P., Giampaoli, S., Vanuzzo, D., Panico, S., Balkau, B., Bonnet, F., Marre, M., De La Cámara, A. G., Rubio Herrera, M. A., Friedlander, Y., McCallum, J., McLachlan, S., Guralnik, J., Phillips, C. L., Wareham, N., Schöttker, B., Saum, K. U., Holleczek, B., Tolonen, H., Vartiainen, E., Jousilahti, P., Harald, K., Massaro, J. M., Pencina, M., Vasan, R., Kayama, T., Kato, T., Oizumi, T., Jespersen, J., Møller, L., Bladbjerg, E. M., Chetrit, A., Wilhelmsen, L., Lissner, L., Dennison, E., Kiyohara, Y., Ninomiya, T., Doi, Y., Nijpels, G., Stehouwer, C. D. A., Kazumasa, Y., Iso, H., Kurl, S., Tuomainen, T. P., Salonen, J. T., Deeg, D. J. H., Nilsson, P. M., Bo, H., Melander, O., De Boer, I. H., DeFilippis, A. P., Verschuren, W. M. M., Watt, G., Verschuren, W. M. M., Tverdal, A., Kirkland, S., Shimbo, D., Shaffer, J., Bakker, S. J. L., Van Der Harst, P., Hillege, H. L., Dallongeville, J., Schulte, H., Trompet, S., Smit, R. A. J., Stott, D. J., Després, J. P., Cantin, B., Dagenais, G. R., Laughlin, G., Wingard, D., Aspelund, T., Eiriksdottir, G., Gudmundsson, E. F., Ikram, A., Van Rooij, F. J. A., Franco, O. H., Rueda-Ochoa, O. L., Muka, T., Glisic, M., Tunstall-Pedoe, H., Howard, B. V., Ying, Z., Jolly, S., Davey-Smith, G., Can, G., Yüksel, H., Nakagawa, H., Morikawa, Y., Miura, K., Ingelsson, M., Giedraitis, V., Gaziano, J. M., Shipley, M., Arndt, V., Ibañez, A. M. & Geleijnse, J. M., Feb 14 2019, In : European heart journal. 40, 7, p. 621-631 11 p.

Research output: Contribution to journal › Article

Open Access
Meta-Analysis
Prospective Studies
Cardiovascular Diseases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Health Services Needs and Demand

Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology

Sasaki, T., Tsuboi, N., Okabayashi, Y., Haruhara, K., Kanzaki, G., Koike, K., Kobayashi, A., Yamamoto, I., Takahashi, S., Ninomiya, T., Shimizu, A., Rule, A. D., Bertram, J. F. & Yokoo, T., Dec 1 2019, In : Scientific reports. 9, 1, 14400.

Research output: Contribution to journal › Article

Open Access
Nephrons
Tomography
Biopsy
Kidney
Tissue Donors

Glucose Tolerance Levels and Circumpapillary Retinal Nerve Fiber Layer Thickness in a General Japanese Population: The Hisayama Study

Fujiwara, K., Yasuda, M., Hata, J., Hirakawa, Y., Hashimoto, S., Ueda, E., Iwase, A., Araie, M., Yoshitomi, T., Ninomiya, T. & Sonoda, K., Sep 1 2019, In : American journal of ophthalmology. 205, p. 140-146 7 p.

Research output: Contribution to journal › Article

Nerve Fibers
Glucose
Population
Prediabetic State
Glucose Intolerance
2 Citations (Scopus)

Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: Findings from the NIPPON DATA2010

Nakamura, M., Ojima, T., Nagahata, T., Kondo, I., Ninomiya, T., Yoshita, K., Arai, Y., Ohkubo, T., Murakami, K., Nishi, N., Murakami, Y., Takashima, N., Okuda, N., Kadota, A., Miyagawa, N., Kondo, K., Okamura, T., Ueshima, H., Okayama, A. & Miura, K., Jan 5 2019, In : Environmental health and preventive medicine. 24, 1, 1.

Research output: Contribution to journal › Article

Serum Albumin
Tooth
Food
Social Class
Oral Health

Longitudinal changes of physical activity and sedentary time in the middle-aged and older Japanese population: The Hisayama study

Yonemoto, K., Honda, T., Kishimoto, H., Yoshida, D., Hata, J., Mukai, N., Shibata, M., Hirakawa, Y., Ninomiya, T. & Kumagai, S., Feb 1 2019, In : Journal of Physical Activity and Health. 16, 2, p. 165-171 7 p.

