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2015
11 Citations (Scopus)

CD30 ligand is a new therapeutic target for central nervous system autoimmunity

Shinoda, K., Sun, X., Oyamada, A., Yamada, H., Muta, H., Podack, E. R., Kira, J. I. & Yoshikai, Y., Feb 1 2015, In : Journal of Autoimmunity. 57, p. 14-23 10 p.

Research output: Contribution to journalArticle

CD30 Ligand
Autoimmunity
Central Nervous System
Th17 Cells
Th1 Cells
Early Medical Intervention
Age Distribution
Vitamin D
Multiple Sclerosis
Japan
61 Citations (Scopus)

Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy

Ogata, H., Yamasaki, R., Hiwatashi, A., Oka, N., Kawamura, N., Matsuse, D., Kuwahara, M., Suzuki, H., Kusunoki, S., Fujimoto, Y., Ikezoe, K., Kishida, H., Tanaka, F., Matsushita, T., Murai, H. & Kira, J. I., Oct 2015, In : Annals of Clinical and Translational Neurology. 2, 10, p. 960-971 12 p.

Research output: Contribution to journalArticle

Polyneuropathies
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Immunoglobulin G
Antibodies
Hypertrophy
7 Citations (Scopus)

Copy number variations in multiple sclerosis and neuromyelitis optica

Sato, S., Yamamoto, K., Matsushita, T., Isobe, N., Kawano, Y., Iinuma, K., Niino, M., Fukazawa, T., Nakamura, Y., Watanabe, M., Yonekawa, T., Masaki, K., Yoshimura, S., Murai, H., Yamasaki, R. & Kira, J. I., Nov 2015, In : Annals of Neurology. 78, 5, p. 762-774 13 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Multiple Sclerosis
T-Cell Antigen Receptor
Odds Ratio
Aquaporin 4
23 Citations (Scopus)

Decreased serum vitamin D levels in Japanese patients with multiple sclerosis

Niino, M., Sato, S., Fukazawa, T., Masaki, K., Miyazaki, Y., Matsuse, D., Yamasaki, R., Takahashi, E., Kikuchi, S. & Kira, J. I., Jan 1 2015, In : Journal of Neuroimmunology. 279, C, p. 40-45 6 p.

Research output: Contribution to journalArticle

Vitamin D
Multiple Sclerosis
Serum
Japan
Vitamin D-Binding Protein
1 Citation (Scopus)

Distinct features of immunoglobulin G2 aquaporin-4 antibody carriers with neuromyelitis optica

Isobe, N., Yonekawa, T., Matsushita, T., Kawano, Y., Masaki, K., Yoshimura, S., Murai, H., Yamasaki, R. & Kira, J-I., May 1 2015, In : Clinical and Experimental Neuroimmunology. 6, 2, p. 154-158 5 p.

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Immunoglobulins
Antibodies
Immunoglobulin G
6 Citations (Scopus)

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., Feb 1 2015, In : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

Research output: Contribution to journalArticle

Galectin 1
Motor Neurons
Transgenic Mice
Amyotrophic Lateral Sclerosis
Axons
4 Citations (Scopus)

Helicobacter pylori infection might prove the hygiene hypothesis in multiple sclerosis

Kira, J. I., Jun 1 2015, In : Journal of Neurology, Neurosurgery and Psychiatry. 86, 6, p. 591-592 2 p.

Research output: Contribution to journalComment/debate

Infection
Hygiene
Multiple Sclerosis
Neuromyelitis Optica
Spinal Cord
White Matter
11 Citations (Scopus)

Japanese POEMS syndrome with thalidomide ( J-POST) trial: Study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial

Katayama, K., Misawa, S., Sato, Y., Sobue, G., Yabe, I., Watanabe, O., Nishizawa, M., Kusunoki, S., Kikuchi, S., Nakashima, I., Ikeda, S. I., Kohara, N., Kanda, T., Kira, J. I., Hanaoka, H. & Kuwabara, S., 2015, In : BMJ open. 5, 1, e007330.

