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2012
40 Citations (Scopus)

A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis

Saida, T., Kikuchi, S., Itoyama, Y., Hao, Q., Kurosawa, T., Nagato, K., Tang, D., Zhang-Auberson, L. & Kira, J., Sep 2012, In : Multiple Sclerosis Journal. 18, 9, p. 1269-1277 9 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Randomized Controlled Trials
Placebos
Gadolinium
Safety
3 Citations (Scopus)

Clinical disability progression and platelet GP IIb/IIIa values in patients with atopic myelitis

Ainiding, G., Yamashita, K. I., Torii, T., Furuta, K., Isobe, N., Matsushita, T., Masaki, K., Matsumoto, S. & Kira, J. I., May 15 2012, In : Journal of Neuroimmunology. 246, 1-2, p. 108-112 5 p.

Research output: Contribution to journalArticle

Platelet Membrane Glycoprotein IIb
Myelitis
Blood Platelets
Platelet Glycoprotein GPIIb-IIIa Complex
20 Citations (Scopus)
Aquaporin 4
Neuroimaging
Central Nervous System
Antibodies
Spinal Cord
30 Citations (Scopus)

Extensive loss of connexins in Baló's disease: Evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/ myelin interaction

Masaki, K., Suzuki, S. O., Matsushita, T., Yonekawa, T., Matsuoka, T., Isobe, N., Motomura, K., Wu, X. M., Tabira, T., Iwaki, T. & Kira, J. I., Jun 1 2012, In : Acta neuropathologica. 123, 6, p. 887-900 14 p.

Research output: Contribution to journalArticle

Aquaporin 4
Connexins
Oligodendroglia
Myelin Sheath
Astrocytes
22 Citations (Scopus)

First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis

Isobe, N., Kanamori, Y., Yonekawa, T., Matsushita, T., Shigeto, H., Kawamura, N. & Kira, J. I., May 15 2012, In : Journal of the Neurological Sciences. 316, 1-2, p. 30-35 6 p.

Research output: Contribution to journalArticle

Myelitis
Multiple Sclerosis
Oligoclonal Bands
Sensitivity and Specificity
Brain
7 Citations (Scopus)
Multiple Sclerosis
Phenotype
MHC Class II Genes
Disease Susceptibility
Helicobacter Infections
45 Citations (Scopus)

Genetic and Infectious Profiles of Japanese Multiple Sclerosis Patients

Yoshimura, S., Isobe, N., Yonekawa, T., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Yamamoto, K. & Kira, J. I., Nov 9 2012, In : PloS one. 7, 11, e48592.

Research output: Contribution to journalArticle

sclerosis
Multiple Sclerosis
Epstein-Barr Virus Nuclear Antigens
Viruses
HLA-DRB1 Chains

Hemicape-like sensory disturbance caused by cortical infarction in the postcentral gyrus

Yamashita, C., Kawamura, N., Torii, T., Ohyagi, Y. & Kira, J-I., Mar 1 2012, In : Clinical Neurology. 52, 3, p. 178-181 4 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Infarction
Hypesthesia
Cerebral Infarction
Arm
6 Citations (Scopus)

HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese

Sato, S., Isobe, N., Yoshimura, S., Kanamori, Y., Masaki, K., Matsushita, T. & Kira, J. I., Oct 15 2012, In : Journal of Neuroimmunology. 251, 1-2, p. 110-113 4 p.

Research output: Contribution to journalArticle

Myelitis
HLA Antigens
Alleles
Neuromyelitis Optica
Immunogenetics
9 Citations (Scopus)

Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model

Kawamura, M. F., Yamasaki, R., Kawamura, N., Tateishi, T., Nagara, Y., Matsushita, T., Ohyagi, Y. & Kira, J-I., Apr 1 2012, In : Experimental Neurology. 234, 2, p. 437-445 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Microglia
T-Lymphocytes
Wounds and Injuries
Axotomy
3 Citations (Scopus)

Inflammatory radiculoneuropathy in an ALS4 patient with a novel SETX mutation

Saiga, T., Tateishi, T., Torii, T., Kawamura, N., Nagara, Y., Shigeto, H., Hashiguchi, A., Takashima, H., Honda, H., Ohyagi, Y. & Kira, J. I., Jul 2012, In : Journal of Neurology, Neurosurgery and Psychiatry. 83, 7, p. 763-764 2 p.