Research output: Contribution to journal › Article

Exercise
Population
Independent Living
Japan
Light

Long-term regular exercise and intraocular pressure: the Hisayama Study

Fujiwara, K., Yasuda, M., Hata, J., Yoshida, D., Kishimoto, H., Hashimoto, S., Yoshitomi, T., Ninomiya, T. & Sonoda, K. H., Nov 1 2019, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 257, 11, p. 2461-2469 9 p.

Research output: Contribution to journal › Article

Intraocular Pressure
Exercise
Linear Models
Blood Pressure
Waist Circumference
4 Citations (Scopus)

Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis

Okazaki, S., Morimoto, T., Kamatani, Y., Kamimura, T., Kobayashi, H., Harada, K., Tomita, T., Higashiyama, A., Takahashi, J. C., Nakagawara, J., Koga, M., Toyoda, K., Washida, K., Saito, S., Takahashi, A., Hirata, M., Matsuda, K., Mochizuki, H., Chong, M., Paré, G. & 9 others, O'Donnell, M., Ago, T., Hata, J., Ninomiya, T., Dichgans, M., Debette, S., Kubo, M., Koizumi, A. & Ihara, M., Jan 8 2019, In : Circulation. 139, 2, p. 295-298 4 p.

Research output: Contribution to journal › Article

RING Finger Domains
Moyamoya Disease
Disease Susceptibility
Genetic Predisposition to Disease
Atherosclerosis

NT-proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study

Nagata, T., Ohara, T., Hata, J., Sakata, S., Furuta, Y., Yoshida, D., Honda, T., Hirakawa, Y., Ide, T., Kanba, S., Kitazono, T., Tsutsui, H. & Ninomiya, T., Sep 3 2019, In : Journal of the American Heart Association. 8, 17, p. e011652

Research output: Contribution to journal › Article

Open Access
Brain Natriuretic Peptide
Dementia
Population
Serum
Alzheimer Disease

Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study

Honda, T., Kishimoto, H., Mukai, N., Hata, J., Yoshida, D., Hirakawa, Y., Shibata, M., Ohara, T., Kumagai, S. & Ninomiya, T., May 2019, In : Journal of Diabetes Investigation. 10, 3, p. 809-816 8 p.

Research output: Contribution to journal › Article

Open Access
Diabetes Mellitus
Insulin Resistance
Population
Homeostasis
Energy Intake
1 Citation (Scopus)

Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., May 1 2019, In : Journal of Dental Research. 98, 5, p. 534-540 7 p.

Research output: Contribution to journal › Article

Periodontitis
Chronic Obstructive Pulmonary Disease
Vital Capacity
Forced Expiratory Volume
Confidence Intervals
1 Citation (Scopus)

Physical component quality of life reflects the impact of time and moderate chronic kidney disease, unlike SF-6D utility and mental component SF-36 quality of life: An AusDiab analysis

Wong, M. G., Ninomiya, T., Liyanage, T., Sukkar, L., Hirakawa, Y., Wang, Y., Wyld, M. L. R., Morton, R. L., Chadban, S., Howard, K. & Jardine, M. J., Jun 2019, In : Nephrology. 24, 6, p. 605-614 10 p.

Research output: Contribution to journal › Article

Glomerular Filtration Rate
Chronic Renal Insufficiency
Albuminuria
Quality of Life
Social Adjustment

Prevalence of adult epilepsy in a general Japanese population: The Hisayama study

Tanaka, A., Hata, J., Akamatsu, N., Mukai, N., Hirakawa, Y., Yoshida, D., Kishimoto, H., Ohara, T., Mizuno, T., Tsuji, S., Kitazono, T. & Ninomiya, T., Mar 2019, In : Epilepsia Open. 4, 1, p. 182-186 5 p.

Research output: Contribution to journal › Article

Open Access
Epilepsy
Population
Cerebrovascular Disorders
Confidence Intervals
Tonic-Clonic Epilepsy

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (Nature Genetics, (2018), 50, 4, (524-537), 10.1038/s41588-018-0058-3)

AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STARNET, Biobank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study & MEGASTROKE Consortium, Jan 1 2019, In : Nature genetics.