Research output: Contribution to journalArticle

POEMS Syndrome
Thalidomide
Clinical Protocols
Placebos
Safety

Japan MG Registry Study: A Sophisti- cated Multi-center Study of Myasthe- nia Gravis A sophisticated multi-center Study of Myasthenia Gravis

Murai, H., Utsugisawa, K., Suzuki, S., Nagane, Y., Imai, T., Motomura, M. & Kira, J. I., Dec 1 2015, In : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 12, p. 309-315 7 p.

Research output: Contribution to journalReview article

Early Medical Intervention
Myasthenia Gravis
Registries
Japan
Quality of Life
8 Citations (Scopus)

Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis

Niino, M., Sato, S., Fukazawa, T., Yoshimura, S., Hisahara, S., Matsushita, T., Isobe, N., Yoshida, K., Houzen, H., Miyazaki, Y., Shimohama, S., Kikuchi, S. & Kira, J. I., Aug 25 2015, In : Multiple Sclerosis. 21, 9, p. 1112-1120 9 p.

Research output: Contribution to journalArticle

Oligoclonal Bands
HLA-DRB1 Chains
Multiple Sclerosis
Cerebrospinal Fluid
Immunoglobulin G

Multimodal diagnostic approach for limbic encephalitis associated with antivoltage-gated potassium channel complex antibodies

Mukaino, T., Shiraishi, W., Kamada, T., Uehara, T., Yamaguchi, H., Shigeto, H., Akutagawa, N., Yoshimura, T., Murai, H. & Kira, J. I., Aug 1 2015, In : Clinical and Experimental Neuroimmunology. 6, 3, p. 318-320 3 p.

Research output: Contribution to journalArticle

Limbic Encephalitis
Potassium Channels
Antibodies
3 Citations (Scopus)

Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection

Shinoda, K., Asahara, H., Uehara, T., Miyoshi, K., Suzuki, S. O., Iwaki, T. & Kira, J. I., Feb 17 2015, In : Multiple Sclerosis Journal. 21, 2, p. 252-254 3 p.

Research output: Contribution to journalLetter

Acute Disseminated Encephalomyelitis
Rubella virus
Rubella
Virus Diseases
Passive Immunization
Acute Disseminated Encephalomyelitis
Rubella virus
Rubella
Virus Diseases
1 Citation (Scopus)
Demyelinating Diseases
Surveys and Questionnaires
13 Citations (Scopus)

Necklace cytoplasmic bodies in hereditary myopathy with early respiratory failure

Uruha, A., Hayashi, Y. K., Oya, Y., Mori-Yoshimura, M., Kanai, M., Murata, M., Kawamura, M., Ogata, K., Matsumura, T., Suzuki, S., Takahashi, Y., Kondo, T., Kawarabayashi, T., Ishii, Y., Kokubun, N., Yokoi, S., Yasuda, R., Kira, J. I., Mitsuhashi, S., Noguchi, S. & 2 others, Nonaka, I. & Nishino, I., May 1 2015, In : Journal of Neurology, Neurosurgery and Psychiatry. 86, 5, p. 483-489 7 p.

Research output: Contribution to journalArticle

Fibronectins
Muscles
Pathology
Sensitivity and Specificity
Muscular Diseases

Neuropathology of multiple sclerosis

Masaki, K. & Kira, J. I., Sep 1 2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 141-149 9 p.

Research output: Contribution to journalArticle

Acute Disease
Meningitis
Multiple Sclerosis
Disease Progression
Chronic Disease
5 Citations (Scopus)

Outcomes of pregnancy during interferon beta-1a therapy in Japanese patients with multiple sclerosis: Interim results of a postmarketing surveillance study

Shimizu, Y., Makioka, H., Harada, N., Nakabayashi, S., Saida, T. & Kira, J-I., Nov 1 2015, In : Clinical and Experimental Neuroimmunology. 6, 4, p. 402-408 7 p.

