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2019

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., Ayano, M., Kimoto, Y., Mitoma, H., Akahoshi, M., Tsukamoto, H., Horiuchi, T., Niiro, H. & Akashi, K., Aug 30 2019, In : Arthritis Research and Therapy. 21, 1, 198.

Research output: Contribution to journalArticle

Open Access
Rheumatoid Arthritis
Joints
Lymphocytes
Cytokines
Synovial Fluid
Phase II Clinical Trials
Clinical Trials, Phase I
Systemic Scleroderma
Hematopoietic Stem Cell Transplantation
Japan
1 Citation (Scopus)

Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis

Fukui, S., Kuwahara-Takaki, A., Ono, N., Sato, S., Koga, T., Kawashiri, S. Y., Iwanaga, N., Iwamoto, N., Ichinose, K., Tamai, M., Nakamura, H., Origuchi, T., Migita, K., Arinobu, Y., Niiro, H., Tada, Y., Akashi, K., Maeda, T. & Kawakami, A., Dec 1 2019, In : Scientific reports. 9, 1, 688.

Research output: Contribution to journalArticle

Takayasu Arteritis
Giant Cell Arteritis
Fibroblast Growth Factor 2
Granulocyte-Macrophage Colony-Stimulating Factor
Serum
2018
9 Citations (Scopus)

Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody

Yamaguchi, K., Mishima, K., Ohmura, H., Hanamura, F., Ito, M., Nakano, M., Tsuchihashi, K., Ota, S. I., Wada, N., Uchi, H., Ariyama, H., Kusaba, H., Niiro, H., Akashi, K. & Baba, E., Oct 2018, In : Cancer Science. 109, 10, p. 3032-3042 11 p.

Research output: Contribution to journalArticle

Th1 Cells
Melanoma
T-Lymphocytes
Antibodies
Phenotype
5 Citations (Scopus)
glycohemoglobin
rheumatoid arthritis
tumor necrosis factors
Glycosylated Hemoglobin A
observational studies
2016
16 Citations (Scopus)

Bi-cytopenia possibly induced by anti-PD-1 antibody for primary malignant melanoma of the esophagus A case report

Inadomi, K., Kumagai, H., Arita, S., Tsuruta, N., Takayoshi, K., Mishima, K., Ota, S. I., Tanaka, M., Okumura, Y., Sagara, K., Nio, K., Nakano, M., Uchi, H., Yamamoto, H., Ariyama, H., Kusaba, H., Niiro, H., Oda, Y., Akashi, K. & Baba, E., Jul 26 2016, In : Medicine (United States). 95, 29, e4283.

Research output: Contribution to journalArticle

Esophagus
Melanoma
Antibodies
Neoplasm Metastasis
Liver
52 Citations (Scopus)
Interleukin-17 Receptors
Psoriasis
Safety
Antibodies
Placebos
11 Citations (Scopus)

Generation mechanism of RANKL+ effector memory B cells: Relevance to the pathogenesis of rheumatoid arthritis

Ota, Y., Niiro, H., Ota, S. I., Ueki, N., Tsuzuki, H., Nakayama, T., Mishima, K., Higashioka, K., Jabbarzadeh-Tabrizi, S., Mitoma, H., Akahoshi, M., Arinobu, Y., Kukita, A., Yamada, H., Tsukamoto, H. & Akashi, K., Mar 16 2016, In : Arthritis Research and Therapy. 18, 1, 67.

Research output: Contribution to journalArticle

B-Lymphocyte Subsets
Rheumatoid Arthritis
B-Lymphocytes
Interferons
Osteoprotegerin
23 Citations (Scopus)

Long-term clinical safety and efficacy of brodalumab in the treatment of Japanese patients with moderate-to-severe plaque psoriasis

the Japanese Brodalumab Study Group, Nov 1 2016, In : Journal of the European Academy of Dermatology and Venereology. 30, 11, p. 1957-1960 4 p.

Research output: Contribution to journalArticle

Psoriasis
Safety
Therapeutics
Interleukin-17 Receptors
Nasopharyngitis
6 Citations (Scopus)

Renal insufficiency in concert with renin-angiotensinaldosterone inhibition is a major risk factor for hyperkalemia associated with low-dose trimethoprim-sulfamethoxazole in adults

Higashioka, K., Niiro, H., Yoshida, K., Oryoji, K., Kamada, K., Mizuki, S. & Yokota, E., Mar 1 2016, In : Internal Medicine. 55, 5, p. 467-471 5 p.