Research output: Contribution to journal › Comment/debate

Open Access
Genome-Wide Association Study
Stroke

Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study

Higashioka, M., Hirakawa, Y., Kawamura, R., Honda, T., Hata, J., Yoshida, D., Takata, Y., Kitazono, T., Osawa, H. & Ninomiya, T., Jan 1 2019, (Accepted/In press) In : Journal of Diabetes Investigation.

Research output: Contribution to journal › Article

Open Access
Resistin
Eicosapentaenoic Acid
Docosahexaenoic Acids
Arachidonic Acid
Serum

Reduced Estimated GFR and Cardiac Remodeling: A Population-Based Autopsy Study

Izumaru, K., Hata, J., Nakano, T., Nakashima, Y., Nagata, M., Fukuhara, M., Oda, Y., Kitazono, T. & Ninomiya, T., Sep 1 2019, In : American Journal of Kidney Diseases. 74, 3, p. 373-381 9 p.

Research output: Contribution to journal › Article

Open Access
Glomerular Filtration Rate
Autopsy
Population
Fibrosis
Cell Size
21 Citations (Scopus)

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

NCD Risk Factor Collaboration (NCD-RisC), May 9 2019, In : Nature. 569, 7755, p. 260-264 5 p.

Research output: Contribution to journal › Letter

Open Access
Body Mass Index
Obesity
Malnutrition
Urbanization
Africa South of the Sahara

Serum ethylamine levels as an indicator of l-theanine consumption and the risk of type 2 diabetes in a general Japanese population: The hisayama study

Ninomiya, T., Kanzaki, N., Hirakawa, Y., Yoshinari, M., Higashioka, M., Honda, T., Shibata, M., Sakata, S., Yoshida, D., Teramoto, T., Takemoto, S., Nishimoto, S., Hata, J. & Kitazono, T., Jan 1 2019, In : Diabetes care. 42, 7, p. 1234-1240 7 p.

Research output: Contribution to journal › Article

Type 2 Diabetes Mellitus
Serum
Population
Eating
Independent Living

Serum Lipopolysaccharide-Binding Protein Levels and the Incidence of Cardiovascular Disease in a General Japanese Population: The Hisayama Study

Asada, M., Oishi, E., Sakata, S., Hata, J., Yoshida, D., Honda, T., Furuta, Y., Shibata, M., Suzuki, K., Watanabe, H., Murayama, N., Kitazono, T., Yamaura, K. & Ninomiya, T., Nov 5 2019, In : Journal of the American Heart Association. 8, 21, e013628.

Research output: Contribution to journal › Article

Open Access
Cardiovascular Diseases
Incidence
Serum
Population
Independent Living
3 Citations (Scopus)