Research output: Contribution to journalArticle

Pregnancy Outcome
Multiple Sclerosis
Recurrence
Postpartum Period
Pregnancy
Central Nervous System Diseases
Demyelinating Diseases
Peripheral Nervous System Diseases
Multiple Sclerosis
Pathology
39 Citations (Scopus)

Peripheral blood T cell dynamics predict relapse in multiple sclerosis patients on fingolimod

Song, Z. Y., Yamasaki, R., Kawano, Y., Sato, S., Masaki, K., Yoshimura, S., Matsuse, D., Murai, H., Matsushita, T. & Kira, J. I., Apr 28 2015, In : PloS one. 10, 4, e0124923.

Research output: Contribution to journalArticle

T-cells
relapse
sclerosis
blood cells
Multiple Sclerosis
20 Citations (Scopus)

Pre-admission CHADS2, CHA2DS2-VASc, and R2CHADS2 scores on severity and functional outcome in acute ischemic stroke with atrial fibrillation

Tanaka, K., Yamada, T., Torii, T., Furuta, K., Matsumoto, S., Yoshimura, T., Takase, K. I., Wakata, Y., Nakashima, N., Kira, J. I. & Murai, H., Jul 1 2015, In : Journal of Stroke and Cerebrovascular Diseases. 24, 7, p. 1629-1635 7 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Stroke
ROC Curve
National Institutes of Health (U.S.)
Area Under Curve
2 Citations (Scopus)

Pure dysarthria and dysarthria-facial paresis syndrome due to internal capsule and/or corona radiata infarction

Tanaka, K., Yamada, T., Torii, T., Yoshimura, T., Takase, K. I., Togao, O., Wakata, Y., Hiwatashi, A., Nakashima, N., Kira, J. I. & Murai, H., Oct 7 2015, In : BMC neurology. 15, 1, 184.

Research output: Contribution to journalArticle

Internal Capsule
Dysarthria
Facial Paralysis
Infarction
Stroke

Tumefactive multiple sclerosis and connexin

Masaki, K. & Kira, J. I., Sep 1 2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 826-834 9 p.

Research output: Contribution to journalArticle

Connexins
Gap Junctions
Cell Communication
Neuroglia
Multiple Sclerosis
2014
2 Citations (Scopus)

[Disease concept, etiology and mechanisms of multiple sclerosis]

Kira, J. I., Nov 1 2014, In : Nihon rinsho. Japanese journal of clinical medicine. 72, 11, p. 1884-1894 11 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Central Nervous System
Genes
Th17 Cells
Th1 Cells

[Genetic factors in multiple sclerosis and neuromyelitis optica]

Sato, S. & Kira, J. I., Nov 1 2014, In : Nihon rinsho. Japanese journal of clinical medicine. 72, 11, p. 1918-1923 6 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Multiple Sclerosis
Disease Resistance
Genome-Wide Association Study
Major Histocompatibility Complex
2 Citations (Scopus)

A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles

Fujii, T., Hayashi, S., Kawamura, N., Higuchi, M. A., Tsugawa, J., Ohyagi, Y., Hayashi, Y. K., Nishino, I. & Kira, J. I., Aug 15 2014, In : Journal of the Neurological Sciences. 343, 1-2, p. 206-210 5 p.

Research output: Contribution to journalArticle

Superficial Back Muscles
Muscular Diseases
Muscles
Atrophy
Mutation
8 Citations (Scopus)

A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy

Shiraishi, W., Hayashi, S., Kamada, T., Isobe, N., Yamasaki, R., Murai, H., Ohyagi, Y. & Kira, J. I., Feb 1 2014, In : Multiple Sclerosis. 20, 2, p. 258-260 3 p.

