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2014
11 Citations (Scopus)

Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

Ainiding, G., Kawano, Y., Sato, S., Isobe, N., Matsushita, T., Yoshimura, S., Yonekawa, T., Yamasaki, R., Murai, H. & Kira, J. I., Feb 15 2014, In : Journal of the Neurological Sciences. 337, 1-2, p. 147-150 4 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Interleukin-2 Receptors
Multiple Sclerosis
Genes
Genotype
3 Citations (Scopus)

Japanese guidelines for fingolimod in multiple sclerosis: Putting into practice

Matsui, M., Shimizu, Y., Doi, H., Tomioka, R., Nakashima, I., Niino, M. & Kira, J-I., Jan 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 34-48 15 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Guidelines
Lysosphingolipid Receptors
Aquaporin 4
Neuromyelitis Optica
Neurosciences
Allergy and Immunology
Myelitis
Multiple Sclerosis
Hyperalgesia
Multiple Sclerosis
Japan
Research

The actual state and problems in neurology training at graduate school

Kira, J-I., Ohyagi, Y., Taniwaki, T., Inuzuka, T., Yoshii, F., Aoki, M., Amano, T., Toyoshima, I., Fukutake, T. & Hashimoto, Y., Jan 1 2014, In : Clinical Neurology. 54, 4, p. 349-358 10 p.

Research output: Contribution to journalArticle

Neurology
Students
Japan
Research
Education

The actual state and problems in neurology training at hospital

Fukutake, T., Hashimoto, Y., Taniwaki, T., Toyoshima, I., Amano, T., Aoki, M., Yoshii, F., Inuzuka, T. & Kira, J-I., Jan 1 2014, In : Clinical Neurology. 54, 4, p. 341-348 8 p.

Research output: Contribution to journalArticle

Neurology
Teaching
Certification
Teaching Hospitals
Education

The actual state and problems in neurology training in medical schools

Taniwaki, T., Inuzuka, T., Yoshii, F., Aoki, M., Amano, T., Toyoshima, I., Fukutake, T., Hashimoto, Y. & Kira, J. I., 2014, In : Clinical Neurology. 54, 4, p. 335-340 6 p.

Research output: Contribution to journalArticle

Neurology
Medical Schools
Education
Graduate Education
Textbooks
Multiple Sclerosis
Fingolimod Hydrochloride
Multiple Sclerosis
Central Nervous System
Lysosphingolipid Receptors
Lymphocytes
Spinal Cord
2013

[Susceptible and resistant factors in neuro-immune disease].

Sato, S. & Kira, J. I., May 2013, In : Unknown Journal. 71, 5, p. 783-788 6 p.

Research output: Contribution to journalReview article

Immune System Diseases
Genetic Research
Microbiology
Allergy and Immunology
Biochemistry
26 Citations (Scopus)

A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis

Saitoh, B. Y., Yamasaki, R., Hayashi, S., Yoshimura, S., Tateishi, T., Ohyagi, Y., Murai, H., Iwaki, T., Yoshida, K. & Kira, J. I., Sep 2013, In : Multiple Sclerosis Journal. 19, 10, p. 1367-1370 4 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Chronic Progressive Multiple Sclerosis
Macrophage Colony-Stimulating Factor
Neurologic Gait Disorders
Dysarthria
4 Citations (Scopus)

A case of medulla oblongata compression by tortuous vertebral arteries presenting with spastic quadriplegia

Kamada, T., Tateishi, T., Yamashita, T., Nagata, S., Ohyagi, Y. & Kira, J. I., Jan 1 2013, In : Clinical Neurology. 53, 5, p. 356-361 6 p.