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study

Larsson, S. C., Traylor, M., Burgess, S., Boncoraglio, G. B., Jern, C., Michaëlsson, K., Markus, H. S., Malik, R., Chauhan, G., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten-Jacobs, L., Giese, A. K., Van Der Laan, S. W., Gretarsdottir, S., Anderson, C. D., Chong, M., Adams, H. H. H., Ago, T. & 237 others, Almgren, P., Amouyel, P., Ay, H., Bartz, R. M., Benavente, O. R., Bevan, S., Brown, R. D., Butterworth, A. S., Carrera, C., Carty, C. L., Chasman, D. I., Chen, W. M., Cole, J. W., Correa, A., Cotlarciuc, I., Cruchaga, C., Danesh, J., De Bakker, P. I. W., Destefano, A. L., Hoed, M. D., Duan, Q., Engelter, S. T., Falcone, G. J., Gottesman, R. F., Grewal, R. P., Gudnason, V., Gustafsson, S., Haessler, J., Harris, T. B., Hassan, A., Havulinna, A. S., Heckbert, S. R., Holliday, E. G., Howard, G., Hsu, F. C., Hyacinth, H. I., Ikram, M. A., Ingelsson, E., Irvin, M. R., Jian, X., Jiménez-Conde, J., Johnson, J. A., Jukema, J. W., Kanai, M., Keene, K. L., Kissela, B. M., Kleindorfer, D. O., Kooperberg, C., Kubo, M., Lange, L. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. M., Lemmens, R., Leys, D., Lewis, C. M., Lin, W. Y., Lindgren, A. G., Lorentzen, E., Magnusson, P. K., Maguire, J., Manichaikul, A., McArdle, P. F., Meschia, J. F., Mitchell, B. D., Mosley, T. H., Nalls, M. A., Ninomiya, T., O'Donnell, M. J., Psaty, B. M., Pulit, S. L., Rannikmäe, K., Reiner, A. P., Rexrode, K. M., Rice, K., Rich, S. S., Ridker, P. M., Rost, N. S., Rothwell, P. M., Rotter, J. I., Rundek, T., Sacco, R. L., Sakaue, S., Sale, M. M., Salomaa, V., Sapkota, B. R., Schmidt, R., Schmidt, C. O., Schminke, U., Sharma, P., Slowik, A., Sudlow, C. L. M., Tanislav, C., Tatlisumak, T., Taylor, K. D., Thijs, V. N. S., Thorleifsson, G., Thorsteinsdottir, U., Tiedt, S., Trompet, S., Tzourio, C., Van Duijn, C. M., Walters, M., Wareham, N. J., Wassertheil-Smoller, S., Wilson, J. G., Wiggins, K. L., Yang, Q., Yusuf, S., Amin, N., Aparicio, H. S., Arnett, D. K., Attia, J., Beiser, A. S., Berr, C., Buring, J. E., Bustamante, M., Caso, V., Cheng, Y. C., Choi, S. H., Chowhan, A., Cullell, N., Dartigues, J. F., Delavaran, H., Delgado, P., Dörr, M., Engström, G., Ford, I., Gurpreet, W. S., Hamsten, A., Heitsch, L., Hozawa, A., Ibanez, L., Ilinca, A., Ingelsson, M., Iwasaki, M., Jackson, R. D., Jood, K., Jousilahti, P., Kaffashian, S., Kalra, L., Kamouchi, M., Kitazono, T., Kjartansson, O., Kloss, M., Koudstaal, P. J., Krupinski, J., Labovitz, D. L., Laurie, C. C., Levi, C. R., Li, L., Lind, L., Lindgren, C. M., Lioutas, V., Liu, Y. M., Lopez, O. L., Makoto, H., Martinez-Majander, N., Matsuda, K., Minegishi, N., Montaner, J., Morris, A. P., Muiño, E., Müller-Nurasyid, M., Norrving, B., Ogishima, S., Parati, E. A., Peddareddygari, L. R., Pedersen, N. L., Pera, J., Perola, M., Pezzini, A., Pileggi, S., Rabionet, R., Riba-Llena, I., Ribasés, M., Romero, J. R., Roquer, J., Rudd, A. G., Sarin, A. P., Sarju, R., Sarnowski, C., Sasaki, M., Satizabal, C. L., Satoh, M., Sattar, N., Sawada, N., Sibolt, G., Sigurdsson, Á., Smith, A., Sobue, K., Soriano-Tárraga, C., Stanne, T., Stine, O. C., Stott, D. J., Strauch, K., Takai, T., Tanaka, H., Tanno, K., Teumer, A., Tomppo, L., Torres-Aguila, N. P., Touze, E., Tsugane, S., Uitterlinden, A. G., Valdimarsson, E. M., Van Der Lee, S. J., Völzke, H., Wakai, K., Weir, D., Williams, S. R., Wolfe, C. D. A., Wong, Q., Xu, H., Yamaji, T., Sanghera, D. K., Melander, O., Strbian, D., Fernandez-Cadenas, I., Longstreth, W. T., Rolfs, A., Hata, J., Woo, D., Rosand, J., Pare, G., Hopewell, J. C., Saleheen, D., Stefansson, K., Worrall, B. B., Kittner, S. J., Seshadri, S., Fornage, M., Howson, J. M. M., Kamatani, Y., Debette, S. & Dichgans, M., Feb 26 2019, In : Neurology. 92, 9, p. E944-E950

Research output: Contribution to journal › Article

Open Access
Random Allocation
Magnesium
Stroke
Calcium
Serum
1 Citation (Scopus)

Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study

Ohara, T., Hata, J., Tanaka, M., Honda, T., Yamakage, H., Yoshida, D., Inoue, T., Hirakawa, Y., Kusakabe, T., Shibata, M., Teraoka, T., Kitazono, T., Kanba, S., Satoh-Asahara, N. & Ninomiya, T., Jan 1 2019, In : Annals of Neurology. 85, 1, p. 47-58 12 p.

