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2019

18F-FDG uptake in PET/CT is a potential predictive biomarker of response to anti-PD-1 antibody therapy in non-small cell lung cancer

Takada, K., Toyokawa, G., Yoneshima, Y., Tanaka, K., Okamoto, I., Shimokawa, M., Wakasu, S., Haro, A., Osoegawa, A., Tagawa, T., Oda, Y., Nakanishi, Y. & Mori, M., Dec 1 2019, In : Scientific reports. 9, 1, 13362.

Research output: Contribution to journalArticle

Open Access
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Cell Death
Biomarkers
Antibodies
4 Citations (Scopus)

A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma

Matsubara, T., Takada, K., Azuma, K., Takamori, S., Toyokawa, G., Haro, A., Osoegawa, A., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Ligands
Lung
CD274 Antigen
Immunotherapy

Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma

Takada, K., Shimokawa, M., Tanaka, K., Kohashi, K., Haro, A., Osoegawa, A., Tagawa, T., Azuma, K., Okamoto, I., Oda, Y. & Mori, M., Jun 2019, In : PloS one. 14, 6, e0217991.

Research output: Contribution to journalArticle

Open Access
Indoleamine-Pyrrole 2,3,-Dioxygenase
Immunologic Factors
adenocarcinoma
Cell death
Tumors
1 Citation (Scopus)

Clinical significance of monitoring EGFR mutation in plasma using multiplexed digital PCR in EGFR mutated patients treated with afatinib (West Japan Oncology Group 8114LTR study)

Akamatsu, H., Koh, Y., Okamoto, I., Fujimoto, D., Bessho, A., Azuma, K., Morita, S., Yamamoto, N. & Nakagawa, K., May 2019, In : Lung Cancer. 131, p. 128-133 6 p.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor Receptor
Japan
Polymerase Chain Reaction
Mutation
Non-Small Cell Lung Carcinoma
1 Citation (Scopus)

First-line afatinib for the treatment of EGFR mutation-positive non-small-cell lung cancer in the ‘real-world’ clinical setting

Park, K., Wan-Teck Lim, D., Okamoto, I. & Yang, J. C. H., Apr 1 2019, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalReview article

Open Access
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Lung
Therapeutics

Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA

Otsubo, K., Sakai, K., Takeshita, M., Harada, D., Azuma, K., Ota, K., Akamatsu, H., Goto, K., Horiike, A., Kurata, T., Nakagaki, N., Nosaki, K., Iwama, E., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2019, In : Oncologist. 24, 8, p. 1022-1026 5 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
DNA

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome

Immune checkpoint protein and cytokine expression by T lymphocytes in pleural effusion of cancer patients receiving anti–PD-1 therapy

Ikematsu, Y., Tanaka, K., Yanagihara, T., Liu, R., Inoue, H., Yoneshima, Y., Ota, K., Iwama, E., Takata, S., Hata, K., Takahata, Y., Wataya, H., Nakanishi, Y. & Okamoto, I., Dec 2019, In : Lung Cancer. 138, p. 58-64 7 p.

Research output: Contribution to journalArticle

Pleural Effusion
Cytokines
T-Lymphocytes
Cell- and Tissue-Based Therapy
Neoplasms

Japanese subgroup analysis of a phase III study of S-1 versus docetaxel in non-small cell lung cancer patients after platinum-based treatment: EAST-LC

Sugawara, S., Nakagawa, K., Yamamoto, N., Nokihara, H., Ohe, Y., Nishio, M., Takahashi, T., Goto, K., Maemondo, M., Ichinose, Y., Seto, T., Sakai, H., Gemma, A., Imamura, F., Shingyoji, M., Saka, H., Inoue, A., Takeda, K., Okamoto, I., Kiura, K. & 2 others, Morita, S. & Tamura, T., May 15 2019, In : International Journal of Clinical Oncology. 24, 5, p. 485-493 9 p.

Research output: Contribution to journalArticle

Open Access
docetaxel
Far East
Platinum
Non-Small Cell Lung Carcinoma
Lung Neoplasms
1 Citation (Scopus)

Localized malignant pleural mesothelioma mimicking an anterior mediastinal tumor

Hino, T., Kamitani, T., Sagiyama, K., Yamasaki, Y., Okamoto, I., Tagawa, T., Ijichi, K., Yamamoto, H., Yabuuchi, H. & Honda, H., Jan 1 2019, In : European Journal of Radiology Open. 6, p. 72-77 6 p.