Research output: Contribution to journalArticle

Leber's Hereditary Optic Atrophy
Aquaporin 4
Neuromyelitis Optica
Optic Nerve
Mitochondrial DNA
1 Citation (Scopus)

A case of non-convulsive status epilepticus after influenza virus B infection

Une, H., Uehara, T., Tateishi, T., Shigetou, H., Oyagi, Y. & Kira, J. I., Mar 2014, In : Clinical Neurology. 54, 3, p. 227-230 4 p.

Research output: Contribution to journalArticle

Status Epilepticus
Virus Diseases
Orthomyxoviridae
Consciousness
etiracetam
15 Citations (Scopus)

Age-related changes across the primary and secondary somatosensory areas: An analysis of neuromagnetic oscillatory activities

Hagiwara, K., Ogata, K., Okamoto, T., Uehara, T., Hironaga, N., Shigeto, H., Kira, J. I. & Tobimatsu, S., May 2014, In : Clinical Neurophysiology. 125, 5, p. 1021-1029 9 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Magnetic Fields
Magnetoencephalography
Somatosensory Evoked Potentials
Median Nerve
68 Citations (Scopus)

A nationwide survey of hypertrophic pachymeningitis in Japan

Yonekawa, T., Murai, H., Utsuki, S., Matsushita, T., Masaki, K., Isobe, N., Yamasaki, R., Yoshida, M., Kusunoki, S., Sakata, K., Fujii, K. & Kira, J. I., Jul 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 7, p. 732-739 8 p.

Research output: Contribution to journalArticle

Meningitis
Japan
Antineutrophil Cytoplasmic Antibodies
Immunoglobulin G
Surveys and Questionnaires
39 Citations (Scopus)

Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis

Niino, M., Mifune, N., Kohriyama, T., Mori, M., Ohashi, T., Kawachi, I., Shimizu, Y., Fukaura, H., Nakashima, I., Kusunoki, S., Miyamoto, K., Yoshida, K., Kanda, T., Nomura, K., Yamamura, T., Yoshii, F., Kira, J. I., Nakane, S., Yokoyama, K., Matsui, M. & 2 others, Miyazaki, Y. & Kikuchi, S., Jan 6 2014, In : BMC neurology. 14, 1, 3.

Research output: Contribution to journalArticle

Apathy
Multiple Sclerosis
Fatigue
Cognition
Depression
6 Citations (Scopus)

Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

Niino, M., Mifune, N., Kohriyama, T., Mori, M., Ohashi, T., Kawachi, I., Shimizu, Y., Fukaura, H., Nakashima, I., Kusunoki, S., Miyamoto, K., Yoshida, K., Kanda, T., Nomura, K., Yamamura, T., Yoshii, F., Kira, J. I., Nakane, S., Yokoyama, K., Matsui, M. & 2 others, Miyazaki, Y. & Kikuchi, S., Oct 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Magnetic Resonance Imaging
Neuropsychological Tests
Brain Stem
Cognition
21 Citations (Scopus)

Clinical features and treatment status of adult myasthenia gravis in Japan

Murai, H., Masuda, M., Utsugisawa, K., Nagane, Y., Suzuki, S., Imai, T., Motomura, M., Konno, S. & Kira, J. I., Feb 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Myasthenia Gravis
Thymoma
Japan
Therapeutics
Age of Onset
20 Citations (Scopus)

Corpus callosum atrophy in patients with hereditary diffuse leukoencephalopathy with neuroaxonal spheroids: An MRI-based study

Kinoshita, M., Kondo, Y., Yoshida, K., Fukushima, K., Hoshi, K. I., Ishizawa, K., Araki, N., Yazawa, I., Washimi, Y., Saitoh, B., Kira, J. I. & Ikeda, S. I., Jan 1 2014, In : Internal Medicine. 53, 1, p. 21-27 7 p.