Research output: Contribution to journal › Article

Myeloid Cells
Dementia
Biomarkers
Alzheimer Disease
Vascular Dementia
1 Citation (Scopus)

Steno-stiffness approach for cardiovascular disease risk assessment in primary prevention

Tomiyama, H., Ohkuma, T., Ninomiya, T., Mastumoto, C., Kario, K., Hoshide, S., Kita, Y., Inoguchi, T., Maeda, Y., Kohara, K., Tabara, Y., Nakamura, M., Ohkubo, T., Watada, H., Munakata, M., Ohishi, M., Ito, N., Nakamura, M., Shoji, T., Vlachopoulos, C. & 2 others, Aboyans, V. & Yamashina, A., Mar 1 2019, In : Hypertension. 73, 3, p. 508-513 6 p.

Research output: Contribution to journal › Article

Primary Prevention
Cardiovascular Diseases

Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study

Hamasaki, H., Honda, H., Suzuki, S., Shijo, M., Ohara, T., Hatabe, Y., Okamoto, T., Ninomiya, T. & Iwaki, T., Dec 1 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 415-423 9 p.

Research output: Contribution to journal › Article

Open Access
Tauopathies
Basal Ganglia
Microtubule-Associated Proteins
Alzheimer Disease
Parkinsonian Disorders

Trends in the prevalence of airflow limitation in a general Japanese population: Two serial cross-sectional surveys from the Hisayama Study

Ogata, H., Hirakawa, Y., Matsumoto, K., Hata, J., Yoshida, D., Fukuyama, S., Inoue, H., Kitazono, T., Ninomiya, T. & Nakanishi, Y., Mar 1 2019, In : BMJ open. 9, 3, e023673.

Research output: Contribution to journal › Review article

Open Access
Cross-Sectional Studies
Smoking
Population
Japan
Environmental Pollution

Trends in the prevalence of myopia and myopic maculopathy in a Japanese population: The hisayama study

Ueda, E., Yasuda, M., Fujiwara, K., Hashimoto, S., Ohno-Matsui, K., Hata, J., Ishibashi, T., Ninomiya, T. & Sonoda, K., Jul 1 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 2781-2786 6 p.

Research output: Contribution to journal › Article

Open Access
Myopia
Atrophy
Population
Refractive Errors
Photography
2 Citations (Scopus)

Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988–2012: the Hisayama Study

Mukai, N., Hata, J., Hirakawa, Y., Ohara, T., Yoshida, D., Nakamura, U., Kitazono, T. & Ninomiya, T., Jul 12 2019, In : Diabetology International. 10, 3, p. 198-205 8 p.

Research output: Contribution to journal › Article

Prediabetic State
Type 2 Diabetes Mellitus
Body Mass Index
Glucose Tolerance Test
Obesity
2018
3 Citations (Scopus)

Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: The hisayama study

Takae, K., Hata, J., Ohara, T., Yoshida, D., Shibata, M., Mukai, N., Hirakawa, Y., Kishimoto, H., Tsuruya, K., Kitazono, T., Kiyohara, Y. & Ninomiya, T., Jan 1 2018, In : Journal of the American Heart Association. 7, 2, e006693.

Research output: Contribution to journal › Article

Independent Living
Vascular Dementia
Albuminuria
Alzheimer Disease
Glomerular Filtration Rate
8 Citations (Scopus)

Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis

collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI), Aug 1 2018, In : Atherosclerosis. 275, p. 141-148 8 p.

Research output: Contribution to journal › Article

Oscillometry
Ankle Brachial Index
Premature Mortality
Meta-Analysis
Cardiovascular Diseases
1 Citation (Scopus)

A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: The Hisayama study

Tanaka, M., Honda, T., Yamakage, H., Hata, J., Yoshida, D., Hirakawa, Y., Shibata, M., Inoue, T., Kusakabe, T., Satoh-Asahara, N. & Ninomiya, T., Dec 1 2018, In : Diabetes Research and Clinical Practice. 146, p. 225-232 8 p.

Research output: Contribution to journal › Article

Myeloid Cells
Insulin Resistance
Serum
Population
Fats
5 Citations (Scopus)

Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community

Ohara, T., Honda, T., Hata, J., Yoshida, D., Mukai, N., Hirakawa, Y., Shibata, M., Kishimoto, H., Kitazono, T., Kanba, S. & Ninomiya, T., Oct 1 2018, In : Journal of the American Geriatrics Society. 66, 10, p. 1911-1918 8 p.