Research output: Contribution to journalArticle

Neoplasms
Pleura
Mediastinum
Differential Diagnosis
Malignant Mesothelioma
1 Citation (Scopus)

Longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor–tyrosine kinase inhibitors

Iwama, E., Sakai, K., Hidaka, N., Inoue, K., Fujii, A., Nakagaki, N., Ota, K., Toyozawa, R., Azuma, K., Nakatomi, K., Harada, T., Hisasue, J., Sakata, S., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2019, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Phosphotransferases
DNA
Protein-Tyrosine Kinases
1 Citation (Scopus)

Osimertinib for Japanese patients with T790M-positive advanced non-small-cell lung cancer: A pooled subgroup analysis

Hirashima, T., Satouchi, M., Hida, T., Nishio, M., Kato, T., Sakai, H., Imamura, F., Kiura, K., Okamoto, I., Kasahara, K., Uchida, H., Vowler, S. L. & Mitsudomi, T., Sep 1 2019, In : Cancer Science. 110, 9, p. 2884-2893 10 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Epidermal Growth Factor Receptor
Safety
Protein-Tyrosine Kinases
1 Citation (Scopus)

Osimertinib versus standard-of-care EGFR-TKI as first-line treatment for EGFRm advanced NSCLC: FLAURA Japanese subset

Ohe, Y., Imamura, F., Nogami, N., Okamoto, I., Kurata, T., Kato, T., Sugawara, S., Ramalingam, S. S., Uchida, H., Hodge, R., Vowler, S. L., Walding, A. & Nakagawa, K., Jan 1 2019, In : Japanese journal of clinical oncology. 49, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

Standard of Care
Confidence Intervals
Disease-Free Survival
Safety
Therapeutics
5 Citations (Scopus)

Osimertinib versus Standard of Care EGFR TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC: FLAURA Asian Subset

Cho, B. C., Chewaskulyong, B., Lee, K. H., Dechaphunkul, A., Sriuranpong, V., Imamura, F., Nogami, N., Kurata, T., Okamoto, I., Zhou, C., Cheng, Y., Cho, E. K., Voon, P. J., Lee, J. S., Mann, H., Saggese, M., Reungwetwattana, T., Ramalingam, S. S. & Ohe, Y., Jan 1 2019, In : Journal of Thoracic Oncology. 14, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

Standard of Care
Protein-Tyrosine Kinases
Disease-Free Survival
Safety
Therapeutics
1 Citation (Scopus)

Pemetrexed and carboplatin combination therapy followed by pemetrexed maintenance in Japanese patients with non-squamous non-small cell lung cancer: A subgroup analysis of elderly patients

Nogami, N., Nishio, M., Okamoto, I., Enatsu, S., Suzukawa, K., Takai, H., Nakagawa, K. & Tamura, T., Jan 2019, In : Respiratory Investigation. 57, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Maintenance
Therapeutics

Phase I safety and pharmacokinetics study of rovalpituzumab tesirine in Japanese patients with advanced, recurrent small cell lung cancer

Udagawa, H., Akamatsu, H., Tanaka, K., Takeda, M., Kanda, S., Kirita, K., Teraoka, S., Nakagawa, K., Fujiwara, Y., Yasuda, I., Okubo, S., Shintani, M., Kosloski, M. P., Scripture, C., Tamura, T. & Okamoto, I., Sep 1 2019, In : Lung Cancer. 135, p. 145-150 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Pharmacokinetics
Safety
Hypoalbuminemia
Retreatment
4 Citations (Scopus)

Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients

Takamori, S., Takada, K., Azuma, K., Jogo, T., Shimokawa, M., Toyokawa, G., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

Ligands
Adenocarcinoma of lung
Immunotherapy
Disease-Free Survival
Survival

Randomized phase II study of pemetrexed or pemetrexed plus bevacizumab for elderly patients with previously untreated non-squamous non-small cell lung cancer: Results of the Lung Oncology Group in Kyushu (LOGIK1201)

Fukuda, M., Kitazaki, T., Ogawara, D., Ichiki, M., Mukae, H., Maruyama, R., Nakagaki, N., Shimada, M., Ikeda, T., Kishimoto, J., Harada, T., Seto, T., Ebi, N., Takayama, K., Okamoto, I., Ichinose, Y. & Sugio, K., Jun 2019, In : Lung Cancer. 132, p. 1-8 8 p.