Research output: Contribution to journalLetter

Mutation
7 Citations (Scopus)
Relapsing-Remitting Multiple Sclerosis
Gadolinium
Brain
Interferon-beta
Therapeutics

Migraine with aura and recurrent vertigo attacks in a patient with hereditary hemorrhagic telangiectasia

Yonekawa, T., Doi, H., Tateishi, T., Tanaka, K., Iura, T., Ohyagi, Y. & Kira, J. I., Jul 1 2012, In : Clinical Neurology. 52, 7, p. 499-502 4 p.

Research output: Contribution to journalArticle

Hereditary Hemorrhagic Telangiectasia
Migraine with Aura
Vertigo
Migraine Disorders
Fistula
4 Citations (Scopus)

Myopathy in autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy

Watanabe, M., Ochi, H., Arahata, H., Matsuo, T., Nagafuchi, S., Ohyagi, Y. & Kira, J. I., Jun 1 2012, In : Muscle and Nerve. 45, 6, p. 904-908 5 p.

Research output: Contribution to journalArticle

Autoimmune Polyendocrinopathies
Muscular Diseases
Regulator Genes
Muscles
Paraspinal Muscles
28 Citations (Scopus)

Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica

Isobe, N., Yonekawa, T., Matsushita, T., Kawano, Y., Masaki, K., Yoshimura, S., Fichna, J., Chen, S., Furmaniak, J., Smith, B. R. & Kira, J. I., Nov 2012, In : Multiple Sclerosis Journal. 18, 11, p. 1541-1551 11 p.

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Antibodies
Myelitis
Immunoglobulin G
13 Citations (Scopus)

Selective impairment of optic flow perception in amnestic mild cognitive impairment: Evidence from event-related potentials

Yamasaki, T., Goto, Y., Ohyagi, Y., Monji, A., Munetsuna, S., Minohara, M., Minohara, K., Kira, J. I., Kanba, S. & Tobimatsu, S., 2012, In : Journal of Alzheimer's Disease. 28, 3, p. 695-708 14 p.

Research output: Contribution to journalArticle

Optic Flow
Evoked Potentials
Alzheimer Disease
Cognitive Dysfunction
Young Adult
17 Citations (Scopus)

The expanding phenotype of CLIPPERS: Is it a disease or a syndrome?

Kira, J. I., Jan 2012, In : Journal of Neurology, Neurosurgery and Psychiatry. 83, 1, p. 2-3 2 p.

Research output: Contribution to journalComment/debate

Phenotype
Syndrome
14 Citations (Scopus)

UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan

Miyake, Y., Tanaka, K., Fukushima, W., Kiyohara, C., Sasaki, S., Tsuboi, Y., Yamada, T., Oeda, T., Shimada, H., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M., Baba, Y., Kobayashi, T., Sawada, H., Mizuta, E., Murase, N., Tsutada, T. & 34 others, Miki, T., Kira, J. I., Kihira, T., Kondo, T., Tomimoto, H., Taniwaki, T., Sugiyama, H., Yoshida, S., Fujimura, H., Saito, T., Saida, K., Fujitake, J., Fujii, N., Naito, M., Arimizu, J., Nakagawa, T., Harada, H., Sueta, T., Kikuta, T., Umemoto, G., Uchio, E., Migita, H., Kazuki, K., Ito, Y., Iwaki, H., Siraki, K., Ataka, S., Yamane, H., Tochino, R., Harada, T., Iwashita, Y., Shimizu, M., Seki, K. & Ando, K., Jul 28 2012, In : BMC neurology. 12, 62.

Research output: Contribution to journalArticle

Parkinson Disease
Japan
Single Nucleotide Polymorphism
Genotype
Caffeine
2011
4 Citations (Scopus)

A case of Charles Bonnet syndrome following syphilitic optic neuritis

Ogata, H., Shigeto, H., Torii, T., Kawamura, N., Ohyagi, Y. & Kira, J. I., Aug 1 2011, In : Clinical Neurology. 51, 8, p. 595-598 4 p.

Research output: Contribution to journalArticle

Optic Neuritis
Hallucinations
olanzapine
Occipital Lobe
Cerebrospinal Fluid

A case of chronic inflammatory demyelinating polyradiculoneuropathy concomitant with acquired von Willebrand syndrome

Ueda, M., Kawamura, N., Tateishi, T., Shigeto, H., Ohyagi, Y. & Kira, J. I., May 1 2011, In : Clinical Neurology. 51, 5, p. 334-337 4 p.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Intravenous Immunoglobulins
Blood-Nerve Barrier
Monoclonal Gammopathy of Undetermined Significance
Paraproteinemias
14 Citations (Scopus)

Activation of glutathione peroxidase and inhibition of p53-related apoptosis by apomorphine

Ma, L., Ohyagi, Y., Nakamura, N., Iinuma, K. M., Miyoshi, K., Himeno, E., Soejima, N., Yanagihara, Y. T., Sakae, N., Yamasaki, R. & Kira, J-I., Jan 1 2011, In : Journal of Alzheimer's Disease. 27, 1, p. 225-237 13 p.