Research output: Contribution to journalArticle

Medulla Oblongata
Quadriplegia
Vertebral Artery
Spastic Paraparesis
Lower Extremity
3 Citations (Scopus)

A case of neuromyelitis optica spectrum disorder associated with a limited cutaneous systemic sclerosis and Sjögren syndrome

Iwanaga, Y., Hayashi, S., Kawamura, N., Ohyagi, Y. & Kira, J. I., Sep 1 2013, In : Clinical Neurology. 53, 9, p. 695-700 6 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Systemic Scleroderma
Skin
Paraparesis
Lower Extremity
2 Citations (Scopus)

A case of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis with multiple mitochondrial DNA deletions

Tanaka, K., Tateishi, T., Kawamura, N., Ohyagi, Y., Urata, M. & Kira, J. I., Mar 1 2013, In : Clinical Neurology. 53, 3, p. 205-211 7 p.

Research output: Contribution to journalArticle

Muscle Weakness
Mitochondrial DNA
Exons
Lactic Acid
Sural Nerve
7 Citations (Scopus)

A guide to facilitate the early treatment of patients with idiopathic demyelinating disease (multiple sclerosis and neuromyelitis optica)

Carroll, W. M., Saida, T., Kim, H. J., Kira, J., Kermode, A. G., Tsai, C. P., Fujihara, K., Kusunoki, S., Tanaka, M., Kim, K. K. & Bates, D., Sep 2013, In : Multiple Sclerosis Journal. 19, 10, p. 1371-1380 10 p.

Research output: Contribution to journalReview article

Neuromyelitis Optica
Demyelinating Diseases
Multiple Sclerosis
Therapeutics
Neurology
2 Citations (Scopus)

Alterations in chemokine receptor expressions on peripheral blood monocytes in multiple sclerosis and neuromyelitis optica

Cui, Y. W., Kawano, Y., Shi, N., Masaki, K., Isobe, N., Yonekawa, T., Matsushita, T., Tateishi, T., Yamasaki, R., Murai, H. & Kira, J. I., Aug 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 2, p. 201-205 5 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Chemokine Receptors
Multiple Sclerosis
Monocytes
Prednisolone
7 Citations (Scopus)

An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis)

Suzuki, M., Kawasaki, H., Masaki, K., Suzuki, S. O., Terada, T., Tsuchida, T., Tokuyama, T., Kono, S., Komori, T., Baba, S., Kira, J. I. & Miyajima, H., Aug 21 2013, In : Internal Medicine. 52, 16, p. 1825-1832 8 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Autopsy
Fatal Outcome
Brain
Cerebrospinal Fluid
7 Citations (Scopus)

A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese

Huang, J., Yoshimura, S., Isobe, N., Matsushita, T., Yonekawa, T., Sato, S., Yamasaki, R. & Kira, J. I., Nov 2013, In : Multiple Sclerosis Journal. 19, 13, p. 1696-1703 8 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Missense Mutation
Multiple Sclerosis
Alleles
Odds Ratio
9 Citations (Scopus)

Anti-KIR4.1 antibodies in Japanese patients with idiopathic central nervous system demyelinating diseases

Watanabe, M., Yamasaki, R., Kawano, Y., Imamura, S. & Kira, J. I., Aug 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 2, p. 241-242 2 p.

Research output: Contribution to journalLetter

Central Nervous System Diseases
Demyelinating Diseases
Anti-Idiotypic Antibodies
92 Citations (Scopus)

Anti-neurofascin antibody in patients with combined central and peripheral demyelination

Kawamura, N., Yamasaki, R., Yonekawa, T., Matsushita, T., Kusunoki, S., Nagayama, S., Fukuda, Y., Ogata, H., Matsuse, D., Murai, H. & Kira, J. I., Aug 20 2013, In : Neurology. 81, 8, p. 714-722 9 p.