Research output: Contribution to journalArticle

Hyperkalemia
Sulfamethoxazole Drug Combination Trimethoprim
Renin
Renal Insufficiency
Potassium
7 Citations (Scopus)

Safety, pharmacokinetics, and pharmacodynamics of epratuzumab in Japanese patients with moderate-to-severe systemic lupus erythematosus: Results from a phase 1/2 randomized study

Tsuru, T., Tanaka, Y., Kishimoto, M., Saito, K., Yoshizawa, S., Takasaki, Y., Miyamura, T., Niiro, H., Morimoto, S., Yamamoto, J., Lledo-Garcia, R., Shao, J., Tatematsu, S., Togo, O. & Koike, T., Jan 2 2016, In : Modern Rheumatology. 26, 1, p. 87-93 7 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Pharmacokinetics
Safety
B-Lymphocytes
Placebos
2015
18 Citations (Scopus)

Amplification of IL-21 signalling pathway through bruton's tyrosine kinase in human B cell activation

Wang, S. P., Iwata, S., Nakayamada, S., Niiro, H., Jabbarzadeh-Tabrizi, S., Kondo, M., Kubo, S., Yoshikawa, M. & Tanaka, Y., May 5 2015, In : Rheumatology (United Kingdom). 54, 8, p. 1488-1497 10 p., keu532.

Research output: Contribution to journalArticle

B-Lymphocytes
Phosphorylation
interleukin-21
Agammaglobulinaemia tyrosine kinase
Genetic Recombination
50 Citations (Scopus)

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Kikushige, Y., Miyamoto, T., Yuda, J., Jabbarzadeh-Tabrizi, S., Shima, T., Takayanagi, S. I., Niiro, H., Yurino, A., Miyawaki, K., Takenaka, K., Iwasaki, H. & Akashi, K., Sep 3 2015, In : Cell stem cell. 17, 3, p. 341-352 12 p., 1815.

Research output: Contribution to journalArticle

Mucin-3
Galectins
Myeloid Progenitor Cells
Myeloid Leukemia
Acute Myeloid Leukemia
20 Citations (Scopus)

Characteristics of MPO-ANCA-positive granulomatosis with polyangiitis: a retrospective multi-center study in Japan

Ono, N., Niiro, H., Ueda, A., Sawabe, T., Nishizaka, H., Furugo, I., Yoshizawa, S., Yoshizawa, S., Tsukamoto, H., Kiyohara, C., Tada, Y. & Horiuchi, T., Jan 1 2015, In : Rheumatology International. 35, 3, p. 555-559 5 p.

Research output: Contribution to journalArticle

Antineutrophil Cytoplasmic Antibodies
Granulomatosis with Polyangiitis
Japan
Microscopic Polyangiitis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Effector B cells in autoimmune diseases

Niiro, H., Jan 1 2015, In : Japanese Journal of Clinical Immunology. 38, 5, p. 412-420 9 p.

Research output: Contribution to journalArticle

B-Lymphocyte Subsets
Autoimmune Diseases
B-Lymphocytes
Regulatory B-Lymphocytes
Self Tolerance
16 Citations (Scopus)
Systemic Scleroderma
Endothelial Cells
Cytokines
T-Lymphocytes
Wounds and Injuries
11 Citations (Scopus)

Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus

Iwata, S., Yamaoka, K., Niiro, H., Jabbarzadeh-Tabrizi, S., Wang, S. P., Kondo, M., Yoshikawa, M., Akashi, K. & Tanaka, Y., Jun 3 2015, In : Lupus. 24, 7, p. 695-704 10 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Systemic Lupus Erythematosus
B-Lymphocytes
Phosphorylation
Tissue Donors
22 Citations (Scopus)

Microarray analysis of gene expression in fibrovascular membranes excised from patients with proliferative diabetic retinopathy

Ishikawa, K., Yoshida, S., Kobayashi, Y., Zhou, Y., Nakama, T., Nakao, S., Sassa, Y., Oshima, Y., Niiro, H., Akashi, K., Kono, T. & Ishibashi, T., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 932-946 15 p.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Microarray Analysis
Gene Expression
Membranes
Genes
8 Citations (Scopus)
Dermatomyositis
Interstitial Lung Diseases
Serum
Polymyositis
Protein S
2014
41 Citations (Scopus)

Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy Keijiro Ishikawa1

Yoshida, S., Nakao, S., Nakama, T., Kita, T., Asato, R., Sassa, Y., Arita, R., Miyazaki, M., Enaida, H., Oshima, Y., Murakami, N., Niiro, H., Ono, J., Matsuda, A., Goto, Y., Akashi, K., Izuhara, K., Kudo, A., Kono, T., Hafezi-Moghadam, A. & 1 others, Ishibashi, T., Jan 2014, In : FASEB Journal. 28, 1, p. 131-142 12 p.

Research output: Contribution to journalArticle

Fibrous membranes
Proliferative Vitreoretinopathy
Retinal Pigments
Membranes
Adhesion
1 Citation (Scopus)

Pleuritis clinically diagnosed as Aspergillosis during the course of microscopic polyangiitis

kimoto, Y., Oryoji, K., Uchino, A., Yoshizawa, S., Niiro, H., Tsukamoto, H. & Horiuchi, T., Jan 1 2014, In : Internal Medicine. 53, 24, p. 2821-2824 4 p.

Research output: Contribution to journalArticle

Microscopic Polyangiitis
Pleurisy
Aspergillosis
Aspergillus
Pleura
16 Citations (Scopus)

Reduced carotid intima-media thickness in systemic lupus erythematosus patients treated with cyclosporine A

Oryoji, K., Kiyohara, C., Horiuchi, T., Tsukamoto, H., Niiro, H., Shimoda, T., Akashi, K. & Yanase, T., Jan 2014, In : Modern Rheumatology. 24, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Carotid Intima-Media Thickness
Systemic Lupus Erythematosus
Cyclosporine
Confidence Intervals
Atherosclerosis
2013
4 Citations (Scopus)

Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature

Ono, N., Yoshihiro, K., Oryoji, D., Matsuda, M., Ueki, Y., Uezono, S., Kai, Y., Himeji, D., Niiro, H. & Ueda, A., May 1 2013, In : Modern Rheumatology. 23, 3, p. 554-563 10 p.

Research output: Contribution to journalArticle

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Microscopic Polyangiitis
Antineutrophil Cytoplasmic Antibodies
Otitis Media
Vasculitis
25 Citations (Scopus)

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells

Yuki, H., Ueno, S., Tatetsu, H., Niiro, H., Iino, T., Endo, S., Kawano, Y., Komohara, Y., Takeya, M., Hata, H., Okada, S., Watanabe, T., Akashi, K., Mitsuya, H. & Okuno, Y., Feb 7 2013, In : Blood. 121, 6, p. 962-970 9 p.

Research output: Contribution to journalArticle

Hodgkin Disease
Tumors
Cells
Apoptosis
Neoplasms
33 Citations (Scopus)

The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factorα

Ueda, N., Tsukamoto, H., Mitoma, H., Ayano, M., Tanaka, A., Ohta, S. I., Inoue, Y., Arinobu, Y., Niiro, H., Akashi, K. & Horiuchi, T., May 1 2013, In : Inflammatory bowel diseases. 19, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Antibody-Dependent Cell Cytotoxicity
Tumor Necrosis Factor-alpha
Crohn Disease
Jurkat Cells
Tumor Necrosis Factor Receptors
2012
21 Citations (Scopus)

Amplification of Toll-like receptor-mediated signaling through spleen tyrosine kinase in human B-cell activation

Iwata, S., Yamaoka, K., Niiro, H., Nakano, K., Wang, S. P., Akashi, K. & Tanaka, Y., Jun 2012, In : Journal of Allergy and Clinical Immunology. 129, 6, p. 1594-1601.e2

Research output: Contribution to journalArticle

Toll-Like Receptors
B-Lymphocytes
TNF Receptor-Associated Factor 6
B-Lymphocyte Subsets
human SYK protein
33 Citations (Scopus)

Cigarette smoking, alcohol consumption, and risk of systemic lupus erythematosus: A case-control study in a Japanese population