Research output: Contribution to journalArticle

Pemetrexed
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Disease-Free Survival
Bevacizumab
2 Citations (Scopus)

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies

Yoneshima, Y., Tanaka, K., Shiraishi, Y., Hata, K., Watanabe, H., Harada, T., Otsubo, K., Iwama, E., Inoue, H., Masuda, S., Nakanishi, Y. & Okamoto, I., Apr 2019, In : Lung Cancer. 130, p. 5-9 5 p.

Research output: Contribution to journalArticle

Antinuclear Antibodies
Non-Small Cell Lung Carcinoma
Safety
Autoimmune Diseases
Disease-Free Survival

Subgroup Analysis of Japanese Patients in a Phase III Study of Atezolizumab in Extensive-stage Small-cell Lung Cancer (IMpower133)

Nishio, M., Sugawara, S., Atagi, S., Akamatsu, H., Sakai, H., Okamoto, I., Takayama, K., Hayashi, H., Nakagawa, Y. & Kawakami, T., Jan 1 2019, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Confidence Intervals
Carboplatin
Placebos
Etoposide

Survival Analysis for Patients with ALK Rearrangement-Positive Non-Small Cell Lung Cancer and a Poor Performance Status Treated with Alectinib: Updated Results of Lung Oncology Group in Kyushu 1401

Iwama, E., Goto, Y., Murakami, H., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Nishitsuji, M., Akamatsu, H., Morinaga, R., Akagi, T., Shimose, T., Tokunaga, S., Yamamoto, N., Nakanishi, Y., Sugio, K. & 1 others, Okamoto, I., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
Survival Analysis
Non-Small Cell Lung Carcinoma
Lung
Survival
Central Nervous System

Updated Survival Data for a Phase I/II Study of Carboplatin plus Nab-Paclitaxel and Concurrent Radiotherapy in Patients with Locally Advanced Non-Small Cell Lung Cancer

Tsuchiya-Kawano, Y., Sasaki, T., Yamaguchi, H., Hirano, K., Horiike, A., Satouchi, M., Hosokawa, S., Morinaga, R., Komiya, K., Inoue, K., Fujita, Y., Toyozawa, R., Kimura, T., Takahashi, K., Nishikawa, K., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
Carboplatin
Non-Small Cell Lung Carcinoma
Radiotherapy
Survival
Disease-Free Survival
2018
2 Citations (Scopus)

Anticancer drug treatment for advanced lung cancer with interstitial lung disease

Otsubo, K., Okamoto, I., Hamada, N. & Nakanishi, Y., Jul 2018, In : Respiratory Investigation. 56, 4, p. 307-311 5 p.

Research output: Contribution to journalReview article

Interstitial Lung Diseases
Lung Neoplasms
Pharmaceutical Preparations
Drug Therapy
Therapeutics

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients

Anai, S., Iwama, E., Yoneshima, Y., Otsubo, K., Tanaka, K., Nakanishi, Y. & Okamoto, I., Dec 2018, In : Lung Cancer. 126, p. 156-161 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Etoposide
Platinum
Alleles
irinotecan
11 Citations (Scopus)

Association of preoperative serum CRP with PD-L1 expression in 508 patients with non-small cell lung cancer: A comprehensive analysis of systemic inflammatory markers

Akamine, T., Takada, K., Toyokawa, G., Kinoshita, F., Matsubara, T., Kozuma, Y., Haratake, N., Takamori, S., Hirai, F., Tagawa, T., Okamoto, T., Yoneshima, Y., Okamoto, I., Shimokawa, M., Oda, Y., Nakanishi, Y. & Maehara, Y., Mar 2018, In : Surgical Oncology. 27, 1, p. 88-94 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
C-Reactive Protein
Blood Proteins
Ligands
Lymphocytes
6 Citations (Scopus)

Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Mukae, N., Hirai, F., Tagawa, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Jan 2018, In : Anticancer research. 38, 1, p. 553-557 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Neoplasm Metastasis
Ligands
Brain
38 Citations (Scopus)

CNS response to osimertinib versus standard epidermal growth factor receptor tyrosine kinase inhibitors in patients with untreated EGFR-mutated advanced non-small-cell lung cancer

Reungwetwattana, T., Nakagawa, K., Cho, B. C., Cobo, M., Cho, E. K., Bertolini, A., Bohnet, S., Zhou, C., Lee, K. H., Nogami, N., Okamoto, I., Leighl, N., Hodge, R., McKeown, A., Brown, A. P., Rukazenkov, Y., Ramalingam, S. S. & Vansteenkiste, J., Nov 20 2018, In : Journal of Clinical Oncology. 36, 33, p. 3290-3297 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
osimertinib
Disease-Free Survival
2 Citations (Scopus)