Research output: Contribution to journalArticle

Apomorphine
Glutathione Peroxidase
Apoptosis
Carmustine
Glutathione Reductase

Analysis of cerebrospinal fluid cytokines and growth factors in multiple sclerosis patients with and without chronic headaches

Doi, H., Matsushita, T., Isobe, N., Tateishi, T. & Kira, J. I., Mar 1 2011, In : Neurology Asia. 16, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Headache Disorders
Multiple Sclerosis
Cerebrospinal Fluid
Intercellular Signaling Peptides and Proteins
Cytokines
97 Citations (Scopus)

Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation

Himeno, E., Ohyagi, Y., Ma, L., Nakamura, N., Miyoshi, K., Sakae, N., Motomura, K., Soejima, N., Yamasaki, R., Hashimoto, T., Tabira, T., M. Laferla, F. & Kira, J. I., Feb 1 2011, In : Annals of Neurology. 69, 2, p. 248-256 9 p.

Research output: Contribution to journalArticle

Apomorphine
Amyloid
Alzheimer Disease
Therapeutics
Oxidative Stress
25 Citations (Scopus)

Astrocytopathy in Baló's disease

Kira, J. I., Jul 2011, In : Multiple Sclerosis Journal. 17, 7, p. 771-779 9 p.

Research output: Contribution to journalReview article

Aquaporin 4
Oligodendroglia
Myelin Sheath
Astrocytes
Multiple Sclerosis
8 Citations (Scopus)

Astrocytopathy in neuromyelitis optica, multiple sclerosis and Baló's disease

Matsushita, T., Masaki, K., Suzuki, S., Matsuoka, T., Yonekawa, T., Wu, X. M., Tabira, T., Iwaki, T. & Kira, J. I., Dec 1 2011, In : Clinical Neurology. 51, 11, p. 898-900 3 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Demyelinating Diseases
Aquaporin 4
Connexin 43
Multiple Sclerosis
37 Citations (Scopus)
Neuromyelitis Optica
Aquaporin 4
Demyelinating Diseases
Autoimmunity
Multiple Sclerosis
3 Citations (Scopus)

Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Kawamura, N., Piao, H., Minohara, M., Matsushita, T., Kusunoki, S., Matsumoto, H., Ikenaka, K., Mizunoe, Y. & Kira, J-I., Dec 15 2011, In : Journal of Neuroimmunology. 240-241, p. 74-78 5 p.

Research output: Contribution to journalArticle

Campylobacter jejuni
DNA-Binding Proteins
Sulfoglycosphingolipids
Enteritis
Myelin Sheath

Care network supporting patients with intractable diseases

Kira, J. I., Dec 1 2011, In : Clinical Neurology. 51, 11, 1 p.

Research output: Contribution to journalArticle

Community Networks
Amyotrophic Lateral Sclerosis
Nervous System Diseases
Patient Care
Japan
76 Citations (Scopus)

Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey

Murai, H., Yamashita, N., Watanabe, M., Nomura, Y., Motomura, M., Yoshikawa, H., Nakamura, Y., Kawaguchi, N., Onodera, H., Araga, S., Isobe, N., Nagai, M. & Kira, J. I., Jun 15 2011, In : Journal of the Neurological Sciences. 305, 1-2, p. 97-102 6 p.

Research output: Contribution to journalArticle

Myasthenia Gravis
Age of Onset
Japan
Thymoma
Cholinergic Receptors
28 Citations (Scopus)
Porifera
Fibroblast Growth Factor 2
Fibroblasts
Stromal Cells
Brain Ischemia
5 Citations (Scopus)
Aptitude
Alzheimer Disease
Crows
Cerebrum
Temporal Lobe
40 Citations (Scopus)

Dietary intake of metals and risk of Parkinson's disease: A case-control study in Japan

Miyake, Y., Tanaka, K., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M., Baba, Y., Kobayashi, T., Sawada, H., Mizuta, E., Murase, N., Tsutada, T. & 34 others, Shimada, H., Kira, J. I., Kihira, T., Kondo, T., Tomimoto, H., Taniwaki, T., Sugiyama, H., Yoshida, S., Fujimura, H., Saito, T., Saida, K., Fujitake, J., Fujii, N., Naito, M., Arimizu, J., Nakagawa, T., Harada, H., Sueta, T., Kikuta, T., Umemoto, G., Uchio, E., Migita, H., Kazuki, K., Ito, Y., Iwaki, H., Siraki, K., Ataka, S., Yamane, H., Tochino, R., Harada, T., Iwashita, Y., Shimizu, M., Seki, K. & Ando, K., Jul 15 2011, In : Journal of the Neurological Sciences. 306, 1-2, p. 98-102 5 p.