Kiyohara, C., Washio, M., Horiuchi, T., Asami, T., Ide, S., Atsumi, T., Kobashi, G., Tada, Y., Takahashi, H., Kodama, H., Akashi, K., Harada, M., Niiro, H., Tsukamoto, H., Hotokebuchi, T., Nagasawa, K., Ushiyama, O., Mori, M., Oura, A., Sinomura, Y. & 15 others, Suzuki, H., Yamamoto, M., Horita, T., Koike, T., Abe, T., Tanaka, H., Nogami, N., Okamoto, K., Sakamoto, N., Sasaki, S., Miyake, Y., Yokoyama, T., Hirota, Y., Inaba, Y. & Nagai, M., Jul 1 2012, In : Journal of Rheumatology. 39, 7, p. 1363-1370 8 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Systemic Lupus Erythematosus
Case-Control Studies
Smoking
Population
11 Citations (Scopus)

CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells

Niiro, H., Jabbarzadeh-Tabrizi, S., Kikushige, Y., Shima, T., Noda, K., Ota, S. I., Tsuzuki, H., Inoue, Y., Arinobu, Y., Iwasaki, H., Shimoda, S., Baba, E., Tsukamoto, H., Horiuchi, T., Taniyama, T. & Akashi, K., Mar 8 2012, In : Blood. 119, 10, p. 2263-2273 11 p.

Research output: Contribution to journalArticle

Antigen Receptors
Lymphoma
B-Lymphocytes
Cells
Phosphorylation
25 Citations (Scopus)

Hereditary angioedema in Japan: Genetic analysis of 13 unrelated cases

Yamamoto, T., Horiuchi, T., Miyahara, H., Yoshizawa, S., Maehara, J., Shono, E., Takamura, K., MacHida, H., Tsujioka, K., Kaneko, T., Uemura, N., Suzawa, K., Inagaki, N., Umegaki, N., Kasamatsu, Y., Hara, A., Arinobu, Y., Inoue, Y., Niiro, H., Kashiwagai, Y. & 4 others, Harashima, S. I., Tahira, T., Tsukamoto, H. & Akashi, K., Mar 2012, In : American Journal of the Medical Sciences. 343, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

Hereditary Angioedemas
Japan
Mutation
Frameshift Mutation
Missense Mutation
3 Citations (Scopus)

Involvement of Syk in pathology of systemic autoimmune disease

Iwata, S., Yamaoka, K., Nakano, K., Wang, S. P., Saito, K., Tanaka, Y., Niiro, H. & Akashi, K., Jan 1 2012, In : Japanese Journal of Clinical Immunology. 35, 1, p. 56-61 6 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Pathology
B-Lymphocytes
Systemic Lupus Erythematosus
Rheumatoid Arthritis
44 Citations (Scopus)

Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

Tanaka, A., Tsukamoto, H., Mitoma, H., Kiyohara, C., Ueda, N., Ayano, M., Ohta, S. I., Inoue, Y., Arinobu, Y., Niiro, H., Horiuchi, T. & Akashi, K., Nov 11 2012, In : Arthritis Research and Therapy. 14, 6, R244.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Serum
Toll-Like Receptor 9
Interleukin-6
Blood Cells
21 Citations (Scopus)

The role of natural killer (NK) and NKT cells in the loss of tolerance in murine primary biliary cirrhosis

Shimoda, S., Tsuneyama, K., Kikuchi, K., Harada, K., Nakanuma, Y., Nakamura, M., Ishibashi, H., Hisamoto, S., Niiro, H., Leung, P. S. C., Ansari, A. A., Gershwin, M. E. & Akashi, K., Jun 1 2012, In : Clinical and Experimental Immunology. 168, 3, p. 279-284 6 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Biliary Liver Cirrhosis
Natural Killer Cells
Immunization
Autoantibodies
2011
34 Citations (Scopus)

Analysis of immune reconstitution after autologous CD34 + stem/progenitor cell transplantation for systemic sclerosis: Predominant reconstitution of Th1 CD4 + t cells

Tsukamoto, H., Nagafuji, K., Horiuchi, T., Mitoma, H., Niiro, H., Arinobu, Y., Inoue, Y., To, K., Miyamoto, T., Iwasaki, H., Teshima, T., Harada, M. & Akashi, K., May 1 2011, In : Rheumatology. 50, 5, p. 944-952 9 p., keq414.