Research output: Contribution to journalArticle

Demyelinating Diseases
Anti-Idiotypic Antibodies
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Antigens
Plasma Exchange
2 Citations (Scopus)
Central Nervous System Diseases
Demyelinating Diseases
1 Citation (Scopus)
Multiple Sclerosis
Steroids
Inflammation
101 Citations (Scopus)
Neuromyelitis Optica
Chronic Progressive Multiple Sclerosis
Cerebrospinal fluid
sclerosis
cerebrospinal fluid
8 Citations (Scopus)

Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica

Isobe, N., Yonekawa, T., Matsushita, T., Masaki, K., Yoshimura, S., Fichna, J., Chen, S., Furmaniak, J., Smith, B. R. & Kira, J. I., May 1 2013, In : Neurochemical Research. 38, 5, p. 997-1001 5 p.

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Antibodies
Serum
Optics
43 Citations (Scopus)

Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica

Masaki, K., Suzuki, S. O., Matsushita, T., Matsuoka, T., Imamura, S., Yamasaki, R., Suzuki, M., Suenaga, T., Iwaki, T. & Kira, J. I., Aug 22 2013, In : PloS one. 8, 8, e72919.

Research output: Contribution to journalArticle

Neuromyelitis Optica
connexins
Connexin 43
sclerosis
Multiple Sclerosis
Graduate Education
Graduate Medical Education
Neurology
Japan
9 Citations (Scopus)

Disrupted connectivity of motor loops in Parkinson's disease during self-initiated but not externally-triggered movements

Taniwaki, T., Yoshiura, T., Ogata, K., Togao, O., Yamashita, K., Kida, H., Miura, S., Kira, J. I. & Tobimatsu, S., Apr 17 2013, In : Brain Research. 1512, p. 45-59 15 p.

Research output: Contribution to journalArticle

Parkinson Disease
Basal Ganglia
Motor Cortex
Cerebellum
Activation Analysis
63 Citations (Scopus)

Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status

Yoshimura, S., Isobe, N., Matsushita, T., Yonekawa, T., Masaki, K., Sato, S., Kawano, Y., Kira, J. I., Miyamoto, K., Kusunoki, S., Nakatsuji, Y., Mochizuki, H., Ochi, K., Matsumoto, M., Kanda, T., Ochi, H., Miki, T., Okada, K. & Tsuji, S., Jan 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Antibodies
HLA Antigens
Epstein-Barr Virus Nuclear Antigens
3 Citations (Scopus)

Distinct genetic profiles between Japanese multiple sclerosis patients with and without Barkhof brain lesions

Huang, J., Isobe, N., Matsushita, T., Yoshimura, S., Sato, S., Yonekawa, T., Yamasaki, R., Murai, H. & Kira, J. I., Aug 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 2, p. 173-180 8 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Brain
Haplotypes
Alleles
Neuromyelitis Optica
6 Citations (Scopus)

Efficacy of methylprednisolone pulse therapy for acute relapse in Japanese patients with multiple sclerosis and neuromyelitis optica: A multicenter retrospective analysis - 1. Whole group analysis

Kira, J. I., Yamasaki, R., Yoshimura, S., Fukazawa, T., Yokoyama, K., Fujihara, K., Ogino, M., Yokota, T., Miyamoto, K., Niino, M., Nomura, K., Tomioka, R., Tanaka, M., Kawachi, I., Ohashi, T., Kaida, K., Matsui, M., Nakatsuji, Y., Ochi, H., Fukaura, H. & 5 others, Kanda, T., Nagaishi, A., Togo, K., Mizusawa, H. & Kawano, Y., Dec 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Methylprednisolone
Multiple Sclerosis
Recurrence
Therapeutics
7 Citations (Scopus)
Neuromyelitis Optica
Multiple Sclerosis
Aquaporin 4
Sanitation
Age of Onset
28 Citations (Scopus)

Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1α in amyotrophic lateral sclerosis

Nagara, Y., Tateishi, T., Yamasaki, R., Hayashi, S., Kawamura, M., Kikuchi, H., Iinuma, K. M., Tanaka, M., Iwaki, T., Matsushita, T., Ohyagi, Y. & Kira, J. I., Sep 1 2013, In : Brain Pathology. 23, 5, p. 534-546 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Cell Nucleus Active Transport
Amyotrophic Lateral Sclerosis
Karyopherins
Anterior Horn Cells
40 Citations (Scopus)

Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease

Soejima, N., Ohyagi, Y., Nakamura, N., Himeno, E., Iinuma, K. M., Sakae, N., Yamasaki, R., Tabira, T., Murakami, K., Irie, K., Kinoshita, N., LaFerla, F. M., Kiyohara, Y., Iwaki, T. & Kira, J. I., Nov 29 2013, In : Current Alzheimer Research. 10, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Endoplasmic Reticulum Stress
Poisons
Amyloid
Alzheimer Disease

Launch of new review/editing system for Clinical and Experimental Neuroimmunology

Yamamura, T., Kira, J-I., Suzumura, A., Kanda, T. & Murai, H., Jun 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

12 Citations (Scopus)

Minimum norm estimates in MEG can delineate the onset of interictal epileptic discharges: A comparison with ECoG findings

Kanamori, Y., Shigeto, H., Hironaga, N., Hagiwara, K., Uehara, T., Chatani, H., Sakata, A., Hashiguchi, K., Morioka, T., Tobimatsu, S. & Kira, J. I., Jun 3 2013, In : NeuroImage: Clinical. 2, 1, p. 663-669 7 p.

Research output: Contribution to journalArticle

Magnetoencephalography
Cerebral Cortex
Epilepsy
Electrocorticography
Drug Resistant Epilepsy
4 Citations (Scopus)

Month of birth in multiple sclerosis with and without longitudinally extensive spinal cord lesions: A study of a Japanese national survey

Araki, Y., Kinoshita, M., Motoyama, R., Matsushita, T., Nakagawa, M., Kira, J. I. & Tanaka, M., Jul 15 2013, In : Journal of the Neurological Sciences. 330, 1-2, p. 67-70 4 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Spinal Cord
Parturition
Population
Surveys and Questionnaires
2 Citations (Scopus)

Multimodality evoked potentials for discrimination of atopic myelitis and multiple sclerosis

Kanamori, Y., Isobe, N., Yonekawa, T., Matsushita, T., Shigeto, H., Kawamura, N., Yamasaki, R., Murai, H., Tobimatsu, S. & Kira, J. I., Jun 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 1, p. 29-35 7 p.

Research output: Contribution to journalReview article

Myelitis
Evoked Potentials
Multiple Sclerosis
Motor Evoked Potentials
Peripheral Nerves

Neuro2013

Kira, J. I., Yamasaki, R. & Masaki, K., Aug 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 2, p. 243-245 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Protein kinase C-η polymorphism rs2230500 does not confer disease susceptibility to multiple sclerosis or neuromyelitis optica

Kawano, Y., Matsushita, T., Cui, Y. W., Isobe, N., Yoshimura, S., Yonekawa, T., Masaki, K., Yamasaki, R., Murai, H. & Kira, J. I., Dec 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 3, p. 283-287 5 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Disease Susceptibility
Protein Kinase C
Multiple Sclerosis
Demyelinating Diseases
15 Citations (Scopus)

Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy

Nakamichi, K., Kishida, S., Tanaka, K., Suganuma, A., Sano, Y., Sano, H., Kanda, T., Maeda, N., Kira, J. I., Itoh, A., Kato, N., Tomimoto, H., Kurane, I., Lim, C. K., Mizusawa, H. & Saijo, M., Jan 1 2013, In : Archives of Virology. 158, 3, p. 639-650 12 p.

Research output: Contribution to journalArticle

JC Virus
Progressive Multifocal Leukoencephalopathy
Cerebrospinal Fluid
Viral Load
Polyomavirus Infections

Shower embolism-like brain lesions in Churg-Strauss syndrome

Shiraishi, W., Hayashi, S., Kamada, T., Murai, H., Ohyagi, Y. & Kira, J. I., Dec 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 3, p. 348-350 3 p.