Research output: Contribution to journalArticle

Parkinson Disease
Case-Control Studies
Japan
Metals
Zinc

Efficacy of high-frequency magnetic stimulation of the sacral root in patients with urinary incontinence following a radical prostatectomy

Kai, N., Kawajiri, M., Seki, N., Takano, N., Kira, J. I., Tobimatsu, S. & Naito, S., Apr 1 2011, In : LUTS: Lower Urinary Tract Symptoms. 3, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

Stress Urinary Incontinence
Urinary Incontinence
Prostatectomy
Urinary Bladder
Therapeutics

Erratum: Recurrent Hopkin's syndrome: A case report and review of the literature (Journal of the Neurological Sciences (2010) 297 (89-91))

Pavone, P., Longo, M. R., Scalia, F., Polosa, R., Kira, J. I. & Falsaperla, R., Apr 15 2011, In : Journal of the Neurological Sciences. 303, 1-2, 1 p.

Research output: Contribution to journalComment/debate

Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome

Doi, H., Arimura, K., Ohyagi, Y. & Kira, J. I., Jun 1 2011, In : Internal Medicine. 50, 10, p. 1113-1115 3 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Frostbite
Muscle Rigidity
Voltage-Gated Potassium Channels
Skin
1 Citation (Scopus)

Hyperexcitability restricted to the lower limb motor system in a patient with stiff-leg syndrome

Iwata, T., Shigeto, H., Ogata, K., Hagiwara, K. I., Kanamori, Y., Uehara, T., Ohyagi, Y., Tobimatsu, S. & Kira, J. I., Dec 1 2011, In : Journal of Clinical Neuroscience. 18, 12, p. 1720-1722 3 p.

Research output: Contribution to journalArticle

Lower Extremity
Leg
Stretch Reflex
Glutamate Decarboxylase
Transcranial Magnetic Stimulation
17 Citations (Scopus)

Impact and characteristics of quality of life in Japanese patients with multiple sclerosis

Kikuchi, H., Mifune, N., Niino, M., Ohbu, S., Kira, J. I., Kohriyama, T., Ota, K., Tanaka, M., Ochi, H., Nakane, S., Maezawa, M. & Kikuchi, S., Feb 1 2011, In : Quality of Life Research. 20, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Quality of Life
Social Adjustment
Medical Staff
Focus Groups
21 Citations (Scopus)

Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians

Fang, L., Isobe, N., Yoshimura, S., Yonekawa, T., Matsushita, T., Masaki, K., Doi, H., Ochi, K., Miyamoto, K., Kawano, Y. & Kira, J., Jun 14 2011, In : Neurology. 76, 24, p. 2125-2127 3 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
Neuromyelitis Optica
Genetic Predisposition to Disease
Gene Frequency
Multiple Sclerosis
59 Citations (Scopus)

Neuromyelitis optica and opticospinal multiple sclerosis: Mechanisms and pathogenesis

Kira, J. I., Feb 1 2011, In : Pathophysiology. 18, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Aquaporin 4
Immunoglobulin G
Myelin Sheath
Antibodies
2 Citations (Scopus)

Peripheral neuropathy, myelopathy, cerebellar ataxia, and subclinical optic neuropathy associated with copper deficiency occurring 23 years after total gastrectomy

Inaba, M., Torii, T., Shinoda, K., Yamasaki, R., Ohyagi, Y. & Kira, J-I., Jun 1 2011, In : Clinical Neurology. 51, 6, p. 412-416 5 p.

Research output: Contribution to journalLetter

Cerebellar Ataxia
Optic Nerve Diseases
Spinal Cord Diseases
Peripheral Nervous System Diseases
Gastrectomy
16 Citations (Scopus)

Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis

Pineda, A. A. M., Minohara, M., Kawamura, N., Matsushita, T., Yamasaki, R., Sun, X., Piao, H., Shimokawa, H. & Kira, J. I., Jul 15 2011, In : Journal of the Neurological Sciences. 306, 1-2, p. 115-120 6 p.