Research output: Contribution to journalArticle

Corpus Callosum
Atrophy
Nervous System
Magnetic Resonance Imaging
Leukoencephalopathies
2 Citations (Scopus)

Decreased CCR2 and CD62L expressions on peripheral blood classical monocytes in amyotrophic lateral sclerosis

Cui, Y. W., Kawano, Y., Yamasaki, R., Shi, N., Masaki, K., Isobe, N., Yonekawa, T., Matsushita, T., Tateishi, T., Hayashi, S. & Kira, J-I., Jan 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 92-96 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Monocytes
Chemotaxis
Immune System
Flow Cytometry
3 Citations (Scopus)

Distinct cytokine and T helper cell profiles between patients with multiple sclerosis who had or had not received interferon-beta

Doi, H., Song, Z. Y., Yoshimura, S., Tateishi, T., Yonekawa, T., Yamasaki, R., Murai, H., Matsushita, T. & Kira, J. I., Oct 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 3, p. 321-327 7 p.

Research output: Contribution to journalArticle

Interferon-beta
Helper-Inducer T-Lymphocytes
Interferons
Multiple Sclerosis
Cytokines
1 Citation (Scopus)

Early inhibition of tumor necrosis factor-α and interleukin-6 in muscle tissue as a therapy for dystrophinopathy in mdx mice

Arahata, H., Ohyagi, Y., Iinuma, K. M., Tanaka, M., Tateishi, T., Yamasaki, R., Matsushita, T. & Kira, J. I., Oct 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 3, p. 371-377 7 p.

Research output: Contribution to journalArticle

Inbred mdx Mouse
Interleukin-6
Tumor Necrosis Factor-alpha
Cytokines
Muscles
72 Citations (Scopus)

Efficiency of a small-world brain network depends on consciousness level: A resting-state fMRI study

Uehara, T., Yamasaki, T., Okamoto, T., Koike, T., Kan, S., Miyauchi, S., Kira, J. I. & Tobimatsu, S., Jun 2014, In : Cerebral Cortex. 24, 6, p. 1529-1539 11 p.

Research output: Contribution to journalArticle

Consciousness
Magnetic Resonance Imaging
Brain
Sleep Stages
Communication
1 Citation (Scopus)

Epilepsy and functional brain networks

Uehara, T., Shigeto, H. & Kira, J-I., Jan 1 2014, In : Clinical Neurology. 54, 12, p. 1139-1141 3 p.

Research output: Contribution to journalArticle

Epilepsy
Brain
Partial Epilepsy
Stroke
Magnetic Resonance Imaging
1 Citation (Scopus)
Drugs
Efficacy
Multiple Sclerosis
Multiple Sclerosis
Pharmaceutical Preparations
28 Citations (Scopus)

Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

Cui, Y., Masaki, K., Yamasaki, R., Imamura, S., Suzuki, S. O., Hayashi, S., Sato, S., Nagara, Y., Kawamura, M. F. & Kira, J. I., Mar 6 2014, In : Journal of neuroinflammation. 11, 42.

Research output: Contribution to journalArticle

Connexins
Amyotrophic Lateral Sclerosis
Disease Progression
Horns
Excitatory Amino Acid Transporter 2
34 Citations (Scopus)

Fingolimod (FTY720) therapy in Japanese patients with relapsing multiple sclerosis over 12 months: Results of a phase 2 observational extension

Kira, J. I., Itoyama, Y., Kikuchi, S., Hao, Q., Kurosawa, T., Nagato, K., Tsumiyama, I., von Rosenstiel, P., Zhang-Auberson, L. & Saida, T., Jan 29 2014, In : BMC neurology. 14, 1, 21.

Research output: Contribution to journalArticle

Multiple Sclerosis
Aquaporin 4
Therapeutics
Safety
Placebos
Meningitis
Japan
Surveys and Questionnaires
8 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Apr 15 2014, In : PloS one. 9, 4, e95367.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
sclerosis
cerebrospinal fluid
Multiple Sclerosis
Cerebrospinal Fluid
12 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Jan 1 2014, In : PloS one. 9, 4, p. e95367

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
sclerosis
cerebrospinal fluid
Multiple Sclerosis
Cerebrospinal Fluid