Research output: Contribution to journalComment/debate

Churg-Strauss Syndrome
Intracranial Embolism
10 Citations (Scopus)

Spontaneous seizures in a rat model of multiple prenatal freeze lesioning

Kamada, T., Sun, W., Takase, K. I., Shigetou, H., Suzuki, S. O., Ohyagi, Y. & Kira, J. I., Aug 1 2013, In : Epilepsy Research. 105, 3, p. 280-291 12 p.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Seizures
Amino Acid Transport System X-AG
Electroencephalography
Animal Models
14 Citations (Scopus)

Structural equation modeling of factors contributing to quality of life in Japanese patients with multiple sclerosis

Kikuchi, H., Mifune, N., Niino, M., Kira, J. I., Kohriyama, T., Ota, K., Tanaka, M., Ochi, H., Nakane, S. & Kikuchi, S., Jan 22 2013, In : BMC neurology. 13, 10.

Research output: Contribution to journalArticle

Multiple Sclerosis
Social Adjustment
Quality of Life
Symptom Assessment
Medical Staff
14 Citations (Scopus)

TAR DNA-binding protein 43 pathology in a case clinically diagnosed with facial-onset sensory and motor neuronopathy syndrome: An autopsied case report and a review of the literature

Sonoda, K., Sasaki, K., Tateishi, T., Yamasaki, R., Hayashi, S., Sakae, N., Ohyagi, Y., Iwaki, T. & Kira, J. I., Sep 15 2013, In : Journal of the Neurological Sciences. 332, 1-2, p. 148-153 6 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Pathology
Spinal Nerve Roots
Upper Extremity
Autopsy
5 Citations (Scopus)
Tropical Spastic Paraparesis
Spinal Cord Diseases
Thiamine
Viruses
Beriberi
2 Citations (Scopus)

Transient interhemispheric disconnection in a case of insulinoma-induced hypoglycemic encephalopathy

Yamashita, C., Shigeto, H., Maeda, N., Kawaguchi, M., Uryu, M., Motomura, S. & Kira, J. I., Dec 15 2013, In : Journal of the Neurological Sciences. 335, 1-2, p. 233-237 5 p.

Research output: Contribution to journalArticle

Insulinoma
Brain Diseases
Hypoglycemic Agents
Hand
Coma
2012
2 Citations (Scopus)

A case of myositis associated with clonal expansion of γδ T cells in peripheral blood and bone marrow

Yamashita, T., Ochi, H., Ishizu, N., Ohyagi, Y., Kira, J. I., Mori, Y., Arahata, S. & Ohshima, K., Jan 1 2012, In : Clinical Neurology. 52, 4, p. 227-233 7 p.

Research output: Contribution to journalArticle

Myositis
Bone Marrow
T-Lymphocytes
Muscle Weakness
Muscles
2 Citations (Scopus)

A deficit of dorsal stream function in patients with mild cognitive impairment and Alzheimer's disease

Yamasaki, T., Goto, Y., Ohyagi, Y., Monji, A., Munetsuna, S., Minohara, M., Minohara, K., Kira, J. I., Kanba, S. & Tobimatsu, S., Oct 24 2012, 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings. p. 28-31 4 p. 6275685. (2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optics
Brain
6 Citations (Scopus)

Alzheimer's disease: diagnosis by different methods of voxel-based morphometry.

Dashjamts, T., Yoshiura, T., Hiwatashi, A., Togao, O., Yamashita, K., Ohyagi, Y., Monji, A., Kamano, H., Kawashima, T., Kira, J. I. & Honda, H., Mar 2012, In : Fukuoka igaku zasshi = Hukuoka acta medica. 103, 3, p. 59-69 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Healthy Volunteers
Gray Matter
ROC Curve
Area Under Curve