Combined therapy with epidermal growth factor receptor tyrosine kinase inhibitors for non–small cell lung cancer

Iwama, E., Nakanishi, Y. & Okamoto, I., Mar 4 2018, In : Expert Review of Anticancer Therapy. 18, 3, p. 267-276 10 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Therapeutics
3 Citations (Scopus)

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., Ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., Takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor
1 Citation (Scopus)

Development of leptomeningeal carcinomatosis during a marked response of brain metastases to pembrolizumab in a patient with non-small-cell lung cancer

Otsubo, K., Seki, N., Nakanishi, Y. & Okamoto, I., Mar 1 2018, In : Annals of Oncology. 29, 3, p. 780-781 2 p.

Research output: Contribution to journalLetter

Meningeal Carcinomatosis
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
pembrolizumab
4 Citations (Scopus)

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis

Ide, M., Tanaka, K., Sunami, S., Asoh, T., Maeyama, T., Tsuruta, N., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Thoracic Cancer. 9, 11, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Non-Small Cell Lung Carcinoma
Pleurisy
Respiratory Function Tests
Neoplasms
6 Citations (Scopus)

Erlotinib Plus Bevacizumab Phase ll Study in Patients with Advanced Non-small-Cell Lung Cancer (JO25567): Updated Safety Results

Kato, T., Seto, T., Nishio, M., Goto, K., Yamamoto, N., Okamoto, I., Tao, L., Yu, W., Khaznadar, T., Tajima, K., Shibata, M., Seki, A. & Yamamoto, N., Feb 1 2018, In : Drug Safety. 41, 2, p. 229-237 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cells
Safety
Epidermal Growth Factor Receptor
Mutation
8 Citations (Scopus)

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Dec 2018, In : Cancer Science. 109, 12, p. 3921-3933 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Polymerase Chain Reaction
Mutation
Neoplasms
2 Citations (Scopus)

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journalArticle

trkB Receptor
Brain-Derived Neurotrophic Factor
Small Cell Lung Carcinoma
Phenotype
Non-Small Cell Lung Carcinoma
2 Citations (Scopus)

Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix-assisted laser desorption ionization mass spectrometry imaging: a pilot study

Ryu, S., Hayashi, M., Aikawa, H., Okamoto, I., Fujiwara, Y. & Hamada, A., Jan 2018, In : British Journal of Pharmacology. 175, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Neuroblastoma
Heterografts
Lasers
Ions
5 Citations (Scopus)

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., Ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., Jul 2018, In : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

Research output: Contribution to journalArticle

Oncogenes
Non-Small Cell Lung Carcinoma
Cell Death
Ligands
STAT3 Transcription Factor

Metastatic lung adenocarcinoma mimicking meningioma

Yanagihara, T., Seki, N., Hiwatashi, A., Arimura, K., Suzuki, S. O. & Okamoto, I., Jan 1 2018, In : Internal Medicine. 57, 7, p. 1057-1058 2 p.

Research output: Contribution to journalComment/debate

Meningioma
Adenocarcinoma of lung
10 Citations (Scopus)

Osimertinib in Japanese patients with EGFR T790M mutation-positive advanced non-small-cell lung cancer: AURA3 trial

Akamatsu, H., Katakami, N., Okamoto, I., Kato, T., Kim, Y. H., Imamura, F., Shinkai, M., Hodge, R. A., Uchida, H. & Hida, T., Jun 2018, In : Cancer Science. 109, 6, p. 1930-1938 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Pemetrexed
Mutation
Protein-Tyrosine Kinases
1 Citation (Scopus)

Osimertinib in patients with epidermal growth factor receptor T790M advanced non-small cell lung cancer selected using cytology samples

Kiura, K., Yoh, K., Katakami, N., Nogami, N., Kasahara, K., Takahashi, T., Okamoto, I., Cantarini, M., Hodge, R. & Uchida, H., Apr 2018, In : Cancer Science. 109, 4, p. 1177-1184 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Biology
Mutation
Confidence Intervals
586 Citations (Scopus)