Research output: Contribution to journalArticle

Systemic Scleroderma
Hematopoietic Stem Cell Transplantation
Stem Cell Transplantation
Stem Cells
Sclerosis
81 Citations (Scopus)

Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis

Shimoda, S., Harada, K., Niiro, H., Shirabe, K., Taketomi, A., Maehara, Y., Tsuneyama, K., Nakanuma, Y., Leung, P., Ansari, A. A., Gershwin, M. E. & Akashi, K., Apr 1 2011, In : Hepatology. 53, 4, p. 1270-1281 12 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Toll-Like Receptors
Bile Ducts
Natural Killer Cells
Ligands
171 Citations (Scopus)

Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia

Kikushige, Y., Ishikawa, F., Miyamoto, T., Shima, T., Urata, S., Yoshimoto, G., Mori, Y., Iino, T., Yamauchi, T., Eto, T., Niiro, H., Iwasaki, H., Takenaka, K. & Akashi, K., Aug 16 2011, In : Cancer Cell. 20, 2, p. 246-259 14 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Hematopoietic Stem Cells
B-Lymphocytes
Clone Cells
Immunoglobulin Genes
2010

[Interleukin-2(IL-2) and its receptor].

Niiro, H., Jan 1 2010, In : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 7, p. 69-71 3 p.

Research output: Contribution to journalArticle

Interleukin-2 Receptors
Immunoenzyme Techniques
Interleukin-2

[Interleukin-3(IL-3), IL-4, IL-5].

Niiro, H., Jan 1 2010, In : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 7, p. 72-74 3 p.

Research output: Contribution to journalArticle

Interleukin-3
Interleukin-5
Interleukin-4
Enzyme-Linked Immunosorbent Assay
18 Citations (Scopus)

A critical role of c-Cbl-interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas through the Ras-ERK pathway

Wakasaki, T., Masuda, M., Niiro, H., Jabbarzadeh-Tabrizi, S., Noda, K., Taniyama, T., Komune, S. & Akashi, K., Oct 2010, In : Neoplasia. 12, 10, p. 789-796 8 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-cbl
MAP Kinase Signaling System
Epidermal Growth Factor Receptor
Proteins
Transforming Growth Factors
60 Citations (Scopus)

CX3CL1 (fractalkine): A signpost for biliary inflammation in primary biliary cirrhosis

Shimoda, S., Harada, K., Niiro, H., Taketomi, A., Maehara, Y., Tsuneyama, K., Kikuchi, K., Nakanuma, Y., Mackay, I. R., Gershwin, M. E. & Akashi, K., Feb 1 2010, In : Hepatology. 51, 2, p. 567-575 9 p.

Research output: Contribution to journalArticle

Chemokine CX3CL1
Biliary Liver Cirrhosis
Inflammation
Liver
Endothelial Cells
44 Citations (Scopus)

Gene expression profile of hyperoxic and hypoxic retinas in a mouse model of oxygen-induced retinopathy

Ishikawa, K., Yoshida, S., Kadota, K., Nakamura, T., Niiro, H., Arakawa, S., Yoshida, A., Akashi, K. & Ishibashi, T., Aug 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 8, p. 4307-4319 13 p.

Research output: Contribution to journalArticle

Transcriptome
Retina
Oxygen
Genes
Inflammation
28 Citations (Scopus)

Safety and potential efficacy of tacrolimus for treatment of lupus nephritis with persistent proteinuria

Uchino, A., Tsukamoto, H., Nakashima, H., Yoshizawa, S., Furugo, I., Mitoma, H., Oryoji, K., Shimoda, T., Niiro, H., Tada, Y., Yano, T., Nonaka, T., Oishi, R., Akashi, K. & Horiuchi, T., Mar 23 2010, In : Clinical and experimental rheumatology. 28, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Tacrolimus
Proteinuria
Safety
Therapeutics
10 Citations (Scopus)

Wegener's granulomatosis detected initially by integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Ueda, N., Inoue, Y., Himeji, D., Shimao, Y., Oryoji, K., Mitoma, H., Arinobu, Y., Niiro, H., Tsukamoto, H., Horiuchi, T., Ueda, A. & Akashi, K., Apr 1 2010, In : Modern Rheumatology. 20, 2, p. 205-209 5 p.

Research output: Contribution to journalArticle

Granulomatosis with Polyangiitis
Fluorodeoxyglucose F18
Early Diagnosis
Mucous Membrane
Biopsy