Research output: Contribution to journalArticle

Experimental Autoimmune Neuritis
rho-Associated Kinases
Therapeutic Uses
Phosphates
Interleukin-4
39 Citations (Scopus)

Reappraisal of aquaporin-4 astrocytopathy in asian neuromyelitis optica and multiple sclerosis patients

Matsuoka, T., Suzuki, S. O., Suenaga, T., Iwaki, T. & Kira, J. I., Sep 1 2011, In : Brain Pathology. 21, 5, p. 516-532 17 p.

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Multiple Sclerosis
Immunoglobulins
Glial Fibrillary Acidic Protein
14 Citations (Scopus)

Simultaneous Arterial Spin Labeling Cerebral Blood Flow and Morphological Assessments for Detection of Alzheimer's Disease

Dashjamts, T., Yoshiura, T., Hiwatashi, A., Yamashita, K., Monji, A., Ohyagi, Y., Kamano, H., Kawashima, T., Kira, J. I. & Honda, H., Dec 1 2011, In : Academic Radiology. 18, 12, p. 1492-1499 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Alzheimer Disease
Regional Blood Flow
Area Under Curve
Healthy Volunteers
18 Citations (Scopus)

SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients

McElroy, J. P., Isobe, N., Gourraud, P. A., Caillier, S. J., Matsushita, T., Kohriyama, T., Miyamoto, K., Nakatsuji, Y., Miki, T., Hauser, S. L., Oksenberg, J. R. & Kira, J., Oct 20 2011, In : Genes and Immunity. 12, 7, p. 523-530 8 p.

Research output: Contribution to journalArticle

HLA Antigens
Multiple Sclerosis
Single Nucleotide Polymorphism
Major Histocompatibility Complex
Aquaporin 4
4 Citations (Scopus)

T cell reactivities to myelin protein-derived peptides in neuromyelitis optica patients with anti-aquaporin-4 antibody

Yonekawa, T., Matsushita, T., Minohara, M., Isobe, N., Masaki, K., Yoshimura, S., Nishimura, Y. & Kira, J. I., Jun 1 2011, In : Neurology Asia. 16, 2, p. 139-142 4 p.

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Myelin Proteins
T-Lymphocytes
Peptides
9 Citations (Scopus)
Muscle Rigidity
Thymus Neoplasms
Encephalomyelitis
Thymectomy
Myoclonus
9 Citations (Scopus)

Tissue binding patterns and in vitro effects of campylobacter jejuni DNA-binding protein from starved cells

Piao, H., Minohara, M., Kawamura, N., Li, W., Matsushita, T., Yamasaki, R., Mizunoe, Y. & Kira, J. I., Jan 1 2011, In : Neurochemical Research. 36, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

Campylobacter jejuni
DNA-Binding Proteins
Tissue
Sulfoglycosphingolipids
Denaturation
1 Citation (Scopus)

Transient vocal cord palsy caused by hypoperfusion of unilateral hemisphere.

Takase, K. I., Shigeto, H., Furuta, K., Sakae, N., Ohyagi, Y. & Kira, J. I., Sep 2011, In : Fukuoka igaku zasshi = Hukuoka acta medica. 102, 9, p. 273-276 4 p.

Research output: Contribution to journalArticle

Vocal Cord Paralysis
Middle Cerebral Artery
Pathologic Constriction
Hoarseness
Dysarthria
13 Citations (Scopus)

Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody

Shinoda, K., Matsushita, T., Furuta, K., Isobe, N., Yonekawa, T., Ohyagi, Y. & Kira, J. I., Jul 2011, In : Multiple Sclerosis Journal. 17, 7, p. 885-887 3 p.

Research output: Contribution to journalLetter

Aquaporin 4
Neuromyelitis Optica
Ocular Motility Disorders
Antibodies
Tegmentum Mesencephali
2010
6 Citations (Scopus)

A case of acute disseminated encephalomyelitis associated with Epstein-Barr virus reactivation during infliximab therapy

Ueda, M., Tateishi, T., Shigeto, H., Yamasaki, R., Ohyagi, Y. & Kira, J. I., Jul 2010, In : Clinical Neurology. 50, 7, p. 461-466 6 p.

Research output: Contribution to journalArticle

Acute Disseminated Encephalomyelitis
Epstein-Barr Virus Infections
Progressive Bulbar Palsy
Human Herpesvirus 4
Ataxia