Osimertinib in untreated EGFR-Mutated advanced non-small-cell lung cancer

Soria, J. C., Ohe, Y., Vansteenkiste, J., Reungwetwattana, T., Chewaskulyong, B., Lee, K. H., Dechaphunkul, A., Imamura, F., Nogami, N., Kurata, T., Okamoto, I., Zhou, C., Cho, B. C., Cheng, Y., Cho, E. K., Voon, P. J., Planchard, D., Su, W. C., Gray, J. E., Lee, S. M. & 4 others, Hodge, R., Marotti, M., Rukazenkov, Y. & Ramalingam, S. S., Jan 11 2018, In : New England Journal of Medicine. 378, 2, p. 113-125 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Confidence Intervals
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Mutation
15 Citations (Scopus)

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., Ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., Apr 2018, In : Lung Cancer. 118, p. 36-40 5 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma of lung
Protein-Tyrosine Kinases
Oncogenes
7 Citations (Scopus)

PD-L2 expression as a potential predictive biomarker for the response to anti-PD-1 drugs in patients with non-small cell lung cancer

Takamori, S., Takada, K., Toyokawa, G., Azuma, K., Shimokawa, M., Jogo, T., Yamada, Y., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5897-5901 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Biomarkers
Ligands
Pharmaceutical Preparations
5 Citations (Scopus)

Phase 3 study of ceritinib vs chemotherapy in ALK-rearranged NSCLC patients previously treated with chemotherapy and crizotinib (ASCEND-5): Japanese subset

Kiura, K., Imamura, F., Kagamu, H., Matsumoto, S., Hida, T., Nakagawa, K., Satouchi, M., Okamoto, I., Takenoyama, M., Fujisaka, Y., Kurata, T., Ito, M., Tokushige, K., Hatano, B. & Nishio, M., Apr 1 2018, In : Japanese journal of clinical oncology. 48, 4, p. 367-375 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Drug Therapy
docetaxel
Pemetrexed
Disease-Free Survival
3 Citations (Scopus)

Phase I/II study of carboplatin plus nab-paclitaxel and concurrent radiotherapy for patients with locally advanced non–small cell lung cancer

Kawano, Y., Sasaki, T., Yamaguchi, H., Hirano, K., Horiike, A., Satouchi, M., Hosokawa, S., Morinaga, R., Komiya, K., Inoue, K., Fujita, Y., Toyozawa, R., Kimura, T., Takahashi, K., Nishikawa, K., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Lung Cancer. 125, p. 136-141 6 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Radiotherapy
Leukopenia
Confidence Intervals
1 Citation (Scopus)
Therapeutic Uses
Platinum
Non-Small Cell Lung Carcinoma
Perfusion
Tomography
18 Citations (Scopus)

Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer

Tanaka, K., Isse, K., Fujihira, T., Takenoyama, M., Saunders, L., Bheddah, S., Nakanishi, Y. & Okamoto, I., Jan 2018, In : Lung Cancer. 115, p. 116-120 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
delta protein
Neoplasms
Sex Characteristics
Japan
2 Citations (Scopus)

Prognostic impact of PD-L2 expression and association with PD-L1 in patients with small-cell lung cancer

Takamori, S., Takada, K., Azuma, K., Jogo, Y., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Toyokawa, G., Hirai, F., Tagawa, T., Okamoto, I., Nakanishi, Y., Kawahara, A., Akiba, J., Oda, Y. & Maehara, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5903-5907 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Cell Death
Ligands
Lung Neoplasms
Programmed Cell Death 1 Ligand 2 Protein
1 Citation (Scopus)

Radiological features of programmed cell death-ligand 2-positive lung adenocarcinoma: A single-institution retrospective study

Takada, K., Toyokawa, G., Azuma, K., Takamori, S., Jogo, T., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Nov 1 2018, In : In Vivo. 32, 6, p. 1541-1550 10 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Cell death
Tomography
Cell Death
Retrospective Studies
13 Citations (Scopus)

Real world treatment and outcomes in EGFR mutation-positive non-small cell lung cancer: Long-term follow-up of a large patient cohort

Okamoto, I., Morita, S., Tashiro, N., Imamura, F., Inoue, A., Seto, T., Yamamoto, N., Ohe, Y., Nakagawa, K. & Fukuoka, M., Mar 2018, In : Lung Cancer. 117, p. 14-19 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Mutation
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Survival

Sensitivity of epidermal growth factor receptor with single or double uncommon mutations to afatinib confirmed by a visual assay

Kimura, S., Tanaka, K., Harada, T., Liu, R., Shibahara, D., Kawano, Y., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Cancer Science. 109, 11, p. 3657-3661 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
BIBW 2992