Research output: Contribution to journal › Article

Dementia
Sleep
Mortality
Hypnotics and Sedatives
Confidence Intervals
4 Citations (Scopus)

Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study

Shibata, M., Ohara, T., Yoshida, D., Hata, J., Mukai, N., Kawano, H., Kanba, S., Kitazono, T. & Ninomiya, T., Sep 1 2018, In : Journal of Affective Disorders. 237, p. 73-79 7 p.

Research output: Contribution to journal › Article

Eicosapentaenoic Acid
Arachidonic Acid
Depression
Serum
Population
9 Citations (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., Jan 2018, In : Brain Pathology. 28, 1, p. 58-71 14 p.

Research output: Contribution to journal › Article

Adipocytes
Hippocampus
Carrier Proteins
Pathology
Alzheimer Disease
12 Citations (Scopus)

Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH–JAPAN study

Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH–JAPAN) Research Group, May 1 2018, In : Journal of Clinical Lipidology. 12, 3, p. 674-684.e5

Research output: Contribution to journal › Article

HDL Cholesterol
Cohort Studies
Mortality
Cardiovascular Diseases
Cause of Death

Author response: Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community

Hata, J., Yubi, T. & Ninomiya, T., Dec 1 2018, In : Neurology: Clinical Practice. 8, 6, p. 464-465 2 p.

Research output: Contribution to journal › Comment/debate

4 Citations (Scopus)

Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: Results from the Asia Pacific Cohort Studies Collaboration

Peters, S. A. E., Wang, X., Lam, T. H., Kim, H. C., Ho, S., Ninomiya, T., Knuiman, M., Vaartjes, I., Bots, M. L. & Woodward, M., Mar 1 2018, In : BMJ open. 8, 3, e019335.

Research output: Contribution to journal › Article

Cluster Analysis
Cohort Studies
Cardiovascular Diseases
Population
Blood Pressure

Comparison of the periodontal condition in Korean and Japanese adults: A cross-sectional study

Furuta, M., Takeuchi, K., Shimazaki, Y., Takeshita, T., Shibata, Y., Hata, J., Yoshida, D., Park, D. Y., Ninomiya, T. & Yamashita, Y., Nov 1 2018, In : BMJ open. 8, 11, e024332.

Research output: Contribution to journal › Article

Japan
Cross-Sectional Studies
Periodontal Diseases
Republic of Korea
Korea
10 Citations (Scopus)

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

NCD Risk Factor Collaboration (NCD-RisC), Jun 2018, In : International Journal of Epidemiology. 47, 3, p. 872-883i

Research output: Contribution to journal › Article

Blood Pressure
Population
Age Groups
Central Asia
Hypertension
4 Citations (Scopus)

Development and validation of a risk assessment tool for gastric cancer in a general Japanese population

Iida, M., Ikeda, F., Hata, J., Hirakawa, Y., Ohara, T., Mukai, N., Yoshida, D., Yonemoto, K., Esaki, M., Kitazono, T., Kiyohara, Y. & Ninomiya, T., May 1 2018, In : Gastric Cancer. 21, 3, p. 383-390 8 p.

Research output: Contribution to journal › Article

Stomach Neoplasms
Population
Pepsinogen A
Proportional Hazards Models
Helicobacter pylori
1 Citation (Scopus)

Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: The Hisayama Study

Honda, T., Yoshida, D., Hata, J., Hirakawa, Y., Ishida, Y., Shibata, M., Sakata, S., Kitazono, T. & Ninomiya, T., Dec 1 2018, In : Atherosclerosis. 279, p. 38-44 7 p.

Research output: Contribution to journal › Article

Cardiovascular Diseases
Decision Support Techniques
Coronary Disease
Stroke
Blood Pressure

Distribution of nephrologists and regional variation in the clinical severity of IgA nephropathy at biopsy diagnosis in Japan: A cross-sectional study

Okabayashi, Y., Tsuboi, N., Amano, H., Miyazaki, Y., Kawamura, T., Ogura, M., Narita, I., Ninomiya, T., Yokoyama, H. & Yokoo, T., Jan 1 2018, In : BMJ open. 8, 10, e024317.

Research output: Contribution to journal › Article

Immunoglobulin A
Japan
Cross-Sectional Studies
Kidney
Biopsy